ST002846 Apolipoprotein E suppresses hyperlipidemia-driven hematopoiesis & inflammation by controlling mitochondrial metabolism
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (3) REACT_850
Abacavir metabolism (6) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (3) REACT_160183
Abnormal metabolism in phenylketonuria (10) REACT_121117
Acetylation (1) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (3) REACT_15309
Acetylcholine regulates insulin secretion (3) REACT_18405
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of G protein gated Potassium channels (1) REACT_75831
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of Rac (2) REACT_19226
Activation of RAS in B cells (2) REACT_118778
Activation of the phototransduction cascade (4) REACT_163932
Adenosine P1 receptors (1) REACT_18288
Adenylate cyclase activating pathway (2) REACT_15312
Adenylate cyclase inhibitory pathway (2) REACT_15333
ADP signalling through P2Y purinoceptor 1 (2) REACT_19140
ADP signalling through P2Y purinoceptor 12 (2) REACT_20653
Adrenaline,noradrenaline inhibits insulin secretion (4) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (2) REACT_19180
Adrenoceptors (2) REACT_16927
Aflatoxin activation and detoxification (6) REACT_228214
Agmatine biosynthesis (4) REACT_14800
alpha-linolenic acid (ALA) metabolism (6) REACT_121147
Alpha-oxidation of phytanate (4) REACT_17003
Amine ligand-binding receptors (1) REACT_16983
Amino acid synthesis and interconversion (transamination) (15) REACT_238
Amino acid transport across the plasma membrane (22) REACT_13796
Androgen biosynthesis (4) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (19) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (17) REACT_75842
ARMS-mediated activation (2) REACT_12002
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
A tetrasaccharide linker sequence is required for GAG synthesis (1) REACT_121408
Attenuation phase (1) REACT_200624
Axonal growth inhibition (RHOA activation) (2) REACT_13815
Axonal growth stimulation (1) REACT_13779
Beta oxidation of butanoyl-CoA to acetyl-CoA (3) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (4) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (4) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (4) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (4) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (4) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (4) REACT_2025
Beta-oxidation of pristanoyl-CoA (4) REACT_17017
Beta-oxidation of very long chain fatty acids (4) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (4) REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (3) REACT_22433
Biotin transport and metabolism (1) REACT_11153
Branched-chain amino acid catabolism (8) REACT_197
Ca2+ pathway (4) REACT_172761
Carnitine synthesis (6) REACT_2125
Catecholamine biosynthesis (8) REACT_15551
CD28 dependent Vav1 pathway (2) REACT_19238
CDO in myogenesis (1) REACT_21402
Cell redox homeostasis (6) REACT_121394
cGMP effects (2) REACT_23767
Cholesterol biosynthesis (7) REACT_9405
Chondroitin sulfate biosynthesis (1) REACT_120989
Citric acid cycle (TCA cycle) (14) REACT_1785
Class A/1 (Rhodopsin-like receptors) (4) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (5) REACT_18319
Class II GLUTs (1) REACT_19281
Clathrin derived vesicle budding (2) REACT_19187
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (11) REACT_163862
Coenzyme A biosynthesis (2) REACT_11218
Collagen biosynthesis and modifying enzymes (4) REACT_121139
Condensation of Prophase Chromosomes (4) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
COPII (Coat Protein 2) Mediated Vesicle Transport (2) REACT_12507
COPI Mediated Transport (2) REACT_11096
Creatine metabolism (9) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
CREB phosphorylation through the activation of Ras (1) REACT_20568
Cross-presentation of particulate exogenous antigens (phagosomes) (2) REACT_111174
Cross-presentation of soluble exogenous antigens (endosomes) (17) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cysteine formation from homocysteine (4) REACT_115589
Cytosolic iron-sulfur cluster assembly (4) REACT_160176
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (17) REACT_15306
DAP12 signaling (2) REACT_147814
DCC mediated attractive signaling (2) REACT_22351
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC (1) REACT_169169
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (3) REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (4) REACT_169439
degradation of AXIN (2) REACT_200766
Degradation of cysteine and homocysteine (6) REACT_115654
Degradation of GABA (7) REACT_23964
Detoxification of Reactive Oxygen Species (4) REACT_172715
DNA methylation (2) REACT_267652
DNA replication initiation (3) REACT_2244
Dopamine clearance from the synaptic cleft (1) REACT_15514
Dopamine Neurotransmitter Release Cycle (1) REACT_15293
Dopamine receptors (1) REACT_16968
Downregulation of SMAD2/3:SMAD4 transcriptional activity (2) REACT_121111
Downstream signal transduction (2) REACT_17025
DSCAM interactions (1) REACT_25299
EGFR downregulation (1) REACT_12484
EGFR Transactivation by Gastrin (2) REACT_121096
Eicosanoids (2) REACT_13645
Electron transport from NADPH to Ferredoxin (3) REACT_150128
Endogenous sterols (3) REACT_13812
Endosomal/Vacuolar pathway (17) REACT_111168
eNOS activation (6) REACT_12477
Enzymatic degradation of dopamine by COMT (4) REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (3) REACT_15511
EPHA-mediated growth cone collapse (2) REACT_228063
EPHB-mediated forward signaling (4) REACT_228085
EPH-ephrin mediated repulsion of cells (2) REACT_228189
Ephrin signaling (2) REACT_228226
ER-Phagosome pathway (17) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Estrogen biosynthesis (2) REACT_11037
Ethanol oxidation (3) REACT_34
Eukaryotic Translation Elongation (2) REACT_1477
Eukaryotic Translation Termination (2) REACT_1986
Factors involved in megakaryocyte development and platelet production (2) REACT_24970
Fatty acids (2) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (5) REACT_1319
FCERI mediated MAPK activation (2) REACT_163701
FMO oxidises nucleophiles (3) REACT_13653
Formation of the active cofactor, UDP-glucuronate (3) REACT_6737
formation of the beta-catenin:TCF transactivating complex (3) REACT_200753
Formation of the ternary complex, and subsequently, the 43S complex (1) REACT_1079
Formation of tubulin folding intermediates by CCT/TriC (1) REACT_16956
Free fatty acid receptors (2) REACT_21268
Frs2-mediated activation (2) REACT_12076
FRS2-mediated cascade (2) REACT_21247
Fructose catabolism (2) REACT_1571
GABA A receptor activation (1) REACT_24987
GABA A (rho) receptor activation (1) REACT_25168
GABA B receptor activation (1) REACT_25031
GABA synthesis (2) REACT_24020
GABA synthesis, release, reuptake and degradation (1) REACT_23947
Galactose catabolism (1) REACT_532
G alpha (12/13) signalling events (4) REACT_18407
G alpha (i) signalling events (16) REACT_19231
G alpha (q) signalling events (14) REACT_18283
G alpha (s) signalling events (9) REACT_19327
G alpha (z) signalling events (4) REACT_19333
Gap junction assembly (2) REACT_9509
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (2) REACT_18274
Glucagon signaling in metabolic regulation (2) REACT_1665
Glucagon-type ligand receptors (1) REACT_18377
Glucocorticoid biosynthesis (5) REACT_11036
Gluconeogenesis (12) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (20) REACT_6960
Glycogen synthesis (3) REACT_169208
Glycolysis (5) REACT_1383
Glycosphingolipid metabolism (3) REACT_116105
Glyoxylate metabolism (7) REACT_16925
Golgi Associated Vesicle Biogenesis (2) REACT_19400
Golgi Cisternae Pericentriolar Stack Reorganization (1) REACT_1100
G-protein activation (2) REACT_15457
GPVI-mediated activation cascade (2) REACT_1695
GRB2 events in EGFR signaling (2) REACT_12606
GRB2 events in ERBB2 signaling (2) REACT_115854
GRB2:SOS provides linkage to MAPK signaling for Integrins (1) REACT_15443
GTP hydrolysis and joining of the 60S ribosomal subunit (2) REACT_2085
HATs acetylate histones (1) REACT_172610
HDMs demethylate histones (2) REACT_228178
Hedgehog 'off' state (2) REACT_267634
Heme biosynthesis (3) REACT_9465
Heme degradation (3) REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1) REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1) REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1) REACT_22223
Histamine receptors (1) REACT_16903
Histidine catabolism (4) REACT_1249
HS-GAG biosynthesis (2) REACT_121248
HS-GAG degradation (2) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydroxycarboxylic acid-binding receptors (2) REACT_163785
Hypusine synthesis from eIF5A-lysine (3) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation of Cdc42 and Rac (2) REACT_19342
Inactivation, recovery and regulation of the phototransduction cascade (4) REACT_163919
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (1) REACT_25004
Integrin alphaIIb beta3 signaling (2) REACT_15523
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (3) REACT_25367
Interconversion of polyamines (5) REACT_14805
Interleukin receptor SHC signaling (2) REACT_23891
Iron uptake and transport (2) REACT_25060
Keratan sulfate biosynthesis (3) REACT_121120
Kinesins (2) REACT_25201
L13a-mediated translational silencing of Ceruloplasmin expression (1) REACT_79
Ligand-gated ion channel transport (3) REACT_25387
Linoleic acid (LA) metabolism (4) REACT_121100
Lysine catabolism (8) REACT_1298
Lysosome Vesicle Biogenesis (2) REACT_19287
Meiotic recombination (2) REACT_27271
MEK activation (1) REACT_962
Metabolism of folate and pterines (7) REACT_11167
Metabolism of nucleotides (5) REACT_1698
Metabolism of polyamines (7) REACT_14820
Metabolism of serotonin (4) REACT_15532
Methionine salvage pathway (3) REACT_75881
Methylation (9) REACT_6946
MHC class II antigen presentation (2) REACT_121399
MicroRNA (miRNA) biogenesis (2) REACT_12417
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane (2) REACT_11039
Mineralocorticoid biosynthesis (4) REACT_11047
Minus-strand DNA synthesis (3) REACT_9055
Miscellaneous substrates (2) REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (3) REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (3) REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (4) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial translation elongation (2) REACT_267677
Mitochondrial translation initiation (2) REACT_267680
Mitochondrial translation termination (2) REACT_267602
Mitochondrial tRNA aminoacylation (17) REACT_15302
Mitotic Prometaphase (2) REACT_682
Molybdenum cofactor biosynthesis (5) REACT_25073
MPS IIIC - Sanfilippo syndrome C (1) REACT_147860
mRNA Capping (5) REACT_1470
mRNA decay by 3' to 5' exoribonuclease (3) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (3) REACT_20518
Mtb iron assimilation by chelation (2) REACT_121118
mTOR signalling (2) REACT_6838
Muscarinic acetylcholine receptors (1) REACT_16943
Na+/Cl- dependent neurotransmitter transporters (24) REACT_20506
NADPH regeneration (3) REACT_16904
NCAM signaling for neurite out-growth (2) REACT_18334
NEP/NS2 Interacts with the Cellular Export Machinery (2) REACT_6179
Neurotransmitter Clearance In The Synaptic Cleft (3) REACT_13583
NGF-independant TRKA activation (1) REACT_11046
N-glycan trimming and elongation in the cis-Golgi (1) REACT_25210
Nicotinamide salvaging (4) REACT_11213
Nicotinate metabolism (5) REACT_11088
Nitric oxide stimulates guanylate cyclase (6) REACT_23862
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (1) REACT_75822
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (1) REACT_75768
NoRC negatively regulates rRNA expression (2) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (4) REACT_15418
NOSIP mediated eNOS trafficking (2) REACT_12510
NOSTRIN mediated eNOS trafficking (2) REACT_12541
NRAGE signals death through JNK (2) REACT_13638
Nuclear import of Rev protein (2) REACT_9395
O-linked glycosylation of mucins (1) REACT_115606
Organic anion transport (3) REACT_22310
Organic anion transporters (6) REACT_19372
Organic cation transport (11) REACT_22357
Orphan transporters (4) REACT_267716
Oxidative Stress Induced Senescence (4) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
p130Cas linkage to MAPK signaling for integrins (1) REACT_15381
P2Y receptors (2) REACT_18289
p38MAPK events (2) REACT_12065
PAOs oxidise polyamines to amines (4) REACT_505
Passive transport by Aquaporins (1) REACT_23826
PCP/CE pathway (1) REACT_172581
Pentose phosphate pathway (hexose monophosphate shunt) (3) REACT_1859
Peptide chain elongation (2) REACT_1404
Peroxisomal lipid metabolism (1) REACT_16957
Phagosomal maturation (early endosomal stage) (6) REACT_121256
Phenylalanine and tyrosine catabolism (10) REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1) REACT_150237
PKA activation in glucagon signalling (1) REACT_1946
Plasmalogen biosynthesis (3) REACT_1407
Platelet degranulation (3) REACT_318
PLC beta mediated events (2) REACT_15426
Post-chaperonin tubulin folding pathway (1) REACT_16967
PRC2 methylates histones and DNA (2) REACT_200808
Pregnenolone biosynthesis (2) REACT_11038
Pre-NOTCH Processing in Golgi (2) REACT_118798
Pre-NOTCH Processing in the Endoplasmic Reticulum (3) REACT_118722
Presynaptic function of Kainate receptors (1) REACT_21254
Processive synthesis on the C-strand of the telomere (3) REACT_8027
Proline catabolism (5) REACT_1002
Propionyl-CoA catabolism (1) REACT_993
Prostacyclin signalling through prostacyclin receptor (2) REACT_23946
Proton-coupled monocarboxylate transport (3) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (17) REACT_19328
Purine catabolism (15) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (13) REACT_1776
Purine salvage (14) REACT_1923
Pyrimidine biosynthesis (13) REACT_21376
Pyrimidine catabolism (19) REACT_1023
Pyrimidine salvage reactions (11) REACT_655
Pyruvate metabolism (6) REACT_2071
RAF activation (1) REACT_2077
RAF phosphorylates MEK (1) REACT_614
Rap1 signalling (2) REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (4) REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (2) REACT_25302
Recruitment of NuMA to mitotic centrosomes (2) REACT_15510
Recycling of bile acids and salts (2) REACT_11042
Recycling of eIF2:GDP (2) REACT_1815
Recycling pathway of L1 (2) REACT_22365
Regulation by TREX1 (3) REACT_163652
Regulation of actin dynamics for phagocytic cup formation (2) REACT_160086
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1) REACT_147797
Regulation of Glucokinase by Glucokinase Regulatory Protein (1) REACT_6804
Regulation of HSF1-mediated heat shock response (2) REACT_200780
Regulation of insulin secretion (1) REACT_18325
Regulation of PLK1 Activity at G2/M Transition (1) REACT_160315
Regulation of pyruvate dehydrogenase (PDH) complex (4) REACT_12528
Regulation of Rheb GTPase activity by AMPK (2) REACT_21393
Regulation of thyroid hormone activity (2) REACT_15297
Release of eIF4E (1) REACT_6836
Removal of the Flap Intermediate (3) REACT_70
Removal of the Flap Intermediate from the C-strand (3) REACT_7999
Resolution of Sister Chromatid Cohesion (3) REACT_150425
Respiratory electron transport (4) REACT_22393
Retinoid cycle disease events (2) REACT_160130
Retinoid metabolism and transport (2) REACT_24968
Retrograde neurotrophin signalling (2) REACT_12435
Reuptake of GABA (3) REACT_23910
Rev-mediated nuclear export of HIV RNA (2) REACT_6190
Rho GTPase cycle (2) REACT_11051
Ribosomal scanning and start codon recognition (1) REACT_931
RMTs methylate histone arginines (2) REACT_228108
RNA Polymerase I Transcription Initiation (1) REACT_953
Role of phospholipids in phagocytosis (1) REACT_160158
S6K1-mediated signalling (1) REACT_6754
Scavenging by Class A Receptors (2) REACT_163699
Sema3A PAK dependent Axon repulsion (1) REACT_19236
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (2) REACT_19279
Sema4D induced cell migration and growth-cone collapse (2) REACT_19277
Sema4D mediated inhibition of cell attachment and migration (2) REACT_19266
Senescence-Associated Secretory Phenotype (SASP) (2) REACT_169168
Separation of Sister Chromatids (3) REACT_150471
Serine biosynthesis (7) REACT_115789
Serotonin and melatonin biosynthesis (5) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
SHC1 events in EGFR signaling (2) REACT_12579
SHC1 events in ERBB2 signaling (2) REACT_115993
SHC1 events in ERBB4 signaling (2) REACT_116005
SHC-mediated cascade (2) REACT_21374
SHC-mediated signalling (2) REACT_661
Sialic acid metabolism (4) REACT_200874
Signaling by constitutively active EGFR (2) REACT_115852
Signaling by FGFR mutants (2) REACT_121398
Signaling by SCF-KIT (2) REACT_111040
Signalling to p38 via RIT and RIN (2) REACT_12077
Signalling to RAS (2) REACT_12033
Signal transduction by L1 (2) REACT_22272
SIRT1 negatively regulates rRNA Expression (4) REACT_200827
snRNP Assembly (1) REACT_11066
Sodium-coupled sulphate, di- and tri-carboxylate transporters (1) REACT_20646
SOS-mediated signalling (2) REACT_524
Sphingolipid de novo biosynthesis (5) REACT_115810
Sterols are 12-hydroxylated by CYP8B1 (2) REACT_13438
Stimuli-sensing channels (1) REACT_160189
STING mediated induction of host immune responses (1) REACT_147841
Sulfide oxidation to sulfate (3) REACT_116010
Sulfur amino acid metabolism (13) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (25) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (5) REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (2) REACT_150134
Synthesis of 5-eicosatetraenoic acids (3) REACT_150209
Synthesis of bile acids and bile salts (2) REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (4) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (4) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (7) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of Dolichyl-phosphate (4) REACT_22230
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (2) REACT_150417
Synthesis of GDP-mannose (1) REACT_22423
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Ketone Bodies (4) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (5) REACT_150420
Synthesis of Lipoxins (LX) (4) REACT_150320
Synthesis of PA (3) REACT_120906
Synthesis of PC (8) REACT_121238
Synthesis of PE (2) REACT_120919
Synthesis of PG (3) REACT_121280
Synthesis of PI (2) REACT_121000
Synthesis of PIPs at the Golgi membrane (1) REACT_120836
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (6) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (4) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (2) REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (1) REACT_24019
Telomere C-strand synthesis initiation (3) REACT_7993
Telomere Extension By Telomerase (3) REACT_7974
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (3) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (7) REACT_111176
The activation of arylsulfatases (2) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (4) REACT_160156
The proton buffering model (2) REACT_6196
The retinoid cycle in cones (daylight vision) (2) REACT_160083
Thrombin signalling through proteinase activated receptors (PARs) (2) REACT_21384
Thromboxane signalling through TP receptor (2) REACT_20647
Thyroxine biosynthesis (5) REACT_15292
Tie2 Signaling (2) REACT_12621
Tolerance by Mtb to nitric oxide produced by macrophages (2) REACT_120983
Transcriptional regulation by small RNAs (1) REACT_267668
Translation initiation complex formation (1) REACT_1979
Translocation of GLUT4 to the plasma membrane (2) REACT_147867
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (4) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (16) REACT_1206
Transport of nucleotide sugars (4) REACT_22151
Transport of vitamins, nucleosides, and related molecules (1) REACT_22285
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (14) REACT_916
Ubiquinol biosynthesis (5) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (9) REACT_847
Utilization of Ketone Bodies (6) REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (2) REACT_24023
VEGFA-VEGFR2 Pathway (5) REACT_228166
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (7) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (2) REACT_11070
Vitamin C (ascorbate) metabolism (5) REACT_11202
Vitamin D (calciferol) metabolism (2) REACT_13523
Vitamins (2) REACT_13450
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
Xenobiotics (2) REACT_13543
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