ST002415 Proteomics and metabolomics of multiple sclerosis
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1) REACT_850
Abacavir metabolism (3) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (1) REACT_121117
Acetylcholine regulates insulin secretion (1) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1) REACT_200686
Activation of Rac (1) REACT_19226
Activation of RAS in B cells (1) REACT_118778
Activation of the phototransduction cascade (2) REACT_163932
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (2) REACT_15312
Adenylate cyclase inhibitory pathway (1) REACT_15333
ADP signalling through P2Y purinoceptor 1 (1) REACT_19140
ADP signalling through P2Y purinoceptor 12 (1) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Aflatoxin activation and detoxification (2) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (2) REACT_17003
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (3) REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1) REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (4) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (4) REACT_75842
Arachidonate production from DAG (1) REACT_19308
ARMS-mediated activation (1) REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Axonal growth inhibition (RHOA activation) (1) REACT_13815
Axonal growth stimulation (1) REACT_13779
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (1) REACT_197
Ca2+ pathway (2) REACT_172761
Cam-PDE 1 activation (2) REACT_15408
Carnitine synthesis (1) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
CD28 dependent Vav1 pathway (1) REACT_19238
cGMP effects (1) REACT_23767
Citric acid cycle (TCA cycle) (2) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Clathrin derived vesicle budding (1) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (1) REACT_12507
COPI Mediated Transport (1) REACT_11096
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1) REACT_20625
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (3) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (4) REACT_15306
DAP12 signaling (1) REACT_147814
DARPP-32 events (2) REACT_15334
DCC mediated attractive signaling (1) REACT_22351
Deadenylation of mRNA (1) REACT_20514
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (2) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary lipid (2) REACT_9518
DNA methylation (1) REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Downstream signal transduction (1) REACT_17025
EGFR Transactivation by Gastrin (1) REACT_121096
Endosomal/Vacuolar pathway (3) REACT_111168
Enzymatic degradation of dopamine by COMT (1) REACT_15548
EPHA-mediated growth cone collapse (1) REACT_228063
EPHB-mediated forward signaling (2) REACT_228085
EPH-ephrin mediated repulsion of cells (1) REACT_228189
Ephrin signaling (1) REACT_228226
ER-Phagosome pathway (3) REACT_111178
Ethanol oxidation (1) REACT_34
Eukaryotic Translation Elongation (1) REACT_1477
Eukaryotic Translation Termination (1) REACT_1986
Factors involved in megakaryocyte development and platelet production (2) REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
FCERI mediated MAPK activation (1) REACT_163701
FCERI mediated NF-kB activation (1) REACT_163994
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (1) REACT_21268
Frs2-mediated activation (1) REACT_12076
FRS2-mediated cascade (1) REACT_21247
GABA synthesis (1) REACT_24020
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (6) REACT_19231
G alpha (q) signalling events (3) REACT_18283
G alpha (s) signalling events (5) REACT_19327
G alpha (z) signalling events (2) REACT_19333
Gap junction assembly (1) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (2) REACT_18274
Glucagon signaling in metabolic regulation (1) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Gluconeogenesis (4) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (5) REACT_6960
Glycogen breakdown (glycogenolysis) (1) REACT_1008
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (1) REACT_116105
Golgi Associated Vesicle Biogenesis (1) REACT_19400
G-protein activation (1) REACT_15457
GPVI-mediated activation cascade (1) REACT_1695
GRB2 events in EGFR signaling (1) REACT_12606
GRB2 events in ERBB2 signaling (1) REACT_115854
GTP hydrolysis and joining of the 60S ribosomal subunit (1) REACT_2085
HCN channels (1) REACT_75862
HDMs demethylate histones (1) REACT_228178
Hedgehog 'off' state (2) REACT_267634
Histidine catabolism (1) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG degradation (1) REACT_120752
Inactivation of Cdc42 and Rac (1) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Integrin alphaIIb beta3 signaling (1) REACT_15523
Interconversion of polyamines (1) REACT_14805
Interleukin receptor SHC signaling (1) REACT_23891
ISG15 antiviral mechanism (1) REACT_115831
Kinesins (1) REACT_25201
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Lysosome Vesicle Biogenesis (1) REACT_19287
Meiotic recombination (1) REACT_27271
Metabolism of folate and pterines (1) REACT_11167
Metabolism of nucleotides (1) REACT_1698
Metabolism of polyamines (2) REACT_14820
Methionine salvage pathway (2) REACT_75881
Methylation (3) REACT_6946
MHC class II antigen presentation (1) REACT_121399
MicroRNA (miRNA) biogenesis (1) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (1) REACT_11039
Miscellaneous substrates (1) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1) REACT_228145
Mitochondrial translation elongation (1) REACT_267677
Mitochondrial translation initiation (1) REACT_267680
Mitochondrial translation termination (1) REACT_267602
Mitochondrial tRNA aminoacylation (4) REACT_15302
Mitotic Prometaphase (1) REACT_682
Molybdenum cofactor biosynthesis (1) REACT_25073
mRNA Capping (3) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (2) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (2) REACT_20518
mTOR signalling (1) REACT_6838
Na+/Cl- dependent neurotransmitter transporters (1) REACT_20506
NCAM signaling for neurite out-growth (1) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (1) REACT_6179
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
NoRC negatively regulates rRNA expression (1) REACT_200856
NRAGE signals death through JNK (1) REACT_13638
Nuclear import of Rev protein (1) REACT_9395
Organic anion transporters (2) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (1) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
p38MAPK events (1) REACT_12065
PAOs oxidise polyamines to amines (1) REACT_505
Passive transport by Aquaporins (2) REACT_23826
PDE3B signalling (2) REACT_1451
Peptide chain elongation (1) REACT_1404
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (3) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
PKA activation (1) REACT_15530
PKA activation in glucagon signalling (1) REACT_1946
Platelet degranulation (1) REACT_318
PLC beta mediated events (1) REACT_15426
PRC2 methylates histones and DNA (1) REACT_200808
Pre-NOTCH Processing in the Endoplasmic Reticulum (1) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Prostacyclin signalling through prostacyclin receptor (1) REACT_23946
Proton/oligonucleotide cotransporters (3) REACT_19328
Purine catabolism (8) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (5) REACT_1776
Purine salvage (8) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (3) REACT_1023
Pyrimidine salvage reactions (3) REACT_655
Rap1 signalling (2) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1) REACT_25302
Recruitment of NuMA to mitotic centrosomes (1) REACT_15510
Recycling of bile acids and salts (2) REACT_11042
Recycling of eIF2:GDP (1) REACT_1815
Recycling pathway of L1 (1) REACT_22365
Regulation of actin dynamics for phagocytic cup formation (1) REACT_160086
Regulation of AMPK activity via LKB1 (1) REACT_21285
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of Rheb GTPase activity by AMPK (2) REACT_21393
Removal of the Flap Intermediate (2) REACT_70
Removal of the Flap Intermediate from the C-strand (2) REACT_7999
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (1) REACT_22393
Retrograde neurotrophin signalling (1) REACT_12435
Rev-mediated nuclear export of HIV RNA (1) REACT_6190
Rho GTPase cycle (1) REACT_11051
RMTs methylate histone arginines (1) REACT_228108
Scavenging by Class A Receptors (1) REACT_163699
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (1) REACT_19279
Sema4D induced cell migration and growth-cone collapse (1) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (1) REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (1) REACT_169168
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (1) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
SHC1 events in EGFR signaling (1) REACT_12579
SHC1 events in ERBB2 signaling (1) REACT_115993
SHC1 events in ERBB4 signaling (1) REACT_116005
SHC-mediated cascade (1) REACT_21374
SHC-mediated signalling (1) REACT_661
Signaling by constitutively active EGFR (1) REACT_115852
Signaling by FGFR mutants (1) REACT_121398
Signaling by SCF-KIT (1) REACT_111040
Signalling to p38 via RIT and RIN (1) REACT_12077
Signalling to RAS (1) REACT_12033
Signal transduction by L1 (1) REACT_22272
SIRT1 negatively regulates rRNA Expression (2) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
SOS-mediated signalling (1) REACT_524
Sphingolipid de novo biosynthesis (2) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (3) REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1) REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (5) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of PC (1) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (1) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
The proton buffering model (1) REACT_6196
Thrombin signalling through proteinase activated receptors (PARs) (1) REACT_21384
Thromboxane signalling through TP receptor (1) REACT_20647
Tie2 Signaling (1) REACT_12621
Translocation of GLUT4 to the plasma membrane (2) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Transport of organic anions (1) REACT_23988
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (2) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Uptake and function of anthrax toxins (1) REACT_228255
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (1) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (2) REACT_24023
VEGFA-VEGFR2 Pathway (1) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (1) REACT_11202
  logo