Data for ST002835
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2-deoxyribose-5P | 103535.00 | 117542.00 | 60606.33 | 95090.67 | 81646.50 | 30600.33 | - | - | - | - | |
| 3-Aminoisobutanoic acid (2-methyl-beta-alanine) | 123717018.43 | 92815383.82 | 99662946.40 | 66667605.60 | 55801886.04 | 61682478.40 | 221097056.10 | 181951211.50 | 259907260.80 | 239710436.20 | |
| 3-Phosphoglyceric acid | 11052137.43 | 11191590.58 | 11442719.36 | 6122286.19 | 8333334.44 | 9523207.28 | 21074035.97 | 11730734.61 | 24394655.20 | 28381299.08 | |
| 3-Ureidopropionate | - | - | - | - | - | - | - | - | - | - | |
| 6-Phosphono-gluconic acid | 8171946.55 | 1832430.33 | 7029218.71 | 4063526.99 | 1181291.87 | 3123760.71 | 3512465.49 | 1378600.28 | 5823422.19 | 5911936.86 | |
| Acetylcarnitine | 7200387713.67 | 7438334901.33 | 1936866882.67 | 8659902786.00 | 8330169660.00 | 2869558711.00 | 2282430800.67 | 1817279908.67 | 2416807125.33 | 2407918120.67 | |
| Acetyl-CoA | 1317879.43 | 1092831.88 | 1222323.51 | 1086779.68 | 1125443.67 | 518736.43 | 105945.05 | 52194.77 | - | 41730.50 | |
| Aconitic acid | 14645766.81 | 6981017.61 | 8491841.16 | 10888062.23 | 5715921.40 | 7407113.93 | 24270312.79 | 21540435.11 | 24270635.92 | 31126268.24 | |
| Adenosine | 365061993.20 | 336403769.67 | 540567251.07 | 370418250.30 | 332380008.63 | 312451667.27 | 44163081.44 | 33266648.53 | 26948001.05 | 32280293.28 | |
| Adenosine diphosphate (ADP) | 63756868.78 | 56353453.77 | 65961675.01 | 60589662.52 | 59324656.92 | 57595521.32 | 70214164.51 | 52488923.81 | 67068410.30 | 70796374.28 | |
| Adenosine monophosphate (AMP) | 8226219.91 | 11244816.91 | 7402281.43 | 8621271.02 | 12340352.77 | 13502059.21 | 12970363.89 | 12648925.96 | 12164061.98 | 13148565.61 | |
| Adenosine triphosphate (ATP) | 209123955.77 | 177783362.63 | 177704416.37 | 190113371.03 | 178282123.70 | 176444859.80 | 191088184.30 | 143764735.05 | 177349069.57 | 219634596.53 | |
| Alanine | 224690784.93 | 169856271.67 | 231108960.50 | 192945315.87 | 146733088.10 | 135095006.00 | 68463822.67 | 87589719.09 | 84380050.69 | 65541456.17 | |
| alpha-Ketoglutaric acid | 37791133.31 | 27918897.15 | 21334325.56 | 34816436.16 | 23633830.86 | 34989965.43 | 69253386.99 | 59752904.91 | 76420448.90 | 73300247.63 | |
| Arginine | 1747021319.67 | 1928827657.00 | 1578154343.67 | 1575867002.67 | 1825137869.33 | 1791105309.33 | 1891760729.00 | 2042126799.33 | 2075198655.00 | 2336296686.50 | |
| Asparagine | 250395102.13 | 251490526.37 | 207592811.83 | 162154239.07 | 180344438.77 | 187188935.97 | 267070188.67 | 195549961.53 | 276167958.47 | 287920615.13 | |
| Aspartic acid | 74548368.95 | 142111615.53 | 97848245.76 | 51356562.10 | 108424788.98 | 91033340.74 | 671210284.07 | 571901753.23 | 669811596.20 | 607810335.17 | |
| Beta-Alanine | 62394568.64 | 38188017.91 | 19825554.72 | 47921429.69 | 28825969.80 | 23123990.92 | 61916525.23 | 57122784.17 | 64557031.99 | 70068147.86 | |
| Citric acid + Isocitric acid | 227852699.93 | 207409174.73 | 263599797.37 | 167725494.93 | 139684658.33 | 232551148.60 | 343974990.23 | 314832944.53 | 341058569.03 | 403653745.97 | |
| Citrulline | 28564578.95 | 2975890.73 | 1854858.57 | 19760056.67 | 2402136.88 | 2665714.00 | 33629352.09 | 37948362.95 | 36057573.05 | 33856237.81 | |
| CMP | 5436254.42 | 5082536.01 | 3207504.60 | 6535723.74 | 7482538.33 | 3879352.38 | 5900667.09 | 6084709.08 | 5586252.59 | 5279909.47 | |
| Creatine | 5097318831.67 | 4417344579.33 | 5355951884.33 | 4739884126.67 | 3829573314.67 | 3736188867.33 | 1634275710.50 | 2080569961.00 | 1877652583.33 | 1487243464.50 | |
| Cysteine | - | - | - | - | - | - | - | - | - | - | |
| cystine | 5010821.57 | 3984336.06 | 8470006.17 | 2871003.08 | 3169215.54 | 2685853.70 | 1236100.48 | 1078740.45 | 994959.60 | 1952165.28 | |
| Cytidine 5^-triphosphate | 31986775.00 | 25120689.38 | 24329953.46 | 32781509.28 | 25377404.47 | 21290653.37 | 23618013.56 | 19668134.76 | 20944701.18 | 26320186.73 | |
| Cytosine | 3472525.64 | 2932055.82 | 1718673.98 | 3531138.67 | 3122458.92 | 1997771.88 | 5567437.31 | 7735333.38 | 6569943.77 | 5931936.76 | |
| d-ADP | 160556.78 | 145161.06 | 129093.99 | 56167.56 | 73678.64 | 68510.16 | - | - | - | 162348.52 | |
| d-AMP | 1409969.21 | 974591.54 | 1583435.16 | 229379.33 | 1142380.54 | 97043.04 | - | - | 40203.93 | 69439.72 | |
| d-ATP | 244066.44 | 120253.74 | 85220.89 | 57698.68 | 43391.08 | 31123.96 | 726897.11 | 67759.39 | 691003.00 | 544665.70 | |
| d-CDP | - | - | - | - | - | - | - | - | - | - | |
| d-CMP | 4327248.31 | 3120599.27 | 3037770.48 | 3462376.15 | 3352547.96 | 2852361.31 | 1808042.68 | 2507785.34 | 3058215.77 | 1818776.14 | |
| Deoxyguanosine diphosphate | 14452397.98 | 12548399.04 | 11117845.80 | 12057196.52 | 10998986.48 | 11235714.36 | 13168013.46 | 8459862.40 | 10217224.82 | 12026075.24 | |
| d-GMP | 2189322.73 | 2154926.87 | 1862467.81 | 2415996.29 | 2296257.09 | 1831506.14 | 2654237.26 | 3399667.66 | 2725387.04 | 2761739.40 | |
| d-GTP | 3860919.49 | 4012222.21 | 1514775.29 | 3915066.86 | 4153365.02 | 2952669.27 | 3436936.95 | 2744223.58 | 3331523.49 | 2305545.30 | |
| Dihydrouracil | 5249730093.33 | 4405812485.00 | 5300757626.67 | 4726170641.33 | 3811246385.33 | 3873967756.00 | 1620775667.00 | 2063749436.33 | 1923324551.33 | 1572232832.00 | |
| Erythrose 4-P | - | - | - | - | - | - | - | - | - | - | |
| Farnesyl -PP | - | - | - | - | - | - | - | - | - | - | |
| "Fructose1,6-bisphosphate" | 8762180.21 | 5070090.75 | 8419632.74 | 4843887.42 | 3405291.95 | 5024463.95 | 32042710.68 | 16298642.55 | 42714449.03 | 45623722.34 | |
| Fumaric acid | 11013946.41 | 11194626.09 | 12855850.54 | 6465443.90 | 9546276.45 | 11143034.32 | 65931876.20 | 48524415.44 | 72286227.01 | 89109893.83 | |
| Glucosamine-6-phosphate | 1616578.14 | 1362933.38 | 1339475.08 | 1091766.88 | 926328.74 | 1025655.20 | 1453053.73 | 1206883.48 | 1372497.29 | 1428878.03 | |
| glucose | 1093599.33 | 957204.33 | 2904879.33 | 1003666.33 | 1327076.33 | 1156424.00 | 1092844.00 | 842153.00 | 952729.00 | 876682.33 | |
| Glucuronic acid | 579815.33 | 533378.00 | 475363.00 | 517991.33 | 533420.33 | 428942.00 | 820365.00 | 910772.00 | 883780.67 | 972688.00 | |
| Glutamic acid | 4976649896.00 | 5454904196.33 | 5038010696.00 | 2882752773.33 | 3315383237.00 | 4250628959.67 | 5003720099.33 | 4357570800.33 | 5307504869.33 | 5631872915.33 | |
| Glutamine | 2152890758.00 | 2395775379.33 | 2158539299.00 | 1631055061.00 | 1735646901.67 | 2030231970.00 | 2316948080.00 | 1979984835.00 | 2485289802.67 | 2602137903.33 | |
| Glutathione oxidized | 848373450.17 | 849737860.80 | 846650514.93 | 820780808.17 | 812738581.73 | 884011701.27 | 580919331.70 | 550742175.43 | 632092501.47 | 580027900.93 | |
| Glutathione (reduced) | 5693817.62 | 19596522.43 | 6057397.04 | 2318130.49 | 14827105.37 | 9897244.58 | 184816635.63 | 66078773.19 | 401201319.96 | 286672454.08 | |
| Glyceraldehyde 3-phosphate + DHAP | 1726789.19 | 894595.64 | 922687.22 | 1359623.20 | 1014723.40 | 728533.71 | 5604608.54 | 3043874.14 | 7959923.36 | 8665012.81 | |
| glycerol | 10993693.56 | 3102463.60 | 2684677.08 | 9742571.25 | 3121038.60 | 3141949.41 | 10345006.09 | 8198705.17 | 7260364.52 | 11040525.52 | |
| Glycine | 19118238.49 | 11834648.11 | 13335152.72 | 11766641.26 | 12071156.07 | 15583494.08 | 26771752.15 | 27910716.49 | 21421433.70 | 30946061.58 | |
| Glyoxylic acid | 708794.33 | 470801.33 | 323045.33 | 677394.00 | 523824.67 | 613895.33 | 1812774.00 | 1863686.33 | 2130390.00 | 1700430.33 | |
| GMP | 1135695.00 | 754103.26 | 313299.39 | 1169973.83 | 1175569.28 | 450474.31 | 1571715.26 | 1536224.15 | 1533342.16 | 1958657.37 | |
| Guanosine | 9636948.50 | 6984612.76 | 5198713.27 | 15658404.29 | 12012661.88 | 7898103.64 | 2794008.47 | 4095349.11 | 2099795.33 | 1617181.93 | |
| Guanosine triphosphate (GTP) | 33484384.46 | 22280224.64 | 22173260.02 | 29323547.88 | 21087409.36 | 21510592.79 | 15941786.10 | 9949211.19 | 11889557.05 | 16737972.69 | |
| Hexose-phosphate | 7412239.70 | 2675599.33 | 10854316.64 | 4910497.21 | 2118434.08 | 3745382.47 | 4571878.31 | 4130630.88 | 8696891.04 | 7527597.78 | |
| Histidine | 51887488.62 | 27859003.17 | 38238584.57 | 32938922.27 | 62160177.27 | 26809198.09 | 110364263.29 | 106652511.64 | 149396281.73 | 142632907.30 | |
| IMP | 4987930.55 | 4760076.42 | 9634255.94 | 4071397.11 | 2919077.57 | 3895941.46 | 8554447.57 | 7337570.20 | 8778172.98 | 11310097.37 | |
| Inositol | 43935905.49 | 40327596.81 | 31751159.24 | 48424460.27 | 48270366.82 | 38790076.47 | 452987499.60 | 512875855.57 | 461259686.50 | 493541091.93 | |
| Isoleucine | 1446036590.67 | 1506335370.67 | 1610479490.00 | 1151557546.33 | 1262188151.67 | 1362208633.00 | 1742835256.00 | 1830262980.00 | 2346998448.67 | 2151547605.33 | |
| Itaconic Acid | 20598485.64 | 12911280.04 | 13775281.68 | 15619719.24 | 12010413.36 | 14239834.82 | 34008530.67 | 28979177.10 | 34261597.55 | 39002487.55 | |
| Lactic Acid | 1228077174.49 | 340063461.87 | 3901121.21 | 1189790797.70 | 388068787.70 | 432403521.53 | 3875499321.33 | 2267093118.67 | 2985610897.33 | 3739643540.00 | |
| Leucine | 898192566.33 | 925669873.00 | 1037354495.33 | 675784357.67 | 727421260.00 | 948066888.00 | 1497307535.33 | 1193691152.67 | 1519061649.33 | 1714315449.33 | |
| Lysine | 133119866.64 | 146190911.37 | 78783849.41 | 138112631.67 | 136744481.74 | 124453010.40 | 257212774.00 | 275721305.77 | 214808196.53 | 307407776.47 | |
| Malic acid | 107432096.42 | 111938525.27 | 137522695.67 | 63437367.53 | 73974970.86 | 106714179.69 | 545631062.17 | 409717838.93 | 594565164.00 | 636213417.97 | |
| Methionine | 459468041.27 | 730582651.53 | 598677315.43 | 459265830.50 | 699454071.40 | 815692180.93 | 1157113164.77 | 1036246405.10 | 1284572491.33 | 1213100481.00 | |
| Mevalonic acid | 2648132.96 | 6806021.61 | 4449335.65 | 11243102.08 | 2916388.35 | 4446916.30 | 12565634.14 | 5071492.01 | 6405344.16 | 4546412.87 | |
| Mevalonic acid 5-P | - | - | - | - | - | - | - | - | - | - | |
| N-Acetyl-glucosamine 1-phosphate | 7247573.24 | 5294904.02 | 5751208.85 | 4718787.60 | 7679304.37 | 4308768.69 | 14974840.35 | 12113846.31 | 10411574.16 | 13743824.68 | |
| N-Acetylneuraminic acid | 14573458.85 | 8216043.96 | 10993860.26 | 9159492.46 | 16986169.54 | 14173845.77 | 48929569.92 | 53439652.28 | 51456421.62 | 58631479.99 | |
| NAD+ | 77609312.21 | 76457599.77 | 82946865.65 | 67813963.65 | 73387950.00 | 78039841.25 | 86430667.61 | 85067359.97 | 88727939.02 | 97889965.61 | |
| NADH | - | - | - | - | - | - | - | - | - | - | |
| NADP+ | 6290585.31 | 6606066.49 | 5141482.95 | 6382931.51 | 8250335.53 | 5560028.11 | 1391757.56 | 1479762.87 | 1162116.56 | 1488616.88 | |
| NADPH | - | - | - | - | - | - | - | - | - | - | |
| Niacin (NA) | 3729927.00 | 2871560.93 | 2318430.65 | 2555501.76 | 3484648.27 | 3685824.52 | 3598753.51 | 3774362.57 | 4188712.76 | 10901727.14 | |
| NMN | - | - | - | - | - | - | - | - | - | - | |
| Ornithine | 10252387.92 | 10981608.17 | 6781331.23 | 8396014.53 | 13557983.25 | 8683291.76 | 23107282.90 | 21415730.27 | 18855235.45 | 28834174.31 | |
| Oxaloacetate | - | - | - | - | - | - | - | - | - | - | |
| pantothenic acid | 521982844.37 | 172177236.93 | 157308497.27 | 454926885.97 | 154526898.63 | 169320339.83 | 88365432.39 | 220064628.33 | 362235386.70 | 141395071.54 | |
| "Pentose - Phosphate (ribose, ribulose and xylulose)" | 2879028.28 | 974724.29 | 1671895.49 | 1922203.43 | 712373.67 | 768208.42 | 1288762.17 | 773658.07 | 2083482.82 | 1880072.26 | |
| Phenylalanine | 1786477286.33 | 1613752291.33 | 1494201914.00 | 1523041172.00 | 1466963675.33 | 1428478991.67 | 2797761640.33 | 2378857816.67 | 2991829440.33 | 3096856369.67 | |
| Phenylpyruvate | 914739.33 | 903314.00 | 598978.33 | 1045877.00 | 1108346.00 | 870002.33 | 2361156.00 | 1777343.33 | 1786937.33 | 2137098.33 | |
| Phosphocreatine | 652122378.50 | 642436346.93 | 609249684.30 | 614658900.40 | 623188209.50 | 608412182.80 | 248260121.00 | 266198494.27 | 246348284.97 | 251447025.17 | |
| Phosphoenolpyruvic acid | 759110.44 | 1680868.88 | 975734.95 | 414230.02 | 1614489.05 | 1326381.43 | 3393076.20 | 1868215.25 | 3263472.88 | 3663676.79 | |
| Proline | 1861684842.67 | 2146683746.00 | 1947492324.33 | 1709743847.67 | 1910852225.33 | 2068308139.33 | 4189609601.33 | 4357953651.67 | 4700163847.67 | 4400561004.00 | |
| Pyruvic acid | 4782057.29 | 5644401.08 | 5576384.05 | 4142131.63 | 3835335.79 | 4395726.88 | 27038334.00 | 19710918.46 | 32432905.46 | 26755057.38 | |
| Sedoheptulose 7-P | 910793.67 | 208306.67 | 308287.67 | 692606.33 | 257433.33 | 200832.67 | 186558.00 | 146225.00 | 433090.00 | 383396.00 | |
| Serine | 72032410.54 | 67516928.89 | 63892493.02 | 44789029.71 | 41931880.56 | 42186282.76 | 63467891.73 | 83514590.30 | 105396476.60 | 86534852.37 | |
| Succinic acid | 64458344.98 | 31803614.96 | 48789851.79 | 49663138.45 | 54012426.00 | 63793952.07 | 72638931.11 | 60490080.16 | 70719309.19 | 101203946.15 | |
| SuccinylCoA | - | - | - | - | - | - | - | - | - | - | |
| Threonine | 33438727.71 | 29644670.94 | 44974741.07 | 21342195.21 | 23455345.33 | 21508707.43 | 33900620.16 | 27352018.56 | 32986940.65 | 35592822.32 | |
| Thymidine | - | - | - | - | - | - | - | - | - | - | |
| Thymidine triphosphate | 985886.80 | 401292.97 | 283358.43 | 328931.67 | 164682.24 | 127777.67 | 1629114.85 | 150016.44 | 1581889.71 | 1856923.39 | |
| Thymine | 2400245.64 | 2718210.95 | 667782.78 | 2450150.49 | 1402028.05 | 1186671.34 | 2319375.10 | 2408958.81 | 2181959.36 | 3310764.13 | |
| TMP | 333461.67 | 125431.00 | 115290.67 | 318269.33 | 55165.00 | 55602.00 | 12562.00 | 47157.50 | 26333.67 | 9211.00 | |
| Tryptophan | 41752845.40 | 128327698.93 | 169292478.73 | 56401264.97 | 116407331.20 | 160578486.23 | 407538783.87 | 295051851.27 | 389633054.13 | 465516040.63 | |
| Tyrosine | 20544170.29 | 23118851.91 | 23131465.02 | 16375147.61 | 21928625.48 | 26191536.19 | 40249220.65 | 32070964.13 | 38271054.64 | 42098943.30 | |
| UDP-GlcNAc | 109115974.40 | 105167063.02 | 124796959.00 | 106653475.37 | 103492764.32 | 110727320.35 | 123551492.10 | 103132105.58 | 145702179.10 | 148164161.93 | |
| Uracil | 9663572.60 | 683741.85 | 258404.96 | 10099174.86 | 713112.90 | 507798.36 | 22282440.22 | 17739721.75 | 18000346.19 | 21784374.69 | |
| Uridine | 89270085.38 | 31207076.18 | 4557438.04 | 81597036.53 | 22797478.48 | 4081578.89 | 608969.07 | 3182586.44 | 1868359.02 | 736731.72 | |
| Uridine 5^-diphosphate (UDP) | 18930728.83 | 16357209.63 | 18065420.82 | 17176260.76 | 14874539.04 | 14304849.73 | 33074241.38 | 24730867.04 | 39195638.27 | 39276462.93 | |
| Uridine 5^-triphosphate | 71571528.72 | 70098524.03 | 67489496.49 | 61558585.55 | 59700406.81 | 61932288.55 | 55373517.78 | 32150519.02 | 57767469.26 | 72979910.00 | |
| Uridine diphosphate glucose | 24303662.38 | 19583799.25 | 26256981.83 | 20769054.38 | 16772938.03 | 20400191.30 | 61148073.47 | 41543203.66 | 72253955.14 | 71514960.96 | |
| Uridine monophosphate | 6363329.67 | 6040774.43 | 6081007.14 | 6272960.95 | 10728819.84 | 6019261.16 | 18479735.87 | 16325058.43 | 21862094.06 | 20730126.53 | |
| Valine | 246859040.43 | 243589424.00 | 212467262.40 | 211308297.90 | 210653236.93 | 236175393.83 | 193303012.83 | 184634451.13 | 182734341.93 | 196222507.27 | |
| Xanthine | 25510266.12 | 2309161.84 | 1986019.65 | 24711634.66 | 2597985.66 | 3064624.31 | 38468778.24 | 43213347.41 | 50278113.91 | 37080529.93 |
Factors:
| F1 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
| F2 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 1h |
| F3 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 24h |
| F4 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
| F5 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 1h |
| F6 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 24h |
| F7 | cell line:ICC21 | treatment:Afatinib | labeling status:N/A |
| F8 | cell line:ICC21 | treatment:Combo | labeling status:N/A |
| F9 | cell line:ICC21 | treatment:control | labeling status:N/A |
| F10 | cell line:ICC21 | treatment:Infigratinib | labeling status:N/A |
