ST002317 Mass spectroscopy‑based proteomics and metabolomics analysis of triple‑positive breast cancer cells treated with tamoxifen
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2) REACT_850
Abacavir metabolism (3) REACT_121388
Abnormal metabolism in phenylketonuria (2) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of the phototransduction cascade (1) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (9) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (3) REACT_197
Ca2+ pathway (1) REACT_172761
Cam-PDE 1 activation (1) REACT_15408
Catecholamine biosynthesis (1) REACT_15551
cGMP effects (1) REACT_23767
Chondroitin sulfate biosynthesis (1) REACT_120989
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Coenzyme A biosynthesis (1) REACT_11218
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8) REACT_111056
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (9) REACT_15306
DARPP-32 events (1) REACT_15334
Deadenylation of mRNA (1) REACT_20514
Degradation of GABA (1) REACT_23964
Dermatan sulfate biosynthesis (1) REACT_120800
Detoxification of Reactive Oxygen Species (1) REACT_172715
Endosomal/Vacuolar pathway (8) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (8) REACT_111178
Ethanol oxidation (1) REACT_34
Factors involved in megakaryocyte development and platelet production (1) REACT_24970
FCERI mediated NF-kB activation (1) REACT_163994
FMO oxidises nucleophiles (1) REACT_13653
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (2) REACT_19231
G alpha (q) signalling events (2) REACT_18283
G alpha (s) signalling events (2) REACT_19327
Gluconeogenesis (2) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (10) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycogen synthesis (1) REACT_169208
Glycolysis (1) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Histidine catabolism (1) REACT_1249
HS-GAG biosynthesis (2) REACT_121248
Interconversion of polyamines (1) REACT_14805
ISG15 antiviral mechanism (1) REACT_115831
Keratan sulfate biosynthesis (3) REACT_121120
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (1) REACT_75881
Methylation (2) REACT_6946
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial tRNA aminoacylation (9) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (1) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
NGF-independant TRKA activation (1) REACT_11046
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transporters (1) REACT_19372
Organic cation transport (1) REACT_22357
PAOs oxidise polyamines to amines (1) REACT_505
PDE3B signalling (1) REACT_1451
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (8) REACT_19328
Purine catabolism (9) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (8) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (4) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation by TREX1 (1) REACT_163652
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of Rheb GTPase activity by AMPK (1) REACT_21393
Removal of the Flap Intermediate (4) REACT_70
Removal of the Flap Intermediate from the C-strand (4) REACT_7999
Respiratory electron transport (1) REACT_22393
Reuptake of GABA (1) REACT_23910
Scavenging by Class A Receptors (1) REACT_163699
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (2) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (7) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PC (1) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Termination of O-glycan biosynthesis (1) REACT_115835
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
Thyroxine biosynthesis (1) REACT_15292
Translocation of GLUT4 to the plasma membrane (1) REACT_147867
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6) REACT_1206
Transport of nucleotide sugars (3) REACT_22151
Tryptophan catabolism (3) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin B5 (pantothenate) metabolism (1) REACT_11172
Vitamin C (ascorbate) metabolism (1) REACT_11202
Xenobiotics (1) REACT_13543
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