Data for ST004205
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-O-Palmitoyl-Cer(d18:1/18:0) | - | - | - | - | - | - | - | - | - | - | |
| 24-Hydroxycholesterol | - | - | - | - | - | - | - | - | - | - | |
| 24-Hydroxycholesterol(d7) | - | - | - | - | - | - | - | - | - | - | |
| 3-O-SulfoLacCer(d18:1/18:0) | - | - | - | - | - | - | - | - | - | - | |
| 4-beta-Hydroxycholesterol | - | - | - | - | - | - | - | - | - | - | |
| 7-keto-Cholesterol | - | - | - | - | - | - | - | - | - | - | |
| CE(16:1) | 0.09 | 0.02 | 0.03 | 0.05 | 0.02 | 0.08 | 0.20 | 0.02 | 0.23 | 0.02 | |
| CE(18:1) | 1.36 | 0.19 | 0.21 | 0.59 | 0.17 | 1.03 | 3.54 | 0.18 | 4.17 | 0.19 | |
| CE(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| CE(18:2) | 0.72 | 0.17 | 0.24 | 0.38 | 0.12 | 0.53 | 1.50 | 0.13 | 1.46 | 0.15 | |
| CE(20:4) | 6.83 | 0.50 | 0.66 | 3.50 | 0.28 | 3.32 | 15.04 | 0.39 | 7.78 | 0.42 | |
| CE(20:5) | 6.68 | 0.19 | 0.19 | 2.68 | 0.08 | 1.95 | 12.29 | 0.11 | 4.76 | 0.12 | |
| CE(22:6) | 8.48 | 0.23 | 0.22 | 2.62 | 0.09 | 3.16 | 14.76 | 0.12 | 12.40 | 0.18 | |
| CE HETE | - | - | - | - | - | - | - | - | - | - | |
| CE HODE | - | - | - | - | - | - | - | - | - | - | |
| CE HpODE | - | - | - | - | - | - | - | - | - | - | |
| CE oxoHETE | - | - | - | - | - | - | - | - | - | - | |
| CE oxoODE | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:0/16:0) | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:0/18:0) | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:0/24:0) | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:0/24:1) | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:1/16:0) | 7.73 | 6.54 | 5.12 | 5.97 | 3.34 | 5.05 | 8.06 | 3.54 | 6.08 | 3.96 | |
| Cer(d18:1/16:0(d7)) | - | - | - | - | - | - | - | - | - | - | |
| Cer(d18:1/18:0) | 6.51 | 2.48 | 1.58 | 5.80 | 1.16 | 2.92 | 6.32 | 1.25 | 6.56 | 0.76 | |
| Cer(d18:1/24:0) | 19.41 | 19.53 | 10.66 | 12.34 | 5.89 | 9.70 | 17.15 | 6.19 | 11.09 | 4.82 | |
| Cer(d18:1/24:1) | 31.41 | 13.41 | 10.02 | 27.33 | 6.68 | 16.50 | 31.28 | 6.23 | 28.80 | 6.33 | |
| Cholesterol | 5.39 | 4.50 | 2.68 | 5.59 | 1.91 | 3.17 | 4.11 | 1.66 | 4.37 | 2.19 | |
| Cholesterol(d7) | - | - | - | - | - | - | - | - | - | - | |
| Cholesteryl hexoside | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.00 | 0.02 | 0.00 | |
| Coenzyme Q10 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | |
| DG(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| DG(16:0_18:1) | 1.47 | 1.13 | 0.71 | 1.54 | 0.42 | 0.98 | 1.07 | 0.44 | 1.42 | 0.78 | |
| DG(16:0_20:4) | 0.44 | 0.27 | 0.20 | 0.66 | 0.10 | 0.25 | 0.36 | 0.12 | 0.31 | 0.12 | |
| DG(18:0_18:1) | 1.11 | 0.43 | 0.30 | 1.79 | 0.28 | 0.65 | 1.00 | 0.29 | 0.82 | 0.32 | |
| DG(18:0_20:4) | 1.65 | 0.38 | 0.25 | 2.92 | 0.14 | 0.79 | 1.48 | 0.13 | 1.17 | 0.16 | |
| DG(18:0_22:6) | 0.08 | 0.11 | 0.64 | 0.29 | 0.38 | 0.40 | 0.59 | 0.39 | 0.64 | 0.35 | |
| DG(18:1/18:1) | 1.22 | 0.69 | 0.50 | 1.30 | 0.21 | 0.79 | 0.88 | 0.21 | 1.69 | 0.72 | |
| DG(18:1_20:4) | 0.37 | 0.20 | 0.15 | 0.49 | 0.06 | 0.21 | 0.28 | 0.06 | 0.38 | 0.13 | |
| GB3(d18:1/16:0) | 0.06 | 0.07 | 0.04 | 0.03 | 0.02 | 0.03 | 0.03 | 0.03 | 0.03 | 0.02 | |
| GB3(d18:1/18:0) | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | |
| GB3(d18:1/18:0(d3)) | - | - | - | - | - | - | - | - | - | - | |
| GB3(d18:1/24:0) | 0.06 | 0.07 | 0.03 | 0.04 | 0.03 | 0.04 | 0.07 | 0.04 | 0.02 | 0.02 | |
| GB3(d18:1/24:1) | 0.10 | 0.10 | 0.07 | 0.06 | 0.05 | 0.07 | 0.11 | 0.08 | 0.06 | 0.05 | |
| GlcCer(d18:1/16:0(d3)) | - | - | - | - | - | - | - | - | - | - | |
| GlcCer(d18:1(d5)/18:0) | - | - | - | - | - | - | - | - | - | - | |
| Glucosylsphingosine(d5) | - | - | - | - | - | - | - | - | - | - | |
| HexCer(d18:1/12:0) | - | - | - | - | - | - | - | - | - | - | |
| HexCer(d18:1/16:0) | 2.35 | 2.48 | 1.62 | 1.87 | 1.48 | 1.84 | 2.08 | 1.42 | 2.29 | 2.14 | |
| HexCer(d18:1/18:0) | 5.75 | 1.14 | 0.66 | 5.68 | 0.69 | 2.54 | 5.76 | 0.66 | 6.55 | 0.63 | |
| HexCer(d18:1/22:0) | 11.09 | 6.25 | 3.65 | 9.62 | 3.41 | 5.92 | 11.25 | 3.83 | 9.32 | 1.79 | |
| HexCer(d18:1/24:0) | 18.52 | 9.40 | 5.43 | 15.19 | 4.94 | 9.51 | 17.96 | 5.32 | 16.41 | 2.34 | |
| HexCer(d18:1/24:1) | 32.33 | 9.19 | 5.52 | 30.33 | 5.30 | 17.03 | 32.39 | 4.88 | 32.94 | 3.92 | |
| Hexosylsphingosine | - | - | - | - | - | - | - | - | - | - | |
| LacCer(d18:1/16:0) | 0.10 | 0.06 | 0.06 | 0.11 | 0.08 | 0.10 | 0.16 | 0.08 | 0.23 | 0.16 | |
| LacCer(d18:1/17:0) | - | - | - | - | - | - | - | - | - | - | |
| LacCer(d18:1/18:0) | 0.05 | 0.01 | 0.01 | 0.05 | 0.01 | 0.03 | 0.07 | 0.01 | 0.07 | 0.02 | |
| LacCer(d18:1/24:0) | 0.09 | 0.07 | 0.04 | 0.07 | 0.04 | 0.06 | 0.10 | 0.04 | 0.09 | 0.04 | |
| LacCer(d18:1/24:1) | 0.10 | 0.05 | 0.03 | 0.08 | 0.03 | 0.07 | 0.12 | 0.03 | 0.15 | 0.06 | |
| Lactosylsphingosine | - | - | - | - | - | - | - | - | - | - | |
| LPC(16:0) | 0.53 | 0.30 | 0.34 | 0.77 | 0.33 | 0.39 | 0.67 | 0.34 | 0.30 | 0.12 | |
| LPC(16:1) | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | |
| LPC(18:0) | 1.07 | 0.54 | 0.62 | 1.55 | 0.67 | 0.75 | 1.25 | 0.65 | 0.63 | 0.25 | |
| LPC(18:1) | 0.23 | 0.15 | 0.15 | 0.30 | 0.14 | 0.17 | 0.25 | 0.14 | 0.19 | 0.09 | |
| LPC(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| LPC(20:4) | 0.05 | 0.07 | 0.05 | 0.04 | 0.04 | 0.05 | 0.06 | 0.06 | 0.03 | 0.02 | |
| LPC(22:6) | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | |
| LPC(24:0) | 0.07 | 0.02 | 0.01 | 0.04 | 0.01 | 0.03 | 0.07 | 0.01 | 0.06 | 0.00 | |
| LPC(24:1) | 0.04 | 0.01 | 0.01 | 0.03 | 0.01 | 0.02 | 0.04 | 0.00 | 0.04 | 0.00 | |
| LPC(26:0) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| LPC(26:1) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| lyso-GB3 | - | - | - | - | - | - | - | - | - | - | |
| lyso-GB3-d7 | - | - | - | - | - | - | - | - | - | - | |
| lyso-GB4 | - | - | - | - | - | - | - | - | - | - | |
| MG(16:0) | 140.70 | 126.05 | 137.78 | 167.03 | 143.45 | 159.98 | 182.26 | 138.43 | 165.91 | 150.19 | |
| MG(16:1) | - | - | - | - | - | - | - | - | - | - | |
| MG(18:0) | 552.68 | 518.99 | 497.67 | 661.15 | 548.36 | 581.97 | 685.99 | 570.55 | 621.62 | 592.91 | |
| MG(18:1) | 19.94 | 18.48 | 16.89 | 23.56 | 19.31 | 21.59 | 24.16 | 19.33 | 23.55 | 21.08 | |
| MG(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| MG(20:4) | - | - | - | - | - | - | - | - | - | - | |
| N-Oleoylethanolamine | - | - | - | 0.00 | 0.00 | - | - | 0.00 | 0.00 | 0.00 | |
| N-Palmitoyl-O-phosphocholineserine | - | - | - | - | - | - | - | - | - | - | |
| Palmitoylethanolamine | 0.00 | 0.00 | 0.00 | - | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| PC(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PC(16:0/5:0(CHO)) | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | |
| PC(16:0/9:0(CHO)) | 0.03 | 0.03 | 0.03 | 0.02 | 0.02 | 0.03 | 0.02 | 0.02 | 0.03 | 0.03 | |
| PC(16:0/9:0(COOH)) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| PC(18:0/20:4(OH[S])) | - | - | - | - | - | - | - | - | - | - | |
| PC(18:0/20:4(OOH[S])) | - | - | - | - | - | - | - | - | - | - | |
| PC(34:1) | 5.00 | 4.94 | 4.01 | 4.39 | 3.19 | 4.20 | 4.22 | 3.15 | 4.68 | 4.21 | |
| PC(36:1) | 3.64 | 2.16 | 1.46 | 3.33 | 1.02 | 2.39 | 3.24 | 1.08 | 3.40 | 1.24 | |
| PC(36:2) | 3.88 | 3.68 | 2.47 | 2.81 | 1.69 | 2.93 | 2.66 | 1.57 | 4.45 | 3.48 | |
| PC(36:4) | 3.73 | 4.09 | 3.28 | 3.64 | 3.33 | 3.34 | 3.59 | 3.20 | 2.46 | 2.10 | |
| PC(38:4) | 2.05 | 2.41 | 1.70 | 1.96 | 1.78 | 1.75 | 1.94 | 1.66 | 1.00 | 0.74 | |
| PC(38:6) | 0.96 | 1.17 | 0.66 | 0.63 | 0.42 | 0.58 | 0.51 | 0.32 | 0.61 | 0.48 | |
| PC(40:5) | 0.54 | 0.58 | 0.38 | 0.44 | 0.33 | 0.38 | 0.41 | 0.33 | 0.28 | 0.22 | |
| PC(40:6) | 0.60 | 0.60 | 0.41 | 0.46 | 0.29 | 0.38 | 0.36 | 0.23 | 0.40 | 0.26 | |
| PC(O-16:0/0:0) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | |
| PC(O-16:0/2:0) | 0.05 | 0.04 | 0.05 | 0.04 | 0.04 | 0.05 | 0.07 | 0.05 | 0.05 | 0.03 | |
| PC(O-18:0/2:0) | 0.02 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.00 | |
| PE(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PE(18:0/20:4(OH[S])) | - | - | - | - | - | - | - | - | - | - | |
| PE(18:0/20:4(OOH[S])) | - | - | - | - | - | - | - | - | - | - | |
| PE(34:1) | 9.86 | 10.42 | 6.09 | 8.27 | 3.51 | 6.51 | 5.60 | 2.85 | 9.28 | 8.01 | |
| PE(36:1) | 27.36 | 23.63 | 14.46 | 22.25 | 9.62 | 16.82 | 19.00 | 9.24 | 25.42 | 15.83 | |
| PE(36:2) | 15.11 | 11.13 | 6.14 | 15.14 | 3.82 | 9.37 | 9.75 | 2.85 | 16.46 | 12.38 | |
| PE(36:4) | 3.15 | 3.80 | 2.05 | 2.81 | 1.69 | 2.02 | 1.91 | 1.34 | 1.82 | 1.44 | |
| PE(38:4) | 26.01 | 32.85 | 20.43 | 20.46 | 16.61 | 19.79 | 18.26 | 14.85 | 18.80 | 17.16 | |
| PE(38:5) | 6.12 | 5.91 | 3.23 | 5.66 | 2.42 | 3.76 | 3.92 | 1.93 | 4.84 | 3.59 | |
| PE(38:6) | 3.31 | 5.00 | 2.73 | 2.82 | 1.95 | 2.25 | 1.57 | 1.30 | 1.93 | 1.93 | |
| PE(40:4) | 6.74 | 9.72 | 5.44 | 4.31 | 3.34 | 4.67 | 3.56 | 3.60 | 4.70 | 4.43 | |
| PE(40:5) | - | - | - | - | - | - | - | - | - | - | |
| PE(40:6) | 8.37 | 10.99 | 6.38 | 6.26 | 4.07 | 5.73 | 4.24 | 3.21 | 6.08 | 5.69 | |
| PE(40:7) | 2.98 | 4.26 | 2.49 | 1.99 | 1.49 | 2.28 | 1.16 | 1.02 | 3.07 | 3.72 | |
| Sitosteryl hexoside | - | - | - | - | - | - | - | - | - | - | |
| SM(d18:1/16:0) | 6.37 | 7.58 | 5.62 | 4.61 | 4.31 | 5.50 | 4.34 | 3.93 | 6.72 | 6.95 | |
| SM(d18:1/18:0) | 2.62 | 2.97 | 1.85 | 2.02 | 1.27 | 1.89 | 1.71 | 1.07 | 2.57 | 1.85 | |
| SM(d18:1/24:0) | 4.36 | 5.40 | 3.11 | 2.41 | 1.73 | 2.89 | 2.33 | 1.51 | 3.26 | 2.25 | |
| SM(d18:1/24:1) | 8.17 | 9.73 | 6.49 | 5.60 | 4.22 | 6.30 | 4.95 | 3.32 | 7.76 | 6.42 | |
| SM(d18:1(d9)/18:1) | - | - | - | - | - | - | - | - | - | - | |
| Sphinganine | - | - | - | - | - | - | - | - | - | - | |
| Sphinganine 1-phosphate | 0.11 | 0.01 | 0.01 | 0.03 | 0.00 | 0.03 | 0.09 | 0.00 | 0.16 | 0.01 | |
| Sphingosine | 18.35 | 1.43 | 1.23 | 10.02 | 0.77 | 7.13 | 20.33 | 1.06 | 24.39 | 0.94 | |
| Sphingosine 1-phosphate | 0.09 | 0.01 | 0.01 | 0.03 | 0.00 | 0.03 | 0.08 | 0.01 | 0.11 | 0.01 | |
| Sphingosine 1-phosphate-d7 | - | - | - | - | - | - | - | - | - | - | |
| Sphingosine 1-phosphocholine | - | - | - | - | - | - | - | - | - | - | |
| Sphingosine(d17:1) | - | - | - | - | - | - | - | - | - | - | |
| TG(15:0/18:1(d7)/15:0) | - | - | - | - | - | - | - | - | - | - | |
| TG(18:0_36:2) | 0.49 | 0.24 | 0.16 | 0.21 | 0.07 | 0.29 | 0.41 | 0.11 | 0.81 | 0.22 | |
| TG(18:1_34:2) | 0.88 | 0.68 | 0.44 | 0.26 | 0.14 | 0.62 | 0.44 | 0.14 | 1.64 | 1.02 | |
| TG(18:1_34:3) | 0.14 | 0.16 | 0.09 | 0.03 | 0.02 | 0.10 | 0.04 | 0.02 | 0.26 | 0.23 | |
| TG(20:4_32:1) | 0.10 | 0.10 | 0.07 | 0.03 | 0.02 | 0.06 | 0.03 | 0.02 | 0.10 | 0.11 | |
| TG(20:4_34:2) | 0.09 | 0.09 | 0.06 | 0.02 | 0.02 | 0.05 | 0.03 | 0.02 | 0.10 | 0.11 | |
| TG(20:4_34:3) | 0.02 | 0.03 | 0.02 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.01 | 0.02 | |
| TG(20:4_36:0) | 0.07 | 0.04 | 0.03 | 0.03 | 0.01 | 0.03 | 0.05 | 0.02 | 0.08 | 0.02 | |
| TG(20:4_36:2) | 0.26 | 0.14 | 0.12 | 0.08 | 0.03 | 0.14 | 0.13 | 0.05 | 0.35 | 0.20 | |
| TG(20:4_36:3) | 0.10 | 0.09 | 0.07 | 0.04 | 0.02 | 0.06 | 0.04 | 0.03 | 0.08 | 0.09 | |
| TG(22:6_36:2) | 0.14 | 0.05 | 0.03 | 0.03 | 0.01 | 0.07 | 0.05 | 0.01 | 0.31 | 0.08 | |
| TG(22:6_38:1) | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | 0.02 | 0.00 | |
| TG(22:6_38:2) | 0.02 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.04 | 0.01 |
Factors:
| F1 | Genotype:GPR34-KO | Treatment:Myelin | Sample source:iMicroglia |
| F2 | Genotype:GPR34 KO | Treatment:PBS | Sample source:iMicroglia |
| F3 | Genotype:GPR34-KO | Treatment:PBS | Sample source:iMicroglia |
| F4 | Genotype:GPR34/TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F5 | Genotype:GPR34/TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F6 | Genotype:NA | Treatment:NA | Sample source:iMicroglia |
| F7 | Genotype:TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F8 | Genotype:TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F9 | Genotype:WT | Treatment:Myelin | Sample source:iMicroglia |
| F10 | Genotype:WT | Treatment:PBS | Sample source:iMicroglia |