Data for ST004206
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-O-Palmitoyl-Cer(d18:1/18:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| 24-Hydroxycholesterol | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| 24-Hydroxycholesterol(d7) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| 3-O-SulfoLacCer(d18:1/18:0) | 0.00 | - | - | 0.00 | - | 0.00 | - | 0.00 | - | - | 0.00 | - | ||||||
| 4-beta-Hydroxycholesterol | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| 7-keto-Cholesterol | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE(16:1) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| CE(18:1) | 0.12 | 0.14 | 0.13 | 0.11 | 0.12 | 0.12 | 0.13 | 0.12 | 0.14 | 0.12 | 0.11 | 0.12 | ||||||
| CE(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE(18:2) | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| CE(20:4) | 0.06 | 0.06 | 0.01 | 0.00 | 0.01 | 0.03 | 0.01 | 0.05 | 0.06 | 0.01 | 0.01 | 0.01 | ||||||
| CE(20:5) | - | 0.00 | 0.00 | - | 0.00 | - | 0.00 | - | 0.00 | 0.00 | - | 0.00 | ||||||
| CE(22:6) | 0.04 | 0.04 | 0.03 | 0.02 | 0.04 | 0.03 | 0.04 | 0.04 | 0.04 | 0.04 | 0.02 | 0.07 | ||||||
| CE HETE | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE HODE | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE HpODE | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE oxoHETE | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| CE oxoODE | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:0/16:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:0/18:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:0/24:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:0/24:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:1/16:0) | 0.07 | 0.19 | 0.06 | 0.04 | 0.04 | 0.06 | 0.06 | 0.08 | 0.17 | 0.07 | 0.04 | 0.05 | ||||||
| Cer(d18:1/16:0(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cer(d18:1/18:0) | 0.17 | 0.38 | 0.14 | 0.06 | 0.08 | 0.12 | 0.10 | 0.16 | 0.34 | 0.15 | 0.07 | 0.08 | ||||||
| Cer(d18:1/24:0) | 0.09 | 0.17 | 0.13 | 0.07 | 0.12 | 0.08 | 0.12 | 0.10 | 0.15 | 0.14 | 0.08 | 0.14 | ||||||
| Cer(d18:1/24:1) | 0.20 | 0.38 | 0.22 | 0.11 | 0.15 | 0.16 | 0.21 | 0.20 | 0.32 | 0.24 | 0.12 | 0.18 | ||||||
| Cholesterol | 0.07 | 0.29 | 0.11 | 0.06 | 0.09 | 0.10 | 0.10 | 0.09 | 0.28 | 0.11 | 0.07 | 0.10 | ||||||
| Cholesterol(d7) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Cholesteryl hexoside | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Coenzyme Q10 | - | - | - | - | 0.00 | - | - | - | - | - | 0.00 | 0.00 | ||||||
| DG(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| DG(16:0_18:1) | 0.15 | 0.13 | 0.43 | 0.15 | 0.43 | 0.14 | 0.46 | 0.14 | 0.08 | 0.43 | 0.15 | 0.46 | ||||||
| DG(16:0_20:4) | 0.01 | 0.13 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.09 | 0.02 | 0.01 | 0.01 | ||||||
| DG(18:0_18:1) | 0.11 | 0.06 | 0.28 | 0.12 | 0.29 | 0.11 | 0.26 | 0.11 | 0.04 | 0.27 | 0.12 | 0.33 | ||||||
| DG(18:0_20:4) | 0.02 | 0.09 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.06 | 0.02 | 0.02 | 0.02 | ||||||
| DG(18:0_22:6) | 0.00 | 1.01 | 0.02 | 0.01 | 0.04 | 0.01 | 2.80 | 0.00 | 0.83 | 0.24 | 0.01 | 0.09 | ||||||
| DG(18:1/18:1) | 0.03 | 0.03 | 0.86 | 0.04 | 0.84 | 0.04 | 0.98 | 0.03 | 0.03 | 0.91 | 0.03 | 0.82 | ||||||
| DG(18:1_20:4) | 0.00 | 0.02 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.02 | 0.01 | 0.01 | 0.01 | ||||||
| GB3(d18:1/16:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GB3(d18:1/18:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GB3(d18:1/18:0(d3)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GB3(d18:1/24:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GB3(d18:1/24:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GlcCer(d18:1/16:0(d3)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| GlcCer(d18:1(d5)/18:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Glucosylsphingosine(d5) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| HexCer(d18:1/12:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| HexCer(d18:1/16:0) | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | ||||||
| HexCer(d18:1/18:0) | 0.02 | 0.04 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.03 | 0.01 | 0.01 | 0.00 | ||||||
| HexCer(d18:1/22:0) | 0.03 | 0.06 | 0.01 | 0.03 | 0.01 | 0.03 | 0.01 | 0.03 | 0.05 | 0.02 | 0.03 | 0.02 | ||||||
| HexCer(d18:1/24:0) | 0.03 | 0.07 | 0.01 | 0.02 | 0.01 | 0.03 | 0.01 | 0.03 | 0.05 | 0.01 | 0.03 | 0.01 | ||||||
| HexCer(d18:1/24:1) | 0.07 | 0.15 | 0.02 | 0.04 | 0.02 | 0.06 | 0.02 | 0.06 | 0.12 | 0.02 | 0.06 | 0.02 | ||||||
| Hexosylsphingosine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LacCer(d18:1/16:0) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| LacCer(d18:1/17:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LacCer(d18:1/18:0) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| LacCer(d18:1/24:0) | - | 0.00 | 0.00 | 0.00 | 0.00 | - | 0.00 | - | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| LacCer(d18:1/24:1) | - | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | - | - | 0.00 | - | 0.00 | 0.00 | ||||||
| Lactosylsphingosine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LPC(16:0) | 0.01 | 0.05 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.04 | 0.01 | 0.00 | 0.01 | ||||||
| LPC(16:1) | - | 0.00 | - | - | - | - | - | 0.00 | 0.00 | - | 0.00 | - | ||||||
| LPC(18:0) | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | ||||||
| LPC(18:1) | 0.01 | 0.03 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | ||||||
| LPC(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LPC(20:4) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | ||||||
| LPC(22:6) | - | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| LPC(24:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LPC(24:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LPC(26:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| LPC(26:1) | 0.00 | - | 0.00 | - | 0.00 | - | 0.00 | - | - | 0.00 | 0.00 | 0.00 | ||||||
| lyso-GB3 | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| lyso-GB3-d7 | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| lyso-GB4 | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| MG(16:0) | 122.31 | 187.74 | 128.44 | 114.50 | 127.68 | 134.33 | 112.21 | 120.34 | 194.58 | 120.27 | 123.57 | 125.27 | ||||||
| MG(16:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| MG(18:0) | 338.73 | 362.03 | 419.16 | 329.48 | 419.63 | 352.91 | 375.92 | 346.78 | 375.43 | 402.54 | 349.46 | 414.97 | ||||||
| MG(18:1) | 15.03 | 10.31 | 20.53 | 14.29 | 21.10 | 16.72 | 17.01 | 14.86 | 10.83 | 18.88 | 15.79 | 21.41 | ||||||
| MG(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| MG(20:4) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| N-Oleoylethanolamine | - | - | 0.00 | - | 0.00 | - | - | - | - | 0.00 | - | 0.00 | ||||||
| N-Palmitoyl-O-phosphocholineserine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Palmitoylethanolamine | - | 0.00 | 0.00 | - | 0.00 | - | 0.00 | - | 0.00 | 0.00 | - | 0.00 | ||||||
| PC(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PC(16:0/5:0(CHO)) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | ||||||
| PC(16:0/9:0(CHO)) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | ||||||
| PC(16:0/9:0(COOH)) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| PC(18:0/20:4(OH[S])) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PC(18:0/20:4(OOH[S])) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PC(34:1) | 0.41 | 0.76 | 0.41 | 0.27 | 0.36 | 0.36 | 0.37 | 0.41 | 0.71 | 0.46 | 0.32 | 0.42 | ||||||
| PC(36:1) | 0.06 | 0.09 | 0.06 | 0.05 | 0.07 | 0.05 | 0.07 | 0.05 | 0.08 | 0.08 | 0.06 | 0.09 | ||||||
| PC(36:2) | 0.06 | 0.10 | 0.07 | 0.05 | 0.06 | 0.06 | 0.06 | 0.06 | 0.10 | 0.08 | 0.05 | 0.07 | ||||||
| PC(36:4) | 0.75 | 1.18 | 0.66 | 0.54 | 0.60 | 0.73 | 0.65 | 0.80 | 1.20 | 0.75 | 0.66 | 0.75 | ||||||
| PC(38:4) | 0.08 | 0.13 | 0.10 | 0.08 | 0.11 | 0.09 | 0.11 | 0.08 | 0.13 | 0.13 | 0.10 | 0.15 | ||||||
| PC(38:6) | 0.05 | 0.07 | 0.06 | 0.03 | 0.05 | 0.05 | 0.05 | 0.05 | 0.07 | 0.07 | 0.04 | 0.07 | ||||||
| PC(40:5) | - | 0.01 | 0.00 | - | 0.00 | - | 0.00 | - | 0.01 | 0.00 | - | 0.00 | ||||||
| PC(40:6) | 0.02 | 0.02 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.02 | 0.03 | 0.02 | 0.03 | ||||||
| PC(O-16:0/0:0) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | ||||||
| PC(O-16:0/2:0) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| PC(O-18:0/2:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PE(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PE(18:0/20:4(OH[S])) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PE(18:0/20:4(OOH[S])) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PE(34:1) | 0.16 | 0.52 | 0.16 | 0.07 | 0.10 | 0.11 | 0.13 | 0.15 | 0.47 | 0.17 | 0.08 | 0.11 | ||||||
| PE(36:1) | 0.12 | 0.33 | 0.12 | 0.09 | 0.12 | 0.10 | 0.12 | 0.10 | 0.28 | 0.13 | 0.11 | 0.14 | ||||||
| PE(36:2) | 0.14 | 0.32 | 0.17 | 0.07 | 0.13 | 0.11 | 0.16 | 0.13 | 0.29 | 0.19 | 0.08 | 0.14 | ||||||
| PE(36:4) | 0.24 | 0.57 | 0.25 | 0.10 | 0.15 | 0.18 | 0.23 | 0.26 | 0.57 | 0.28 | 0.12 | 0.19 | ||||||
| PE(38:4) | 0.47 | 1.05 | 0.61 | 0.37 | 0.57 | 0.44 | 0.63 | 0.50 | 1.08 | 0.74 | 0.46 | 0.70 | ||||||
| PE(38:5) | 0.13 | 0.26 | 0.18 | 0.08 | 0.15 | 0.11 | 0.21 | 0.14 | 0.27 | 0.22 | 0.10 | 0.19 | ||||||
| PE(38:6) | 0.64 | 1.17 | 0.78 | 0.27 | 0.47 | 0.47 | 0.68 | 0.63 | 1.16 | 0.81 | 0.31 | 0.53 | ||||||
| PE(40:4) | 0.07 | 0.15 | 0.08 | 0.05 | 0.07 | 0.06 | 0.08 | 0.07 | 0.15 | 0.09 | 0.05 | 0.08 | ||||||
| PE(40:5) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| PE(40:6) | 0.50 | 1.16 | 0.79 | 0.42 | 0.80 | 0.46 | 0.86 | 0.49 | 1.20 | 0.96 | 0.51 | 0.89 | ||||||
| PE(40:7) | 0.22 | 0.31 | 0.31 | 0.11 | 0.22 | 0.17 | 0.34 | 0.22 | 0.32 | 0.36 | 0.14 | 0.25 | ||||||
| Sitosteryl hexoside | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| SM(d18:1/16:0) | 0.09 | 0.19 | 0.08 | 0.06 | 0.07 | 0.07 | 0.07 | 0.09 | 0.18 | 0.09 | 0.06 | 0.08 | ||||||
| SM(d18:1/18:0) | 0.04 | 0.12 | 0.05 | 0.03 | 0.04 | 0.03 | 0.04 | 0.04 | 0.11 | 0.05 | 0.03 | 0.05 | ||||||
| SM(d18:1/24:0) | 0.01 | 0.03 | 0.02 | 0.01 | 0.02 | 0.01 | 0.02 | 0.01 | 0.03 | 0.02 | 0.01 | 0.02 | ||||||
| SM(d18:1/24:1) | 0.06 | 0.15 | 0.07 | 0.05 | 0.07 | 0.05 | 0.06 | 0.06 | 0.14 | 0.07 | 0.05 | 0.08 | ||||||
| SM(d18:1(d9)/18:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphinganine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphinganine 1-phosphate | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphingosine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphingosine 1-phosphate | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphingosine 1-phosphate-d7 | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphingosine 1-phosphocholine | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| Sphingosine(d17:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| TG(15:0/18:1(d7)/15:0) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| TG(18:0_36:2) | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | ||||||
| TG(18:1_34:2) | 0.00 | 0.00 | 0.04 | 0.00 | 0.04 | 0.00 | 0.05 | 0.00 | 0.00 | 0.05 | 0.00 | 0.04 | ||||||
| TG(18:1_34:3) | - | 0.00 | 0.02 | 0.00 | 0.02 | - | 0.03 | 0.00 | 0.00 | 0.02 | 0.00 | 0.02 | ||||||
| TG(20:4_32:1) | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | - | - | 0.00 | 0.00 | 0.00 | - | - | ||||||
| TG(20:4_34:2) | - | 0.00 | - | 0.00 | 0.00 | - | - | - | 0.00 | - | - | - | ||||||
| TG(20:4_34:3) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| TG(20:4_36:0) | - | - | 0.00 | 0.00 | 0.00 | - | - | 0.00 | - | 0.00 | 0.00 | 0.00 | ||||||
| TG(20:4_36:2) | 0.00 | 0.00 | 0.00 | - | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| TG(20:4_36:3) | 0.00 | 0.00 | 0.00 | 0.00 | - | - | - | 0.00 | 0.00 | - | - | - | ||||||
| TG(22:6_36:2) | 0.00 | - | 0.00 | 0.00 | 0.00 | 0.00 | - | 0.00 | - | 0.00 | 0.00 | 0.00 | ||||||
| TG(22:6_38:1) | - | - | - | - | - | - | - | - | - | - | - | - | ||||||
| TG(22:6_38:2) | - | - | - | - | - | - | - | - | - | - | - | - |
Factors:
| F1 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:16 months | Sample source:Microglia |
| F2 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:24 months | Sample source:Microglia |
| F3 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:4 months | Sample source:Microglia |
| F4 | Genotype:GPR34-KO | Disease_State:APP-KI | Age_months:8 months | Sample source:Microglia |
| F5 | Genotype:GPR34-KO | Disease_State:WT | Age_months:16 months | Sample source:Microglia |
| F6 | Genotype:GPR34-KO | Disease_State:WT | Age_months:4 months | Sample source:Microglia |
| F7 | Genotype:GPR34-KO | Disease_State:WT | Age_months:8 months | Sample source:Microglia |
| F8 | Genotype:NA | Disease_State:NA | Age_months:16 months | Sample source:Microglia |
| F9 | Genotype:NA | Disease_State:NA | Age_months:4 months | Sample source:Microglia |
| F10 | Genotype:NA | Disease_State:NA | Age_months:8 months | Sample source:Microglia |
| F11 | Genotype:WT | Disease_State:APP-KI | Age_months:16 months | Sample source:Microglia |
| F12 | Genotype:WT | Disease_State:APP-KI | Age_months:24 months | Sample source:Microglia |
| F13 | Genotype:WT | Disease_State:APP-KI | Age_months:4 months | Sample source:Microglia |
| F14 | Genotype:WT | Disease_State:APP-KI | Age_months:8 months | Sample source:Microglia |
| F15 | Genotype:WT | Disease_State:WT | Age_months:16 months | Sample source:Microglia |
| F16 | Genotype:WT | Disease_State:WT | Age_months:4 months | Sample source:Microglia |
| F17 | Genotype:WT | Disease_State:WT | Age_months:8 months | Sample source:Microglia |