ST002208 Metabolomic analysis to assess response to immunotherapy for malignant brain tumors: Part 2
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (3) REACT_121117
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (2) REACT_238
Amino acid transport across the plasma membrane (7) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (6) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (6) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Branched-chain amino acid catabolism (3) REACT_197
Carnitine synthesis (2) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Creatine metabolism (2) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (6) REACT_111056
Cytosolic tRNA aminoacylation (6) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (2) REACT_23964
Endosomal/Vacuolar pathway (6) REACT_111168
ER-Phagosome pathway (6) REACT_111178
Ethanol oxidation (1) REACT_34
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (1) REACT_21268
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (1) REACT_18283
Gluconeogenesis (2) REACT_1520
Glutathione synthesis and recycling (6) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (1) REACT_16925
HDMs demethylate histones (2) REACT_228178
Histidine catabolism (1) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
Hydrolysis of LPC (1) REACT_120977
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Lysine catabolism (1) REACT_1298
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (6) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (7) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (2) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (2) REACT_22357
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
Phenylalanine and tyrosine catabolism (4) REACT_1786
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (6) REACT_19328
Pyrimidine catabolism (2) REACT_1023
Pyruvate metabolism (1) REACT_2071
Recycling of bile acids and salts (1) REACT_11042
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (1) REACT_115789
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sulfur amino acid metabolism (1) REACT_115639
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The fatty acid cycling model (1) REACT_6258
Thyroxine biosynthesis (2) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Tryptophan catabolism (3) REACT_916
Utilization of Ketone Bodies (1) REACT_59
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