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ST002317 Mass spectroscopy‑based proteomics and metabolomics analysis of triple‑positive breast cancer cells treated with tamoxifenList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (3)
REACT_121388
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of the phototransduction cascade (1)
REACT_163932
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
alpha-linolenic acid (ALA) metabolism (1)
REACT_121147
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (3)
REACT_238
Amino acid transport across the plasma membrane (9)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (8)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9)
REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (3)
REACT_197
Ca2+ pathway (1)
REACT_172761
Cam-PDE 1 activation (1)
REACT_15408
Catecholamine biosynthesis (1)
REACT_15551
cGMP effects (1)
REACT_23767
Chondroitin sulfate biosynthesis (1)
REACT_120989
Class C/3 (Metabotropic glutamate/pheromone receptors) (2)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Coenzyme A biosynthesis (1)
REACT_11218
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (1)
REACT_6812
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (8)
REACT_111056
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (9)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Degradation of GABA (1)
REACT_23964
Dermatan sulfate biosynthesis (1)
REACT_120800
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Endosomal/Vacuolar pathway (8)
REACT_111168
eNOS activation (1)
REACT_12477
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (8)
REACT_111178
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (1)
REACT_13653
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (2)
REACT_19231
G alpha (q) signalling events (2)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Gluconeogenesis (2)
REACT_1520
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (10)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycogen synthesis (1)
REACT_169208
Glycolysis (1)
REACT_1383
Glycosphingolipid metabolism (1)
REACT_116105
Histidine catabolism (1)
REACT_1249
HS-GAG biosynthesis (2)
REACT_121248
Interconversion of polyamines (1)
REACT_14805
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (3)
REACT_121120
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (1)
REACT_1298
Metabolism of folate and pterines (1)
REACT_11167
Metabolism of polyamines (2)
REACT_14820
Methionine salvage pathway (1)
REACT_75881
Methylation (2)
REACT_6946
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
Mitochondrial tRNA aminoacylation (9)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
mRNA Capping (1)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (8)
REACT_20506
NGF-independant TRKA activation (1)
REACT_11046
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
Organic anion transporters (1)
REACT_19372
Organic cation transport (1)
REACT_22357
PAOs oxidise polyamines to amines (1)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (2)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
Pre-NOTCH Processing in Golgi (1)
REACT_118798
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (8)
REACT_19328
Purine catabolism (9)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3)
REACT_1776
Purine salvage (8)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (4)
REACT_1023
Pyrimidine salvage reactions (3)
REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Regulation by TREX1 (1)
REACT_163652
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (4)
REACT_70
Removal of the Flap Intermediate from the C-strand (4)
REACT_7999
Respiratory electron transport (1)
REACT_22393
Reuptake of GABA (1)
REACT_23910
Scavenging by Class A Receptors (1)
REACT_163699
Serine biosynthesis (1)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sialic acid metabolism (1)
REACT_200874
Sphingolipid de novo biosynthesis (1)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (2)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (7)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of CL (1)
REACT_120920
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PC (1)
REACT_121238
Synthesis of PE (1)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1)
REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Termination of O-glycan biosynthesis (1)
REACT_115835
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (1)
REACT_15292
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6)
REACT_1206
Transport of nucleotide sugars (3)
REACT_22151
Tryptophan catabolism (3)
REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (3)
REACT_847
VEGFR2 mediated cell proliferation (1)
REACT_228024
VEGFR2 mediated vascular permeability (1)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (1)
REACT_11070
Vitamin B5 (pantothenate) metabolism (1)
REACT_11172
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Xenobiotics (1)
REACT_13543
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