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ST002115 LC-MS analysis of metabolic changes induced by GPX4 inhibitor treatment in cultured HT1080 cellsList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (6)
REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (2)
REACT_160183
Abnormal metabolism in phenylketonuria (9)
REACT_121117
Acetylation (1)
REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Acetylcholine regulates insulin secretion (2)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of G protein gated Potassium channels (1)
REACT_75831
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of Rac (2)
REACT_19226
Activation of RAS in B cells (2)
REACT_118778
Activation of the phototransduction cascade (2)
REACT_163932
Adenylate cyclase activating pathway (2)
REACT_15312
Adenylate cyclase inhibitory pathway (2)
REACT_15333
ADP signalling through P2Y purinoceptor 1 (2)
REACT_19140
ADP signalling through P2Y purinoceptor 12 (2)
REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (2)
REACT_18339
Aflatoxin activation and detoxification (5)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
alpha-linolenic acid (ALA) metabolism (6)
REACT_121147
Alpha-oxidation of phytanate (5)
REACT_17003
Amino acid synthesis and interconversion (transamination) (12)
REACT_238
Amino acid transport across the plasma membrane (18)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (3)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (20)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19)
REACT_75842
ARMS-mediated activation (2)
REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (2)
REACT_121408
Attenuation phase (1)
REACT_200624
Axonal growth inhibition (RHOA activation) (2)
REACT_13815
Axonal growth stimulation (1)
REACT_13779
Beta oxidation of butanoyl-CoA to acetyl-CoA (3)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (4)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (4)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (4)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (4)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (4)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (4)
REACT_2025
Beta-oxidation of pristanoyl-CoA (4)
REACT_17017
Beta-oxidation of very long chain fatty acids (4)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (3)
REACT_22433
Biotin transport and metabolism (2)
REACT_11153
Branched-chain amino acid catabolism (10)
REACT_197
Ca2+ pathway (2)
REACT_172761
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (5)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
CD28 dependent Vav1 pathway (2)
REACT_19238
CDO in myogenesis (1)
REACT_21402
Cell redox homeostasis (4)
REACT_121394
Cholesterol biosynthesis (5)
REACT_9405
Chondroitin sulfate biosynthesis (2)
REACT_120989
Citric acid cycle (TCA cycle) (11)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (3)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Class II GLUTs (1)
REACT_19281
Clathrin derived vesicle budding (2)
REACT_19187
Cobalamin (Cbl, vitamin B12) transport and metabolism (6)
REACT_163862
Coenzyme A biosynthesis (2)
REACT_11218
Collagen biosynthesis and modifying enzymes (3)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (2)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (2)
REACT_12507
COPI Mediated Transport (2)
REACT_11096
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
CREB phosphorylation through the activation of Ras (1)
REACT_20568
Cross-presentation of particulate exogenous antigens (phagosomes) (1)
REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (18)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic iron-sulfur cluster assembly (3)
REACT_160176
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (19)
REACT_15306
DAP12 signaling (2)
REACT_147814
DARPP-32 events (1)
REACT_15334
DCC mediated attractive signaling (2)
REACT_22351
Deadenylation of mRNA (1)
REACT_20514
Defective B3GAT3 causes JDSSDHD (1)
REACT_267659
Defective CHSY1 causes TPBS (1)
REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1)
REACT_267674
Defective EXT2 causes exostoses 2 (1)
REACT_267654
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (2)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (3)
REACT_115654
Degradation of GABA (6)
REACT_23964
Detoxification of Reactive Oxygen Species (3)
REACT_172715
DNA replication initiation (3)
REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Downstream signal transduction (2)
REACT_17025
DSCAM interactions (1)
REACT_25299
EGFR downregulation (1)
REACT_12484
EGFR Transactivation by Gastrin (2)
REACT_121096
Eicosanoids (1)
REACT_13645
Electron transport from NADPH to Ferredoxin (2)
REACT_150128
Endogenous sterols (2)
REACT_13812
Endosomal/Vacuolar pathway (18)
REACT_111168
eNOS activation (4)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHA-mediated growth cone collapse (2)
REACT_228063
EPHB-mediated forward signaling (4)
REACT_228085
EPH-ephrin mediated repulsion of cells (2)
REACT_228189
Ephrin signaling (2)
REACT_228226
ER-Phagosome pathway (18)
REACT_111178
Establishment of Sister Chromatid Cohesion (1)
REACT_150266
Estrogen biosynthesis (1)
REACT_11037
Ethanol oxidation (4)
REACT_34
Eukaryotic Translation Elongation (2)
REACT_1477
Eukaryotic Translation Termination (2)
REACT_1986
Factors involved in megakaryocyte development and platelet production (3)
REACT_24970
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (2)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated MAPK activation (2)
REACT_163701
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (2)
REACT_13653
Formation of the active cofactor, UDP-glucuronate (4)
REACT_6737
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
Formation of the ternary complex, and subsequently, the 43S complex (1)
REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (1)
REACT_16956
Frs2-mediated activation (2)
REACT_12076
FRS2-mediated cascade (2)
REACT_21247
GABA A receptor activation (1)
REACT_24987
GABA A (rho) receptor activation (1)
REACT_25168
GABA B receptor activation (1)
REACT_25031
GABA synthesis (2)
REACT_24020
GABA synthesis, release, reuptake and degradation (1)
REACT_23947
Galactose catabolism (1)
REACT_532
G alpha (12/13) signalling events (2)
REACT_18407
G alpha (i) signalling events (8)
REACT_19231
G alpha (q) signalling events (6)
REACT_18283
G alpha (s) signalling events (4)
REACT_19327
G alpha (z) signalling events (2)
REACT_19333
Gap junction assembly (2)
REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (2)
REACT_18274
Glucagon signaling in metabolic regulation (2)
REACT_1665
Glucagon-type ligand receptors (1)
REACT_18377
Glucocorticoid biosynthesis (3)
REACT_11036
Gluconeogenesis (12)
REACT_1520
Glucuronidation (2)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (20)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycogen synthesis (3)
REACT_169208
Glycolysis (7)
REACT_1383
Glycosphingolipid metabolism (3)
REACT_116105
Glyoxylate metabolism (6)
REACT_16925
Golgi Associated Vesicle Biogenesis (2)
REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (1)
REACT_1100
G-protein activation (2)
REACT_15457
GPVI-mediated activation cascade (2)
REACT_1695
GRB2 events in EGFR signaling (2)
REACT_12606
GRB2 events in ERBB2 signaling (2)
REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1)
REACT_15443
GTP hydrolysis and joining of the 60S ribosomal subunit (2)
REACT_2085
HATs acetylate histones (1)
REACT_172610
HDMs demethylate histones (2)
REACT_228178
Hedgehog 'off' state (2)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Heme degradation (3)
REACT_22297
Histidine catabolism (3)
REACT_1249
HS-GAG biosynthesis (3)
REACT_121248
HS-GAG degradation (2)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Hypusine synthesis from eIF5A-lysine (2)
REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation of Cdc42 and Rac (2)
REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (3)
REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1)
REACT_25004
Integrin alphaIIb beta3 signaling (2)
REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
Interconversion of polyamines (2)
REACT_14805
Interleukin receptor SHC signaling (2)
REACT_23891
Iron uptake and transport (1)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (3)
REACT_121120
Kinesins (2)
REACT_25201
L13a-mediated translational silencing of Ceruloplasmin expression (1)
REACT_79
Ligand-gated ion channel transport (2)
REACT_25387
Linoleic acid (LA) metabolism (4)
REACT_121100
Lysine catabolism (7)
REACT_1298
Lysosome Vesicle Biogenesis (2)
REACT_19287
MEK activation (1)
REACT_962
Metabolism of folate and pterines (5)
REACT_11167
Metabolism of nucleotides (3)
REACT_1698
Metabolism of polyamines (1)
REACT_14820
Metabolism of serotonin (3)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (5)
REACT_6946
MHC class II antigen presentation (2)
REACT_121399
MicroRNA (miRNA) biogenesis (2)
REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (2)
REACT_11039
Mineralocorticoid biosynthesis (3)
REACT_11047
Minus-strand DNA synthesis (3)
REACT_9055
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (4)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (4)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (4)
REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial translation elongation (2)
REACT_267677
Mitochondrial translation initiation (2)
REACT_267680
Mitochondrial translation termination (2)
REACT_267602
Mitochondrial tRNA aminoacylation (19)
REACT_15302
Mitotic Prometaphase (2)
REACT_682
Molybdenum cofactor biosynthesis (4)
REACT_25073
MPS IIIC - Sanfilippo syndrome C (1)
REACT_147860
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3)
REACT_20518
Mtb iron assimilation by chelation (1)
REACT_121118
mTOR signalling (2)
REACT_6838
Na+/Cl- dependent neurotransmitter transporters (17)
REACT_20506
NADPH regeneration (2)
REACT_16904
NCAM signaling for neurite out-growth (2)
REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (2)
REACT_6179
N-glycan trimming and elongation in the cis-Golgi (1)
REACT_25210
Nicotinate metabolism (5)
REACT_11088
Nitric oxide stimulates guanylate cyclase (3)
REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1)
REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1)
REACT_75768
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (2)
REACT_12510
NOSTRIN mediated eNOS trafficking (2)
REACT_12541
NRAGE signals death through JNK (2)
REACT_13638
Nuclear import of Rev protein (2)
REACT_9395
O-linked glycosylation of mucins (1)
REACT_115606
Organic anion transport (3)
REACT_22310
Organic anion transporters (3)
REACT_19372
Orphan transporters (4)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
p130Cas linkage to MAPK signaling for integrins (1)
REACT_15381
P2Y receptors (2)
REACT_18289
p38MAPK events (2)
REACT_12065
PAOs oxidise polyamines to amines (1)
REACT_505
PCP/CE pathway (1)
REACT_172581
PDE3B signalling (1)
REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
Peptide chain elongation (2)
REACT_1404
Peroxisomal lipid metabolism (1)
REACT_16957
Phagosomal maturation (early endosomal stage) (4)
REACT_121256
Phenylalanine and tyrosine catabolism (9)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
PKA activation in glucagon signalling (1)
REACT_1946
Plasmalogen biosynthesis (2)
REACT_1407
Platelet degranulation (2)
REACT_318
PLC beta mediated events (2)
REACT_15426
Post-chaperonin tubulin folding pathway (1)
REACT_16967
PPARA activates gene expression (1)
REACT_116145
Pregnenolone biosynthesis (1)
REACT_11038
Pre-NOTCH Processing in Golgi (2)
REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (2)
REACT_118722
Presynaptic function of Kainate receptors (1)
REACT_21254
Processive synthesis on the C-strand of the telomere (3)
REACT_8027
Proline catabolism (5)
REACT_1002
Prostacyclin signalling through prostacyclin receptor (2)
REACT_23946
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (18)
REACT_19328
Purine catabolism (6)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (10)
REACT_1776
Purine salvage (4)
REACT_1923
Pyrimidine biosynthesis (5)
REACT_21376
Pyrimidine catabolism (8)
REACT_1023
Pyrimidine salvage reactions (3)
REACT_655
Pyruvate metabolism (6)
REACT_2071
RAF activation (1)
REACT_2077
RAF phosphorylates MEK (1)
REACT_614
Rap1 signalling (2)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (4)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recruitment of NuMA to mitotic centrosomes (2)
REACT_15510
Recycling of bile acids and salts (3)
REACT_11042
Recycling of eIF2:GDP (2)
REACT_1815
Recycling pathway of L1 (2)
REACT_22365
Regulation of actin dynamics for phagocytic cup formation (2)
REACT_160086
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of PLK1 Activity at G2/M Transition (1)
REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (4)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (3)
REACT_21393
Regulation of thyroid hormone activity (1)
REACT_15297
Release of eIF4E (1)
REACT_6836
Removal of the Flap Intermediate (3)
REACT_70
Removal of the Flap Intermediate from the C-strand (3)
REACT_7999
Resolution of Sister Chromatid Cohesion (3)
REACT_150425
Respiratory electron transport (5)
REACT_22393
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (1)
REACT_24968
Retrograde neurotrophin signalling (2)
REACT_12435
Reuptake of GABA (1)
REACT_23910
Rev-mediated nuclear export of HIV RNA (2)
REACT_6190
Rho GTPase cycle (2)
REACT_11051
Ribosomal scanning and start codon recognition (1)
REACT_931
RNA Polymerase I Transcription Initiation (1)
REACT_953
S6K1-mediated signalling (1)
REACT_6754
Sema3A PAK dependent Axon repulsion (1)
REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (2)
REACT_19279
Sema4D induced cell migration and growth-cone collapse (2)
REACT_19277
Sema4D mediated inhibition of cell attachment and migration (2)
REACT_19266
Separation of Sister Chromatids (3)
REACT_150471
Serine biosynthesis (6)
REACT_115789
Serotonin and melatonin biosynthesis (2)
REACT_15439
SHC1 events in EGFR signaling (2)
REACT_12579
SHC1 events in ERBB2 signaling (2)
REACT_115993
SHC1 events in ERBB4 signaling (2)
REACT_116005
SHC-mediated cascade (2)
REACT_21374
SHC-mediated signalling (2)
REACT_661
Sialic acid metabolism (4)
REACT_200874
Signaling by constitutively active EGFR (2)
REACT_115852
Signaling by FGFR mutants (2)
REACT_121398
Signaling by SCF-KIT (2)
REACT_111040
Signalling to p38 via RIT and RIN (2)
REACT_12077
Signalling to RAS (2)
REACT_12033
Signal transduction by L1 (2)
REACT_22272
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
SOS-mediated signalling (2)
REACT_524
Sphingolipid de novo biosynthesis (4)
REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1)
REACT_13438
Stimuli-sensing channels (2)
REACT_160189
STING mediated induction of host immune responses (1)
REACT_147841
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (6)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (17)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (4)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (2)
REACT_150209
Synthesis of bile acids and bile salts (2)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (4)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (4)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7)
REACT_11041
Synthesis of CL (1)
REACT_120920
Synthesis of Dolichyl-phosphate (3)
REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of GDP-mannose (1)
REACT_22423
Synthesis of glycosylphosphatidylinositol (GPI) (1)
REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (2)
REACT_150352
Synthesis of Ketone Bodies (3)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (4)
REACT_150420
Synthesis of Lipoxins (LX) (3)
REACT_150320
Synthesis of PA (3)
REACT_120906
Synthesis of PC (3)
REACT_121238
Synthesis of PE (3)
REACT_120919
Synthesis of PG (3)
REACT_121280
Synthesis of PI (2)
REACT_121000
Synthesis of PIPs at the Golgi membrane (1)
REACT_120836
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (4)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Telomere C-strand synthesis initiation (3)
REACT_7993
Telomere Extension By Telomerase (3)
REACT_7974
Termination of O-glycan biosynthesis (1)
REACT_115835
TET1,2,3 and TDG demethylate DNA (2)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (5)
REACT_111176
The activation of arylsulfatases (2)
REACT_121036
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The proton buffering model (2)
REACT_6196
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (2)
REACT_21384
Thromboxane signalling through TP receptor (2)
REACT_20647
Thyroxine biosynthesis (4)
REACT_15292
Tie2 Signaling (2)
REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (2)
REACT_120983
Transcriptional regulation by small RNAs (1)
REACT_267668
Translation initiation complex formation (1)
REACT_1979
Translocation of GLUT4 to the plasma membrane (3)
REACT_147867
Transport of inorganic cations/anions and amino acids/oligopeptides (4)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3)
REACT_1206
Transport of nucleotide sugars (3)
REACT_22151
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (3)
REACT_1190
Tryptophan catabolism (10)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (6)
REACT_847
Utilization of Ketone Bodies (4)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (2)
REACT_24023
VEGFA-VEGFR2 Pathway (4)
REACT_228166
VEGFR2 mediated cell proliferation (1)
REACT_228024
VEGFR2 mediated vascular permeability (5)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (4)
REACT_11070
Vitamin C (ascorbate) metabolism (4)
REACT_11202
Vitamin D (calciferol) metabolism (1)
REACT_13523
Vitamins (1)
REACT_13450
Vitamins B6 activation to pyridoxal phosphate (3)
REACT_25012
Xenobiotics (1)
REACT_13543
Metabolomics Workbench
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