Clustering data with hclust algorithm for (Study ST002068)
HILIC NEGATIVE ION MODE (Analysis AN003371)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AICAR | ME477072 | 0.72 | 1.27 | 4.77 | 0.76 | 0.89 | 1.39 | 0.32 | 0.90 | 0.41 | 0.25 | 0.77 | 0.41 |
| Citric acid | ME477071 | 0.66 | 1.93 | 0.65 | 0.83 | 1.99 | 0.91 | 0.36 | 2.07 | 0.21 | 0.62 | 1.39 | 0.64 |
| Aminoadipic acid | ME476999 | 1.56 | 1.58 | 1.07 | 2.21 | 2.18 | 1.54 | 0.34 | 0.37 | 0.24 | 0.26 | 0.39 | 0.26 |
| Hippuric acid | ME477008 | 1.08 | 3.07 | 0.44 | 0.94 | 0.54 | 0.74 | 0.78 | 2.97 | 0.13 | 0.82 | 0.76 | 0.55 |
| Guanosine monophosphate | ME477042 | 0.54 | 1.56 | 1.08 | 1.21 | 1.20 | 1.41 | 0.95 | 1.54 | 0.81 | 0.78 | 0.84 | 0.68 |
| Adenosine | ME476991 | 0.03 | 0.17 | 2.24 | 0.29 | 0.07 | 0.60 | 0.65 | 1.28 | 2.33 | 2.02 | 0.73 | 1.90 |
| Choline | ME477058 | 1.09 | 1.38 | 0.32 | 1.35 | 1.41 | 1.10 | 0.86 | 1.17 | 0.23 | 0.95 | 1.14 | 0.76 |
| Citicoline | ME477046 | 0.17 | 0.22 | 3.05 | 0.30 | 0.15 | 0.58 | 0.49 | 0.94 | 4.47 | 0.87 | 0.51 | 1.45 |
| Creatine | ME477006 | 0.81 | 0.91 | 1.05 | 0.97 | 0.98 | 1.07 | 0.99 | 1.25 | 1.10 | 1.00 | 1.02 | 1.01 |
| Adenine | ME476921 | 0.39 | 0.34 | 1.50 | 0.37 | 0.45 | 0.54 | 1.17 | 1.50 | 1.64 | 1.76 | 1.24 | 1.22 |
| 2-Oxo-4-methylthiobutanoic acid | ME476938 | 1.03 | 1.26 | 0.77 | 0.42 | 0.37 | 1.99 | 0.67 | NA | NA | 0.36 | NA | 3.47 |
| Adenosine monophosphate | ME477016 | 0.12 | 0.44 | 1.80 | 0.35 | 0.41 | 0.55 | 0.61 | 2.40 | 2.83 | 1.07 | 1.31 | 1.20 |
| Argininosuccinic acid | ME477060 | 1.93 | 1.30 | 1.62 | 0.71 | 1.26 | 1.04 | 0.71 | 1.15 | 0.39 | 0.47 | 0.78 | 0.47 |
| Hypotaurine | ME477034 | 0.80 | 1.29 | 1.40 | 0.98 | 1.85 | 1.71 | 0.52 | 0.82 | 0.65 | 0.73 | 0.70 | 0.60 |
| Indolelactic acid | ME476961 | 1.48 | 2.98 | 0.93 | 0.73 | 1.18 | 0.91 | 0.75 | 1.78 | 0.20 | 0.38 | 0.61 | 0.59 |
| Cyclic AMP | ME476872 | 0.23 | 0.18 | 2.48 | 0.12 | NA | 0.81 | 0.77 | 0.26 | 0.53 | 0.22 | 0.18 | 2.90 |
| Dimethylglycine | ME476990 | 0.69 | 0.92 | 0.09 | 1.00 | 0.97 | 0.38 | 2.16 | 1.73 | 0.15 | 1.59 | 1.59 | 0.65 |
| D-2-Hydroxyglutaric acid | ME477010 | 1.07 | 1.14 | 2.14 | 0.76 | 1.56 | 1.16 | 1.03 | 0.87 | 0.95 | 0.56 | 0.60 | 0.57 |
| Glycerol 3-phosphate | ME477065 | 0.34 | 0.35 | 4.42 | 0.24 | 0.42 | 0.98 | 0.34 | 0.89 | 3.26 | 0.49 | 0.43 | 1.40 |
| Deoxyribose 5-phosphate | ME476968 | 1.45 | 1.29 | 0.39 | 0.67 | 1.31 | 0.55 | 0.84 | 1.17 | NA | 0.17 | 1.42 | 1.32 |
| D-Glucose | ME476870 | 1.24 | 1.05 | 0.51 | 0.49 | 1.62 | 0.42 | 1.41 | 1.03 | 0.42 | 0.67 | 2.08 | 0.70 |
| Gluconic acid | ME477032 | 0.80 | 1.39 | 0.87 | 0.82 | 1.70 | 2.20 | 0.47 | 1.25 | 0.29 | 0.62 | 0.85 | 0.63 |
| D-Ribulose 5-phosphate | ME476943 | 0.99 | 1.36 | 0.37 | 1.02 | 1.19 | 1.28 | 1.40 | 1.77 | 0.15 | 0.50 | 1.22 | 0.94 |
| Fructose 6-phosphate | ME476925 | 1.51 | 1.43 | 0.39 | 0.64 | 0.67 | 0.74 | 0.98 | 1.37 | 0.42 | 0.51 | 2.12 | 0.95 |
| Deoxyinosine | ME476898 | 0.79 | 0.88 | 0.52 | 0.60 | 0.76 | 1.11 | 0.95 | 0.59 | 0.81 | 0.58 | 0.43 | 3.62 |
| Arachidonic acid | ME476981 | 0.84 | 1.48 | 0.24 | 0.82 | 1.46 | 0.95 | 1.45 | 2.11 | 0.08 | 1.00 | 1.27 | 0.43 |
| Indole-3-carboxylic acid | ME477030 | 1.25 | 1.34 | 0.94 | 1.03 | 0.86 | 1.06 | 1.26 | 0.63 | 0.99 | 0.76 | 0.93 | 1.12 |
| 4-Pyridoxic acid | ME477066 | 1.59 | 2.71 | 0.24 | 1.28 | 2.53 | 1.85 | 0.23 | 0.43 | 0.12 | 0.27 | 0.32 | 0.14 |
| dGDP | ME476940 | 0.24 | 0.32 | 1.44 | 0.43 | 0.36 | 1.15 | 0.73 | 2.74 | 2.87 | 0.80 | 1.13 | 0.96 |
| 3-Hydroxybutyric acid | ME477047 | 0.76 | 1.24 | 1.08 | 0.70 | 1.35 | 0.97 | 0.91 | 1.31 | 0.46 | 0.86 | 1.13 | 1.27 |
| Guanosine diphosphate | ME476908 | 0.75 | NA | 0.79 | 0.78 | 0.90 | 2.06 | 0.72 | 1.09 | 0.91 | 0.90 | 1.08 | 0.96 |
| 4-Hydroxyproline | ME476918 | 0.94 | 1.41 | 1.35 | 1.35 | 1.60 | 1.91 | 0.42 | 0.58 | 0.49 | 0.65 | 0.68 | 0.63 |
| Guanosine | ME476977 | 1.45 | 1.44 | 0.82 | 1.54 | 1.68 | 1.51 | 0.46 | 0.55 | 0.35 | 0.77 | 0.46 | 0.61 |
| Creatinine | ME476989 | 0.73 | 0.92 | 0.82 | 0.95 | 0.94 | 1.10 | 1.17 | 1.40 | 0.78 | 1.05 | 1.28 | 0.96 |
| 3-Methylhistidine | ME476901 | 1.00 | 1.41 | 1.35 | 1.58 | 1.56 | 0.90 | 0.63 | 1.42 | 0.48 | 0.79 | 0.88 | 0.37 |
| D-Glyceraldehyde 3-phosphate | ME476986 | 0.25 | 0.57 | 0.54 | 0.37 | 0.35 | 0.66 | 1.53 | 1.69 | 2.78 | 0.95 | 1.48 | 1.37 |
| Acetylcholine | ME476941 | 1.04 | 1.36 | 1.73 | 1.08 | 1.14 | 1.94 | 0.49 | 0.76 | 0.96 | 0.44 | 0.79 | 0.55 |
| cis-Aconitic acid | ME477039 | 0.62 | 1.48 | 2.10 | 0.63 | 1.51 | 1.35 | 0.41 | 1.54 | 0.54 | 0.55 | 0.93 | 0.86 |
| Carnosine | ME477068 | 0.79 | 1.29 | 1.86 | 1.59 | 2.01 | 2.05 | 0.21 | 0.36 | 0.28 | 0.62 | 0.47 | 0.53 |
| 5^-Methylthioadenosine | ME476887 | 0.63 | 1.24 | 0.79 | 1.21 | 1.34 | 1.21 | 0.72 | 1.47 | 0.92 | 0.89 | 0.91 | 0.95 |
| Cytosine | ME476911 | 0.98 | 0.94 | 0.98 | 0.92 | 1.00 | 1.06 | 0.89 | 1.18 | 0.43 | 0.94 | 1.42 | 1.06 |
| D-Glucuronic acid | ME477043 | 1.00 | 1.37 | 1.43 | 0.83 | 0.96 | 1.01 | 0.84 | 0.98 | 0.71 | 0.76 | 0.96 | 1.28 |
| 3-Methylthiopropionic acid | ME477056 | 0.66 | 1.08 | NA | 0.57 | 0.85 | 1.56 | 0.73 | 0.79 | NA | 0.95 | 0.45 | 2.81 |
| 5-Thymidylic acid | ME476964 | NA | NA | 1.00 | NA | NA | 0.92 | 0.48 | 1.93 | 1.18 | NA | NA | 0.77 |
| 3-Phosphoglyceric acid | ME476884 | 2.23 | 1.00 | 0.55 | 0.58 | 0.77 | 0.99 | 0.87 | 2.71 | 0.26 | 0.54 | 0.78 | 0.45 |
| Indoxyl sulfate | ME476878 | 1.22 | 2.76 | 2.63 | 0.44 | 0.83 | 0.96 | 0.63 | 1.22 | 0.87 | 0.32 | 0.66 | 0.46 |
| Galactonic acid | ME477048 | 1.51 | 1.85 | 1.15 | 1.19 | 1.52 | 1.16 | 0.45 | 1.03 | 0.51 | 0.54 | 0.69 | 0.44 |
| Inosine | ME477027 | 0.93 | 1.22 | 0.37 | 1.17 | 1.11 | 1.18 | 1.11 | 1.19 | 0.26 | 1.21 | 1.05 | 0.93 |
| Guanine | ME477078 | 1.19 | 0.96 | 2.47 | 1.09 | 0.96 | 1.90 | 0.48 | 0.39 | 1.07 | 0.53 | 0.39 | 0.82 |
| Betaine | ME476995 | 1.15 | 1.40 | 1.27 | 1.28 | 1.36 | 1.33 | 0.84 | 0.97 | 0.48 | 0.71 | 0.72 | 0.63 |
| D-Ribose | ME476954 | 1.62 | 1.86 | 0.07 | 1.32 | 2.51 | 1.16 | 0.63 | 0.61 | 0.04 | 0.57 | 0.67 | 0.39 |
| D-Sedoheptulose 7-phosphate | ME476909 | 2.24 | 1.33 | 0.48 | 1.26 | 1.39 | 1.24 | 0.87 | 0.81 | 0.15 | 0.44 | 0.76 | 0.43 |
| 1-Methyladenosine | ME477015 | 0.51 | 0.81 | 1.20 | 0.84 | 0.76 | 1.27 | 0.81 | 1.19 | 0.73 | 0.92 | 1.07 | 1.95 |
| Fumaric acid | ME476904 | 1.17 | 1.44 | 0.81 | 0.90 | 1.14 | 1.08 | 1.12 | 1.25 | 0.47 | 0.56 | 1.23 | 0.93 |
| Glucose 6-phosphate | ME476996 | 1.07 | 1.76 | 0.32 | 0.82 | 1.95 | 1.60 | 0.43 | 1.74 | 0.38 | 0.58 | 0.73 | 0.54 |
| Glucosamine | ME476983 | 1.65 | 1.41 | 1.32 | 0.49 | 0.78 | 0.38 | 0.43 | 1.50 | 0.58 | 0.73 | 1.72 | 0.78 |
| 6-Phosphonoglucono-D-lactone | ME477070 | 1.31 | 0.80 | 0.58 | NA | NA | 0.97 | 0.77 | 1.17 | NA | NA | 0.99 | NA |
| Glycine | ME477002 | 1.53 | 1.46 | 1.70 | 1.49 | 1.58 | 1.86 | 0.36 | 0.53 | 0.36 | 0.39 | 0.36 | 0.38 |
| Hexanoylcarnitine | ME477063 | 0.43 | 0.65 | 1.14 | 1.00 | 0.55 | 0.68 | 1.34 | 1.84 | 1.47 | 1.53 | 0.85 | 1.02 |
| Glycerophosphocholine | ME477073 | 0.31 | 2.27 | 1.04 | 1.48 | 2.03 | 2.70 | 0.15 | 0.66 | 0.41 | 0.17 | 0.73 | 0.57 |
| Guanidoacetic acid | ME477000 | 1.03 | 1.23 | 1.98 | 1.08 | 1.16 | 1.81 | 0.63 | 0.90 | 0.60 | 0.61 | 0.71 | 0.53 |
| GDP-glucose | ME476893 | NA | NA | 0.69 | 0.37 | NA | 1.31 | 0.71 | 1.32 | 1.20 | 1.01 | 0.61 | 1.62 |
| Deoxyuridine | ME476936 | 1.01 | 0.96 | 0.70 | 0.69 | 0.89 | 1.17 | 1.03 | 1.22 | 0.72 | 0.76 | 1.06 | 1.64 |
| D-Fructose | ME477041 | 1.23 | 1.72 | 0.33 | 0.78 | 2.15 | 0.89 | 0.52 | 0.66 | 0.26 | 0.70 | 1.69 | 0.52 |
| Glutathione | ME477029 | 0.03 | 0.02 | 8.57 | 0.02 | 0.04 | 3.49 | 0.07 | 0.03 | 1.21 | 0.06 | 0.03 | 0.37 |
| 2-Hydroxyvaleric acid | ME477050 | 0.34 | 0.81 | 1.07 | 1.22 | 1.30 | 1.34 | 0.39 | 0.85 | 0.46 | 1.20 | 1.46 | 1.30 |
| Allantoin | ME476902 | 0.92 | 1.29 | 1.77 | 0.84 | 1.10 | 1.22 | 0.76 | 1.27 | 0.71 | 0.73 | 0.98 | 0.74 |
| Cholic acid | ME476917 | 0.64 | 0.74 | 4.22 | NA | 1.24 | 1.82 | 0.25 | 1.23 | 0.16 | 0.67 | 0.21 | 0.30 |
| Hydrocinnamic acid | ME476979 | 0.93 | 1.12 | 0.84 | 1.12 | 1.00 | 1.00 | 0.93 | 1.32 | 0.64 | 1.06 | 1.02 | 1.02 |
| Hypoxanthine | ME476949 | 0.52 | 1.68 | 1.42 | 0.37 | 1.27 | 1.81 | 0.42 | 1.39 | 0.87 | 0.69 | 0.91 | 0.95 |
| ADP | ME476886 | 0.25 | 0.28 | 1.56 | 0.43 | 0.39 | 1.12 | 0.76 | 2.63 | 2.80 | 0.77 | 1.17 | 1.00 |
| 3-Hydroxymethylglutaric acid | ME476980 | 1.17 | 1.57 | 0.81 | 1.24 | 1.34 | 1.03 | 0.69 | 0.99 | 0.52 | 0.92 | 0.91 | 0.71 |
| Caprylic acid | ME476919 | 0.77 | 1.16 | 1.28 | 0.92 | 1.17 | 1.32 | 0.69 | 1.22 | 0.79 | 1.11 | 0.66 | 0.97 |
| Cytidine monophosphate | ME476993 | 0.43 | 0.45 | 2.25 | 0.44 | 0.34 | 0.69 | 1.50 | 2.46 | 1.05 | 1.16 | 1.18 | 0.91 |
| Deoxyadenosine | ME477051 | 0.19 | 0.24 | 3.01 | 0.25 | 0.20 | 1.99 | 1.13 | 1.25 | 1.97 | 0.69 | 0.73 | 1.35 |
| Butyrylcarnitine | ME476899 | 0.36 | 0.55 | 2.15 | 0.61 | 0.68 | 0.65 | 0.47 | 1.62 | 2.59 | 0.67 | 1.04 | 1.60 |
| Acetylcysteine | ME476973 | 0.38 | 0.61 | 3.28 | 0.33 | 0.95 | 3.80 | 0.35 | 0.49 | 0.51 | 0.45 | 0.51 | 0.58 |
| CDP-Ethanolamine | ME476903 | 0.19 | 0.20 | 3.01 | 0.21 | 0.16 | 0.71 | 0.55 | 1.15 | 4.47 | 0.68 | 0.65 | 1.32 |
| Asymmetric dimethylarginine | ME476930 | 1.12 | 0.84 | 1.83 | 0.89 | 0.85 | 1.04 | 0.92 | 1.00 | 1.09 | 0.82 | 0.85 | 0.96 |
| 2-Hydroxycaproic acid | ME477007 | 0.77 | 1.08 | 0.91 | 1.04 | 1.13 | 1.24 | 0.83 | 1.17 | 0.65 | 0.88 | 1.12 | 1.18 |
| 3-hydroxyhexadecanoic acid | ME476992 | 1.27 | 0.80 | 0.70 | 1.29 | 0.70 | 1.05 | 0.77 | 1.17 | 0.51 | 0.88 | 1.50 | 1.06 |
| 3-Indolepropionic acid | ME477003 | 0.66 | 0.84 | 1.51 | 1.65 | 1.25 | 1.92 | 0.62 | 0.80 | 0.57 | 0.52 | 0.86 | 1.05 |
| Citrulline | ME476976 | 1.00 | 1.38 | 1.35 | 1.01 | 1.06 | 1.01 | 0.84 | 1.54 | 0.95 | 0.70 | 0.92 | 0.71 |
| Cytidine | ME476920 | 0.97 | 1.27 | 1.04 | 1.19 | 1.26 | 1.30 | 0.78 | 1.29 | 0.43 | 0.83 | 0.90 | 0.81 |
| dCMP | ME476928 | 0.19 | NA | NA | 0.54 | NA | 1.13 | 0.44 | 1.92 | 0.52 | 1.60 | 1.14 | 0.37 |
Factors:
| F1 | Genotype:CHCHD10 S55L+/- | Sex:F | Age (d):125 |
| F2 | Genotype:CHCHD10 S55L+/- | Sex:F | Age (d):225 |
| F3 | Genotype:CHCHD10 S55L+/- | Sex:F | Age (d):75 |
| F4 | Genotype:CHCHD10 S55L+/- | Sex:M | Age (d):125 |
| F5 | Genotype:CHCHD10 S55L+/- | Sex:M | Age (d):225 |
| F6 | Genotype:CHCHD10 S55L+/- | Sex:M | Age (d):75 |
| F7 | Genotype:WT | Sex:F | Age (d):125 |
| F8 | Genotype:WT | Sex:F | Age (d):225 |
| F9 | Genotype:WT | Sex:F | Age (d):75 |
| F10 | Genotype:WT | Sex:M | Age (d):125 |
| F11 | Genotype:WT | Sex:M | Age (d):225 |
| F12 | Genotype:WT | Sex:M | Age (d):75 |