Clustering data with hclust algorithm for (Study ST002161)
(Analysis AN003540)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 | F32 | F33 | F34 | F35 | F36 | F37 | F38 | F39 | F40 | F41 | F42 | F43 | F44 | F45 | F46 | F47 | F48 | F49 | F50 | F51 | F52 | F53 | F54 | F55 | F56 | F57 | F58 | F59 | F60 | F61 | F62 | F63 | F64 | F65 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Glycerate_M0 | ME528512 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.02 | 0.03 | 0.26 | NA | NA | NA | 0.02 | 0.05 | 0.08 | 0.07 | 0.11 | 0.11 | 0.06 | 0.09 | 0.01 | 0.04 | 0.06 | 0.04 | 0.09 | 0.05 | 0.07 | 0.04 | 3.22 | 15.41 | 10.33 | 11.82 | 7.31 | 5.81 | 0.16 | 0.11 | 0.02 | 0.08 | 0.08 | 0.08 | 0.25 | NA | NA | NA | 0.02 | 0.05 | 0.12 | 0.08 | 0.14 | 0.09 | 0.06 | 0.09 | 0.01 | 0.06 | 0.07 | 0.06 | 0.09 | 0.06 | 0.08 | 0.08 | 0.12 | 0.02 | 0.11 | 0.08 | 0.11 |
| Glycerate_M1 | ME528513 | 0.00 | 0.03 | NA | 0.01 | NA | 0.03 | NA | 0.07 | 1.17 | NA | NA | NA | 0.03 | 0.78 | 0.09 | 0.38 | 0.61 | 1.06 | 0.84 | 0.03 | 0.03 | 0.42 | 0.42 | 0.37 | 0.74 | 0.61 | 1.37 | NA | 3.46 | 4.40 | 10.98 | 13.29 | 4.71 | 0.78 | 0.06 | 0.47 | NA | 0.06 | 0.55 | NA | 1.00 | NA | NA | NA | 0.05 | 0.43 | 0.10 | 0.48 | 0.59 | 0.57 | 0.56 | 0.14 | 0.04 | 0.99 | 0.32 | 0.52 | 0.52 | 0.61 | 0.98 | NA | 0.91 | 0.13 | 0.33 | 0.05 | 0.19 |
| Glycerate_M2 | ME528514 | NA | 0.03 | 0.03 | 0.03 | NA | NA | NA | NA | 1.92 | NA | NA | NA | NA | 0.64 | 0.55 | 0.50 | 1.20 | 1.51 | 1.21 | NA | NA | 0.53 | 0.36 | 0.95 | 1.18 | 1.12 | 1.41 | NA | NA | NA | NA | 0.29 | NA | NA | NA | 1.25 | NA | NA | NA | NA | 2.56 | NA | NA | NA | NA | 0.67 | 0.25 | 1.20 | 1.03 | 1.22 | 1.07 | NA | NA | 1.44 | 0.43 | 0.43 | 0.88 | 1.10 | 1.81 | NA | 2.02 | NA | 0.10 | 0.23 | NA |
| Glucose_M1 | ME528506 | 0.01 | 0.09 | 0.03 | 0.08 | NA | 0.07 | 0.00 | 0.02 | NA | NA | NA | NA | 0.19 | 1.58 | 0.36 | 1.06 | 1.96 | 2.54 | 2.64 | NA | 0.17 | 0.79 | 0.37 | 0.56 | 2.20 | 1.71 | 2.02 | NA | 0.00 | NA | NA | 0.02 | NA | NA | NA | 0.02 | 0.03 | NA | NA | 0.00 | NA | NA | NA | NA | 0.25 | 1.40 | 0.51 | 1.25 | 2.23 | 2.70 | 2.27 | NA | 0.28 | 1.79 | 0.56 | 1.17 | 2.36 | 2.97 | 1.88 | NA | 0.02 | 0.04 | 0.11 | 0.13 | 0.01 |
| Glucose_M5 | ME528510 | NA | 0.03 | NA | 0.04 | NA | 0.01 | 0.02 | 0.04 | NA | NA | NA | NA | 0.42 | 0.39 | 0.88 | 2.15 | 2.79 | 2.26 | 2.11 | 0.12 | 0.38 | 0.26 | 0.76 | 1.35 | 2.82 | 1.39 | 1.67 | 0.71 | 0.03 | 0.02 | 0.04 | 0.02 | 0.03 | 0.04 | 0.04 | 0.05 | 0.04 | 0.22 | 0.16 | 0.04 | NA | NA | NA | NA | 0.57 | 0.58 | 1.45 | 2.78 | 4.17 | 3.77 | 2.72 | 0.05 | 0.53 | 0.86 | 1.12 | 2.55 | 3.81 | 3.75 | 2.28 | 0.14 | 0.09 | 0.07 | 0.53 | 0.51 | 0.05 |
| Glucose_M4 | ME528509 | 0.00 | 0.05 | 0.04 | 0.10 | NA | NA | NA | NA | NA | NA | NA | NA | 0.40 | 0.35 | 0.67 | 1.58 | 2.35 | 2.03 | 1.94 | NA | 0.23 | 0.19 | 0.62 | 0.75 | 2.38 | 1.23 | 1.35 | NA | 0.01 | NA | NA | 0.02 | 0.01 | 0.02 | 0.02 | 0.03 | 0.03 | 0.17 | 0.10 | NA | NA | NA | NA | NA | 0.48 | 0.55 | 0.92 | 2.00 | 3.03 | 2.87 | 2.30 | NA | 0.43 | 0.72 | 0.86 | 1.78 | 3.00 | 2.90 | 1.75 | NA | 0.07 | 0.06 | 0.40 | 0.38 | NA |
| Glucose_M3 | ME528508 | 0.04 | 0.06 | 0.06 | 0.13 | NA | NA | NA | NA | 0.03 | NA | NA | NA | 0.68 | 0.37 | 0.89 | 1.41 | 2.09 | 1.62 | 1.27 | NA | 0.46 | 0.20 | 0.84 | 0.72 | 2.22 | 1.03 | 0.99 | NA | NA | NA | NA | NA | NA | NA | NA | 0.03 | 0.05 | 0.28 | 0.25 | NA | 0.08 | NA | NA | NA | 0.80 | 0.63 | 1.16 | 1.95 | 2.93 | 2.54 | 1.68 | NA | 0.84 | 0.84 | 1.13 | 1.83 | 2.87 | 2.66 | 1.39 | NA | 0.08 | 0.10 | 0.70 | 0.73 | NA |
| Glucose_M6 | ME528511 | 0.01 | 0.01 | 0.04 | 0.06 | NA | 0.00 | NA | 0.00 | NA | NA | NA | NA | 0.70 | 0.16 | 1.21 | 1.75 | 2.49 | 1.56 | 1.20 | 0.00 | 0.36 | 0.09 | 0.93 | 0.81 | 2.31 | 0.94 | 0.85 | 0.01 | NA | NA | NA | NA | NA | NA | NA | 0.14 | 0.06 | 0.47 | 0.26 | NA | NA | NA | NA | NA | 1.11 | 0.35 | 1.60 | 2.36 | 3.40 | 2.35 | 1.75 | 0.00 | 0.81 | 0.44 | 1.33 | 1.98 | 3.10 | 2.33 | 1.40 | 0.00 | 0.18 | 0.09 | 0.80 | 0.63 | NA |
| Fructose_M2 | ME528500 | NA | NA | NA | NA | NA | 0.58 | 0.26 | 0.50 | 0.23 | NA | NA | NA | 0.45 | 1.18 | 1.34 | 1.01 | 1.25 | 1.46 | 1.46 | 1.51 | 0.46 | 1.09 | 1.27 | 0.79 | 1.32 | 1.69 | 1.24 | 1.04 | NA | NA | NA | NA | NA | NA | NA | 0.01 | 0.09 | NA | NA | 0.85 | 0.40 | NA | NA | NA | 0.47 | 1.16 | 2.19 | 1.12 | 1.76 | 1.40 | 1.69 | 1.82 | 0.49 | 1.30 | 1.45 | 0.95 | 1.33 | 1.65 | 1.40 | 1.64 | NA | 0.05 | 0.06 | 0.25 | 0.78 |
| Glucose_M0 | ME528505 | 0.07 | 0.04 | 0.03 | 0.04 | 0.06 | 1.46 | 1.45 | 1.61 | 0.08 | NA | NA | NA | 1.19 | 1.13 | 0.94 | 1.00 | 1.55 | 1.67 | 1.00 | 1.19 | 0.80 | 0.62 | 0.88 | 0.54 | 1.87 | 1.18 | 0.93 | 0.55 | 0.92 | 0.81 | 0.78 | 0.80 | 0.86 | 0.91 | 1.14 | 0.10 | 0.41 | 1.22 | 1.28 | 1.65 | 0.11 | NA | NA | NA | 1.18 | 0.92 | 1.20 | 0.98 | 1.60 | 1.36 | 0.95 | 1.31 | 1.27 | 1.21 | 1.25 | 0.96 | 1.72 | 1.61 | 0.87 | 1.41 | 0.11 | 0.55 | 1.43 | 1.57 | 2.09 |
| Fructose_M6 | ME528504 | 0.03 | 0.00 | 0.03 | 0.02 | NA | 0.00 | 0.00 | NA | 13.64 | NA | NA | NA | 1.44 | 0.01 | 1.34 | 0.88 | 0.70 | 0.25 | 0.11 | 0.00 | 0.42 | 0.01 | 0.75 | 0.37 | 0.31 | 0.10 | 0.04 | 0.00 | NA | NA | NA | NA | NA | NA | NA | 3.61 | 0.62 | 0.03 | 0.00 | NA | 17.50 | NA | NA | NA | 1.48 | 0.02 | 1.45 | 0.90 | 0.88 | 0.23 | 0.14 | 0.00 | 0.49 | 0.01 | 0.57 | 0.35 | 0.43 | 0.11 | 0.05 | 0.00 | 3.06 | 0.67 | 0.03 | 0.01 | NA |
| Glycerate_M3 | ME528515 | 0.00 | 0.01 | 0.01 | 0.01 | NA | NA | NA | NA | 3.73 | NA | NA | NA | 0.04 | 0.08 | 0.46 | 0.76 | 0.44 | 0.35 | 0.20 | NA | 0.02 | 0.04 | 0.41 | 0.40 | 0.39 | 0.19 | 0.21 | NA | NA | NA | NA | NA | NA | NA | NA | 2.35 | 0.01 | 0.04 | NA | NA | 10.88 | NA | NA | NA | 0.07 | 0.16 | 1.55 | 4.57 | 0.75 | 0.74 | 0.52 | NA | 0.03 | 0.19 | 1.15 | 2.95 | 0.54 | 0.52 | 0.48 | NA | 5.93 | NA | 0.19 | 0.10 | NA |
Factors:
| F1 | Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water |
| F2 | Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water |
| F3 | Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water |
| F4 | Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water |
| F5 | Genotype:KHK-c-KO | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water |
| F6 | Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Fructose injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water |
| F7 | Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Glycerate injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water |
| F8 | Genotype:Wild-type | Diet:CD | Diet Duration:12 weeks | Treatment:Saline injection | Tissue:Systemic Serum | Collection Time (minute):1440 | Drinking:Water |
| F9 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water |
| F10 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water |
| F11 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water |
| F12 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water |
| F13 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water |
| F14 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water |
| F15 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water |
| F16 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water |
| F17 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water |
| F18 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water |
| F19 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water |
| F20 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water |
| F21 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water |
| F22 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water |
| F23 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water |
| F24 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water |
| F25 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water |
| F26 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water |
| F27 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water |
| F28 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water |
| F29 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):120 | Drinking:Water |
| F30 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):15 | Drinking:Water |
| F31 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):30 | Drinking:Water |
| F32 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):45 | Drinking:Water |
| F33 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):60 | Drinking:Water |
| F34 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):90 | Drinking:Water |
| F35 | Genotype:Wild-type | Diet:CD | Diet Duration:3 days | Treatment:Glycerate injection | Tissue:Tail Vein Serum | Collection Time (minute):- | Drinking:Water |
| F36 | Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water |
| F37 | Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water |
| F38 | Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water |
| F39 | Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water |
| F40 | Genotype:Wild-type | Diet:CD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water |
| F41 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water |
| F42 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):45 | Drinking:Water |
| F43 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):60 | Drinking:Water |
| F44 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Pancreas | Collection Time (minute):- | Drinking:Water |
| F45 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water |
| F46 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):120 | Drinking:Water |
| F47 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):15 | Drinking:Water |
| F48 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):30 | Drinking:Water |
| F49 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):45 | Drinking:Water |
| F50 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):60 | Drinking:Water |
| F51 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):90 | Drinking:Water |
| F52 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):- | Drinking:Water |
| F53 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water |
| F54 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):120 | Drinking:Water |
| F55 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):15 | Drinking:Water |
| F56 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):30 | Drinking:Water |
| F57 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):45 | Drinking:Water |
| F58 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):60 | Drinking:Water |
| F59 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):90 | Drinking:Water |
| F60 | Genotype:Wild-type | Diet:HFD | Diet Duration:3 days | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Water |
| F61 | Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Jejunum | Collection Time (minute):10 | Drinking:Water |
| F62 | Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Liver | Collection Time (minute):10 | Drinking:Water |
| F63 | Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Portal Vein Serum | Collection Time (minute):10 | Drinking:Water |
| F64 | Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):10 | Drinking:Water |
| F65 | Genotype:Wild-type | Diet:HFD | Diet Duration:4 weeks | Treatment:Control | Tissue:Systemic Serum | Collection Time (minute):- | Drinking:Fructose water |
