Clustering data with hclust algorithm for (Study ST002163)
(Analysis AN003544)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| 2-Methylhippuric acid | ME529429 | 0.69 | 0.61 | NA | 0.54 | NA | 2.16 |
| 2-Hydroxyisovaleric acid | ME529378 | 1.14 | 0.71 | NA | 1.43 | NA | 0.71 |
| Cysteinesulfinic acid | ME529431 | 1.76 | 0.55 | NA | 1.32 | NA | 0.37 |
| N-Acetyl-Ala | ME529405 | 2.01 | 0.27 | NA | 1.37 | NA | 0.34 |
| N-Acetyl-Asp | ME529401 | 2.03 | 0.28 | NA | 1.17 | NA | 0.52 |
| CDP | ME529343 | 1.51 | 0.70 | NA | 1.03 | NA | 0.77 |
| CTP | ME529347 | 1.63 | 0.42 | NA | 1.23 | NA | 0.72 |
| 2-Hydroxy glutaric acid | ME529389 | 1.68 | 0.56 | NA | 1.19 | NA | 0.56 |
| FBP | ME529348 | 1.60 | 0.60 | NA | 1.08 | NA | 0.72 |
| 6PG | ME529337 | 1.57 | 0.56 | NA | 1.22 | NA | 0.65 |
| Cysteic acid | ME529432 | 1.55 | 0.58 | NA | 1.16 | NA | 0.71 |
| N-Carbamoyl-Asp | ME529422 | 1.76 | 0.76 | NA | 1.03 | NA | 0.44 |
| Glutaric acid | ME529379 | 1.57 | 0.93 | NA | 0.99 | NA | 0.52 |
| PropionylGly | ME529398 | 1.69 | 0.83 | NA | 0.76 | NA | 0.71 |
| Quinolinic acid | ME529381 | 1.68 | 0.88 | NA | 0.86 | NA | 0.58 |
| Maltotetraose | ME529423 | 0.54 | 1.24 | NA | 0.44 | NA | 1.78 |
| Creatine phosphate | ME529421 | 0.76 | 1.01 | NA | 0.57 | NA | 1.66 |
| S7P | ME529355 | 0.68 | 1.10 | NA | 0.70 | NA | 1.52 |
| 2-Dehydrogluconate | ME529417 | 0.73 | 1.42 | NA | 0.42 | NA | 1.42 |
| F6P | ME529349 | 0.72 | 1.41 | NA | 0.48 | NA | 1.38 |
| G1P | ME529351 | 0.69 | 1.24 | NA | 0.53 | NA | 1.54 |
| G6P | ME529352 | 0.67 | 1.33 | NA | 0.51 | NA | 1.50 |
| Hippuric acid | ME529380 | 0.72 | 1.20 | NA | 0.47 | NA | 1.61 |
| PEP | ME529366 | 0.81 | 1.22 | NA | 0.41 | NA | 1.57 |
| 2-Hydroxyisobutyric acid | ME529375 | 0.92 | 0.57 | NA | 1.13 | NA | 1.39 |
| GDP-Man | ME529428 | 1.05 | 1.02 | NA | 0.77 | NA | 1.16 |
| Arabinose | ME529408 | 1.02 | 1.06 | NA | 0.78 | NA | 1.14 |
| Succinyl AMP | ME529424 | 1.05 | 1.05 | NA | 0.79 | NA | 1.11 |
| FAD | ME529356 | 0.96 | 1.10 | NA | 0.75 | NA | 1.19 |
| Glucose | ME529393 | 0.98 | 1.07 | NA | 0.80 | NA | 1.16 |
| Mal | ME529363 | 1.06 | 0.94 | NA | 0.70 | NA | 1.30 |
| ThPP | ME529370 | 0.98 | 0.98 | NA | 0.77 | NA | 1.26 |
| AICARP | ME529425 | 0.98 | 0.98 | NA | 0.76 | NA | 1.28 |
| Pyridoxal-5P | ME529418 | 0.98 | 0.98 | NA | 0.74 | NA | 1.29 |
| Allantoin | ME529403 | 1.02 | 0.93 | NA | 0.86 | NA | 1.20 |
| Pantothenate | ME529412 | 0.98 | 0.98 | NA | 0.80 | NA | 1.24 |
| 2-Methyl-3-Hydroxybutyric acid | ME529387 | 0.96 | 0.96 | NA | 0.84 | NA | 1.25 |
| 2-Propylglutaric acid | ME529388 | 0.97 | 0.97 | NA | 0.85 | NA | 1.21 |
| Glucuronic acid | ME529353 | 0.88 | 1.15 | NA | 0.77 | NA | 1.21 |
| NAD | ME529364 | 0.85 | 1.18 | NA | 0.72 | NA | 1.26 |
| Pyr | ME529368 | 0.86 | 1.14 | NA | 0.57 | NA | 1.43 |
| Sorbitol-6P | ME529413 | 0.87 | 1.16 | NA | 0.58 | NA | 1.38 |
| F1P | ME529384 | 0.93 | 1.13 | NA | 0.61 | NA | 1.34 |
| Ga1P | ME529385 | 0.86 | 1.19 | NA | 0.65 | NA | 1.30 |
| M6P | ME529391 | 0.88 | 1.18 | NA | 0.61 | NA | 1.33 |
| IsoCit | ME529362 | 0.93 | 1.05 | NA | 0.67 | NA | 1.35 |
| N-Acetyl-galactosamine | ME529426 | 0.81 | 1.13 | NA | 0.67 | NA | 1.39 |
| Beta-Lactose | ME529410 | 0.84 | 1.09 | NA | 0.69 | NA | 1.38 |
| IMP | ME529361 | 0.86 | 1.11 | NA | 0.68 | NA | 1.35 |
| N-Acetyl-Glu | ME529420 | 1.11 | 1.22 | NA | 0.94 | NA | 0.73 |
| UDP-glucuronate | ME529414 | 1.01 | 1.10 | NA | 1.00 | NA | 0.89 |
| IsovalerylGly | ME529399 | 1.17 | 1.29 | NA | 0.63 | NA | 0.92 |
| N-Acetyl-Leu | ME529402 | 1.30 | 1.07 | NA | 0.71 | NA | 0.92 |
| NADPH | ME529365 | 1.17 | 1.17 | NA | 0.75 | NA | 0.92 |
| ADP-Rib | ME529340 | 1.11 | 1.11 | NA | 0.82 | NA | 0.97 |
| Gluconic acid | ME529350 | 1.07 | 1.14 | NA | 0.76 | NA | 1.03 |
| Arabitol | ME529409 | 1.10 | 0.97 | NA | 0.95 | NA | 0.97 |
| 3-Hydroxybutyric acid | ME529336 | 1.11 | 1.00 | NA | 0.91 | NA | 0.97 |
| GMP | ME529359 | 1.12 | 1.00 | NA | 0.88 | NA | 1.00 |
| AMP | ME529341 | 1.01 | 1.04 | NA | 0.89 | NA | 1.06 |
| CoA | ME529346 | 1.00 | 1.00 | NA | 1.00 | NA | 1.00 |
| Uridine | ME529395 | 1.01 | 0.96 | NA | 1.01 | NA | 1.01 |
| 2KG | ME529335 | 1.05 | 0.95 | NA | 0.90 | NA | 1.10 |
| Glucaric acid | ME529386 | 1.05 | 0.95 | NA | 0.95 | NA | 1.05 |
| UDP-N-acetyl-glucosamine | ME529415 | 1.05 | 0.96 | NA | 0.96 | NA | 1.03 |
| N-Acetyl-glucosamine-6P | ME529433 | 1.25 | 0.93 | NA | 0.89 | NA | 0.93 |
| R5P | ME529354 | 1.21 | 0.90 | NA | 0.90 | NA | 0.99 |
| 2-Ethylhexanoic acid | ME529382 | 1.09 | 0.83 | NA | 1.04 | NA | 1.04 |
| GDP | ME529358 | 1.13 | 0.91 | NA | 0.98 | NA | 0.98 |
| Oxalic acid | ME529376 | 1.13 | 0.87 | NA | 0.96 | NA | 1.04 |
| PyroGlu | ME529400 | 1.15 | 0.88 | NA | 0.95 | NA | 1.02 |
| ADP-Glc | ME529339 | 1.16 | 0.84 | NA | 0.70 | NA | 1.30 |
| UDP-Glc | ME529372 | 1.27 | 0.76 | NA | 0.70 | NA | 1.27 |
| 3-Hydroxymethylglutaric acid | ME529392 | 1.09 | 0.78 | NA | 0.99 | NA | 1.14 |
| O-Acetyl-homoSer | ME529396 | 1.17 | 0.69 | NA | 0.85 | NA | 1.28 |
| Allantoic acid | ME529406 | 1.07 | 0.80 | NA | 0.87 | NA | 1.27 |
| UDP-Galac | ME529390 | 1.10 | 0.74 | NA | 0.91 | NA | 1.25 |
| Acetyl-Gly | ME529397 | 1.14 | 0.80 | NA | 0.86 | NA | 1.20 |
| N-Acetyl-Gln | ME529407 | 1.07 | 0.86 | NA | 0.86 | NA | 1.21 |
| PRPP | ME529367 | 1.32 | 0.76 | NA | 0.90 | NA | 1.02 |
| cis-Aco | ME529344 | 1.25 | 0.81 | NA | 0.81 | NA | 1.13 |
| N-Acetyl-glucosamine-1P | ME529419 | 1.22 | 0.83 | NA | 0.87 | NA | 1.09 |
| UTP | ME529374 | 1.25 | 0.78 | NA | 0.86 | NA | 1.10 |
| GTP | ME529360 | 1.15 | 0.92 | NA | 0.86 | NA | 1.07 |
| ATP | ME529342 | 1.11 | 0.91 | NA | 0.86 | NA | 1.11 |
| UMP | ME529373 | 1.11 | 0.94 | NA | 0.83 | NA | 1.11 |
| ADP | ME529338 | 1.14 | 0.93 | NA | 0.79 | NA | 1.14 |
| Cit | ME529345 | 1.11 | 0.94 | NA | 0.77 | NA | 1.19 |
| Threonic acid | ME529383 | 1.11 | 0.89 | NA | 0.78 | NA | 1.22 |
| 3-Hydroxypropionic acid | ME529377 | 1.20 | 1.01 | NA | 0.74 | NA | 1.06 |
| UDP | ME529371 | 1.26 | 0.90 | NA | 0.74 | NA | 1.10 |
| Suc | ME529369 | 1.24 | 0.79 | NA | 1.04 | NA | 0.93 |
| Taurine | ME529404 | 1.20 | 0.73 | NA | 1.13 | NA | 0.93 |
| 2,3-BPG | ME529416 | 1.42 | 0.89 | NA | 0.78 | NA | 0.91 |
| Glucosamine 1P | ME529427 | 1.38 | 0.83 | NA | 0.83 | NA | 0.97 |
| Homocysteic acid | ME529430 | 1.31 | 0.97 | NA | 0.97 | NA | 0.75 |
| N-Acetyl-Asn | ME529411 | 1.35 | 0.92 | NA | 0.88 | NA | 0.85 |
| Uracil | ME529394 | 0.16 | 0.07 | 2.17 | 1.04 | 1.85 | 0.92 |
| Fum | ME529357 | 0.68 | 0.53 | 1.29 | 0.95 | 1.52 | 1.10 |
| 10-Camphorsulfonic acid (IS) | ME529333 | 0.98 | 0.65 | 1.09 | 0.91 | 1.16 | 1.18 |
| PIPES (IS) | ME529334 | 0.92 | 0.78 | 1.04 | 0.90 | 1.16 | 1.17 |
Factors:
| F1 | Genotype:NNMT KO | Sample group:4T1 | Sex:female | Treatment:No treatment |
| F2 | Genotype:NNMT KO | Sample group:Sham | Sex:female | Treatment:No treatment |
| F3 | Genotype:WT | Sample group:4T1 | Sex:female | Treatment:MNAM treatment |
| F4 | Genotype:WT | Sample group:4T1 | Sex:female | Treatment:No treatment |
| F5 | Genotype:WT | Sample group:Sham | Sex:female | Treatment:MNAM treatment |
| F6 | Genotype:WT | Sample group:Sham | Sex:female | Treatment:No treatment |
