ST002407 Spatial, temporal, and inter-subject variation of the metabolome along the human upper intestinal tract
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (3) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (14) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (12) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (12) REACT_75842
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (2) REACT_197
Ca2+ pathway (1) REACT_172761
cGMP effects (1) REACT_23767
Circadian Clock (1) REACT_24941
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (6) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Conjugation of benzoate with glycine (2) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (2) REACT_6812
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (12) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (12) REACT_15306
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Endosomal/Vacuolar pathway (12) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (12) REACT_111178
Fructose catabolism (1) REACT_1571
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (4) REACT_18283
Gluconeogenesis (3) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (12) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (2) REACT_16925
Histidine catabolism (2) REACT_1249
HS-GAG degradation (1) REACT_120752
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Iron uptake and transport (1) REACT_25060
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (12) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (11) REACT_20506
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (3) REACT_23862
Organic anion transport (1) REACT_22310
Organic anion transporters (2) REACT_19372
Orphan transporters (2) REACT_267716
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
PPARA activates gene expression (1) REACT_116145
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (12) REACT_19328
Purine catabolism (5) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3) REACT_1776
Purine salvage (5) REACT_1923
Pyrimidine biosynthesis (4) REACT_21376
Pyrimidine catabolism (8) REACT_1023
Pyrimidine salvage reactions (6) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (1) REACT_11042
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid metabolism and transport (1) REACT_24968
REV-ERBA represses gene expression (1) REACT_118789
RORA activates circadian gene expression (1) REACT_118659
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (3) REACT_15439
Sialic acid metabolism (1) REACT_200874
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of organic anions (1) REACT_23988
Tryptophan catabolism (5) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (6) REACT_847
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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