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ST002759 Metabolic responses of normal rat kidneys to a high salt intake (Kidney cortex)List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (4)
REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (7)
REACT_121117
Acetylation (1)
REACT_6732
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (4)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of the phototransduction cascade (1)
REACT_163932
Adenosine P1 receptors (1)
REACT_18288
Adenylate cyclase activating pathway (1)
REACT_15312
Aflatoxin activation and detoxification (3)
REACT_228214
Agmatine biosynthesis (2)
REACT_14800
alpha-linolenic acid (ALA) metabolism (2)
REACT_121147
Alpha-oxidation of phytanate (3)
REACT_17003
Amine ligand-binding receptors (1)
REACT_16983
Amino acid synthesis and interconversion (transamination) (12)
REACT_238
Amino acid transport across the plasma membrane (23)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (1)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (20)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (21)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1)
REACT_2025
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (3)
REACT_416
Biotin transport and metabolism (2)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4)
REACT_111118
Branched-chain amino acid catabolism (6)
REACT_197
Ca2+ pathway (1)
REACT_172761
Cam-PDE 1 activation (2)
REACT_15408
Carnitine synthesis (3)
REACT_2125
Catecholamine biosynthesis (4)
REACT_15551
Cell redox homeostasis (1)
REACT_121394
cGMP effects (1)
REACT_23767
Cholesterol biosynthesis (1)
REACT_9405
Circadian Clock (4)
REACT_24941
Citric acid cycle (TCA cycle) (6)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (5)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (7)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (2)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (4)
REACT_163862
Coenzyme A biosynthesis (3)
REACT_11218
Collagen biosynthesis and modifying enzymes (3)
REACT_121139
Condensation of Prophase Chromosomes (3)
REACT_172744
Conjugation of benzoate with glycine (4)
REACT_6933
Conjugation of phenylacetate with glutamine (2)
REACT_6800
Conjugation of salicylate with glycine (4)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (7)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (20)
REACT_111056
Cysteine formation from homocysteine (3)
REACT_115589
Cytosolic iron-sulfur cluster assembly (2)
REACT_160176
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (21)
REACT_15306
DARPP-32 events (2)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (2)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (5)
REACT_115654
Degradation of GABA (5)
REACT_23964
Detoxification of Reactive Oxygen Species (2)
REACT_172715
Digestion of dietary carbohydrate (2)
REACT_9472
Digestion of dietary lipid (3)
REACT_9518
DNA methylation (1)
REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Eicosanoid ligand-binding receptors (1)
REACT_18352
Eicosanoids (1)
REACT_13645
Electron transport from NADPH to Ferredoxin (1)
REACT_150128
Endogenous sterols (3)
REACT_13812
Endosomal/Vacuolar pathway (20)
REACT_111168
eNOS activation (4)
REACT_12477
Enzymatic degradation of dopamine by COMT (2)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (20)
REACT_111178
Estrogen biosynthesis (1)
REACT_11037
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (4)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (2)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (2)
REACT_13653
formation of the beta-catenin:TCF transactivating complex (1)
REACT_200753
Free fatty acid receptors (8)
REACT_21268
GABA synthesis (2)
REACT_24020
G alpha (i) signalling events (12)
REACT_19231
G alpha (q) signalling events (10)
REACT_18283
G alpha (s) signalling events (8)
REACT_19327
G alpha (z) signalling events (1)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Glucocorticoid biosynthesis (1)
REACT_11036
Gluconeogenesis (9)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (22)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycolysis (5)
REACT_1383
Glycosphingolipid metabolism (1)
REACT_116105
Glyoxylate metabolism (6)
REACT_16925
HCN channels (1)
REACT_75862
HDMs demethylate histones (2)
REACT_228178
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Histamine receptors (1)
REACT_16903
Histidine catabolism (5)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (2)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (3)
REACT_25367
Interconversion of polyamines (3)
REACT_14805
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (1)
REACT_121120
Ligand-gated ion channel transport (2)
REACT_25387
Linoleic acid (LA) metabolism (2)
REACT_121100
Lysine catabolism (4)
REACT_1298
Lysosphingolipid and LPA receptors (1)
REACT_18365
Meiotic recombination (1)
REACT_27271
Metabolism of folate and pterines (3)
REACT_11167
Metabolism of nucleotides (1)
REACT_1698
Metabolism of polyamines (3)
REACT_14820
Metabolism of serotonin (3)
REACT_15532
Methionine salvage pathway (3)
REACT_75881
Methylation (5)
REACT_6946
Mineralocorticoid biosynthesis (1)
REACT_11047
Miscellaneous substrates (3)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1)
REACT_160
Mitochondrial iron-sulfur cluster biogenesis (3)
REACT_150353
Mitochondrial tRNA aminoacylation (21)
REACT_15302
Molybdenum cofactor biosynthesis (5)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (22)
REACT_20506
NADPH regeneration (1)
REACT_16904
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (1)
REACT_23862
NoRC negatively regulates rRNA expression (1)
REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (2)
REACT_12510
NOSTRIN mediated eNOS trafficking (2)
REACT_12541
Organic anion transport (2)
REACT_22310
Organic anion transporters (3)
REACT_19372
Organic cation transport (4)
REACT_22357
Orphan transporters (8)
REACT_267716
Oxidative Stress Induced Senescence (3)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
PAOs oxidise polyamines to amines (3)
REACT_505
PDE3B signalling (2)
REACT_1451
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
Phagosomal maturation (early endosomal stage) (3)
REACT_121256
Phenylalanine and tyrosine catabolism (7)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (2)
REACT_150237
phospho-PLA2 pathway (1)
REACT_15466
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
Plasmalogen biosynthesis (2)
REACT_1407
Platelet degranulation (1)
REACT_318
PPARA activates gene expression (5)
REACT_116145
PRC2 methylates histones and DNA (1)
REACT_200808
Pregnenolone biosynthesis (1)
REACT_11038
Pre-NOTCH Processing in Golgi (1)
REACT_118798
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (3)
REACT_1002
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (20)
REACT_19328
Purine catabolism (14)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (7)
REACT_1776
Purine salvage (11)
REACT_1923
Pyrimidine biosynthesis (5)
REACT_21376
Pyrimidine catabolism (14)
REACT_1023
Pyrimidine salvage reactions (6)
REACT_655
Pyruvate metabolism (2)
REACT_2071
Rap1 signalling (1)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (7)
REACT_11042
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4)
REACT_19241
Regulation of ornithine decarboxylase (ODC) (1)
REACT_13565
Regulation of pyruvate dehydrogenase (PDH) complex (2)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (3)
REACT_70
Removal of the Flap Intermediate from the C-strand (3)
REACT_7999
Respiratory electron transport (3)
REACT_22393
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (3)
REACT_24968
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (4)
REACT_118789
RMTs methylate histone arginines (1)
REACT_228108
Role of phospholipids in phagocytosis (1)
REACT_160158
RORA activates circadian gene expression (4)
REACT_118659
Scavenging by Class A Receptors (2)
REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (1)
REACT_169168
Serine biosynthesis (5)
REACT_115789
Serotonin and melatonin biosynthesis (5)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
Sialic acid metabolism (2)
REACT_200874
SIRT1 negatively regulates rRNA Expression (2)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sphingolipid de novo biosynthesis (5)
REACT_115810
Stimuli-sensing channels (2)
REACT_160189
Sulfide oxidation to sulfate (3)
REACT_116010
Sulfur amino acid metabolism (9)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (7)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (3)
REACT_150209
Synthesis of bile acids and bile salts (1)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (8)
REACT_11041
Synthesis of CL (1)
REACT_120920
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of Ketone Bodies (1)
REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (5)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PE (2)
REACT_120919
Synthesis of PG (2)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (4)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (9)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (5)
REACT_23824
Termination of O-glycan biosynthesis (1)
REACT_115835
TET1,2,3 and TDG demethylate DNA (3)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (4)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (3)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (4)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (4)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (6)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (13)
REACT_1206
Transport of nucleotide sugars (2)
REACT_22151
Transport of organic anions (3)
REACT_23988
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (8)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (6)
REACT_847
Utilization of Ketone Bodies (2)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFA-VEGFR2 Pathway (1)
REACT_228166
VEGFR2 mediated cell proliferation (2)
REACT_228024
VEGFR2 mediated vascular permeability (3)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (4)
REACT_11070
Vitamin C (ascorbate) metabolism (3)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (6)
REACT_25012
Xenobiotics (1)
REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4)
REACT_118713
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