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ST002776 Zebrafish Optic Nerve Regeneration, Tectum Metabolomics - 3 Days Post CrushList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (3)
REACT_121388
Abnormal metabolism in phenylketonuria (3)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (1)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (1)
REACT_14800
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (16)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (14)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (14)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1)
REACT_121408
Biotin transport and metabolism (1)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1)
REACT_111118
Branched-chain amino acid catabolism (2)
REACT_197
Carnitine synthesis (2)
REACT_2125
Catecholamine biosynthesis (3)
REACT_15551
Circadian Clock (1)
REACT_24941
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3)
REACT_163862
Collagen biosynthesis and modifying enzymes (1)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (1)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
COX reactions (1)
REACT_1396
Creatine metabolism (4)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (14)
REACT_111056
Cysteine formation from homocysteine (2)
REACT_115589
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (14)
REACT_15306
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (1)
REACT_267635
Defective B4GALT7 causes EDS, progeroid type (1)
REACT_267711
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (3)
REACT_115654
Degradation of GABA (1)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
DNA methylation (2)
REACT_267652
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endosomal/Vacuolar pathway (14)
REACT_111168
eNOS activation (2)
REACT_12477
Enzymatic degradation of dopamine by COMT (2)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (14)
REACT_111178
Fatty acids (2)
REACT_13814
formation of the beta-catenin:TCF transactivating complex (2)
REACT_200753
Free fatty acid receptors (1)
REACT_21268
GABA synthesis (1)
REACT_24020
Galactose catabolism (1)
REACT_532
G alpha (i) signalling events (3)
REACT_19231
G alpha (q) signalling events (4)
REACT_18283
G alpha (s) signalling events (1)
REACT_19327
Gluconeogenesis (2)
REACT_1520
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione conjugation (1)
REACT_6926
Glutathione synthesis and recycling (15)
REACT_6960
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histidine catabolism (3)
REACT_1249
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (1)
REACT_120977
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Insulin effects increased synthesis of Xylulose-5-Phosphate (1)
REACT_939
Integration of energy metabolism (1)
REACT_1505
Interconversion of polyamines (1)
REACT_14805
Keratan sulfate biosynthesis (2)
REACT_121120
Lysine catabolism (3)
REACT_1298
Meiotic recombination (2)
REACT_27271
Metabolism of folate and pterines (2)
REACT_11167
Metabolism of nucleotides (1)
REACT_1698
Metabolism of polyamines (1)
REACT_14820
Methionine salvage pathway (2)
REACT_75881
Methylation (5)
REACT_6946
Miscellaneous substrates (2)
REACT_13425
Mitochondrial ABC transporters (1)
REACT_111108
Mitochondrial tRNA aminoacylation (14)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
mRNA Capping (2)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (14)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
N-Glycan antennae elongation (1)
REACT_25085
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
NoRC negatively regulates rRNA expression (2)
REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
O-linked glycosylation of mucins (1)
REACT_115606
Organic anion transporters (1)
REACT_19372
Organic cation transport (1)
REACT_22357
Orphan transporters (1)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
PAOs oxidise polyamines to amines (1)
REACT_505
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
Phagosomal maturation (early endosomal stage) (3)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
phospho-PLA2 pathway (1)
REACT_15466
PPARA activates gene expression (1)
REACT_116145
PRC2 methylates histones and DNA (2)
REACT_200808
Pre-NOTCH Processing in Golgi (2)
REACT_118798
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (1)
REACT_1002
Proton/oligonucleotide cotransporters (14)
REACT_19328
Purine catabolism (8)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4)
REACT_1776
Purine salvage (7)
REACT_1923
Pyrimidine biosynthesis (3)
REACT_21376
Pyrimidine catabolism (5)
REACT_1023
Pyrimidine salvage reactions (4)
REACT_655
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Recycling of bile acids and salts (1)
REACT_11042
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1)
REACT_19241
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (1)
REACT_118789
RMTs methylate histone arginines (2)
REACT_228108
Role of phospholipids in phagocytosis (2)
REACT_160158
RORA activates circadian gene expression (1)
REACT_118659
Scavenging by Class A Receptors (1)
REACT_163699
Senescence-Associated Secretory Phenotype (SASP) (2)
REACT_169168
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (3)
REACT_15439
Sialic acid metabolism (1)
REACT_200874
SIRT1 negatively regulates rRNA Expression (3)
REACT_200827
snRNP Assembly (1)
REACT_11066
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (6)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (4)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (2)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (2)
REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of CL (1)
REACT_120920
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (6)
REACT_121238
Synthesis of PE (2)
REACT_120919
Synthesis of PG (2)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (3)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1)
REACT_23824
Termination of O-glycan biosynthesis (1)
REACT_115835
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
Thyroxine biosynthesis (1)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (1)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (1)
REACT_27161
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9)
REACT_1206
Transport of nucleotide sugars (2)
REACT_22151
Tryptophan catabolism (4)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (4)
REACT_847
VEGFR2 mediated vascular permeability (2)
REACT_228016
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (1)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1)
REACT_118713
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