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ST003024 Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa - Part 1List of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (4)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (2)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of the phototransduction cascade (1)
REACT_163932
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Adenosine P1 receptors (1)
REACT_18288
Aflatoxin activation and detoxification (1)
REACT_228214
Amino acid synthesis and interconversion (transamination) (4)
REACT_238
Amino acid transport across the plasma membrane (14)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (13)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (13)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Biotin transport and metabolism (1)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (2)
REACT_111118
Branched-chain amino acid catabolism (4)
REACT_197
Ca2+ pathway (1)
REACT_172761
Carnitine synthesis (1)
REACT_2125
Cell redox homeostasis (1)
REACT_121394
cGMP effects (1)
REACT_23767
Circadian Clock (2)
REACT_24941
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4)
REACT_18319
Cleavage of the damaged pyrimidine (2)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of CaMKII (1)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (13)
REACT_111056
Cysteine formation from homocysteine (1)
REACT_115589
Cytosolic sulfonation of small molecules (1)
REACT_6913
Cytosolic tRNA aminoacylation (13)
REACT_15306
Degradation of cysteine and homocysteine (1)
REACT_115654
Degradation of GABA (1)
REACT_23964
Digestion of dietary carbohydrate (1)
REACT_9472
Digestion of dietary lipid (2)
REACT_9518
Endosomal/Vacuolar pathway (13)
REACT_111168
eNOS activation (2)
REACT_12477
EPHB-mediated forward signaling (1)
REACT_228085
ER-Phagosome pathway (13)
REACT_111178
Fatty acids (1)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (3)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
Free fatty acid receptors (6)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (4)
REACT_19231
G alpha (q) signalling events (6)
REACT_18283
G alpha (s) signalling events (1)
REACT_19327
Gluconeogenesis (2)
REACT_1520
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione synthesis and recycling (14)
REACT_6960
Glycolysis (1)
REACT_1383
Glyoxylate metabolism (3)
REACT_16925
Histidine catabolism (3)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
Hydrolysis of LPC (1)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Inactivation, recovery and regulation of the phototransduction cascade (2)
REACT_163919
Inositol transporters (1)
REACT_19188
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (2)
REACT_1298
Metabolism of folate and pterines (2)
REACT_11167
Methionine salvage pathway (1)
REACT_75881
Methylation (2)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mitochondrial iron-sulfur cluster biogenesis (1)
REACT_150353
Mitochondrial tRNA aminoacylation (13)
REACT_15302
Molybdenum cofactor biosynthesis (2)
REACT_25073
Na+/Cl- dependent neurotransmitter transporters (13)
REACT_20506
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (1)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
Organic anion transporters (3)
REACT_19372
Organic cation transport (1)
REACT_22357
Orphan transporters (2)
REACT_267716
Passive transport by Aquaporins (1)
REACT_23826
Pentose phosphate pathway (hexose monophosphate shunt) (1)
REACT_1859
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (4)
REACT_1786
Plasmalogen biosynthesis (1)
REACT_1407
PPARA activates gene expression (2)
REACT_116145
Presynaptic function of Kainate receptors (1)
REACT_21254
Proline catabolism (2)
REACT_1002
Proton-coupled monocarboxylate transport (1)
REACT_20515
Proton-coupled neutral amino acid transporters (2)
REACT_19348
Proton/oligonucleotide cotransporters (13)
REACT_19328
Purine catabolism (2)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2)
REACT_1776
Purine salvage (1)
REACT_1923
Pyrimidine biosynthesis (2)
REACT_21376
Pyrimidine catabolism (6)
REACT_1023
Pyrimidine salvage reactions (2)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (1)
REACT_20546
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (2)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (3)
REACT_24968
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (2)
REACT_118789
RORA activates circadian gene expression (2)
REACT_118659
Serine biosynthesis (2)
REACT_115789
Serotonin and melatonin biosynthesis (1)
REACT_15439
Sialic acid metabolism (1)
REACT_200874
Sphingolipid de novo biosynthesis (1)
REACT_115810
Sulfur amino acid metabolism (4)
REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1)
REACT_21330
Synthesis of IP2, IP, and Ins in the cytosol (1)
REACT_150352
Synthesis of Leukotrienes (LT) and Eoxins (EX) (1)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PG (2)
REACT_121280
Synthesis of PI (1)
REACT_121000
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (1)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (5)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (3)
REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Thyroxine biosynthesis (1)
REACT_15292
Transcriptional activation of mitochondrial biogenesis (2)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (2)
REACT_27161
Transport of fatty acids (6)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (1)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (3)
REACT_1206
Triglyceride Biosynthesis (2)
REACT_1190
Tryptophan catabolism (6)
REACT_916
Ubiquinol biosynthesis (1)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (1)
REACT_20594
Urea cycle (3)
REACT_847
VEGFR2 mediated vascular permeability (1)
REACT_228016
Vitamins B6 activation to pyridoxal phosphate (1)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (2)
REACT_118713
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