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ST003131 Untargeted Metabolomics on mouse caecal contentsList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (2)
REACT_850
Abacavir metabolism (3)
REACT_121388
ABCA transporters in lipid homeostasis (1)
REACT_111158
ABH2 mediated Reversal of Alkylation Damage (2)
REACT_526
ABH3 mediated Reversal of Alkylation Damage (2)
REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1)
REACT_160183
Abnormal metabolism in phenylketonuria (7)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of gene expression by SREBF (SREBP) (4)
REACT_147904
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Activation of the phototransduction cascade (1)
REACT_163932
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Adenosine P1 receptors (1)
REACT_18288
Adenylate cyclase activating pathway (1)
REACT_15312
Advanced glycosylation endproduct receptor signaling (1)
REACT_25195
Aflatoxin activation and detoxification (2)
REACT_228214
Agmatine biosynthesis (4)
REACT_14800
alpha-linolenic acid (ALA) metabolism (3)
REACT_121147
Alpha-oxidation of phytanate (3)
REACT_17003
Amine ligand-binding receptors (1)
REACT_16983
Amino acid synthesis and interconversion (transamination) (11)
REACT_238
Amino acid transport across the plasma membrane (24)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Androgen biosynthesis (1)
REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (20)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (21)
REACT_75842
Arachidonate production from DAG (2)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2)
REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1)
REACT_2025
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (4)
REACT_416
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (1)
REACT_22433
Biotin transport and metabolism (3)
REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (4)
REACT_111118
Branched-chain amino acid catabolism (7)
REACT_197
Ca2+ pathway (1)
REACT_172761
Cam-PDE 1 activation (2)
REACT_15408
Carnitine synthesis (5)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Cell redox homeostasis (1)
REACT_121394
Cell surface interactions at the vascular wall (1)
REACT_12051
cGMP effects (1)
REACT_23767
Cholesterol biosynthesis (3)
REACT_9405
Chylomicron-mediated lipid transport (1)
REACT_6841
Circadian Clock (4)
REACT_24941
Citric acid cycle (TCA cycle) (6)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (8)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (6)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (2)
REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (3)
REACT_163862
Coenzyme A biosynthesis (3)
REACT_11218
Collagen biosynthesis and modifying enzymes (2)
REACT_121139
Condensation of Prophase Chromosomes (2)
REACT_172744
Conjugation of benzoate with glycine (4)
REACT_6933
Conjugation of phenylacetate with glutamine (4)
REACT_6800
Conjugation of salicylate with glycine (3)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (6)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (20)
REACT_111056
Cysteine formation from homocysteine (3)
REACT_115589
Cytosolic iron-sulfur cluster assembly (2)
REACT_160176
Cytosolic sulfonation of small molecules (5)
REACT_6913
Cytosolic tRNA aminoacylation (21)
REACT_15306
DARPP-32 events (2)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective HLCS causes multiple carboxylase deficiency (1)
REACT_169312
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (2)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (2)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (5)
REACT_115654
Degradation of GABA (3)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (1)
REACT_163773
Digestion of dietary carbohydrate (2)
REACT_9472
Digestion of dietary lipid (8)
REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Electron transport from NADPH to Ferredoxin (1)
REACT_150128
Endogenous sterols (4)
REACT_13812
Endosomal/Vacuolar pathway (20)
REACT_111168
eNOS activation (5)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (20)
REACT_111178
ER Quality Control Compartment (ERQC) (1)
REACT_25091
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (4)
REACT_19193
Fatty acid, triacylglycerol, and ketone body metabolism (2)
REACT_22279
Fatty Acyl-CoA Biosynthesis (3)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (2)
REACT_13653
Free fatty acid receptors (13)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (i) signalling events (12)
REACT_19231
G alpha (q) signalling events (12)
REACT_18283
G alpha (s) signalling events (10)
REACT_19327
G alpha (z) signalling events (1)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Gluconeogenesis (8)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutamate Neurotransmitter Release Cycle (2)
REACT_12591
Glutathione synthesis and recycling (21)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycogen synthesis (1)
REACT_169208
Glycolysis (4)
REACT_1383
Glycosphingolipid metabolism (2)
REACT_116105
Glyoxylate metabolism (6)
REACT_16925
HCN channels (1)
REACT_75862
HDL-mediated lipid transport (1)
REACT_13621
HDMs demethylate histones (2)
REACT_228178
Hedgehog ligand biogenesis (1)
REACT_228111
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (3)
REACT_9465
Heme degradation (2)
REACT_22297
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histamine receptors (1)
REACT_16903
Histidine catabolism (4)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (2)
REACT_494
HS-GAG biosynthesis (1)
REACT_121248
HS-GAG degradation (1)
REACT_120752
Hydrolysis of LPC (2)
REACT_120977
Hydrolysis of LPE (1)
REACT_120785
Hydroxycarboxylic acid-binding receptors (4)
REACT_163785
Hypusine synthesis from eIF5A-lysine (1)
REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1)
REACT_163919
Inositol transporters (1)
REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (2)
REACT_25367
Interconversion of polyamines (4)
REACT_14805
IP6 and IP7 transport between cytosol and nucleus (1)
REACT_150169
IPs transport between cytosol and ER lumen (1)
REACT_150204
IPs transport between nucleus and ER lumen (1)
REACT_150265
Iron uptake and transport (2)
REACT_25060
ISG15 antiviral mechanism (1)
REACT_115831
Keratan sulfate biosynthesis (2)
REACT_121120
LDL-mediated lipid transport (1)
REACT_6934
Ligand-gated ion channel transport (2)
REACT_25387
Linoleic acid (LA) metabolism (3)
REACT_121100
Lysine catabolism (4)
REACT_1298
Metabolism of folate and pterines (4)
REACT_11167
Metabolism of polyamines (5)
REACT_14820
Metabolism of serotonin (3)
REACT_15532
Methionine salvage pathway (3)
REACT_75881
Methylation (5)
REACT_6946
Miscellaneous substrates (3)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (1)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (1)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1)
REACT_160
Mitochondrial iron-sulfur cluster biogenesis (2)
REACT_150353
Mitochondrial tRNA aminoacylation (21)
REACT_15302
Molybdenum cofactor biosynthesis (4)
REACT_25073
mRNA Capping (1)
REACT_1470
mRNA decay by 3' to 5' exoribonuclease (4)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (4)
REACT_20518
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (23)
REACT_20506
Na+-dependent glucose transporters (1)
REACT_19165
NADPH regeneration (1)
REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (3)
REACT_11213
Nicotinate metabolism (3)
REACT_11088
Nitric oxide stimulates guanylate cyclase (2)
REACT_23862
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (2)
REACT_12510
NOSTRIN mediated eNOS trafficking (2)
REACT_12541
Organic anion transport (3)
REACT_22310
Organic anion transporters (5)
REACT_19372
Organic cation transport (9)
REACT_22357
Orphan transporters (13)
REACT_267716
Oxidative Stress Induced Senescence (2)
REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2)
REACT_120916
PAOs oxidise polyamines to amines (4)
REACT_505
Passive transport by Aquaporins (2)
REACT_23826
PDE3B signalling (2)
REACT_1451
Phagosomal maturation (early endosomal stage) (3)
REACT_121256
Phenylalanine and tyrosine catabolism (8)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
phospho-PLA2 pathway (1)
REACT_15466
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
Plasmalogen biosynthesis (2)
REACT_1407
Platelet degranulation (1)
REACT_318
Platelet sensitization by LDL (1)
REACT_23879
PPARA activates gene expression (7)
REACT_116145
Pregnenolone biosynthesis (1)
REACT_11038
Pre-NOTCH Processing in Golgi (1)
REACT_118798
Presynaptic function of Kainate receptors (1)
REACT_21254
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 (1)
REACT_25396
Proline catabolism (3)
REACT_1002
Proton-coupled monocarboxylate transport (2)
REACT_20515
Proton-coupled neutral amino acid transporters (3)
REACT_19348
Proton/oligonucleotide cotransporters (20)
REACT_19328
Purine catabolism (15)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (6)
REACT_1776
Purine salvage (13)
REACT_1923
Pyrimidine biosynthesis (7)
REACT_21376
Pyrimidine catabolism (18)
REACT_1023
Pyrimidine salvage reactions (10)
REACT_655
Pyruvate metabolism (3)
REACT_2071
Rap1 signalling (1)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Reactions specific to the complex N-glycan synthesis pathway (1)
REACT_25302
Recycling of bile acids and salts (10)
REACT_11042
Regulation by TREX1 (3)
REACT_163652
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of cholesterol biosynthesis by SREBP (SREBF) (1)
REACT_147797
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (4)
REACT_19241
Regulation of pyruvate dehydrogenase (PDH) complex (2)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (4)
REACT_70
Removal of the Flap Intermediate from the C-strand (4)
REACT_7999
Respiratory electron transport (3)
REACT_22393
Retinoid cycle disease events (2)
REACT_160130
Retinoid metabolism and transport (5)
REACT_24968
Reuptake of GABA (2)
REACT_23910
REV-ERBA represses gene expression (4)
REACT_118789
RIP-mediated NFkB activation via ZBP1 (1)
REACT_118563
Role of phospholipids in phagocytosis (2)
REACT_160158
RORA activates circadian gene expression (4)
REACT_118659
Scavenging by Class A Receptors (4)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Scavenging by Class H Receptors (2)
REACT_164002
Scavenging of heme from plasma (1)
REACT_160163
Serine biosynthesis (3)
REACT_115789
Serotonin and melatonin biosynthesis (2)
REACT_15439
Serotonin clearance from the synaptic cleft (1)
REACT_15391
Serotonin Neurotransmitter Release Cycle (1)
REACT_15425
Serotonin receptors (1)
REACT_17064
Sialic acid metabolism (2)
REACT_200874
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2)
REACT_20646
Sphingolipid de novo biosynthesis (5)
REACT_115810
Stimuli-sensing channels (2)
REACT_160189
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (9)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (10)
REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts (4)
REACT_11054
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2)
REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (4)
REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (12)
REACT_11041
Synthesis of CL (1)
REACT_120920
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of IP2, IP, and Ins in the cytosol (2)
REACT_150352
Synthesis of IPs in the ER lumen (1)
REACT_150253
Synthesis of IPs in the nucleus (1)
REACT_150275
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3)
REACT_150420
Synthesis of PA (2)
REACT_120906
Synthesis of PC (3)
REACT_121238
Synthesis of PE (1)
REACT_120919
Synthesis of PG (4)
REACT_121280
Synthesis of PI (2)
REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2)
REACT_150149
Synthesis of PS (2)
REACT_120823
Synthesis of pyrophosphates in the cytosol (1)
REACT_150188
Synthesis of UDP-N-acetyl-glucosamine (2)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (3)
REACT_380
Synthesis, secretion, and deacylation of Ghrelin (2)
REACT_19189
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (14)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (5)
REACT_23824
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (1)
REACT_21281
Termination of O-glycan biosynthesis (1)
REACT_115835
TET1,2,3 and TDG demethylate DNA (2)
REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (3)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (4)
REACT_160156
The retinoid cycle in cones (daylight vision) (2)
REACT_160083
Thyroxine biosynthesis (3)
REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (1)
REACT_120983
TRAF6 mediated NF-kB activation (1)
REACT_24969
Trafficking of dietary sterols (1)
REACT_13781
Transcriptional activation of mitochondrial biogenesis (4)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (4)
REACT_27161
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of fatty acids (7)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (3)
REACT_19305
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (3)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (14)
REACT_1206
Transport of nucleotide sugars (3)
REACT_22151
Transport of organic anions (5)
REACT_23988
Transport of vitamins, nucleosides, and related molecules (1)
REACT_22285
Triglyceride Biosynthesis (2)
REACT_1190
Tryptophan catabolism (8)
REACT_916
Ubiquinol biosynthesis (2)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (9)
REACT_847
Utilization of Ketone Bodies (1)
REACT_59
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFA-VEGFR2 Pathway (1)
REACT_228166
VEGFR2 mediated cell proliferation (1)
REACT_228024
VEGFR2 mediated vascular permeability (4)
REACT_228016
Vitamin B1 (thiamin) metabolism (2)
REACT_11117
Vitamin B2 (riboflavin) metabolism (4)
REACT_11070
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (6)
REACT_25012
YAP1- and WWTR1 (TAZ)-stimulated gene expression (4)
REACT_118713
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