List of Studies ( Metabolite:N-Methylalanine)
Study_id | Analysis_id | Study_title | Source | Species | Disease | Institute | Units(range) |
---|---|---|---|---|---|---|---|
ST000962 | AN001576 | Metabolomics Involved in Early-Life Single Pulse Antibiotic Exposures - Liver (part I) | Liver | Mouse | Antibiotic resistance | NRI, UNC-CH | - |
ST000967 | AN001581 | Metabolomics Involved in Early-Life Single Pulse Antibiotic Exposures - Serum (part II) | Blood | Mouse | Antibiotic resistance | NRI, UNC-CH | - |
ST001680 | AN002739 | Metabolome of NAFLD in high fat diet mouse model | Liver | Mouse | Fatty liver disease | Weill Cornell Medicine | Abundance |
ST001062 | AN001737 | Arabidopsis Nit1 knockout metabolomics | Plant | Arabidopsis thaliana | University of California, Davis | Arbitrary units | |
ST003254 | AN005333 | The impact of grass- and grain-finishing on metabolomic profiles of North American Black Angus Beef cattle. | Bovine meat | Cow | Duke University | Arbitrary Units | |
ST001814 | AN002942 | Searching for prognostic biomarkers of Parkinson´s Disease development in the Spanish EPIC cohort through a multiplatform metabolomics approach | Blood | Human | Parkinsons disease | Universidad CEU San Pablo | AREA |
ST001901 | AN003092 | Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress | Yeast cells | Yeast | University of Utah School of Medicine | area under the curve | |
ST003028 | AN004965 | Chronic stress dampens Lactobacillus johnsonii-mediated tumor suppression to enhance colorectal cancer progression | Colon | Mouse | Cancer | China Pharmaceutical University | count per second (cps) |
ST000368 | AN000602 | Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer | Blood | Human | Cancer | University of California, Davis | Counts |
ST000369 | AN000603 | Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (part II) | Blood | Human | Cancer | University of California, Davis | Counts |
ST000379 | AN000613 | Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures | Cultured cells | Human | University of California, Davis | Counts | |
ST000381 | AN000615 | Urinary Metabolites in IC/PBS Diagnosis (part I) | Urine | Human | Interstitial cystitis | University of California, Davis | Counts |
ST000383 | AN000618 | Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women | Blood | Human | Diabetes | University of California, Davis | Counts |
ST000389 | AN000625 | Serum phosphatidylethanolamine levels distinguish benign from malignant solitary pulmonary nodules and represent a potential diagnostic biomarker for lung cancer (part II) | Blood | Human | Cancer | University of California, Davis | Counts |
ST000390 | AN000626 | Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma (part I) | Lung | Human | Cancer | University of California, Davis | Counts |
ST000392 | AN000628 | Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry | Blood | Human | Cancer | University of California, Davis | Counts |
ST000396 | AN000633 | Lung Cancer Plasma Discovery | Blood | Human | Cancer | University of California, Davis | Counts |
ST000397 | AN000634 | Long-term neural and physiological phenotyping of a single human | Blood | Human | University of California, Davis | Counts | |
ST000401 | AN000640 | Inhibition of diamine oxidase promotes uptake of putrescine from rat small intestine | Intestine | Rat | University of California, Davis | Counts | |
ST000402 | AN000641 | Impact of glucose on the central metabolome of C. minutissima | Cells | Chlorella | University of California, Davis | Counts | |
ST000404 | AN000644 | Role of HVCN1 in B cell malignancies | Cells | Human | Cancer | University of California, Davis | Counts |
ST000412 | AN000652 | Metabolic profiling during ex vivo machine perfusion of the human liver | Liver | Human | University of California, Davis | Counts | |
ST000419 | AN000661 | Impact Of High Sugar Diet On L-Arginine Metabolism In The Lung | Lung | Mouse | University of California, Davis | Counts | |
ST000495 | AN000761 | Metabolomic profiles along the gastrointestinal tract of the healthy dog | Intestine | Dog | University of California, Davis | Counts | |
ST000658 | AN001287 | Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part IV) | Blood | Mouse | Obesity | University of California, Davis | Counts |
ST000660 | AN001522 | Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part I) | Blood | Mouse | Obesity | University of California, Davis | Counts |
ST000878 | AN001428 | Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease | Kidney | Mouse | Kidney disease | University of California, Davis | Counts |
ST000884 | AN001441 | Evidence that COG0325 proteins are involved in PLP homeostasis | Cells | E. coli | University of California, Davis | Counts | |
ST000968 | AN001582 | Impact of thiamine metabolites and spent medium from Chlorella sorokiniana on metabolism in the green algae Auxenochlorella prototheciodes (part I) | Cultured cells | Auxenochlorella | University of California, Davis | Counts | |
ST000969 | AN001583 | Impact of thiamine metabolites and spent medium from Chlorella sorokiniana on metabolism in the green algae Auxenochlorella prototheciodes (part II) | Cultured cells | Auxenochlorella | University of California, Davis | Counts | |
ST000979 | AN001603 | Metabolomic profiles in healthy research cats receiving clindamycin with a synbiotic or a placebo: a randomized, controlled trial | Feces | Cat | Antibiotic resistance | University of California, Davis | Counts |
ST000981 | AN001607 | Metabolomic profiles in healthy research cats receiving clindamycin with a synbiotic or a placebo: a randomized, controlled trial (Part II) | Feces | Cat | Antibiotic resistance | University of California, Davis | Counts |
ST002155 | AN003530 | Longitudinal metabolomic stool dynamics in primary C. difficile infections | Feces | Human | Bacterial infection | Brigham Women's Hospital | intensity |
ST001834 | AN002976 | A metabolomics comparison of plant-based meat and grass-fed meat indicates large nutritional differences despite comparable nutrition facts labels | Other | Duke University | Log-transformed deconvoluted spectra | ||
ST000784 | AN001240 | metabolome in a group of AA and EA matched pairs of prostate cancer (PCa) and benign adjacent tissues | Prostate | Human | Cancer | Baylor College of Medicine | log transform with internal standard normalization |
ST001940 | AN003155 | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement | Feces | Human | Irritable bowel syndrome | University of California, Los Angeles | Metabolon original scale |
ST001940 | AN003156 | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement | Feces | Human | Irritable bowel syndrome | University of California, Los Angeles | Metabolon original scale |
ST001940 | AN003157 | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement | Feces | Human | Irritable bowel syndrome | University of California, Los Angeles | Metabolon original scale |
ST001940 | AN003158 | Cognitive Behavioral Therapy for Irritable Bowel Syndrome Induces Bidirectional Alterations in the Brain-Gut-Microbiome Axis Associated with Gastrointestinal Symptom Improvement | Feces | Human | Irritable bowel syndrome | University of California, Los Angeles | Metabolon original scale |
ST002377 | AN003873 | Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups (Pnpla7-knockout) | Liver | Mouse | Tokyo Metropolitan Institute of Medical Science | nmol | |
ST000570 | AN000878 | Metabolome analysis of the cecal contents of GF mice and GF mice colonized with dominant gut microbes present in the ceca of neonatal and adult mice | Feces | Mouse | Keio University | nmol/g | |
ST001250 | AN002075 | Luminal metabolome profiles of mice developed dextran sulfate sodium (DSS) colitis | Feces | Mouse | Colitis | University of Michigan | nmol/g |
ST001300 | AN002164 | Luminal metabolome profiles ofUC-HMA mice transplanted with a healthy human-derived fecal microbiota (FMT). | Feces | Mouse | Bacterial infection | University of Michigan | nmol/g |
ST001301 | AN002166 | Luminal metabolome profiles of human microbiota-associated (HMA) mice treated with anti-IL-22 antibody or control antibody | Feces | Mouse | Bacterial infection | University of Michigan | nmol/g |
ST002170 | AN003555 | Cecal metabolome of specific-pathogen-free mice fed with five distinct rodent diets with varying fiber content and source. | Cecum | Mouse | Luxembourg Institute of Health | nmol/g | |
ST002172 | AN003559 | Cecal metabolome of gnotobiotic (containing a 14-member synthetic human gut microbiota), and germ-free mice fed with two distinct rodent diets with varying fiber content. | Cecum | Mouse | Luxembourg Institute of Health | nmol/g | |
ST002476 | AN004077 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Mouse) | Intestine | Mouse | COVID-19 | Keio University | nmol/g |
ST002476 | AN004077 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Mouse) | Intestine | Mouse | Influenza | Keio University | nmol/g |
ST002479 | AN004079 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Hamster) | Intestine | Mouse | COVID-19 | Keio University | nmol/g |
ST002479 | AN004079 | High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection (Hamster) | Intestine | Mouse | Influenza | Keio University | nmol/g |
ST002763 | AN004492 | Metabolomic and lipidomic characterization of Haemophilus influenzae Rd KW20 | Bacterial cells | Haemophilus influenzae | Universidad CEU San Pablo | normalized abundances (IS: tricosane) | |
ST003277 | AN005365 | LC-MS/MS spatial analysis of mouse GI | Intestine | Mouse | Brown University | normalized imputed data | |
ST002027 | AN003297 | Metabolomics Analysis of Blood Plasma and Stool from Six Week Flaxseed Dietary Intervention in Postmenopausal Women (Serum/HILIC) | Blood | Human | UC Davis | normalized peak height | |
ST002711 | AN004394 | Metabolomic analysis of maternal mid-gestation plasma and cord blood: biogenic amines | Blood | Human | Autism | Columbia University | normalized peak heights |
ST002020 | AN003290 | TIPs Metabolomics (urine) | Urine | Human | Vanderbilt University Medical Center | osmolality normalized scaled imputed | |
ST000048 | AN000084 | Metabolomic & lipidomic profiles in response to exogenous insulin & GLP-1 infusions during prolonged fasting (GCMS) | Blood | Seal | Diabetes | University of California, Davis | Peak area |
ST000057 | AN000095 | Combined Metabolomics and Lipidomics of Type 1 Diabetes (GCMS) | Mouse | Diabetes | University of California, Davis | Peak area | |
ST000061 | AN000099 | Metabolic Profiling of Visceral and Subcutaneous Adipose Tissue from Colorectal Cancer Patients: GC-TOF MS analyis of subcutaneous and visceral adipose tissue samples | Adipose tissue | Human | University of California, Davis | Peak area | |
ST000062 | AN000100 | Biomarkers for Depression in Human Plasma in a Population Sample | Blood | Human | University of California, Davis | Peak area | |
ST000063 | AN000101 | Biomarkers for Depression in Human Cerebrospinal Fluid in a Population Sample | Cerebrospinal fluid | Human | University of California, Davis | Peak area | |
ST000065 | AN000103 | Metabolic Profiling of Visceral and Subcutaneous Adipose Tissue from Colorectal Cancer Patients: GC-TOF MS analyis of serum samples | Adipose tissue | Human | Cancer | University of California, Davis | Peak area |
ST000117 | AN000198 | Metabolomics analysis of multiple metabolic functions in the YjgF/YER057c/UK114 (Rid) protein family GC-MS (Part 1) | Bacterial cells | E. coli | University of California, Davis | Peak area | |
ST000117 | AN000198 | Metabolomics analysis of multiple metabolic functions in the YjgF/YER057c/UK114 (Rid) protein family GC-MS (Part 1) | Bacterial cells | Salmonella | University of California, Davis | Peak area | |
ST000118 | AN000199 | Metabolomics analysis of multiple metabolic functions in the YjgF/YER057c/UK114 (Rid) protein family GCMS (part 2) | Bacterial cells | E. coli | University of California, Davis | Peak area | |
ST000118 | AN000199 | Metabolomics analysis of multiple metabolic functions in the YjgF/YER057c/UK114 (Rid) protein family GCMS (part 2) | Bacterial cells | Salmonella | University of California, Davis | Peak area | |
ST000385 | AN000620 | Study1 Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (training set) | Blood | Human | Cancer | University of California, Davis | Peak area |
ST000386 | AN000621 | Study 2 Investigation of metabolomic blood biomarkers for detection of adenocarcinoma lung cancer (test/validation) | Blood | Human | Cancer | University of California, Davis | Peak area |
ST000918 | AN001503 | GC/MS metabolomic plasma analysis | Blood | Human | Cancer | Universidad de los Andes, Colombia | Peak area |
ST001158 | AN001916 | The gut microbiota plays a central role to modulate the plasma metabolome in response to chronic Angiotensin II infusion (part-II) | Feces | Mouse | Johns Hopkins University School of Medicine | Peak area | |
ST001218 | AN002031 | Wild type versus TRACK Mice on regular chow and Vitamin A deprived diet | Kidney | Mouse | Cancer | weill cornell medicine | Peak area |
ST001606 | AN002639 | Aromatic amino acid metabolism by the anaerobic gut bacterium Clostridium sporogenes | Blood | Mouse | Stanford University | Peak area | |
ST001606 | AN002639 | Aromatic amino acid metabolism by the anaerobic gut bacterium Clostridium sporogenes | Feces | Mouse | Stanford University | Peak area | |
ST001606 | AN002639 | Aromatic amino acid metabolism by the anaerobic gut bacterium Clostridium sporogenes | Intestine | Mouse | Stanford University | Peak area | |
ST001606 | AN002639 | Aromatic amino acid metabolism by the anaerobic gut bacterium Clostridium sporogenes | Urine | Mouse | Stanford University | Peak area | |
ST001935 | AN003145 | Metabolomic profiling of spontaneous macaque model for diabetes mellitus | Blood | Macaque monkey | Diabetes | Xiamen University | Peak area |
ST001935 | AN003145 | Metabolomic profiling of spontaneous macaque model for diabetes mellitus | Liver | Macaque monkey | Diabetes | Xiamen University | Peak area |
ST002376 | AN003871 | Hepatic Phosphatidylcholine Catabolism Driven by PNPLA7 and PNPLA8 Supplies Endogenous Choline to Replenish the Methionine Cycle with Methyl Groups(Pnpla8-knockout) | Liver | Mouse | Tokyo Metropolitan Institute of Medical Science | Peak area | |
ST002787 | AN004534 | Metabolomic analysis of gut metabolites in colorectal cancer patients: correlation with disease development and outcome | Feces | Human | Cancer | Wuhan University of Science and Technology | Peak Area |
ST000589 | AN000904 | Effects of dilution on analyte identification and quantification | Blood | Human | Duke University | Peak area (Log2 transformed) | |
ST001937 | AN003150 | Comprehensive plasma metabolomics and lipidomics based management of benign and malignant solitary pulmonary nodules | Blood | Human | Cancer | China Pharmaceutical University | peak height |
ST000002 | AN000002 | Intestinal Samples II pre/post transplantation | Intestine | Human | University of California, Davis | Peak height | |
ST000007 | AN000021 | Rice Infection Study | Plant | Rice | Bacterial infection | University of California, Davis | Peak height |
ST000900 | AN001466 | Evidence that the metabolite repair enzyme NAD(P)HX epimerase has a moonlighting function | Cells | E. coli | University of California, Davis | Peak height | |
ST001122 | AN001847 | Identification of urine metabolites in patients with interstitial cystitis using untargeted metabolomics (part II) | Urine | Human | Interstitial cystitis | University of California, Davis | Peak height |
ST001131 | AN001856 | Presentation of different serum metabolites in trauma patients versus healthy volunteers. | Blood | Human | Trauma | Texas Tech University | Peak height |
ST001234 | AN002052 | The effect of weaning stress, sex and temperament on fecal microbiota and metabolites in Brahman calves. | Blood | Cow | Texas A&M University | Peak height | |
ST001274 | AN002115 | Metabolomics-based profiling of the mode of action of Pathogen Box compounds in Trypanosoma brucei (part-I) | Cultured cells | Trypanosoma brucei | Sleeping sickness | Monash University | Peak height |
ST001637 | AN002675 | A Metabolome Atlas of the Aging Mouse Brain | Brain | Mouse | University of California, Davis | Peak height | |
ST001637 | AN002676 | A Metabolome Atlas of the Aging Mouse Brain | Brain | Mouse | University of California, Davis | Peak height | |
ST001888 | AN003057 | A Metabolome Atlas of the Aging Mouse Brain (Study part II) | Brain | Mouse | University of California, Davis | Peak height | |
ST001888 | AN003058 | A Metabolome Atlas of the Aging Mouse Brain (Study part II) | Brain | Mouse | University of California, Davis | Peak height | |
ST001928 | AN003136 | Metabolomics profiles of premenopausal women are different based on O-desmethylangolensin metabotype | Urine | Human | George Mason University | Peak height | |
ST003179 | AN005221 | Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4 | Plasmodium cells | Plasmodium falciparum | Malaria | Monash University | Peak height |
ST001794 | AN002912 | Metabolomics Analysis of Time-Series Gastrointestinal Lumen Samples | Intestine | Human | University of California, Davis | Peak Height Intensity | |
ST001949 | AN003173 | Plasma Metabolome Normalization in Rheumatoid Arthritis following initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy | Blood | Human | Rheumatoid arthritis | University of Kansas | Peak Height Intensity |
ST001318 | AN002194 | Atg32-mediated mitophagy promotes heat stress tolerance in Saccharomyces cerevisiae by sustaining spermidine and nitric oxide levels | Yeast cells | Yeast | West Coast Metabolomics Center - UC Davis | Peak height normalized with creatinine | |
ST001523 | AN002541 | The effect of fasting and sirtuin overexpression on serum metabolome. | Blood | Mouse | Bar Ilan University | Peak height normalized with creatinine | |
ST001700 | AN002771 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Serum) part-II | Blood | Mouse | National Institutes of Health | Peak height normalized with creatinine | |
ST001701 | AN002772 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Liver) part-III | Liver | Mouse | National Institutes of Health | Peak height normalized with creatinine | |
ST001702 | AN002773 | A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice (Heart) part-IV | Heart | Mouse | National Institutes of Health | Peak height normalized with creatinine | |
ST002950 | AN004839 | Investigate the impact of feeding time on the hexosamine biosynthetic pathway (HBP) in the mouse liver and heart using targeted metabolomics: biogenic amines | Heart | Mouse | University of California, Davis | peak heights | |
ST002950 | AN004839 | Investigate the impact of feeding time on the hexosamine biosynthetic pathway (HBP) in the mouse liver and heart using targeted metabolomics: biogenic amines | Liver | Mouse | University of California, Davis | peak heights | |
ST002493 | AN004086 | Composition of raw plant-based food items Pilot Study | Plant | Plants | Massachusetts Institute of Technology | peak intensity | |
ST002493 | AN004087 | Composition of raw plant-based food items Pilot Study | Plant | Plants | Massachusetts Institute of Technology | peak intensity | |
ST000415 | AN000657 | Toxicokinetics and Metabolomic Disrupting of the Flame Retardant Mixture Firemaster 550 | Placenta | Rat | RTI International | Peak intensity | |
ST000418 | AN000660 | The role of CFTR in the regulation of intrinsic defense mechanisms of exocrine secretions | Saliva | Human | Cystic fibrosis | RTI International | Peak intensity |
ST000569 | AN000876 | Effect of minimal and complex media on the metabolite profiles | Bacterial cells | Yeast | Graduate school of Korea University | Peak intensity | |
ST000614 | AN000941 | Tobacco-specific carcinogens in Bladder Cancer | Bladder | Human | Cancer | Baylor College of Medicine | Peak intensity |
ST000614 | AN000943 | Tobacco-specific carcinogens in Bladder Cancer | Bladder | Human | Cancer | Baylor College of Medicine | Peak intensity |
ST001745 | AN002838 | Metabolomic profiling of the rat hippocampus across developmental ages and after learning | Brain | Rat | New York University | pmoles/l | |
ST002094 | AN003420 | Commensal intestinal microbiota regulates host luminal proteolytic activity and intestinal barrier integrity through β-glucuronidase activity (Part 1) | Feces | Human | Irritable bowel syndrome | Mayo Clinic | raw intensity |
ST003131 | AN005135 | Untargeted Metabolomics on mouse caecal contents | Cecum | Mouse | University College Cork | Raw Peak Area | |
ST003132 | AN005139 | Untargeted Metabolomics on Mouse colonic mucosa | Colonic mucosa | Mouse | University College Cork | Raw Peak Area | |
ST002836 | AN004633 | Bacterial tryptophan metabolites increased by prebiotic galactooligosaccharide reduce microglial reactivity and are associated with lower anxiety-like behavior (Intestine) | Intestine | Mouse | Anxiety | National Center for Advancing Translational Sciences | Relative Abundance |
ST002206 | AN003609 | Lipolysis-derived Lipids Determine Autophagy Initiation during Fasting | Worms | C. elegans | Seoul National University | relative area | |
ST001668 | AN002720 | D-Allulose effects on hepatic metabolomics profile in rodents | Liver | Rat | Matsutani Chemical Industry Co., Ltd. | Relative Area | |
ST003298 | AN005402 | Annual changes on metabolomics profile in latex | Latex | Plant | Sumitomo Riko Co., Ltd. | Relative Area | |
ST002263 | AN003696 | Intermittent fasting induces rapid hepatocyte proliferation to maintain the hepatostat | Liver | Mouse | Stanford University | relative counts | |
ST002509 | AN004131 | Time course 1: Growth of Eggerthella lenta in defined media | Bacterial culture supernatant | Eggerthella lenta | University of California, San Francisco | relative ion counts | |
ST002510 | AN004134 | Strain supernatants: Strain diversity of Eggerthella lenta metabolites in defined media | Bacterial culture supernatant | Eggerthella lenta | University of California, San Francisco | relative ion counts | |
ST002089 | AN003410 | Plasma metabolomic signatures of COPD: A metabolomic severity score for airflow obstruction and emphysema. | Blood | Human | COPD | National Jewish Health | relativeMedian |
ST001870 | AN003032 | Effects of GP130 Antagonism on Right Ventricular Metabolism in Monocrotaline Rats | Heart | Rat | University of Minnesota | relative value | |
ST002018 | AN003288 | Multi-omic analysis of the microbiome and metabolome in healthy subjects (feces) | Feces | Human | Vanderbilt University Medical Center | scaled imputed | |
ST001515 | AN002511 | A Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans | Blood | Human | Obesity | Translational Research Institute- AdventHealth Orlando | scaled units |
ST002212 | AN003616 | Human fecal metabolome profiles under 3 different dietary terms | Feces | Human | Keio University | µmol/g |