ST003024 Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa - Part 1
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (1) REACT_121388
Abnormal metabolism in phenylketonuria (4) REACT_121117
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (2) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Activation of the phototransduction cascade (1) REACT_163932
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adenosine P1 receptors (1) REACT_18288
Aflatoxin activation and detoxification (1) REACT_228214
Amino acid synthesis and interconversion (transamination) (4) REACT_238
Amino acid transport across the plasma membrane (14) REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (13) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (13) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2) REACT_111118
Branched-chain amino acid catabolism (4) REACT_197
Ca2+ pathway (1) REACT_172761
Carnitine synthesis (1) REACT_2125
Cell redox homeostasis (1) REACT_121394
cGMP effects (1) REACT_23767
Circadian Clock (2) REACT_24941
Class A/1 (Rhodopsin-like receptors) (1) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cleavage of the damaged pyrimidine (2) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Creatine metabolism (2) REACT_813
CREB phosphorylation through the activation of CaMKII (1) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (13) REACT_111056
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (1) REACT_6913
Cytosolic tRNA aminoacylation (13) REACT_15306
Degradation of cysteine and homocysteine (1) REACT_115654
Degradation of GABA (1) REACT_23964
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (2) REACT_9518
Endosomal/Vacuolar pathway (13) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (1) REACT_228085
ER-Phagosome pathway (13) REACT_111178
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3) REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1) REACT_22279
Fatty Acyl-CoA Biosynthesis (1) REACT_1319
Free fatty acid receptors (6) REACT_21268
GABA synthesis (1) REACT_24020
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (6) REACT_18283
G alpha (s) signalling events (1) REACT_19327
Gluconeogenesis (2) REACT_1520
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (14) REACT_6960
Glycolysis (1) REACT_1383
Glyoxylate metabolism (3) REACT_16925
Histidine catabolism (3) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
Hydrolysis of LPC (1) REACT_120977
Hydrolysis of LPE (1) REACT_120785
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2) REACT_163919
Inositol transporters (1) REACT_19188
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of folate and pterines (2) REACT_11167
Methionine salvage pathway (1) REACT_75881
Methylation (2) REACT_6946
Miscellaneous substrates (1) REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (13) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (13) REACT_20506
NGF-independant TRKA activation (1) REACT_11046
Nicotinamide salvaging (1) REACT_11213
Nicotinate metabolism (1) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
Organic anion transporters (3) REACT_19372
Organic cation transport (1) REACT_22357
Orphan transporters (2) REACT_267716
Passive transport by Aquaporins (1) REACT_23826
Pentose phosphate pathway (hexose monophosphate shunt) (1) REACT_1859
Phagosomal maturation (early endosomal stage) (1) REACT_121256
Phenylalanine and tyrosine catabolism (4) REACT_1786
Plasmalogen biosynthesis (1) REACT_1407
PPARA activates gene expression (2) REACT_116145
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (2) REACT_1002
Proton-coupled monocarboxylate transport (1) REACT_20515
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (13) REACT_19328
Purine catabolism (2) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Purine salvage (1) REACT_1923
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (6) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1) REACT_20546
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2) REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Retinoid cycle disease events (1) REACT_160130
Retinoid metabolism and transport (3) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (2) REACT_118789
RORA activates circadian gene expression (2) REACT_118659
Serine biosynthesis (2) REACT_115789
Serotonin and melatonin biosynthesis (1) REACT_15439
Sialic acid metabolism (1) REACT_200874
Sphingolipid de novo biosynthesis (1) REACT_115810
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of IP2, IP, and Ins in the cytosol (1) REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1) REACT_150420
Synthesis of PA (1) REACT_120906
Synthesis of PG (2) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1) REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (5) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3) REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3) REACT_160156
The retinoid cycle in cones (daylight vision) (1) REACT_160083
Thyroxine biosynthesis (1) REACT_15292
Transcriptional activation of mitochondrial biogenesis (2) REACT_200608
Transcriptional regulation of white adipocyte differentiation (2) REACT_27161
Transport of fatty acids (6) REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3) REACT_1206
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (6) REACT_916
Ubiquinol biosynthesis (1) REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1) REACT_20594
Urea cycle (3) REACT_847
VEGFR2 mediated vascular permeability (1) REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2) REACT_118713
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