ST003365 Intracellular and medium metabolomics for BT-474 breast cancer cells treated with a range of Fasnall and GSK2194069 concentrations for 24 h
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (8) REACT_121117
Acetylation (2) REACT_6732
Acetylcholine Neurotransmitter Release Cycle (2) REACT_15309
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (4) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (3) REACT_121147
Alpha-oxidation of phytanate (4) REACT_17003
Amino acid synthesis and interconversion (transamination) (12) REACT_238
Amino acid transport across the plasma membrane (22) REACT_13796
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (20) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (20) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Attenuation phase (1) REACT_200624
Beta oxidation of butanoyl-CoA to acetyl-CoA (2) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (3) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (3) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (3) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (3) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (3) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (3) REACT_2025
Beta-oxidation of pristanoyl-CoA (4) REACT_17017
Beta-oxidation of very long chain fatty acids (4) REACT_17062
Biotin transport and metabolism (2) REACT_11153
Branched-chain amino acid catabolism (8) REACT_197
Carnitine synthesis (5) REACT_2125
Catecholamine biosynthesis (1) REACT_15551
Cell redox homeostasis (2) REACT_121394
Cholesterol biosynthesis (3) REACT_9405
Citric acid cycle (TCA cycle) (9) REACT_1785
Class A/1 (Rhodopsin-like receptors) (2) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (4) REACT_18319
Cobalamin (Cbl, vitamin B12) transport and metabolism (3) REACT_163862
Coenzyme A biosynthesis (1) REACT_11218
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (1) REACT_6933
Conjugation of phenylacetate with glutamine (1) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (3) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (20) REACT_111056
Cysteine formation from homocysteine (2) REACT_115589
Cytosolic tRNA aminoacylation (20) REACT_15306
Defective HLCS causes multiple carboxylase deficiency (1) REACT_169312
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (5) REACT_115654
Degradation of GABA (5) REACT_23964
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endosomal/Vacuolar pathway (20) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (20) REACT_111178
Establishment of Sister Chromatid Cohesion (1) REACT_150266
Ethanol oxidation (4) REACT_34
Fatty Acyl-CoA Biosynthesis (4) REACT_1319
Formation of the active cofactor, UDP-glucuronate (2) REACT_6737
formation of the beta-catenin:TCF transactivating complex (1) REACT_200753
Free fatty acid receptors (3) REACT_21268
GABA synthesis (1) REACT_24020
Galactose catabolism (1) REACT_532
G alpha (i) signalling events (4) REACT_19231
G alpha (q) signalling events (7) REACT_18283
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (11) REACT_1520
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione synthesis and recycling (20) REACT_6960
Glycolysis (5) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (3) REACT_16925
HATs acetylate histones (1) REACT_172610
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
Histidine catabolism (3) REACT_1249
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (2) REACT_120752
Hydrolysis of LPC (1) REACT_120977
Hydroxycarboxylic acid-binding receptors (1) REACT_163785
Hypusine synthesis from eIF5A-lysine (2) REACT_12469
Import of palmitoyl-CoA into the mitochondrial matrix (1) REACT_11082
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Inositol transporters (1) REACT_19188
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Interconversion of polyamines (1) REACT_14805
Ligand-gated ion channel transport (1) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (5) REACT_1298
Metabolism of folate and pterines (4) REACT_11167
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (2) REACT_15532
Methionine salvage pathway (1) REACT_75881
Methylation (2) REACT_6946
Mineralocorticoid biosynthesis (2) REACT_11047
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (3) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (2) REACT_150353
Mitochondrial tRNA aminoacylation (20) REACT_15302
Molybdenum cofactor biosynthesis (3) REACT_25073
MPS IIIC - Sanfilippo syndrome C (1) REACT_147860
Na+/Cl- dependent neurotransmitter transporters (19) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinate metabolism (3) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (2) REACT_22310
Organic anion transporters (7) REACT_19372
Organic cation transport (1) REACT_22357
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
Peroxisomal lipid metabolism (1) REACT_16957
Phagosomal maturation (early endosomal stage) (2) REACT_121256
Phenylalanine and tyrosine catabolism (8) REACT_1786
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (4) REACT_1002
Proton-coupled monocarboxylate transport (2) REACT_20515
Proton-coupled neutral amino acid transporters (3) REACT_19348
Proton/oligonucleotide cotransporters (20) REACT_19328
Purine ribonucleoside monophosphate biosynthesis (6) REACT_1776
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyruvate metabolism (5) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of pyruvate dehydrogenase (PDH) complex (3) REACT_12528
Resolution of Sister Chromatid Cohesion (1) REACT_150425
Respiratory electron transport (2) REACT_22393
Retinoid cycle disease events (1) REACT_160130
RNA Polymerase I Transcription Initiation (1) REACT_953
Role of phospholipids in phagocytosis (1) REACT_160158
Separation of Sister Chromatids (1) REACT_150471
Serine biosynthesis (5) REACT_115789
Serotonin and melatonin biosynthesis (2) REACT_15439
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (3) REACT_115810
Sulfide oxidation to sulfate (1) REACT_116010
Sulfur amino acid metabolism (5) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (2) REACT_21330
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (2) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (2) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (4) REACT_11041
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of IP2, IP, and Ins in the cytosol (2) REACT_150352
Synthesis of Ketone Bodies (3) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2) REACT_150420
Synthesis of Lipoxins (LX) (2) REACT_150320
Synthesis of PA (3) REACT_120906
Synthesis of PC (2) REACT_121238
Synthesis of PG (1) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (2) REACT_150149
Synthesis of PS (2) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (3) REACT_22394
Synthesis, secretion, and deacylation of Ghrelin (1) REACT_19189
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The activation of arylsulfatases (2) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
The fatty acid cycling model (1) REACT_6258
Thyroxine biosynthesis (2) REACT_15292
Tolerance by Mtb to nitric oxide produced by macrophages (2) REACT_120983
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (1) REACT_19305
Transport of inorganic cations/anions and amino acids/oligopeptides (3) REACT_19397
Transport of vitamins, nucleosides, and related molecules (2) REACT_22285
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (8) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (6) REACT_847
Utilization of Ketone Bodies (4) REACT_59
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (1) REACT_25012
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