ST002250 Ramadan diurnal intermittent fasting is associated with significant plasma metabolomics changes in overweight and obese subjects: A prospective cohort study
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (2) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (1) REACT_163932
Adenylate cyclase activating pathway (1) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (2) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1) REACT_19180
Adrenoceptors (1) REACT_16927
Agmatine biosynthesis (2) REACT_14800
Amino acid synthesis and interconversion (transamination) (2) REACT_238
Amino acid transport across the plasma membrane (7) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (7) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (6) REACT_75842
ARMS-mediated activation (1) REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Branched-chain amino acid catabolism (1) REACT_197
Ca2+ pathway (1) REACT_172761
Catecholamine biosynthesis (1) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
CDO in myogenesis (1) REACT_21402
Citric acid cycle (TCA cycle) (1) REACT_1785
Class C/3 (Metabotropic glutamate/pheromone receptors) (3) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of Ras (1) REACT_20568
Cross-presentation of soluble exogenous antigens (endosomes) (6) REACT_111056
CYP2E1 reactions (1) REACT_13797
Cytosolic sulfonation of small molecules (3) REACT_6913
Cytosolic tRNA aminoacylation (6) REACT_15306
DAP12 signaling (1) REACT_147814
DCC mediated attractive signaling (1) REACT_22351
Downstream signal transduction (1) REACT_17025
DSCAM interactions (1) REACT_25299
EGFR downregulation (1) REACT_12484
EGFR Transactivation by Gastrin (1) REACT_121096
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (6) REACT_111168
eNOS activation (1) REACT_12477
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (1) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (6) REACT_111178
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
FCERI mediated MAPK activation (1) REACT_163701
FMO oxidises nucleophiles (1) REACT_13653
Formation of the ternary complex, and subsequently, the 43S complex (1) REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (1) REACT_16956
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
G alpha (12/13) signalling events (2) REACT_18407
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (4) REACT_18283
G alpha (s) signalling events (3) REACT_19327
G alpha (z) signalling events (2) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (1) REACT_1520
Glucuronidation (2) REACT_6784
Glutathione synthesis and recycling (7) REACT_6960
Golgi Associated Vesicle Biogenesis (1) REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (1) REACT_1100
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1) REACT_15443
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
Hedgehog 'off' state (1) REACT_267634
Histidine catabolism (1) REACT_1249
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interleukin receptor SHC signaling (1) REACT_23891
Kinesins (1) REACT_25201
L13a-mediated translational silencing of Ceruloplasmin expression (1) REACT_79
Ligand-gated ion channel transport (1) REACT_25387
Lysosome Vesicle Biogenesis (1) REACT_19287
MEK activation (1) REACT_962
Metabolism of serotonin (2) REACT_15532
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (2) REACT_13425
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (6) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (1) REACT_1470
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
Organic anion transport (2) REACT_22310
Organic cation transport (3) REACT_22357
Orphan transporters (1) REACT_267716
p130Cas linkage to MAPK signaling for integrins (1) REACT_15381
p38MAPK events (1) REACT_12065
Passive transport by Aquaporins (1) REACT_23826
PCP/CE pathway (1) REACT_172581
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
PKA activation in glucagon signalling (1) REACT_1946
Platelet degranulation (2) REACT_318
PLC beta mediated events (1) REACT_15426
Post-chaperonin tubulin folding pathway (1) REACT_16967
Pregnenolone biosynthesis (1) REACT_11038
Proline catabolism (1) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (6) REACT_19328
Purine catabolism (4) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1) REACT_1776
Purine salvage (3) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
RAF activation (1) REACT_2077
RAF phosphorylates MEK (1) REACT_614
Rap1 signalling (1) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of insulin secretion (1) REACT_18325
Regulation of PLK1 Activity at G2/M Transition (1) REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Regulation of thyroid hormone activity (1) REACT_15297
Release of eIF4E (1) REACT_6836
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Retrograde neurotrophin signalling (1) REACT_12435
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
Ribosomal scanning and start codon recognition (1) REACT_931
S6K1-mediated signalling (1) REACT_6754
Sema3A PAK dependent Axon repulsion (1) REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Separation of Sister Chromatids (1) REACT_150471
Serotonin and melatonin biosynthesis (2) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of PIPs at the Golgi membrane (1) REACT_120836
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2) REACT_111176
The proton buffering model (1) REACT_6196
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Thyroxine biosynthesis (1) REACT_15292
Tie2 Signaling (1) REACT_12621
Transcriptional regulation by small RNAs (1) REACT_267668
Translation initiation complex formation (1) REACT_1979
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2) REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (4) REACT_916
Urea cycle (2) REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1) REACT_24023
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamins (1) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
Xenobiotics (1) REACT_13543
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