Clustering data with hclust algorithm for (Study ST001507)

(Analysis AN002498)
MetaboliteStructureF1F2F3F4F5F6F7F8
IMPME3617811.310.450.980.431.890.721.650.63
3-hydroxybutyric acidME3616041.620.471.540.401.510.611.300.59
acetyl-cysteineME3617471.800.431.420.420.980.751.360.58
Adenosine + 3ME3618260.460.720.431.020.911.770.612.08
HydroxyprolineME3618740.500.900.640.940.751.740.781.74
Hydroxyproline + 1ME3618750.340.940.550.980.671.820.662.01
Palmitic acid+3ME3617090.520.600.480.741.102.100.771.25
5-Oxoproline (pyroglutamic Acid) +1ME3618180.310.890.330.641.171.801.181.69
GlycerateME3617730.400.940.460.981.011.721.121.38
Lactate+1ME3616910.431.430.441.240.671.790.631.36
acetyl-aspartate (N)ME3617440.781.530.631.080.681.380.661.23
Alanine+1ME3616200.551.570.521.190.621.450.621.45
CystathionineME3617630.521.220.621.470.471.320.931.41
Glutamate +1ME3616700.721.150.811.250.561.160.641.68
aKG +5ME3616180.491.120.670.480.491.461.020.84
CDPME3617570.470.970.391.100.611.910.780.95
ArginineME3616240.750.720.931.190.820.702.000.88
Hydroxyproline + 2ME3618761.180.691.340.960.501.621.500.56
G6P + 2ME3616570.701.701.211.250.551.250.710.59
NADPHME3617051.181.520.800.990.461.440.730.85
Sedoheptulose-7-phosphate (D) + 1ME3618790.781.390.921.030.881.350.980.66
ATPME3616350.931.200.961.000.801.490.900.71
GuanineME3617750.981.190.900.940.771.331.030.85
NADHME3617030.861.261.080.530.610.911.210.51
S-Adenosyl-L-methionineME3618031.271.041.271.090.910.720.960.75
Serotonin (nv)ME3618921.280.991.421.390.660.670.870.69
FructoseME3616451.160.881.350.831.130.961.010.69
dihydroxyacetone phosphate (DHAP)ME3618901.171.071.211.060.721.041.130.57
Fructose-6-phosphate + 1ME3616500.941.271.430.990.900.941.000.48
G6P + 1ME3616561.051.241.511.020.840.881.000.46
Fructose-6-phosphateME3616481.131.041.480.891.040.841.130.47
G6PME3616551.171.101.610.920.930.761.080.44
Myristoyl-carnitineME3618951.080.781.790.840.960.910.700.95
Palmitoyl-carnitineME3618960.840.951.491.280.780.910.661.08
acetyl-glutamineME3617481.080.800.890.831.700.840.851.15
3-hydroxybutyric acid+1ME3616051.390.641.310.461.271.051.010.90
Ascorbic AcidME3617521.580.781.270.591.001.130.780.85
GlutamineME3616751.350.641.390.631.340.671.430.58
ArgininosuccinateME3618291.160.781.140.841.130.831.510.63
Sedoheptulose-7-phosphate (D)ME3618781.140.901.300.741.240.891.320.48
2-HydroxyglutarateME3617431.000.601.210.741.150.791.570.95
AspartateME3616301.190.521.190.881.100.751.351.03
UrateME3618141.360.751.180.950.990.591.450.72
HomocysteineME3617791.360.611.570.881.080.491.290.72
GlutamateME3616691.270.651.400.950.980.711.130.92
PyroglutamateME3617991.240.681.400.861.090.691.250.81
Acetyl CoAME3616091.070.811.030.691.021.391.310.68
Acetyl CoA+1ME3616101.050.811.020.700.991.471.320.64
cis-aconitateME3618401.340.680.840.861.171.001.270.85
CitrateME3616371.270.780.850.890.961.141.160.95
TrehaloseME3618091.110.880.830.561.261.271.200.90
GlucoseME3616621.090.850.950.591.471.141.250.68
RiboseME3618001.130.911.000.611.411.131.200.65
GuanosineME3617761.060.770.840.821.461.071.210.79
Guanosine + 1ME3617771.110.720.810.791.541.081.260.72
MalateME3616961.440.701.160.661.220.771.240.83
UridineME3618151.070.571.240.721.460.841.170.95
hypoxanthineME3617801.260.591.090.761.240.961.210.91
Ribose phosphateME3618011.150.741.120.641.380.931.270.79
Succinic AcidME3617321.070.761.000.631.410.951.340.87
XanthineME3618161.110.661.020.641.331.001.300.96
methyl-lysine (N)ME3617840.840.730.930.751.031.531.021.17
Docosahexaenoic acidME3617670.930.801.020.641.111.400.921.19
S-Adenosyl-L-HomocysteineME3618020.930.870.960.681.141.220.971.24
MethionineME3617010.820.730.800.791.191.171.141.38
Adenosine + 2ME3618250.860.650.850.871.321.251.021.20
AdenosineME3618230.890.640.870.861.351.211.041.16
Adenosine + 1ME3618240.890.640.880.861.331.221.041.17
Arachidonic acidME3617510.820.780.990.821.131.291.011.17
acetyl-lysineME3617490.830.810.940.941.101.211.071.11
LysineME3616950.910.850.970.901.051.121.111.10
PhenylalanineME3617950.920.860.930.921.051.141.081.11
AllantoinME3618860.760.850.900.971.031.351.081.06
AMPME3616230.850.830.890.831.001.291.031.27
UMPME3618130.830.930.840.821.051.330.991.21
ValineME3618930.810.940.770.881.031.331.031.22
GMPME3617740.850.880.850.791.031.351.091.17
CMPME3617600.820.890.800.851.031.311.131.18
IsoLeucineME3616890.860.900.790.871.021.241.141.17
TryptophanME3617410.860.900.830.871.011.211.131.18
SerineME3617281.030.900.740.921.051.011.221.12
ThreonineME3617400.920.800.830.991.011.071.171.22
LeucineME3616940.900.820.840.841.091.151.181.18
Fructose +1ME3616460.960.770.810.731.261.111.221.15
TyrosineME3618100.930.850.820.751.181.131.181.17
Butyric acidME3617540.920.820.960.841.241.011.161.06
nicotinamideME3617860.950.900.880.831.201.141.061.06
aKGME3616131.110.830.900.571.411.090.941.18
GlycerolME3618910.850.890.880.671.471.191.120.96
Palmitoleic acidME3617940.810.591.000.541.431.271.311.08
SuccinyladenosineME3618050.870.760.890.711.301.361.081.04
Linoleic acidME3617820.920.711.010.561.481.260.981.11
Oleic acidME3617890.930.711.060.661.381.151.111.02
Oleic acid + 1ME3617900.920.691.070.661.401.151.111.02
Palmitic acid+2ME3617080.910.650.980.611.271.321.111.17
Palmitic acidME3617060.940.681.010.601.291.261.121.13
Palmitic acid+1ME3617070.940.691.000.621.281.251.121.12
betaineME3617531.011.071.340.911.060.980.720.92
acetyl-carnitineME3617451.010.951.150.901.011.190.900.88
Butyryl-carnitineME3617550.950.921.300.971.011.010.910.93
AlanineME3616190.981.140.900.911.140.981.120.85
TaurineME3617370.840.991.071.031.081.100.911.00
Taurine + 1ME3617380.860.981.061.021.081.110.920.97
2-hydroxy isocapric acidME3617420.820.931.031.031.001.131.051.00
Beta-hydroxyvaleric AcidME3618880.810.801.081.081.001.141.130.97
Dodecanoic acid/Lauric acidME3617681.010.951.020.781.101.021.071.05
UDP-GlcNAcME3618120.920.930.990.761.051.151.181.03
GABAME3617720.980.990.931.060.911.060.981.09
GlycineME3616860.941.000.990.901.011.091.071.00
GSHME3618631.070.991.020.910.991.061.030.94
GSH +1ME3618641.031.010.980.910.961.110.991.01
aminoadipateME3618870.860.941.240.800.680.901.321.23
OrnithineME3617910.820.801.220.900.881.121.241.01
ornithine +1ME3617920.800.811.240.910.861.131.231.01
CytidineME3617650.850.691.170.950.881.171.051.24
Propionyl-carnitineME3617970.840.741.260.930.871.120.861.37
Myristic acidME3617850.990.781.120.751.051.231.011.06
Stearic acidME3618041.160.641.200.680.991.161.091.08
LactateME3616900.681.120.691.021.171.351.110.88
OxypurinolME3617930.640.920.620.811.401.411.290.94
ADPME3616120.881.050.860.850.911.501.000.95
UDPME3618110.770.950.821.000.991.530.960.97
Glucose +1ME3616630.831.050.730.721.131.520.961.07
FADME3617710.921.040.810.791.061.370.951.06
NAD+ME3617020.971.160.730.801.031.430.960.93
GSSGME3618970.810.690.720.781.071.631.171.14
GSSG +1ME3618980.730.650.660.770.971.591.061.13
CreatinineME3618890.640.810.640.920.971.661.071.29
NADP+ME3617040.700.890.670.701.031.681.101.24
AdenineME3617500.560.900.690.961.101.461.131.21
PhosphocreatineME3617960.730.890.681.010.851.521.201.10
Glycerol 3-phosphateME3616850.730.940.571.100.801.301.241.32
Serine+1ME3617290.950.990.540.930.981.131.181.30
nicotinamide N-oxideME3617870.721.210.660.840.781.520.981.29
PEPME3617140.621.210.770.930.721.560.951.21
ProlineME3617180.681.130.741.200.831.240.881.28
AsparagineME3616250.671.170.731.230.731.300.841.31
Proline +1ME3617190.651.170.701.210.801.280.851.32
carnitineME3617560.821.170.811.020.891.450.731.11
Glutamine +1ME3616760.831.150.851.030.821.240.881.19
Glycine+1ME3616870.831.090.890.940.931.200.991.11
cAMPME3616360.610.611.221.070.741.071.521.15
Ethanolamine phosphateME3617700.770.671.021.570.740.921.051.26
CitrullineME3618470.950.961.041.031.020.851.370.78
beta AlanineME3618940.880.861.151.220.860.881.180.96
CreatineME3617610.790.920.841.250.891.041.161.10
SuccinylCysME3618060.440.440.670.991.201.331.241.54
5-Oxoproline (pyroglutamic Acid)ME3618170.620.640.640.541.741.141.760.98
PyridoxalME3617980.420.310.560.621.741.551.581.23
Fructose +2ME3616470.670.550.650.351.510.811.251.40
gama-GlutamylcysteineME3618540.980.630.810.571.211.061.461.30
Decanoic acidME3617661.100.470.980.381.521.321.101.16
Octanoic acidME3617881.060.450.990.431.421.500.991.18
Hexanoic acidME3617780.730.690.730.581.401.311.281.28
PyruvateME3617240.640.740.530.531.781.401.231.19
Eicosapentaenoic acidME3617690.700.700.710.431.751.311.281.18
Linolenic acidME3617830.740.620.850.411.671.391.161.20
CTPME361762NA0.851.181.05NA0.970.98NA
Glyceraldehyde 3-phosphate +1ME361682NA1.020.811.560.761.021.18NA
GSH +8ME3618720.71NA0.841.430.69NA0.74NA
ThymidineME3618080.570.471.212.040.420.421.330.99
GSSG +8ME3619050.580.640.582.240.490.570.680.87
SuccinylGSHME3618070.461.190.482.400.640.780.730.87
gama-Glutamylcysteine +1ME3618550.480.600.300.440.741.490.992.74
GSSG +2ME3618990.030.900.040.870.043.310.052.56
GSSG +3ME3619000.030.660.020.590.022.530.032.07
Pyruvate+1ME3617250.190.900.110.450.752.570.422.42
Pyruvate+2ME3617260.080.540.070.210.141.940.051.93
Glucose +6ME361668NA0.54NA0.21NA1.51NA1.73
GSSG +4ME361901NA0.200.020.21NA1.82NA1.62
GSSG +5ME361902NA0.12NA0.14NA1.71NA1.57
Adenosine + 4ME361827NA0.18NA0.18NA0.51NA1.55
gama-Glutamylcysteine +4ME361858NANA0.290.41NA0.38NA2.26
gama-Glutamylcysteine +2ME361856NA0.40NA0.23NA1.06NA2.10
gama-Glutamylcysteine +3ME361857NA0.25NA0.19NA0.76NA2.22
Palmitic acid+4ME361710NA0.48NA0.22NA2.66NA0.45
Glycine+2ME3616880.600.95NANANA1.71NA0.99
aKG +4ME361617NA0.67NA0.18NA2.06NA0.71
citrate +5ME361642NA0.88NA0.39NA1.88NA0.78
citrulline +3ME361850NA0.99NA1.54NA0.39NA0.90
citrulline +4ME361851NA0.66NA1.48NA0.50NA0.60
Argininosuccinate +5ME361835NA0.891.080.83NA1.23NA1.05
Sedoheptulose-7-phosphate (D) + 3ME361881NA1.18NA0.820.061.36NA0.56
3-hydroxybutyric acid+3ME361607NA1.20NA0.84NA1.17NA0.67
Glutamine +5ME3616800.001.180.000.94NA1.18NA0.84
Asparagine+2ME361627NA1.13NA0.95NA1.13NA0.79
Glutamine +4ME361679NA1.08NA0.96NA1.11NA0.84
Glutamate +3ME361672NA0.93NA0.84NA0.90NA1.32
Proline +5ME361723NA1.05NA0.87NA0.89NA1.19
citrulline +5ME361852NA0.97NA1.07NA1.02NA0.93
Glutamate +4ME361673NA0.97NA1.04NA0.96NA1.03
Glutamate +5ME361674NA1.03NA0.99NA0.97NA1.01
Alanine+3ME361622NA1.11NA0.94NA0.96NA0.99
Proline +2ME361720NA1.11NA1.04NA0.82NA1.03
Proline +3ME361721NA1.10NA0.93NA0.86NA1.11
Proline +4ME361722NA1.09NA0.95NA0.88NA1.07
Succinic Acid + 4ME361736NA1.07NA0.68NA1.22NA1.04
cis-aconitate + 2ME361842NA0.94NA0.75NA1.15NA1.10
Succinic Acid + 2ME361734NA0.95NA0.72NA1.19NA1.14
cis-aconitate + 3ME361843NA1.03NA0.59NA1.10NA1.21
Succinic Acid + 3ME361735NA1.00NA0.64NA1.19NA1.17
Glutamine +2ME361677NA1.01NA0.90NA1.06NA1.03
glutamine +3ME361678NA1.02NA0.84NA1.10NA1.03
malate +4ME361700NA1.17NA0.74NA0.99NA1.09
malate +2ME361698NA1.02NA0.73NA1.04NA1.20
Alanine+2ME361621NA1.08NA0.77NA1.04NA1.10
malate +3ME361699NA1.08NA0.73NA1.02NA1.16
citrate +6ME361643NA0.74NA0.82NA1.16NA0.98
Lactate+3ME361693NA0.94NA0.91NA1.28NA0.87
3-hydroxybutyric acid+2ME361606NA0.89NA0.82NA1.30NA0.99
Lactate+2ME361692NA0.94NA0.80NA1.26NA0.99
5-Oxoproline (pyroglutamic Acid) +2ME3618190.290.810.310.62NA1.48NA1.37
cis-aconitate + 1ME3618410.251.060.170.980.201.480.181.29
3-hydroxybutyric acid+4ME361608NA1.31NA0.32NA1.34NA1.03
5-Oxoproline (pyroglutamic Acid) +4ME361821NA1.040.040.33NA1.700.051.04
citrate +3ME3616400.000.960.000.660.001.580.011.20
citrate +4ME361641NA0.86NA0.50NA1.63NA1.01
Pyruvate+3ME361727NA0.79NA0.48NA1.52NA1.21
PEP+1ME361715NA0.40NA0.46NA1.00NA1.33
Aspartate + 4ME361634NA0.87NA0.73NA0.97NA1.43
Aspartate + 2ME361632NA0.78NA0.75NA0.98NA1.49
Aspartate + 3ME361633NA0.81NA0.70NA1.00NA1.49
Glucose +3ME361665NA0.950.000.640.001.670.001.47
GSH +2ME3618660.000.900.000.700.001.450.001.66
aKG +2ME3616150.010.980.020.47NA1.290.011.46
aKG +3ME361616NA0.94NA0.26NA1.23NA1.52
GSH +3ME3618670.000.790.000.52NA1.31NA1.51
GSH +4ME361868NA0.72NA0.59NA1.21NA1.43
GSH +5ME361869NA0.75NA0.52NA1.20NA1.46
5-Oxoproline (pyroglutamic Acid) +3ME361820NA0.68NA0.39NA1.53NA1.40
Glucose +4ME361666NA0.75NA0.47NA1.39NA1.40
Glucose +5ME361667NA0.70NA0.40NA1.43NA1.48
Argininosuccinate +4ME361834NA1.90NA0.87NA0.45NA0.73
Asparagine+3ME361628NA1.50NA0.92NA0.420.460.72
Argininosuccinate +2ME3618320.041.760.031.430.041.190.061.03
Argininosuccinate +3ME361833NA1.42NA1.04NA0.810.030.80
Fructose-6-phosphate + 3ME361649NA1.56NA0.85NA1.13NA0.34
G6P + 3ME361658NA1.410.051.02NA1.190.040.47
Acetyl CoA+2ME3616110.321.330.351.250.422.880.600.81
Fructose-6-phosphate + 2ME3616510.432.110.921.730.361.160.430.53
Sedoheptulose-7-phosphate (D) + 2ME3618800.192.090.401.400.272.170.440.94
Argininosuccinate +1ME3618300.471.880.421.630.451.440.641.03
citrulline +1ME3618480.371.810.401.640.391.490.531.33
Asparagine+1ME3616260.191.890.191.750.201.940.241.53
citrulline +2ME3618490.141.930.192.080.211.480.351.56
Glutamate +2ME3616710.001.700.011.880.011.780.012.54
citrate +2ME3616390.021.610.021.430.022.450.031.90
aKG +1ME3616140.431.460.250.570.591.910.282.44
Aspartate + 1ME3616310.401.210.401.210.371.590.452.32
Glucose +2ME3616640.251.440.240.980.352.370.322.00
citrate +1ME3616380.401.500.241.280.302.140.381.72
malate +1ME3616970.351.690.281.260.291.770.302.01
Succinic Acid + 1ME3617330.281.580.271.170.381.990.361.92
CysteineME3616442.921.152.410.640.160.080.220.18
CystineME3617641.630.870.980.49NANA0.240.29
Serine+2ME3617301.011.241.01NANANANA0.74

Factors:

F1Age:Old | Genotype:SIRT6-tg | Treatment:N/A
F2Age:Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate
F3Age:Old | Genotype:Wild-type | Treatment:N/A
F4Age:Old | Genotype:Wild-type | Treatment:[U-13C]Lactate
F5Age:Young | Genotype:SIRT6-tg | Treatment:N/A
F6Age:Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate
F7Age:Young | Genotype:Wild-type | Treatment:N/A
F8Age:Young | Genotype:Wild-type | Treatment:[U-13C]Lactate
Data matrix
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