Data for ST000876   

(Analysis AN001413): Average values per metabolite and experimental factor (Units:uM)

Metabolite structureAll dataF1F2F3F4F5F6F7F8F9F10F11F12
1-methylhistamine
0.00 0.01 0.01 0.00 0.01 0.00 0.00 0.00 0.01 0.01 0.00 0.00
2-Aminoisobutyric acid
2.33 2.15 1.58 2.56 2.20 2.25 2.34 1.62 1.41 1.89 1.49 1.59
2-deoxyuridine
- - - - - - - - - - - -
3-Hydroxyanthranilic acid
0.18 - 0.14 0.19 0.22 0.21 0.18 0.23 0.07 0.22 0.14 0.14
3-OH-DL-KYNURENINE
0.05 0.07 0.07 0.07 0.06 0.06 0.06 0.07 0.05 0.06 0.06 0.05
4-Pyridoxic Acid
0.04 0.04 0.03 0.01 0.01 0.01 0.01 0.01 0.05 0.04 0.02 0.04
5-Deoxy-5Methylthio Adenosine
- - - - - - - - - - - -
5-Hydroxyindole-3-acetic acid
0.05 0.03 0.07 0.05 0.04 0.04 0.03 0.05 0.06 0.04 0.04 0.06
Acetoacetic acid
520.32 418.57 328.70 337.88 342.44 195.36 363.78 247.41 432.33 430.36 181.24 242.45
Acetylcarnitine
13.98 11.33 11.79 12.72 9.47 8.08 12.04 11.05 10.42 12.46 9.95 12.07
Adenine
0.01 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Adenosine
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Alanine
381.79 425.59 393.50 398.63 444.32 433.47 360.17 476.84 412.60 446.22 460.12 422.61
Allantoin
2.82 0.87 1.16 1.10 0.89 3.52 0.84 1.67 0.32 1.31 1.62 1.65
Aminodipic Acid
1.99 2.82 2.96 1.38 1.94 1.87 1.90 1.55 1.72 1.79 1.88 1.52
AMP
0.11 0.02 0.04 0.03 0.03 0.12 0.02 0.06 0.04 0.03 0.08 0.03
Arachidyl Carnitine
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Arginine
113.52 115.40 107.79 95.67 101.59 102.16 104.61 106.85 133.30 108.32 105.14 103.10
Asparagine
34.76 32.59 32.49 36.97 37.03 41.10 33.81 38.86 35.48 35.13 35.67 30.69
Aspartate
16.74 11.05 11.22 12.99 18.39 19.13 11.58 16.68 13.85 12.80 16.34 13.24
Asymmetric dimethylarginine
0.94 1.10 1.13 0.74 0.96 0.92 0.87 0.79 0.86 1.15 0.84 0.85
Betaine
92.52 74.71 112.48 89.15 110.47 80.64 97.73 78.20 93.32 70.41 108.41 98.35
cAMP
0.01 0.01 0.01 0.00 0.00 0.00 0.01 0.00 0.01 0.02 0.00 0.01
Carnitine
51.18 40.11 46.08 39.68 38.96 46.34 45.25 49.56 44.61 48.91 37.56 48.14
Carnosine
0.37 0.28 0.21 0.22 0.18 0.23 0.28 0.20 0.22 0.23 0.27 0.24
cGMP
0.00 0.01 0.00 - - - 0.00 - - - - 0.00
Chenodeoxycholic Acid
28.73 28.02 12.70 14.00 9.26 19.24 13.12 16.39 22.64 13.37 10.73 16.33
Cholic Acid
1.19 1.21 - - - - - - - - 2.77 -
Choline
45.15 40.94 44.79 49.04 47.27 44.85 48.79 39.03 39.94 30.10 48.60 45.50
Citrulline
42.20 57.17 45.94 39.12 36.73 44.43 35.93 36.93 41.94 40.10 47.11 41.45
Cotinine
0.08 - - - - - - - - - 0.01 -
Creatine
125.61 104.41 83.03 104.59 78.44 142.96 111.39 99.66 80.27 91.31 80.82 80.92
Creatinine
42.83 47.45 54.54 45.79 49.30 38.15 50.99 54.89 53.93 52.17 46.69 49.48
Cystathionine
0.02 0.03 0.02 0.02 0.03 0.03 0.04 0.02 0.02 0.02 0.02 0.02
Cysteine
55.72 49.93 52.96 48.41 45.50 52.64 48.07 50.80 49.07 49.36 48.59 49.54
Cytidine
0.28 0.23 0.24 0.23 0.21 0.21 0.27 0.25 0.24 0.28 0.19 0.26
Cytosine
0.02 0.01 0.06 0.01 0.00 0.01 0.00 0.00 0.01 0.01 0.02 0.05
Decanoylcarnitine
0.20 0.18 0.16 0.16 0.16 0.11 0.17 0.16 0.19 0.19 0.11 0.14
deoxycytidine
0.21 0.22 0.18 0.17 0.14 0.17 0.18 0.17 0.14 0.18 0.14 0.17
D-Glucuronic acid
2.14 2.64 1.99 1.54 1.68 1.41 1.21 1.44 1.24 2.16 1.46 2.07
DimethylGlycine
0.62 0.52 1.05 0.65 1.16 0.42 0.75 0.36 0.89 0.50 0.73 0.66
Dodecanoyl Carnitine
0.42 0.46 0.33 0.42 0.31 0.17 0.36 0.30 0.42 0.37 0.22 0.16
D-Ribose 5-phosphate
0.26 0.15 0.28 0.43 0.18 0.18 0.24 0.20 0.17 0.12 0.28 0.14
Folic Acid
- - - - - - - - - - - -
GABA
0.30 0.21 0.27 0.38 0.29 0.35 0.19 0.22 0.26 0.82 0.22 0.23
Gamma-Glutamylcysteine
9.75 11.59 8.76 8.70 8.02 12.36 7.87 10.00 9.92 9.94 11.09 12.10
Glutamine
1644.30 1647.88 1717.31 1532.92 1692.22 1353.03 1469.39 1579.04 1690.79 1645.15 1628.15 1426.95
Glutathione
0.11 0.05 0.12 0.06 - 0.14 0.07 - 0.10 - - -
Glyceraldehyde
224.48 199.06 182.39 178.84 191.03 284.07 169.25 186.04 178.84 170.39 242.48 174.72
Glycine
216.42 208.45 222.42 166.98 332.74 234.11 239.45 315.55 301.18 239.01 259.88 205.31
Glycocholic Acid
0.29 0.42 0.17 0.20 0.12 0.17 0.25 0.32 0.20 0.16 0.18 0.25
Guanidinoacetic Acid
2.27 2.14 3.41 1.64 3.34 1.55 1.97 2.83 2.93 2.06 2.70 1.68
Guanosine
0.05 0.42 0.12 0.07 0.04 0.07 0.18 0.06 0.64 0.10 0.04 0.08
Hexanoylcarnitine
0.08 0.07 0.06 0.07 0.06 0.04 0.06 0.06 0.06 0.08 0.04 0.06
Hippuric acid
3.29 5.43 52.10 28.18 5.27 3.81 3.48 28.24 12.17 5.11 44.40 9.64
Histidine
81.81 77.38 75.49 67.54 67.74 76.91 67.00 67.57 74.74 73.93 80.63 65.41
Homocysteine
0.17 - - - - - - - - - - -
Homogentisic acid
0.71 0.24 0.32 0.29 0.47 0.24 0.23 0.28 0.42 0.33 0.16 0.30
Homoserine
- - - - - - - - - - - -
Hydroxyproline
13.48 13.85 8.86 8.34 12.99 8.52 7.46 9.72 9.64 9.88 11.05 8.45
Hypoxanthine
5.98 4.25 6.12 4.49 5.87 7.33 5.14 7.25 4.67 6.77 5.92 5.08
IMP
0.26 0.11 0.16 0.07 0.10 0.37 0.06 0.15 0.14 0.10 0.20 0.07
Inosine
0.45 1.28 0.42 0.31 0.40 0.80 0.89 0.88 2.23 0.97 0.43 0.41
Isobutyrylcarnitine
0.25 0.28 0.25 0.17 0.18 0.24 0.23 0.27 0.23 0.28 0.19 0.21
Isoleucine
73.63 62.13 57.79 66.45 52.20 52.99 60.42 55.03 54.06 51.54 54.67 43.88
Isovalerylcarnitine
0.09 0.14 0.10 0.08 0.07 0.08 0.09 0.09 0.09 0.10 0.07 0.07
Kynurenic Acid
0.03 0.02 0.03 0.03 0.02 0.02 0.02 0.02 0.01 0.02 0.02 0.03
L-5-Hydroxytryptophan
0.04 0.04 0.03 0.04 0.03 0.03 0.05 0.02 0.04 0.05 0.02 0.03
Leucine
137.23 137.17 132.29 116.94 122.68 138.41 126.32 130.16 126.81 128.60 113.49 104.96
L-Glutamic Acid
23.09 17.67 23.16 28.94 28.38 35.14 26.70 31.57 19.73 22.94 34.64 23.62
L-Kynurenine
1.52 1.54 1.45 1.39 1.44 1.42 1.34 1.21 1.38 1.37 1.40 1.28
L-Methionine
21.75 18.26 20.04 17.48 20.88 20.70 15.73 15.91 17.82 15.98 19.81 15.52
Lysine
235.09 243.50 226.22 229.60 214.29 247.28 217.37 240.18 219.52 226.09 212.35 199.83
Myoinositol
11.72 11.94 12.61 14.78 12.69 16.28 10.37 11.69 10.30 16.06 14.59 12.38
Myristoyl Carnitine
0.02 0.06 0.04 0.06 0.05 0.02 0.06 0.05 0.05 0.04 0.05 0.02
NAD
0.05 0.00 0.01 0.00 0.01 0.05 0.00 0.02 0.00 0.00 0.01 0.00
Neopterin
- 0.00 0.00 0.00 0.00 0.01 0.01 0.00 0.00 0.01 0.01 0.01
Niacinamide
0.18 0.17 0.20 0.22 0.17 0.17 0.24 0.31 0.13 0.08 0.23 0.15
Nicotinic Acid
0.09 - - - - - - - - - - -
Normetanephrine
0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
Octanoylcarnitine
0.31 0.24 0.20 0.21 0.20 0.12 0.20 0.16 0.23 0.25 0.12 0.17
Ornithine
100.64 102.95 74.26 92.62 85.19 92.80 79.98 83.44 57.54 84.11 110.71 74.09
Orotic acid
- - - - - - - - - - - -
Palmitoyl Carnitine
0.01 0.08 0.10 0.12 0.15 0.02 0.15 0.13 0.11 0.04 0.12 0.03
Pantothenic Acid
0.19 0.18 0.16 0.18 0.21 0.22 0.20 0.22 0.19 0.20 0.16 0.24
Phenylalanine
62.19 55.63 52.10 52.65 56.18 62.82 49.96 50.77 55.51 51.51 54.71 48.93
Phosphoethanolamine
2.18 2.20 3.12 2.31 2.54 2.10 2.36 1.96 2.40 1.92 2.79 2.45
Proline
246.56 370.96 357.78 219.56 242.92 313.19 207.48 251.08 265.58 274.51 294.92 253.59
Propionylcarnitine
0.42 0.45 0.36 0.32 0.27 0.35 0.37 0.39 0.31 0.40 0.27 0.35
Pyridoxine
- - - - - - - - - - - -
S-5-Adenosyl-L-Methionine Chloride
1.93 2.31 5.53 3.27 1.53 6.63 1.48 5.15 5.14 3.35 7.15 2.66
S-Adenosyl-L-Homocysteine
0.02 0.01 0.02 0.02 0.01 0.03 0.02 0.02 0.01 0.01 0.02 0.01
Serine
186.80 171.32 168.11 236.01 373.10 257.90 310.83 309.63 336.89 326.35 139.73 100.43
Sorbitol
6.74 4.30 5.12 7.25 5.14 8.86 4.98 4.97 5.74 4.92 6.54 18.29
Spermidine
0.13 0.10 0.11 0.19 0.11 0.23 0.12 0.14 0.09 0.13 0.13 0.09
Stearoyl Carnitine
0.01 0.02 0.03 0.02 0.05 0.00 0.05 0.02 0.03 0.01 0.03 0.01
Succinate
5.99 6.43 5.91 5.46 5.85 4.59 5.17 5.06 5.31 5.22 6.25 6.99
Sucrose
1.45 1.64 1.83 1.40 1.30 2.67 1.12 1.26 2.14 1.73 2.06 1.76
Symmetric dimethylarginine
1.15 1.04 1.12 1.15 1.36 1.32 1.24 1.46 1.35 1.39 1.08 1.23
Taurine
184.65 127.10 158.37 145.92 157.85 182.45 136.24 174.23 96.62 144.53 181.94 160.37
Taurochenodeoxycholic Acid
0.30 0.35 0.08 0.17 0.07 0.09 0.19 0.26 0.16 0.09 0.17 0.14
Taurocholic Acid
0.04 0.05 0.01 0.03 0.02 0.01 0.03 0.04 0.03 0.02 0.02 0.03
Threonine
158.87 147.38 146.13 141.13 132.87 131.25 151.79 129.35 114.95 127.65 147.67 126.01
Trimethylamine-N-Oxide
2.72 2.43 3.58 2.77 5.90 1.98 3.10 3.58 2.88 4.32 1.86 2.61
Tryptophan
33.69 33.67 31.99 30.08 31.44 32.95 31.10 29.89 31.76 30.79 34.30 28.56
Tyrosine
133.32 159.86 133.79 133.24 131.45 128.40 130.12 133.60 150.94 167.71 147.15 126.17
UDP-Glucose
9.41 0.89 1.97 1.11 1.83 9.54 0.81 4.28 1.63 - 4.59 1.03
Uracil
0.59 0.38 0.61 0.64 0.65 0.26 0.36 0.27 0.80 0.52 0.23 0.43
Valine
410.19 508.37 459.68 435.27 392.70 428.98 397.62 365.65 365.29 364.20 423.45 338.85
Xanthine
5.01 3.81 4.85 5.26 4.56 5.64 4.44 4.42 3.64 5.85 4.88 3.85
Xanthosine
0.12 0.07 0.07 0.08 0.06 0.11 0.07 0.08 0.06 0.08 0.10 0.07

Factors:

F1L-serine (mg/kg/day):100 | time point (weeks):6
F2L-serine (mg/kg/day):200 | time point (weeks):52
F3L-serine (mg/kg/day):200 | time point (weeks):9
F4L-serine (mg/kg/day):300 | time point (weeks):12
F5L-serine (mg/kg/day):400 | time point (weeks):15
F6L-serine (mg/kg/day):400 | time point (weeks):18
F7L-serine (mg/kg/day):400 | time point (weeks):21
F8L-serine (mg/kg/day):400 | time point (weeks):30
F9L-serine (mg/kg/day):400 | time point (weeks):38
F10L-serine (mg/kg/day):400 | time point (weeks):44
F11L-serine (mg/kg/day):50 | time point (weeks):3
F12L-serine (mg/kg/day):- | time point (weeks):-
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