ST002235 Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Acetylcholine Neurotransmitter Release Cycle (1) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (5) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (5) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (5) REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Branched-chain amino acid catabolism (1) REACT_197
Carnitine synthesis (1) REACT_2125
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Conjugation of phenylacetate with glutamine (2) REACT_6800
Creatine metabolism (1) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (5) REACT_111056
Cytosolic tRNA aminoacylation (5) REACT_15306
Degradation of GABA (1) REACT_23964
Endosomal/Vacuolar pathway (5) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (5) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Free fatty acid receptors (1) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (3) REACT_18283
Glucocorticoid biosynthesis (1) REACT_11036
Gluconeogenesis (1) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (5) REACT_6960
Histidine catabolism (2) REACT_1249
Hydrolysis of LPC (1) REACT_120977
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Mitochondrial tRNA aminoacylation (5) REACT_15302
Na+/Cl- dependent neurotransmitter transporters (4) REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transporters (1) REACT_19372
Organic cation transport (1) REACT_22357
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (1) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (5) REACT_19328
Purine catabolism (1) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Role of phospholipids in phagocytosis (1) REACT_160158
Serine biosynthesis (1) REACT_115789
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
Transport of fatty acids (1) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (1) REACT_1206
Tryptophan catabolism (1) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (2) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
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