ST002211 Effects of Medwakh Smoking on Oxidative Stress and Inflammation Among Youth in UAE using Liquid chromatography-mass spectrometry
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (4) REACT_228214
Agmatine biosynthesis (2) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (10) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (2) REACT_197
Carnitine synthesis (1) REACT_2125
Cell redox homeostasis (1) REACT_121394
Cholesterol biosynthesis (1) REACT_9405
Citric acid cycle (TCA cycle) (2) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of particulate exogenous antigens (phagosomes) (1) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (9) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cytosolic iron-sulfur cluster assembly (1) REACT_160176
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (9) REACT_15306
Defective BTD causes biotidinase deficiency (1) REACT_169403
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC (1) REACT_169169
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1) REACT_169439
degradation of AXIN (1) REACT_200766
Degradation of GABA (1) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (1) REACT_9472
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Eicosanoids (1) REACT_13645
Electron transport from NADPH to Ferredoxin (1) REACT_150128
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (9) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (9) REACT_111178
Estrogen biosynthesis (1) REACT_11037
Ethanol oxidation (1) REACT_34
Fatty acids (1) REACT_13814
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
FMO oxidises nucleophiles (2) REACT_13653
Free fatty acid receptors (1) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (4) REACT_18283
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (2) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (10) REACT_6960
Glycogen synthesis (1) REACT_169208
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
Heme biosynthesis (1) REACT_9465
Heme degradation (1) REACT_22297
Histidine catabolism (2) REACT_1249
HS-GAG biosynthesis (2) REACT_121248
Iron uptake and transport (1) REACT_25060
Keratan sulfate biosynthesis (1) REACT_121120
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (3) REACT_1298
Metabolism of folate and pterines (3) REACT_11167
Methionine salvage pathway (1) REACT_75881
Methylation (2) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (2) REACT_13425
Mitochondrial tRNA aminoacylation (9) REACT_15302
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Mtb iron assimilation by chelation (1) REACT_121118
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
NADPH regeneration (1) REACT_16904
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Passive transport by Aquaporins (1) REACT_23826
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
Pregnenolone biosynthesis (1) REACT_11038
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (9) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (7) REACT_1023
Pyrimidine salvage reactions (5) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of thyroid hormone activity (1) REACT_15297
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (1) REACT_24968
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
Sphingolipid de novo biosynthesis (2) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (1) REACT_13438
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (4) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1) REACT_150134
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts (1) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Dolichyl-phosphate (1) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1) REACT_150417
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (8) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Tryptophan catabolism (4) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (3) REACT_847
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin D (calciferol) metabolism (1) REACT_13523
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (2) REACT_25012
Xenobiotics (1) REACT_13543
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