Data for ST003499
| Metabolite structure | All data | F1 | F2 | F3 |
|---|---|---|---|---|
| 2/3-phosphoglycerate | 43648501.44 | 20544068.79 | 28737558.67 | |
| 2-aminoadipic acid | 3845420.78 | 3174641.78 | 4743509.42 | |
| 2-hydroxyglutarate | 108143475.51 | 80553373.97 | 63542190.04 | |
| 2-ketoglutarate | 137798263.92 | 48492731.71 | 28720034.60 | |
| 4-guanidinobutanoate | 133856872.18 | 289797442.02 | 189791007.90 | |
| acetylcarnitine | 1588437437.60 | 3505011052.00 | 4366307033.20 | |
| acetylcholine | 643045414.04 | 661568917.74 | 1092400979.80 | |
| acetyl-CoA | 1692393.72 | 2213800.56 | 1350963.40 | |
| adenosine | 130633721.88 | 82921354.81 | 168126918.45 | |
| adenylosuccinate | 118150.45 | 156459.58 | 1849355.06 | |
| ADP | 200742541.74 | 140306797.20 | 173825334.60 | |
| ADP-ribose | 1983714.11 | 1959400.79 | 2771114.51 | |
| alanine | 242757040.90 | 446295584.18 | 171513957.42 | |
| aminobutyrate | 241050367.62 | 100262906.82 | 177237119.70 | |
| AMP | 174417018.90 | 112669812.21 | 131599593.64 | |
| arginine | 1791487847.80 | 1726776519.40 | 1521291006.60 | |
| argininosuccinate | 5712260.78 | 7302380.68 | 3868348.64 | |
| asparagine | 325506246.20 | 238614886.06 | 222612234.26 | |
| aspartate | 1259183015.60 | 820311876.62 | 1194885891.20 | |
| aspartylglucosamine | 1293434.08 | 1391921.60 | 1614457.51 | |
| ATP | 213955430.86 | 119125759.67 | 150690511.34 | |
| beta-alanine | 64938529.34 | 168601281.38 | 74785495.38 | |
| beta-citrylglutamic acid | 5990659.45 | 15290151.35 | 6531775.88 | |
| betaine | 3132955485.60 | 2453906330.80 | 7828219676.80 | |
| butyrylcarnitine | 205869566.38 | 467765847.86 | 1075655181.02 | |
| cAMP | 466662.67 | 586785.82 | 318301.56 | |
| carnitinamide | 95564491.39 | 47849140.61 | 60446913.76 | |
| carnitine | 2268692037.60 | 5776848096.80 | 6858248158.60 | |
| carnosine | 7705963.26 | 4456066.97 | 4693172.58 | |
| CDP | 14582918.07 | 7474824.94 | 10637354.18 | |
| CDP-ethanolamine | 10136804.07 | 1919962.35 | 6468946.38 | |
| C-glycosyltryptophan | - | - | - | |
| choline | 2491732475.00 | 1421661053.20 | 1955310380.60 | |
| cis-aconitate | 114590784.18 | 88627816.45 | 97470838.04 | |
| citicoline | 16941167.50 | 7134842.37 | 6934592.83 | |
| citrate | 959671043.26 | 340347134.14 | 661510110.20 | |
| citrulline | 23151293.45 | 24939469.53 | 16071183.82 | |
| CMP | 5658346.45 | 3416662.23 | 4616146.29 | |
| CMP-acetylneuraminic acid | 4632836.39 | 3005301.92 | 3501097.78 | |
| creatine | 7176346497.40 | 6362021210.40 | 13996368520.80 | |
| creatinine | 822785578.22 | 599960845.78 | 609350408.20 | |
| CTP | 9627977.89 | 4030929.77 | 6149502.25 | |
| cyclic ADP-ribose | 16109647.28 | 18290645.69 | 15265004.30 | |
| Cys-Gly | 16079721.65 | 15410051.98 | 19518274.99 | |
| cystathionine | 997801.07 | 488938.81 | 395627.35 | |
| cysteic acid | 180502.02 | 115495.60 | 222358.35 | |
| cystine | 1384402.10 | 386311.22 | 220903.27 | |
| cytidine | 10455315.86 | 3072822.08 | 2734122.49 | |
| deoxycytidine | 19282068.21 | 39231969.92 | 20585928.16 | |
| deoxyribose 5-phosphate | 1108546.96 | 935789.23 | 1326326.75 | |
| dihydroorotate | 3713230.13 | 5104330.75 | 5416147.24 | |
| dihydroxyacetone phosphate | 6418098.74 | 3943535.82 | 3777083.39 | |
| dimethylarginine | 59437441.64 | 77272223.07 | 51549702.23 | |
| dimethyllysine | 3639817.46 | 6902690.49 | 3341782.23 | |
| dTTP | 1380429.28 | 1041767.72 | 993470.93 | |
| ethanolamine phosphate | 74837248.89 | 6223614.62 | 54560503.24 | |
| FAD | 1454563.77 | 890949.31 | 1162040.67 | |
| fructose 1,6-bisphosphate | 11403951.63 | 6432428.73 | 8602673.16 | |
| fructose 6-Phosphate | 10769204.84 | 7119721.45 | 5355976.87 | |
| fumarate | 112219417.60 | 144052019.64 | 72258784.45 | |
| GDP | 11895986.93 | 6650118.70 | 10398423.80 | |
| GDP-glucose | 1471947.74 | 1588115.23 | 1197056.38 | |
| gluconate | 270851888.36 | 294946438.44 | 135632496.30 | |
| glucose 6-phosphate | 8036455.63 | 5964543.94 | 3330962.79 | |
| glucuronic acid | 8551905.95 | 5679743.89 | 7936443.54 | |
| glutamate | 4317114817.40 | 1776462906.20 | 3154454008.20 | |
| glutamine | 10696428327.60 | 6768720582.40 | 8397157238.60 | |
| glutamylcysteine | 1398522.68 | 1145904.34 | 1049548.26 | |
| glutamylproline | 10082405.07 | 10295152.60 | 10600385.16 | |
| glutathione | 1402855585.40 | 1307464987.20 | 1667685469.00 | |
| glyceraldehyde 3-phosphate | 35849978.63 | 28219495.86 | 24790515.38 | |
| glycerol 3-phosphate | 7923165.88 | 2554479.50 | 2576892.18 | |
| glycerophosphoethanolamine | 37961538.56 | 12935143.35 | 8209438.33 | |
| glycerophosphoinositol | 11388422.03 | 15467081.49 | 11699929.37 | |
| glycerophosphorylcholine | 1368723241.40 | 441326405.28 | 232674759.58 | |
| glycerophosphoserine | 543087.49 | 552110.52 | 384850.28 | |
| glycerylphosphorylcholine | 1368723241.40 | 441326405.28 | 232674759.58 | |
| glycine | 133086526.95 | 16962656.21 | 22184793.05 | |
| glycylglycine | 1913356.45 | 1765013.87 | 2611133.25 | |
| GMP | 8471917.12 | 5379614.86 | 8618081.43 | |
| GTP | 7635072.55 | 4003294.78 | 6155298.04 | |
| guanidineacetic acid | 45835355.42 | 59023073.01 | 187020127.58 | |
| guanine | 3228184.96 | 316765.64 | 1424230.46 | |
| guanosine | 5703699.21 | 724335.87 | 2618794.17 | |
| histidine | 837839624.32 | 771531682.06 | 582298960.50 | |
| homoarginine | 7380903.48 | 7471674.14 | 6012070.78 | |
| hydantoin-5-propionic acid | 892361.53 | 619269.61 | 823455.28 | |
| hydroxyphenyllactate | 85848821.85 | 27847687.16 | 39141236.34 | |
| hydroxyproline | 1899904380.60 | 1710871602.60 | 958397592.88 | |
| hydroxytrimethyllysine | 5068637.43 | 4387902.04 | 2639043.56 | |
| hypotaurine | 17426171.68 | 23045884.55 | 21625974.67 | |
| hypoxanthine | 159002483.45 | 30019588.74 | 37838167.89 | |
| IMP | 20571846.91 | 6481746.56 | 9761548.60 | |
| indole | - | - | - | |
| inosine | 25232437.80 | 5086161.03 | 7289110.53 | |
| inositol | 486902243.76 | 535712241.66 | 450365432.50 | |
| isoleucine | 1298280879.80 | 1129204878.04 | 939951808.40 | |
| isovalerylcarnitine C5 | 65683526.23 | 90159921.04 | 124339835.18 | |
| ketoleucine+ketoisoleucine | - | - | - | |
| ketovaline | - | - | - | |
| kynurenine | 2571319.01 | 4383837.15 | 6222050.73 | |
| lactate | 1800394995.60 | 2832888638.00 | 1197772138.54 | |
| leucine | 1233910810.60 | 870841995.88 | 855240863.26 | |
| lysine | 26220691.00 | 15900960.12 | 20934561.23 | |
| malate | 1607180144.20 | 2020004329.00 | 1039487658.50 | |
| methionine | 308928915.70 | 149028071.94 | 204003359.18 | |
| methionine sulfoxide | 28777023.53 | 25432497.42 | 20187368.98 | |
| N-acetylarginine | 2621918.75 | 2893648.42 | 1923797.47 | |
| N-acetylaspartate | 130120878.62 | 153338743.90 | 188144348.10 | |
| N-acetylaspartylglutamate | 470534.94 | 1728307.64 | 1030879.91 | |
| N-acetylglutamate | 64669269.97 | 62050283.98 | 61914097.65 | |
| N-acetylhexosamine phosphate | 13826367.96 | 6393606.78 | 7299097.06 | |
| N-acetylhistidine | 34434817.40 | 36690009.95 | 21692315.99 | |
| N-acetylneuramic acid | 6754863.44 | 4484728.34 | 4812313.67 | |
| N-acetylornithine | 45280352.81 | 45398448.88 | 34181425.27 | |
| N-acetylserine | 374463907.70 | 481024612.56 | 526104983.76 | |
| NAD | 129499863.90 | 139627988.34 | 117579428.68 | |
| NADH | 2762163.34 | 3309701.12 | 6959134.31 | |
| NADP | 1818952.99 | 1273239.01 | 1747243.66 | |
| NADPH | 2203578.34 | 1748743.04 | 2462138.53 | |
| N-carbamoylaspartate | 1504390.25 | 4979032.75 | 2202785.81 | |
| N-carbamoylglutamate | 1217350.14 | 1007708.95 | 1510407.36 | |
| nicotinamide riboside | 4537107.31 | 5062217.33 | 3268451.72 | |
| ophthalmic acid | 3516101.54 | 904439.05 | 2118047.74 | |
| ornithine | 38307007.06 | 33726292.17 | 28902206.67 | |
| orotate | 35288913.19 | 5089587.00 | 4937226.38 | |
| orotidine | 50752897.67 | 63562760.20 | 61498325.99 | |
| oxidized glutathione | 7012941.71 | 4123288.35 | 5932560.34 | |
| pantothenate | 483786044.50 | 177003456.36 | 214971442.72 | |
| phenylalanine | 447363160.60 | 281704576.10 | 317436012.72 | |
| phosphocholine | 17547108863.60 | 11557643070.60 | 18003414214.00 | |
| phosphocreatine | 33306161.16 | 12255472.46 | 11997194.42 | |
| phosphoenolpyruvate | 6324265.61 | 4772700.36 | 4422878.10 | |
| phosphoethanolamine | 49458092.52 | 3759992.60 | 35532623.62 | |
| phosphorylcholine | 17479677653.60 | 11511998053.00 | 17937277091.80 | |
| proline | 18327775319.20 | 16326463906.60 | 15207493154.40 | |
| propionylcarnitine | 366701106.76 | 637413693.42 | 595009015.18 | |
| propionylcholine | 56258083.29 | 118135062.66 | 120468059.60 | |
| pyroglutamic acid | 3238239377.80 | 3295738065.00 | 2592588177.40 | |
| pyruvate | 45959509.64 | 48698377.81 | 10524242.37 | |
| quinolinic acid | 24410293.83 | 25211712.28 | 2057685.92 | |
| S-(2-succinyl)cysteine | 538866.09 | 512909.61 | 250563.53 | |
| S-(2-Succinyl)glutathione | 510837.53 | 750971.90 | 462677.00 | |
| saccharopine | - | - | - | |
| S-adenosylhomocysteine | 8789955.43 | 9574624.20 | 11955846.21 | |
| S-adenosylmethionine | 124034850.70 | 83928069.33 | 92204298.55 | |
| SAICAR | - | - | 2704535.85 | |
| sarcosine | 4269569.73 | 4241882.33 | 3578421.87 | |
| sedoheptulose 7-phosphate | 4985334.83 | 2222920.03 | 6326629.63 | |
| serine | 53698549.52 | 9012262.71 | 25857452.89 | |
| S-lactoylglutathione | 2080882.12 | 4079411.86 | 1857167.80 | |
| succinate | 92805211.60 | 72492252.64 | 43286421.44 | |
| succinyladenosine | - | 541988.75 | 7589956.35 | |
| succinylcarnitine | 865277.43 | 2201546.07 | 1737938.40 | |
| succinylglutathione | 510837.53 | 750971.90 | 462677.00 | |
| taurine | 1293554460.00 | 1632695270.20 | 1672173543.40 | |
| thiamine | 19808800.54 | 57872508.21 | 30133043.52 | |
| threonine | 311884402.18 | 132266576.08 | 193968301.52 | |
| trimethyllysine | 24133619.43 | 39253449.08 | 25493580.90 | |
| tryptamine | - | - | - | |
| tryptophan | 40168226.47 | 20279124.98 | 29544758.52 | |
| tyrosine | 188083016.68 | 158129810.52 | 136696149.18 | |
| UDP | 61411131.29 | 31541144.49 | 43269676.32 | |
| UDP-GlcNac | 188727275.48 | 126590412.02 | 102109807.94 | |
| UDP-glucose | 119973037.68 | 36707709.37 | 70395075.12 | |
| UDP-hexose | 120012898.02 | 36707709.37 | 70401821.51 | |
| UMP | 20738649.28 | 12275885.79 | 16605814.87 | |
| uric acid | 23917984.30 | 26126804.41 | 18330533.51 | |
| uridine | 10294900.60 | 2359432.27 | 3095557.98 | |
| UTP | 50129068.97 | 23007954.26 | 30057196.99 | |
| valine | 262954702.32 | 183468481.52 | 189187983.90 | |
| valine-d8 | 2263839286.00 | 2347423526.60 | 2281988567.60 | |
| xanthine | 58720855.76 | 51066404.34 | 45268832.96 |
Factors:
| F1 | Phenotype:Control | Genotype:Wildtype |
| F2 | Phenotype:Mild | Genotype:R309H/c.1191+5G->C |
| F3 | Phenotype:Mild | Genotype:T450S/D332H |
