Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST000282)

(Analysis AN000449)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14
Lactate_13C_3	ME703080	0.02	0.01	0.03	0.02	0.01	0.01	1.26	11.30	0.01	0.08	1.14	0.81	0.02	0.00
Adenosine triphosphate_13C_5	ME703037	0.06	0.07	0.09	0.05	0.02	0.04	4.03	6.52	0.08	0.14	0.42	0.11	0.25	0.02
Fructose 1,6-bisphosphate_13C_6	ME703055	NA	0.09	0.23	0.18	0.13	NA	2.85	4.41	0.28	0.43	0.22	NA	0.29	0.05
Adenosine triphosphate_13C_4	ME703036	0.87	0.26	NA	0.08	0.36	0.19	2.50	5.64	0.29	0.27	0.44	0.07	0.23	NA
Fructose 1,6-bisphosphate_13C_5	ME703054	NA	0.01	0.00	0.00	0.01	NA	2.75	5.48	0.01	0.00	NA	NA	0.00	0.00
Glutamate_13C_4	ME703075	0.89	0.57	0.50	0.35	0.93	0.72	0.15	5.52	1.28	1.40	0.10	0.15	NA	NA
Adenosine diphosphate_13C_2	ME703019	0.32	0.52	0.30	0.48	0.58	0.70	1.68	6.84	0.32	1.21	0.46	0.29	0.28	0.02
Glutamate_13C_2	ME703073	1.04	0.77	0.41	0.32	0.25	0.24	1.06	8.20	0.46	0.96	0.24	0.28	0.14	0.10
Adenosine diphosphate_13C_5	ME703022	NA	0.02	0.11	0.05	NA	NA	0.77	8.64	0.05	0.25	0.19	0.09	0.06	NA
Lactate_13C_2	ME703079	0.08	0.07	0.14	NA	NA	0.08	1.03	8.68	0.04	0.50	1.15	0.76	0.34	0.05
Glucose 6-phosphate or fructose-6-phosphate_13C_2	ME703062	0.19	0.23	NA	0.67	NA	NA	0.23	1.30	0.23	6.05	0.69	NA	0.89	0.27
Nicotinamide Adenine Dinucleotide reduced	ME703001	4.94	0.47	0.31	0.07	4.46	0.80	0.30	NA	0.60	0.26	0.04	0.04	0.12	NA
Citrate or Isocitrate_13C_5	ME703043	0.45	0.48	0.45	0.66	0.65	1.11	0.14	0.93	1.28	0.73	0.43	0.37	5.34	1.56
Sucrose_13C_1	ME703116	1.21	0.75	0.27	0.30	0.38	0.36	0.33	1.34	1.13	1.15	1.16	0.73	4.19	1.24
Lactate_13C_1	ME703078	0.45	0.37	1.77	0.98	NA	0.13	1.52	2.51	0.15	NA	2.05	1.04	0.30	0.21
2 or 3-phosphoglycerate_13C_2	ME703006	0.26	NA	0.90	NA	0.41	NA	3.08	NA	0.24	NA	0.61	0.56	0.49	0.36
Phosphoenolpyruvate_13C_2	ME703100	NA	NA	0.55	NA	0.73	NA	1.32	1.66	NA	NA	1.14	0.68	0.60	NA
Sedoheptulose 7-phosphate_13C_4	ME703112	NA	NA	1.02	NA	0.82	NA	1.89	1.12	0.56	NA	0.86	0.84	NA	0.00
3-Glycerophosphate_13C_1	ME703068	0.42	0.17	0.04	0.10	0.23	0.12	5.45	0.30	0.21	0.85	1.56	0.71	0.13	0.08
Glucose 6-phosphate or fructose-6-phosphate_13C_5	ME703065	0.00	0.00	0.00	NA	0.01	0.00	4.63	0.00	0.01	NA	2.01	1.69	0.01	0.00
Nicotinamide Adenine Dinucleotide oxidized_13C_2	ME703090	0.02	0.23	0.05	NA	0.08	0.19	2.65	1.76	0.83	0.92	2.65	1.08	0.49	0.58
2 or 3-phosphoglycerate_13C_3	ME703007	0.11	0.07	0.07	0.07	NA	0.08	4.96	1.85	0.23	0.07	1.38	0.39	0.42	0.09
Adenosine triphosphate_13C_2	ME703034	NA	NA	NA	0.08	0.73	0.88	3.50	2.36	0.41	0.23	0.50	0.23	0.08	0.09
Glucose 6-phosphate or fructose-6-phosphate_13C_6	ME703066	0.06	0.11	0.11	NA	0.21	0.26	3.60	2.45	0.24	0.14	1.68	1.26	0.14	0.15
ADP	ME703121	1.41	4.09	1.05	0.95	2.45	1.12	0.48	0.39	0.94	0.66	0.27	0.19	0.34	0.24
AMP	ME703120	2.21	4.91	0.94	2.07	1.58	0.62	0.26	0.31	0.45	1.09	0.17	0.19	0.30	0.17
Glutamate_13C_1	ME703072	2.62	2.29	1.14	0.68	0.40	0.30	0.19	3.31	0.71	2.91	0.08	0.06	0.22	0.17
Aspartate_13C_2	ME703030	2.41	2.17	0.79	0.50	0.61	0.47	0.77	3.27	1.83	0.25	0.06	0.07	0.14	0.07
Aspartate_13C_3	ME703031	1.35	0.93	0.67	0.47	0.70	0.84	0.97	2.26	2.96	0.22	0.12	0.15	0.28	0.14
Aspartate	ME703028	1.58	1.60	0.96	0.70	1.13	0.86	2.46	1.70	0.97	0.32	0.08	0.07	0.10	0.04
Adenosine triphosphate_13C_3	ME703035	0.89	0.54	0.36	0.04	0.70	0.43	3.31	3.86	0.36	0.18	0.44	0.16	0.26	0.15
Glutamate	ME703071	1.16	0.97	0.89	0.71	0.81	0.66	2.38	3.21	0.60	0.82	0.26	0.21	0.19	0.15
Aspartate_13C_4	ME703032	2.34	1.98	0.96	0.60	1.45	0.99	0.01	0.20	3.47	0.23	0.01	0.02	0.20	0.06
Fructose 1,6-bisphosphate_13C_2	ME703051	2.91	0.61	0.57	NA	NA	1.09	0.79	NA	0.93	NA	NA	NA	0.30	NA
Ribose-5-phosphate or xylulose 5-phosphate	ME703102	0.53	0.45	1.15	1.10	2.21	0.95	0.40	0.04	3.43	0.35	0.11	0.04	0.70	0.70
2 or 3-phosphoglycerate_2PG/3PG	ME703004	1.34	0.46	1.12	0.70	3.10	1.76	0.49	0.32	1.91	0.28	0.24	0.17	1.30	0.40
Phosphoenolpyruvate	ME703002	0.72	0.42	1.34	1.45	1.97	1.96	0.39	NA	1.61	0.11	0.37	0.30	1.87	0.50
Glucose 6-phosphate or fructose-6-phosphate	ME703060	1.46	0.93	1.17	1.83	2.94	0.71	0.40	NA	1.38	0.32	0.22	0.20	1.33	0.30
Citrate or Isocitrate_13C_4	ME703042	1.55	1.09	1.37	1.55	2.04	1.54	0.16	0.90	1.36	0.66	0.37	0.47	0.98	0.46
Malate_13C_4	ME703084	1.76	1.11	1.06	0.86	2.14	1.19	0.06	0.22	1.83	0.76	0.09	0.13	1.90	1.00
Fructose 1,6-bisphosphate_13C_1	ME703050	1.87	NA	NA	1.34	3.80	0.72	0.10	0.64	0.46	NA	NA	NA	0.50	NA
ATP	ME703122	3.88	2.05	1.02	0.36	2.68	1.48	0.55	0.13	1.17	0.09	0.14	0.13	0.43	0.14
3-phosphoglyceraldehyde	ME703056	2.35	1.38	0.53	1.24	3.51	0.89	0.50	0.47	1.25	0.62	0.41	0.23	0.57	0.33
Fructose 1,6-bisphosphate	ME702998	2.63	1.75	1.07	0.81	3.26	0.88	0.50	0.25	1.35	0.32	0.21	0.31	0.56	0.25
Adenosine monophosphate_13C_1	ME703023	1.21	0.28	2.48	0.62	2.41	0.42	1.25	0.90	0.89	1.39	1.21	0.13	0.42	0.14
Glucose 6-phosphate or fructose-6-phosphate_13C_1	ME703061	0.75	NA	2.85	0.63	1.95	0.24	0.07	NA	1.23	0.68	0.79	NA	0.83	0.76
6-Phosphogluconate	ME703008	0.29	0.40	0.56	0.72	4.32	0.58	1.48	0.33	2.14	0.32	0.27	0.20	0.47	0.28
Ribose-5-phosphate or xylulose 5-phosphate_13C_1	ME703103	NA	0.30	1.78	1.21	3.07	0.45	1.21	NA	0.63	0.37	NA	NA	0.43	0.35
Nicotinamide Adenine Dinucleotide oxidized_13C_1	ME703089	1.52	1.10	1.95	NA	NA	1.29	0.26	NA	0.58	1.75	0.64	0.36	0.96	0.59
Citrate or Isocitrate_13C_1	ME703039	1.93	1.38	1.37	1.70	0.35	0.65	0.29	1.35	0.72	1.53	0.43	0.70	1.22	0.65
Glutamate_13C_3	ME703074	2.60	1.89	1.29	0.91	1.22	0.99	0.08	1.57	1.54	1.67	0.04	0.07	0.31	0.18
Sucrose_13C_4	ME703119	1.57	0.93	0.33	0.75	0.74	0.47	NA	0.12	0.81	3.71	NA	NA	1.16	0.62
Acetyl-CoA	ME703015	0.73	0.81	0.39	0.32	2.77	0.55	0.81	NA	1.07	2.79	NA	NA	0.52	0.35
Glutamate_13C_5	ME703076	1.72	1.12	1.14	0.72	2.10	1.50	0.01	0.12	2.50	2.10	0.00	0.01	0.30	0.14
Sedoheptulose 7-phosphate	ME703108	0.60	0.39	1.14	0.84	2.10	0.87	0.28	0.22	2.20	2.01	0.16	0.12	1.58	1.00
3-Glycerophosphate	ME703067	0.48	0.18	0.35	0.16	0.89	0.37	1.24	1.31	2.52	3.14	0.33	0.18	0.76	0.32
Erythrose 4-phosphate_13C_2	ME703047	NA	NA	0.86	NA	0.80	0.95	0.97	NA	0.69	2.12	0.53	0.69	1.35	1.07
Lactate	ME703077	1.35	0.89	0.88	0.61	1.68	0.76	0.68	0.77	1.12	2.48	0.56	0.53	1.31	0.56
Sucrose	ME703003	0.83	0.67	1.06	0.51	1.06	1.01	1.24	1.47	1.14	2.19	0.71	0.78	0.34	0.61
Adenosine diphosphate_13C_1	ME703018	0.23	0.76	1.01	0.83	2.47	1.03	0.59	2.97	0.54	1.77	0.25	NA	0.64	0.33
Nicotinamide Adenine Dinucleotide reduced_13C_1	ME703094	0.10	0.54	NA	NA	1.17	1.97	0.28	1.94	1.25	0.49	NA	NA	NA	NA
Adenosine triphosphate_13C_1	ME703033	NA	NA	1.27	0.08	NA	NA	1.20	1.42	2.05	0.44	0.44	0.09	1.18	0.56
2 or 3-phosphoglycerate_13C_1	ME703005	0.22	1.25	0.04	NA	NA	0.61	1.42	0.79	1.34	0.55	0.79	NA	2.07	1.15
Nicotinamide Adenine Dinucleotide oxidized	ME703000	1.25	1.28	1.02	0.84	1.06	0.68	0.69	NA	1.30	0.81	0.67	0.33	2.17	0.91
Malate_13C_1	ME703081	2.23	1.64	0.60	0.92	0.55	0.29	0.26	2.02	0.64	0.44	0.83	1.15	2.28	1.25
Malate	ME702999	1.10	0.84	1.20	1.20	1.49	1.03	1.50	1.29	0.50	0.42	1.57	1.05	0.20	0.62
Citrate or Isocitrate	ME703038	0.75	0.68	1.32	1.47	1.36	1.17	1.05	1.00	0.89	0.97	1.14	0.86	0.83	0.58
Malonyl-CoA	ME703085	0.92	0.75	1.15	1.08	1.31	1.08	1.03	1.21	1.06	0.93	0.81	0.88	1.01	0.67
Citrate or Isocitrate_13C_3	ME703041	1.06	0.56	0.70	0.91	0.90	1.14	0.28	2.23	1.14	0.83	0.76	0.77	2.36	0.93
Citrate or Isocitrate_13C_6	ME703044	0.52	0.42	0.73	0.84	1.72	0.83	0.80	2.29	0.99	0.93	1.02	1.22	1.25	0.64
Malate_13C_3	ME703083	0.85	0.84	0.38	0.40	0.74	0.58	0.54	1.92	1.82	0.45	1.87	1.56	0.43	1.27
Citrate or Isocitrate_13C_2	ME703040	1.04	0.68	0.81	1.01	0.52	0.45	1.02	3.67	0.61	0.62	1.46	1.31	0.74	0.43
Malate_13C_2	ME703082	1.72	1.15	0.97	0.92	0.80	0.67	0.48	2.53	0.82	0.63	1.62	1.09	0.37	0.93

Factors:

F1	Cell line:MCF10A \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F2	Cell line:MCF10A \| 13C Label:Glutamine \| RhoC overexpression:yes \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F3	Cell line:MDA-MB-231 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F4	Cell line:MDA-MB-231 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:yes
F5	Cell line:MDA-MB-231 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:yes \| RhoC drug:no
F6	Cell line:MDA-MB-231 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:yes \| RhoC knockdown:no \| RhoC drug:no
F7	Cell line:SUM149 \| 13C Label:Glucose \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F8	Cell line:SUM149 \| 13C Label:Glucose \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:yes
F9	Cell line:SUM149 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F10	Cell line:SUM149 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:yes
F11	Cell line:SUM190 \| 13C Label:Glucose \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F12	Cell line:SUM190 \| 13C Label:Glucose \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:yes \| RhoC drug:no
F13	Cell line:SUM190 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:no \| RhoC drug:no
F14	Cell line:SUM190 \| 13C Label:Glutamine \| RhoC overexpression:no \| RhoA knockdown:no \| RhoC knockdown:yes \| RhoC drug:no

Data matrix