ST002475 Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college students via modulating the gut microbiota and its metabolism
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (1) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Agmatine biosynthesis (1) REACT_14800
Alpha-oxidation of phytanate (1) REACT_17003
Amino acid synthesis and interconversion (transamination) (2) REACT_238
Amino acid transport across the plasma membrane (3) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (2) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (2) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (2) REACT_197
Carnitine synthesis (1) REACT_2125
Citric acid cycle (TCA cycle) (3) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Cleavage of the damaged purine (1) REACT_1729
Collagen biosynthesis and modifying enzymes (1) REACT_121139
Condensation of Prophase Chromosomes (1) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (2) REACT_111056
Cytosolic tRNA aminoacylation (2) REACT_15306
Defective BTD causes biotidinase deficiency (1) REACT_169403
Degradation of GABA (2) REACT_23964
Digestion of dietary lipid (3) REACT_9518
Endogenous sterols (1) REACT_13812
Endosomal/Vacuolar pathway (2) REACT_111168
eNOS activation (1) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (2) REACT_111178
Fatty Acyl-CoA Biosynthesis (2) REACT_1319
Free fatty acid receptors (1) REACT_21268
Fructose catabolism (1) REACT_1571
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (3) REACT_19231
G alpha (q) signalling events (3) REACT_18283
Gluconeogenesis (4) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (3) REACT_6960
Glycolysis (2) REACT_1383
Glyoxylate metabolism (1) REACT_16925
HDMs demethylate histones (1) REACT_228178
Heme degradation (1) REACT_22297
Histidine catabolism (1) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Iron uptake and transport (1) REACT_25060
Lysine catabolism (1) REACT_1298
Metabolism of folate and pterines (1) REACT_11167
Metabolism of polyamines (1) REACT_14820
Methionine salvage pathway (1) REACT_75881
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (1) REACT_13425
Mitochondrial tRNA aminoacylation (2) REACT_15302
Na+/Cl- dependent neurotransmitter transporters (2) REACT_20506
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (1) REACT_23862
Organic anion transporters (4) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (1) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (1) REACT_120916
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (2) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (1) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton/oligonucleotide cotransporters (2) REACT_19328
Purine catabolism (1) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (1) REACT_1776
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (1) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (1) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of Glucokinase by Glucokinase Regulatory Protein (1) REACT_6804
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Reuptake of GABA (1) REACT_23910
Serine biosynthesis (1) REACT_115789
Sialic acid metabolism (1) REACT_200874
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (2) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (2) REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PG (1) REACT_121280
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
TET1,2,3 and TDG demethylate DNA (1) REACT_200682
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Transport of organic anions (2) REACT_23988
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (2) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (2) REACT_847
Utilization of Ketone Bodies (1) REACT_59
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
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