Clustering data with hclust algorithm for (Study ST000880)
(Analysis AN001433)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Spermidine | ME227246 | 0.26 | 0.30 | 0.66 | 0.04 | 0.04 | 0.25 | 0.89 | 1.04 | 7.77 | 0.06 | 0.14 | 0.47 |
Deoxyadenosine | ME227156 | 2.33 | 0.69 | 6.53 | 0.13 | 0.08 | 0.37 | 0.73 | 1.76 | 0.33 | 0.13 | 0.11 | 0.18 |
Xanthosine | ME227255 | 3.00 | 0.72 | 7.65 | 0.15 | 0.09 | 0.15 | 0.28 | 0.13 | 0.18 | 0.45 | 0.08 | 0.78 |
Histamine | ME227219 | 2.26 | 4.04 | 6.56 | 0.04 | 0.04 | 0.02 | 0.17 | 0.04 | 0.06 | 0.02 | 0.11 | 0.03 |
N-Acetylhistamine | ME227260 | 1.83 | 4.54 | 6.90 | 0.01 | 0.01 | 0.01 | 0.06 | 0.03 | 0.03 | 0.00 | 0.06 | 0.00 |
Aspartic acid | ME227172 | 2.53 | 2.06 | 4.92 | 0.18 | 0.34 | 0.09 | 0.96 | 0.63 | 0.72 | 0.13 | 0.17 | 0.23 |
cis-3-hydroxyproline | ME227222 | 2.69 | 3.08 | 5.45 | 0.28 | 0.26 | 0.21 | 0.14 | 0.08 | 0.13 | 0.25 | 0.16 | 0.38 |
Niacinamide | ME227232 | 1.32 | 0.32 | 0.64 | 0.27 | 0.19 | 0.26 | 0.43 | 0.39 | 0.71 | 0.28 | 6.64 | 0.44 |
Putrescine | ME227239 | 0.30 | 0.25 | 0.46 | 0.80 | 3.90 | 0.21 | 0.11 | 0.07 | 0.05 | 0.28 | 4.92 | 0.52 |
Imidazoleacetic acid | ME227258 | 0.54 | 2.89 | 0.50 | 0.50 | 0.08 | 0.11 | 5.17 | 1.07 | 0.12 | 0.55 | 0.04 | 0.30 |
Gamma-Aminobutyric acid | ME227215 | 0.61 | 1.06 | 0.60 | 4.15 | 0.74 | 1.23 | 1.03 | 0.96 | 1.07 | 0.04 | 0.30 | 0.09 |
Valine | ME227254 | 0.25 | 0.30 | 0.42 | 3.03 | 1.70 | 1.93 | 1.29 | 1.40 | 0.81 | 0.36 | 0.16 | 0.19 |
1-methyl nicotinamide | ME227155 | 0.01 | 0.07 | 0.01 | 4.05 | 1.90 | 0.78 | 1.28 | 0.01 | 0.01 | 1.19 | 2.09 | 0.36 |
CAR(5:0) | ME227198 | 0.22 | 0.03 | 0.02 | 2.94 | 1.56 | 1.12 | 0.26 | 0.02 | 0.22 | 3.07 | 1.07 | 1.22 |
Creatine | ME227210 | 0.27 | 0.09 | 0.10 | 2.15 | 1.75 | 1.41 | 0.59 | 0.26 | 0.17 | 1.74 | 1.82 | 1.41 |
Creatinine | ME227211 | 0.34 | 0.38 | 0.03 | 2.16 | 1.53 | 0.77 | 1.72 | 0.34 | 0.04 | 1.41 | 1.89 | 1.14 |
CAR(2:0) | ME227189 | 2.07 | 0.24 | 0.51 | 2.29 | 0.09 | 0.78 | 1.01 | 0.10 | 0.26 | 2.68 | 0.14 | 1.70 |
CAR(7:0) | ME227202 | 1.72 | NA | NA | 0.67 | 0.18 | 0.49 | NA | NA | 0.15 | 1.77 | 0.54 | 2.18 |
CAR(6:0) | ME227201 | 0.35 | 0.06 | 0.04 | 3.66 | 0.33 | 2.15 | 0.09 | 0.03 | 0.07 | 2.60 | 0.27 | 2.13 |
CAR(9:0) | ME227204 | NA | NA | NA | 2.04 | 0.34 | 0.88 | NA | NA | NA | 1.27 | 0.34 | 1.13 |
CAR(10:2) | ME227177 | 0.05 | NA | NA | 2.06 | 0.59 | 0.87 | NA | NA | 0.09 | 2.12 | 0.64 | 1.33 |
CAR(5:1) | ME227199 | 0.26 | NA | 0.09 | 2.10 | 0.86 | 0.79 | 0.06 | 0.01 | 0.03 | 2.55 | 0.63 | 1.39 |
CAR(10:0) | ME227176 | 0.01 | 0.01 | NA | 2.05 | 0.28 | 2.17 | 0.00 | NA | 0.02 | 1.97 | 0.19 | 1.82 |
CAR(8:0) | ME227203 | 0.02 | 0.01 | NA | 2.22 | 0.11 | 1.52 | NA | 0.00 | 0.02 | 1.96 | 0.08 | 1.59 |
CAR(12:1) | ME227179 | 0.10 | NA | NA | 1.54 | 0.38 | 1.49 | NA | NA | 0.09 | 1.43 | 0.30 | 2.23 |
CAR(12:0) | ME227178 | 0.03 | 0.04 | 0.01 | 1.84 | 0.61 | 1.80 | 0.07 | NA | 0.10 | 2.08 | 0.48 | 2.73 |
CAR(14:2) | ME227182 | 0.18 | 0.07 | 0.00 | 1.88 | 0.54 | 1.96 | 0.03 | NA | 0.50 | 1.38 | 0.45 | 2.81 |
Cysteine | ME227212 | NA | 0.06 | NA | 1.15 | 0.94 | 0.30 | NA | 0.04 | 0.02 | 1.28 | 1.37 | 1.68 |
Pyroglutamic acid | ME227240 | NA | NA | 0.07 | 1.35 | 1.11 | 1.53 | NA | NA | NA | 0.43 | 0.77 | 1.03 |
3-Hydroxyanthranilic acid | ME227158 | 0.65 | 0.62 | 1.67 | 1.11 | 0.77 | 0.29 | 3.81 | 1.01 | 1.19 | 0.07 | 0.14 | 0.22 |
Serotonin | ME227245 | 1.08 | 0.90 | 1.10 | 0.55 | 0.43 | 0.58 | 3.04 | 0.96 | 1.58 | 0.24 | 0.58 | 1.00 |
CAR(20:0) | ME227190 | 0.42 | 0.82 | 0.71 | 0.53 | 0.42 | 0.85 | 1.44 | 2.16 | 2.59 | 0.30 | 0.38 | 1.06 |
Aminoisobutyric acid | ME227167 | 1.45 | 1.12 | 1.10 | NA | 0.18 | NA | 1.15 | 0.65 | 1.53 | NA | 0.11 | 0.07 |
Homocysteine | ME227221 | 0.98 | 1.77 | 0.93 | 0.86 | 0.48 | NA | 1.03 | 0.99 | 0.80 | 0.87 | NA | NA |
Urocanic acid | ME227261 | 1.59 | 1.38 | 1.99 | 0.07 | 0.02 | 0.02 | 1.77 | 0.66 | 2.01 | 0.60 | 0.99 | 1.16 |
Taurine | ME227247 | 1.75 | 1.61 | 0.78 | 0.36 | 0.33 | 0.22 | 1.86 | 2.02 | 2.47 | 0.18 | 0.16 | 0.20 |
Lysine | ME227226 | 1.04 | 0.90 | 1.24 | 0.60 | 0.31 | 0.44 | 1.35 | 1.47 | 2.37 | 1.14 | 0.26 | 0.94 |
5-Hydroxy-L-tryptophan | ME227160 | 0.88 | 0.82 | 1.40 | 0.70 | 0.24 | 0.30 | 1.66 | 1.44 | 1.83 | 1.63 | 0.25 | 0.94 |
Tryptophan | ME227252 | 1.10 | 0.81 | 0.98 | 0.54 | 0.31 | 0.35 | 1.63 | 1.36 | 1.45 | 1.94 | 0.38 | 1.14 |
Thiamine | ME227248 | 0.70 | 0.48 | 2.04 | 0.74 | 0.45 | 0.84 | 1.94 | 1.53 | 1.58 | 0.60 | 0.42 | 0.94 |
Arginine | ME227170 | 1.53 | 0.75 | 0.78 | 0.43 | 0.19 | 0.52 | 2.11 | 1.91 | 1.60 | 0.43 | 0.66 | 1.05 |
Beta-Alanine | ME227173 | 1.28 | 1.26 | 1.93 | 0.93 | 0.35 | 0.33 | 2.09 | 1.13 | 1.38 | 0.63 | 0.45 | 0.47 |
Methionine sulfoxide | ME227228 | 1.46 | 1.38 | 2.11 | 1.40 | 0.31 | 0.19 | 1.78 | 1.27 | 0.94 | 0.86 | 0.38 | 0.21 |
Tyrosine | ME227253 | 1.24 | 1.12 | 1.32 | 0.42 | 0.39 | 0.32 | 1.91 | 1.44 | 1.60 | 1.08 | 0.57 | 0.67 |
Methionine | ME227227 | 1.38 | 1.17 | 1.44 | 0.68 | 0.28 | 0.23 | 2.08 | 1.57 | 1.94 | 0.50 | 0.44 | 0.40 |
Sarcosine | ME227242 | 1.28 | 1.39 | 1.25 | 0.81 | 0.35 | 0.28 | 1.56 | 1.80 | 1.74 | 0.67 | 0.46 | 0.46 |
Leucine | ME227225 | 1.01 | 1.07 | 1.02 | 1.20 | 0.52 | 0.40 | 1.67 | 1.59 | 1.78 | 0.69 | 0.56 | 0.49 |
Alanine | ME227164 | 1.15 | 1.18 | 1.45 | 1.01 | 0.39 | 0.33 | 1.59 | 1.48 | 1.79 | 0.78 | 0.45 | 0.50 |
Phenylalanine | ME227235 | 1.29 | 1.14 | 1.27 | 1.10 | 0.42 | 0.32 | 1.90 | 1.54 | 1.68 | 0.58 | 0.44 | 0.38 |
Acetylcholine | ME227161 | 0.75 | 0.77 | 1.09 | 0.34 | 0.42 | 0.61 | 0.79 | 0.96 | 1.09 | 1.72 | 0.46 | 3.01 |
Thymidine | ME227250 | 1.20 | 0.81 | 1.12 | NA | NA | NA | 0.51 | 0.44 | 0.38 | 1.16 | NA | 2.42 |
NMMA | ME227233 | 1.32 | 1.04 | 1.17 | 1.15 | 0.41 | 0.33 | 0.50 | 0.44 | 0.65 | 2.58 | 0.32 | 2.13 |
Histidine | ME227220 | 1.11 | 0.91 | 1.15 | 0.31 | 0.12 | 0.28 | 1.14 | 0.82 | 1.80 | 1.83 | 0.35 | 2.21 |
Glutamine | ME227217 | 1.23 | 1.41 | 0.76 | 0.08 | 0.03 | 0.52 | 1.33 | 1.13 | 1.29 | 2.50 | 0.06 | 1.60 |
Serine | ME227244 | 0.94 | 1.00 | 0.85 | 0.35 | 0.27 | 0.28 | 1.09 | 1.24 | 1.43 | 2.50 | 0.43 | 1.58 |
1-Methylhistamine | ME227154 | 1.31 | 1.64 | 2.10 | 1.27 | 1.06 | 0.34 | 1.48 | 0.71 | 0.49 | 0.54 | 0.70 | 0.64 |
Isoleucine | ME227223 | 0.73 | 0.93 | 1.02 | 1.62 | 0.68 | 0.46 | 1.28 | 1.47 | 1.54 | 0.99 | 0.64 | 0.65 |
Cotinine | ME227209 | 0.85 | 1.07 | 1.43 | 0.91 | 1.03 | 0.72 | 1.30 | 0.76 | 0.97 | 1.43 | 0.73 | 0.90 |
methyl-hydroxyisobutyric acid | ME227229 | 0.97 | 1.24 | 1.09 | 1.02 | 0.95 | 0.69 | 0.84 | 0.94 | 0.96 | 0.92 | 1.37 | 1.03 |
phenylalanine-d8 (Internal Standard) | ME227152 | 1.07 | 1.03 | 1.09 | 1.03 | 0.88 | 0.88 | 1.15 | 1.05 | 1.09 | 0.94 | 0.90 | 0.92 |
Trimethylamine N-oxide | ME227251 | 0.92 | 1.00 | 0.93 | 1.04 | 1.05 | 1.10 | 1.03 | 0.97 | 1.04 | 0.93 | 1.01 | 0.96 |
valine-d8 (Internal Standard) | ME227153 | 0.98 | 0.99 | 0.97 | 0.93 | 1.00 | 0.96 | 0.99 | 1.02 | 1.03 | 1.06 | 1.01 | 1.05 |
Betaine | ME227174 | 0.88 | 0.71 | 0.64 | 1.45 | 0.91 | 1.18 | 0.62 | 0.53 | 0.54 | 1.57 | 1.09 | 1.79 |
Glycine | ME227218 | 0.73 | 0.66 | 0.91 | 2.20 | 0.98 | 0.69 | 0.69 | 0.92 | 0.91 | 1.46 | 0.63 | 1.21 |
Dimethylarginine | ME227163 | 1.54 | 0.95 | 2.31 | 1.18 | 0.43 | 0.68 | 0.43 | 0.21 | 0.78 | 1.41 | 0.59 | 1.83 |
Symmetric dimethyl-L-arginine | ME227243 | 1.17 | 1.34 | 2.04 | 1.09 | 0.32 | 0.66 | 1.03 | 0.25 | 1.06 | 1.15 | 0.57 | 1.58 |
5-amino-levulinic acid | ME227159 | 1.54 | 1.34 | 1.12 | 0.79 | 0.84 | 0.46 | 0.35 | 0.33 | 0.29 | 1.87 | 1.33 | 1.75 |
N-6-trimethyllysine | ME227259 | 1.72 | 1.08 | 1.31 | 1.67 | 0.84 | 0.74 | 0.49 | 0.32 | 0.49 | 1.15 | 0.94 | 1.32 |
CAR(16:0(OH)) | ME227184 | 0.46 | 0.16 | 0.27 | 0.74 | 0.51 | 1.92 | 3.48 | 0.11 | 0.80 | 1.02 | 0.51 | 1.84 |
CAR(3:0) | ME227193 | 1.06 | 0.12 | 0.45 | 3.38 | 0.19 | 1.48 | 0.96 | 0.06 | 0.74 | 1.51 | 1.12 | 0.44 |
CAR(DC3:0) | ME227194 | 1.25 | 0.28 | 0.80 | 1.86 | 0.69 | 0.41 | 2.88 | 0.66 | 0.58 | 1.10 | 0.88 | 0.57 |
Carnitine | ME227206 | 1.44 | 0.29 | 0.69 | 1.94 | 0.89 | 1.36 | 0.89 | 0.31 | 1.58 | 1.24 | 0.38 | 0.91 |
C3-DC-CH3 carnitine | ME227195 | 0.97 | 0.07 | 0.12 | 1.92 | 1.03 | 1.08 | 1.89 | 0.36 | 0.76 | 1.01 | 1.10 | 0.79 |
C5-DC carnitine | ME227200 | 0.97 | 0.05 | 0.01 | 1.59 | 1.04 | 1.30 | 1.58 | 0.19 | 1.46 | 0.83 | 1.25 | 0.74 |
Ureidopropionic acid | ME227231 | 0.87 | 0.90 | 0.94 | 1.22 | 0.83 | 3.02 | 0.94 | 0.36 | 0.96 | 0.31 | 0.51 | 1.14 |
CAR(18:0) | ME227185 | 0.12 | 0.16 | 0.17 | 1.18 | 0.84 | 1.57 | 1.33 | 0.67 | 1.45 | 1.39 | 0.75 | 2.17 |
CAR(20:4) | ME227191 | 0.27 | 0.18 | 0.21 | 1.97 | 0.45 | 2.45 | 0.46 | 0.05 | 1.84 | 0.65 | 0.62 | 2.18 |
CAR(18:1) | ME227186 | 0.24 | 0.22 | 0.27 | 0.34 | 0.38 | 2.92 | 0.49 | 0.20 | 2.36 | 0.31 | 0.38 | 3.71 |
CAR(18:2) | ME227188 | 0.45 | 0.24 | 0.30 | 0.46 | 0.46 | 3.26 | 0.43 | 0.07 | 1.32 | 0.45 | 0.64 | 3.76 |
CAR(14:1) | ME227181 | 0.13 | 0.05 | 0.06 | 1.34 | 0.59 | 2.58 | 0.16 | 0.00 | 0.32 | 1.45 | 0.51 | 4.33 |
CAR(16:0) | ME227183 | 0.17 | 0.13 | 0.17 | 0.57 | 0.64 | 2.48 | 0.56 | 0.27 | 1.16 | 1.11 | 0.70 | 3.83 |
Kynurenic acid | ME227224 | 0.36 | 0.18 | 0.69 | 0.69 | 0.72 | 1.67 | 0.74 | 0.21 | 0.95 | 1.18 | 0.76 | 3.78 |
5^-Methylthioadenosine | ME227230 | 1.20 | 0.60 | 0.06 | 0.26 | 0.06 | 0.54 | 0.27 | 0.17 | 0.50 | 5.29 | 0.37 | 2.45 |
sn-glycero-3-phosphocholine | ME227166 | 2.63 | 0.63 | 0.42 | 0.14 | 0.11 | 0.37 | 0.30 | 0.05 | 0.15 | 3.93 | 0.11 | 3.02 |
Proline | ME227238 | 0.60 | 0.48 | 0.58 | 0.18 | 0.19 | 0.12 | 0.76 | 0.60 | 0.68 | 2.71 | 2.55 | 2.44 |
Cytosine | ME227213 | 0.42 | 0.38 | 1.07 | 0.04 | 0.01 | 0.09 | 1.14 | 1.22 | 0.58 | 2.59 | 0.20 | 4.28 |
Deoxycytidine | ME227157 | 0.36 | 0.36 | 0.32 | 0.04 | 0.01 | 0.09 | 1.10 | 1.24 | 0.55 | 2.83 | 0.01 | 4.42 |
Choline | ME227207 | 0.74 | 0.53 | 0.88 | 0.22 | 0.25 | 0.31 | 0.63 | 0.34 | 0.65 | 2.76 | 0.27 | 4.40 |
Guanine | ME227256 | 0.65 | 0.64 | 0.87 | 0.75 | 0.09 | 0.65 | 0.84 | 0.59 | 0.59 | 2.67 | 0.22 | 3.43 |
CAR(14:0) | ME227180 | 0.12 | 0.08 | 0.09 | 1.37 | 0.90 | 1.89 | 0.47 | 0.05 | 0.38 | 2.94 | 0.64 | 2.85 |
Ornithine | ME227234 | 0.23 | 0.43 | 0.39 | 1.57 | 0.24 | 1.22 | 0.23 | 0.22 | 0.60 | 3.54 | 0.16 | 3.04 |
Asparagine | ME227171 | 0.20 | 0.92 | 0.03 | 1.39 | 0.01 | 0.81 | 0.91 | 1.03 | 1.20 | 2.93 | 0.01 | 2.31 |
Threonine | ME227249 | 0.64 | 0.80 | 0.62 | 0.29 | 0.21 | 0.19 | 0.76 | 0.90 | 0.89 | 3.80 | 0.28 | 2.53 |
Anserine | ME227168 | 0.94 | 0.65 | 2.95 | 0.06 | 0.04 | 0.45 | 0.90 | 0.36 | 4.05 | 0.17 | 0.18 | 1.50 |
CAR(4:0(OH)) | ME227197 | 3.10 | 0.47 | 1.44 | 0.91 | 0.53 | 0.32 | 2.00 | 0.24 | 0.67 | 1.13 | 0.47 | 0.81 |
CAR(18:1(OH)) | ME227187 | 3.25 | 0.35 | 0.60 | 0.50 | 0.38 | 1.48 | 1.28 | 0.04 | 1.11 | 0.66 | 0.65 | 1.60 |
S-Adenosylmethionine | ME227241 | 3.00 | 0.57 | NA | NA | NA | 0.60 | 0.93 | 0.42 | 0.85 | 0.42 | NA | 0.82 |
CAR(4:0) | ME227196 | 5.00 | 0.33 | 0.76 | 0.53 | 0.09 | 0.38 | 2.76 | 0.10 | 0.93 | 0.47 | 0.08 | 0.52 |
Dimethylglycine | ME227214 | 5.52 | 0.70 | 1.71 | 0.70 | 0.45 | 0.39 | 0.76 | 0.13 | 0.54 | 0.49 | 0.44 | 0.34 |
Glutamic acid | ME227216 | 2.53 | 1.66 | 2.77 | 0.34 | 0.31 | 0.70 | 1.12 | 0.82 | 0.93 | 0.38 | 0.24 | 0.66 |
Pipecolic acid | ME227237 | 3.52 | 1.75 | 2.95 | 0.64 | 1.09 | 0.11 | 0.81 | 0.37 | 0.80 | 0.09 | 0.28 | 0.09 |
Adenosine | ME227162 | 4.38 | 0.91 | 3.65 | 0.18 | 0.10 | 0.26 | 0.82 | 0.83 | 0.75 | 0.19 | 0.19 | 0.40 |
L-Histidinol | ME227257 | 3.02 | 1.12 | 3.96 | 0.24 | 0.04 | 0.14 | 1.38 | 1.29 | 1.35 | 0.02 | 0.17 | 0.02 |
3-Dehydroxycarnitine | ME227175 | 2.26 | 1.16 | 2.63 | 0.37 | 0.28 | 0.01 | 1.97 | 2.08 | 1.36 | 0.01 | 0.27 | 0.01 |
Citrulline | ME227208 | 1.91 | 1.74 | 3.49 | 0.50 | 0.26 | 0.19 | 1.37 | 0.46 | 2.11 | 0.37 | 0.05 | 0.16 |
2-Aminobenzoic acid | ME227169 | 1.59 | 3.99 | 0.89 | 0.54 | 0.25 | 0.45 | 0.77 | 0.56 | 1.57 | 0.13 | 0.34 | 0.13 |
Choline phosphate | ME227236 | 2.79 | 2.10 | 1.25 | 0.09 | 0.04 | 0.04 | 1.21 | 0.39 | 2.18 | 0.34 | 0.13 | 0.32 |
Factors:
F1 | Diet:Chow | Treatment:none | Strain:129Jax |
F2 | Diet:Chow | Treatment:none | Strain:129Tac |
F3 | Diet:Chow | Treatment:none | Strain:B6Jax |
F4 | Diet:HFD | Treatment:metronidazole | Strain:129Jax |
F5 | Diet:HFD | Treatment:metronidazole | Strain:129Tac |
F6 | Diet:HFD | Treatment:metronidazole | Strain:B6Jax |
F7 | Diet:HFD | Treatment:placebo | Strain:129Jax |
F8 | Diet:HFD | Treatment:placebo | Strain:129Tac |
F9 | Diet:HFD | Treatment:placebo | Strain:B6Jax |
F10 | Diet:HFD | Treatment:vancomycin | Strain:129Jax |
F11 | Diet:HFD | Treatment:vancomycin | Strain:129Tac |
F12 | Diet:HFD | Treatment:vancomycin | Strain:B6Jax |