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ST002711 Metabolomic analysis of maternal mid-gestation plasma and cord blood: biogenic aminesList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (4)
REACT_121388
Abnormal metabolism in phenylketonuria (7)
REACT_121117
Acetylation (1)
REACT_6732
Acetylcholine Neurotransmitter Release Cycle (1)
REACT_15309
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of the phototransduction cascade (1)
REACT_163932
Aflatoxin activation and detoxification (3)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
alpha-linolenic acid (ALA) metabolism (3)
REACT_121147
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (9)
REACT_238
Amino acid transport across the plasma membrane (21)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (2)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (18)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (19)
REACT_75842
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1)
REACT_121408
Beta oxidation of butanoyl-CoA to acetyl-CoA (1)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1)
REACT_2025
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (1)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Branched-chain amino acid catabolism (5)
REACT_197
Ca2+ pathway (1)
REACT_172761
Cam-PDE 1 activation (1)
REACT_15408
Carnitine synthesis (3)
REACT_2125
Catecholamine biosynthesis (2)
REACT_15551
Cell redox homeostasis (1)
REACT_121394
cGMP effects (1)
REACT_23767
Cholesterol biosynthesis (1)
REACT_9405
Chondroitin sulfate biosynthesis (2)
REACT_120989
Circadian Clock (2)
REACT_24941
Citric acid cycle (TCA cycle) (4)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (2)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Condensation of Prophase Chromosomes (1)
REACT_172744
Conjugation of benzoate with glycine (3)
REACT_6933
Conjugation of phenylacetate with glutamine (3)
REACT_6800
Conjugation of salicylate with glycine (3)
REACT_6812
Creatine metabolism (6)
REACT_813
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (18)
REACT_111056
CYP2E1 reactions (1)
REACT_13797
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic iron-sulfur cluster assembly (1)
REACT_160176
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (19)
REACT_15306
DARPP-32 events (1)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective B3GAT3 causes JDSSDHD (1)
REACT_267659
Defective CHSY1 causes TPBS (2)
REACT_267682
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (1)
REACT_267674
Defective EXT2 causes exostoses 2 (1)
REACT_267654
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (2)
REACT_115654
Degradation of GABA (1)
REACT_23964
Detoxification of Reactive Oxygen Species (2)
REACT_172715
Digestion of dietary carbohydrate (1)
REACT_9472
Digestion of dietary lipid (2)
REACT_9518
DNA methylation (1)
REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Electron transport from NADPH to Ferredoxin (1)
REACT_150128
Endogenous sterols (2)
REACT_13812
Endosomal/Vacuolar pathway (18)
REACT_111168
eNOS activation (4)
REACT_12477
Enzymatic degradation of dopamine by COMT (2)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (18)
REACT_111178
ER Quality Control Compartment (ERQC) (1)
REACT_25091
Estrogen biosynthesis (2)
REACT_11037
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (2)
REACT_13653
Formation of the active cofactor, UDP-glucuronate (1)
REACT_6737
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
Free fatty acid receptors (4)
REACT_21268
Fructose catabolism (2)
REACT_1571
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (4)
REACT_19231
G alpha (q) signalling events (8)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Glucocorticoid biosynthesis (2)
REACT_11036
Gluconeogenesis (6)
REACT_1520
Glucuronidation (3)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (20)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycogen synthesis (1)
REACT_169208
Glycolysis (3)
REACT_1383
Glyoxylate metabolism (4)
REACT_16925
Heme biosynthesis (2)
REACT_9465
Heme degradation (2)
REACT_22297
Histamine receptors (1)
REACT_16903
Histidine catabolism (4)
REACT_1249
HS-GAG biosynthesis (2)
REACT_121248
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
Interconversion of polyamines (2)
REACT_14805
Iron uptake and transport (1)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (1)
REACT_121120
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (2)
REACT_121100
Lysine catabolism (3)
REACT_1298
Meiotic recombination (1)
REACT_27271
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of nucleotides (1)
REACT_1698
Metabolism of polyamines (3)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (3)
REACT_75881
Methylation (3)
REACT_6946
Miscellaneous substrates (2)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1)
REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (19)
REACT_15302
Molybdenum cofactor biosynthesis (3)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (19)
REACT_20506
Na+-dependent glucose transporters (1)
REACT_19165
Neurotransmitter Clearance In The Synaptic Cleft (1)
REACT_13583
Nicotinamide salvaging (2)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
NoRC negatively regulates rRNA expression (1)
REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (1)
REACT_12510
NOSTRIN mediated eNOS trafficking (1)
REACT_12541
O-linked glycosylation of mucins (1)
REACT_115606
Organic anion transporters (4)
REACT_19372
Organic cation transport (7)
REACT_22357
Orphan transporters (3)
REACT_267716
Oxidative Stress Induced Senescence (1)
REACT_169436
PAOs oxidise polyamines to amines (2)
REACT_505
PDE3B signalling (1)
REACT_1451
Phagosomal maturation (early endosomal stage) (4)
REACT_121256
Phenylalanine and tyrosine catabolism (7)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2)
REACT_150237
Plasmalogen biosynthesis (2)
REACT_1407
PPARA activates gene expression (2)
REACT_116145
PRC2 methylates histones and DNA (1)
REACT_200808
Presynaptic function of Kainate receptors (1)
REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1)
REACT_25396
Proline catabolism (3)
REACT_1002
Proton-coupled monocarboxylate transport (1)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (18)
REACT_19328
Purine catabolism (10)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7)
REACT_1776
Purine salvage (9)
REACT_1923
Pyrimidine biosynthesis (5)
REACT_21376
Pyrimidine catabolism (6)
REACT_1023
Pyrimidine salvage reactions (2)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recycling of bile acids and salts (4)
REACT_11042
Regulation by TREX1 (2)
REACT_163652
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of Glucokinase by Glucokinase Regulatory Protein (1)
REACT_6804
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (3)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (3)
REACT_70
Removal of the Flap Intermediate from the C-strand (3)
REACT_7999
Respiratory electron transport (2)
REACT_22393
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (3)
REACT_24968
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (2)
REACT_118789
RMTs methylate histone arginines (1)
REACT_228108
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (2)
REACT_118659
Scavenging by Class A Receptors (3)
REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1)
REACT_169168
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (3)
REACT_15439
Sialic acid metabolism (1)
REACT_200874
SIRT1 negatively regulates rRNA Expression (2)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1)
REACT_20646
Sphingolipid de novo biosynthesis (2)
REACT_115810
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (3)
REACT_116010
Sulfur amino acid metabolism (6)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (9)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (5)
REACT_11041
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PE (2)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2)
REACT_150149
Synthesis of PS (3)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2)
REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (2)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (3)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (5)
REACT_1206
Transport of nucleotide sugars (4)
REACT_22151
Transport of organic anions (2)
REACT_23988
Tryptophan catabolism (8)
REACT_916
Ubiquinol biosynthesis (3)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Urea cycle (6)
REACT_847
VEGFA-VEGFR2 Pathway (1)
REACT_228166
VEGFR2 mediated vascular permeability (3)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (3)
REACT_11070
Vitamin C (ascorbate) metabolism (2)
REACT_11202
Vitamins (1)
REACT_13450
Vitamins B6 activation to pyridoxal phosphate (2)
REACT_25012
Xenobiotics (1)
REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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