Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002248)

(Analysis AN003674)

Metabolite	Structure	F1	F2	F3	F4
PC(16:0/16:0)	ME543192	4.23	0.60	1.11	0.27
2-Hydroxycaproic acid	ME543085	0.24	0.42	0.64	2.41
5-Thymidylic acid	ME543098	0.41	0.35	0.34	2.91
L-Proline	ME543170	0.50	0.43	2.47	0.53
L-Glutamic acid	ME543164	2.32	0.54	0.81	1.94
PC(18:1(9Z)/18:1(9Z))	ME543193	0.17	1.71	1.31	0.56
3,4-Dihydroxyphenylglycol	ME543090	0.68	2.03	0.71	0.50
Azythromycin	ME543114	0.76	1.83	1.08	0.36
1-Methylnicotinamide	ME543076	NA	NA	1.14	0.59
Taurodeoxycholic acid	ME543216	NA	0.89	1.27	0.97
Protocatechuic acid	ME543200	0.81	0.52	0.70	2.07
1-Butanol	ME543074	1.11	0.66	0.70	1.53
Norepinephrine	ME543185	1.22	0.46	0.89	1.44
Nutriacholic acid	ME543187	1.33	0.45	0.69	1.53
Terephthalic acid	ME543217	1.16	0.43	0.75	1.59
7-Ketocholesterol	ME543100	1.28	0.55	0.42	1.60
Asymmetric dimethylarginine	ME543113	1.45	0.64	0.61	1.33
Aspartame	ME543112	0.90	0.55	1.87	0.63
L-Valine	ME543173	0.96	0.55	1.50	0.99
Thymidine	ME543220	0.80	0.59	1.65	0.96
Trimethylamine	ME543225	0.83	0.64	1.66	0.86
Oxypurinol	ME543190	1.10	0.87	1.41	0.63
Threonic acid	ME543219	1.20	0.99	1.29	0.53
Glycine	ME543143	1.34	0.41	1.26	0.99
Acetylcysteine	ME543104	1.15	0.57	1.19	1.08
Methylhippuric acid	ME543178	1.18	0.48	1.28	1.00
L-Norleucine	ME543168	1.18	0.54	1.25	1.03
L-Tyrosine	ME543172	1.18	0.56	1.27	0.99
Benzoic acid	ME543116	1.20	0.56	1.25	0.98
m-Coumaric acid	ME543175	1.22	0.55	1.26	0.97
Indole	ME543151	1.35	0.54	1.14	0.97
Pantothenic acid	ME543191	1.37	0.57	1.15	0.91
Indoleacrylic acid	ME543155	1.27	0.55	1.18	1.00
L-Tryptophan	ME543171	1.22	0.57	1.19	1.02
L-Phenylalanine	ME543169	1.24	0.60	1.12	1.04
Cinnamic acid	ME543119	1.26	0.55	1.11	1.03
Indole-3-carboxylic acid	ME543153	1.30	0.53	1.10	1.06
Benzaldehyde	ME543115	1.28	0.64	1.12	0.97
Indole-3-carbinol	ME543152	1.21	0.66	1.09	0.99
L-Methionine	ME543167	1.20	0.70	1.04	1.02
N,N-Dimethylformamide	ME543180	1.07	0.51	1.03	1.32
L-Arginine	ME543162	1.03	0.48	1.23	1.25
Pyroglutamic acid	ME543205	1.13	0.43	1.26	1.19
Anserine	ME543111	0.71	1.18	1.05	1.10
Rhamnose	ME543207	0.68	1.42	0.88	1.02
Adenine	ME543105	1.15	1.22	0.70	0.93
Succinic acid	ME543213	1.12	1.26	0.76	0.86
Cyclic AMP	ME543124	0.97	1.26	0.70	1.10
Deoxyadenosine	ME543127	0.94	1.12	0.67	1.19
Pyrimidine	ME543204	1.07	0.75	1.35	0.83
Perillic acid	ME543194	0.99	0.74	1.24	1.03
5-Methoxytryptophol	ME543096	0.88	0.86	1.23	1.03
Inosine	ME543156	0.91	0.84	1.19	1.05
4-Aminohippuric acid	ME543094	0.86	0.87	1.29	0.99
Alpha-N-phenylacetyl-L-glutamine	ME543110	0.89	0.79	1.32	1.01
7-Methylguanosine	ME543101	0.85	0.86	1.44	1.05
Pyridoxal	ME543202	0.84	0.79	1.41	0.93
3-Phenoxypropionic acid	ME543093	0.73	0.89	1.36	1.02
Phenylpropanolamine	ME543197	0.80	0.97	1.29	0.94
Creatine	ME543123	0.92	0.63	0.96	1.49
3,4,5-Trimethoxycinnamic acid	ME543089	0.99	0.94	0.71	1.36
Elaidic acid	ME543136	0.93	0.97	0.82	1.28
Sphingosine	ME543212	0.98	0.96	0.85	1.21
6-Dimethylaminopurine	ME543099	0.78	0.92	0.89	1.42
Vitamin D3	ME543233	0.91	0.79	0.92	1.37
Uridine diphosphate-N-acetylglucosamine	ME543230	0.89	0.80	0.99	1.29
2-Pyrrolidinone	ME543088	0.91	0.86	0.92	1.30
N-Acetylputrescine	ME543181	0.87	0.89	0.92	1.32
Propanal	ME543199	0.85	0.96	0.93	1.26
5-Dodecenoic acid	ME543095	0.82	0.92	1.02	1.23
Triethylamine	ME543224	0.88	0.90	1.05	1.18
2,3-Diaminopropionic acid	ME543080	1.15	0.73	0.94	1.19
Rutin	ME543208	1.06	0.76	0.94	1.24
Succinylacetone	ME543214	1.08	0.78	0.89	1.25
Alloxan	ME543107	1.09	0.82	1.00	1.09
Phenylacetaldehyde	ME543195	1.14	0.86	0.89	1.11
Hypoxanthine	ME543149	1.11	0.81	0.94	1.15
3-Methylindole	ME543092	1.13	0.81	0.89	1.15
Alpha-ketoisovaleric acid	ME543109	1.15	0.81	0.90	1.13
L-Acetylcarnitine	ME543161	1.33	0.87	0.95	0.86
Diphenhydramine	ME543133	1.18	0.83	0.98	1.03
Octadecanedioic acid	ME543189	1.16	0.86	1.00	0.96
Isovalerylcarnitine	ME543159	1.18	0.82	1.09	0.91
Niacinamide	ME543184	1.22	0.77	1.04	0.97
Normetanephrine	ME543186	1.29	0.76	1.04	0.92
2-Phenylglycine	ME543087	1.45	0.69	0.92	0.91
Dextromethorphan	ME543131	1.26	0.80	0.86	1.05
Verapamil	ME543232	1.36	0.78	0.83	1.02
Adenosine monophosphate	ME543106	1.32	0.89	1.07	0.68
Gluconolactone	ME543139	1.17	0.96	1.05	0.82
Glutathione	ME543141	1.15	0.98	1.04	0.83
17-Hydroxyprogesterone	ME543078	1.13	1.11	0.92	0.85
Phenylacetic acid	ME543196	1.28	1.05	0.90	0.77
Deoxyguanosine	ME543130	1.22	1.03	0.98	0.77
Guanosine	ME543146	1.20	1.04	0.92	0.84
L-Dopa	ME543163	0.92	1.27	0.99	0.81
2-Hydroxybutyric acid	ME543084	0.99	1.06	0.83	1.12
L-Glutamine	ME543165	0.94	1.06	0.84	1.16
5-Phenylvaleric acid	ME543097	0.93	1.07	0.91	1.09
Ibuprofen	ME543150	0.86	1.11	0.90	1.13
D-Glucurono-6,3-lactone	ME543125	0.86	1.01	1.11	1.08
L-Malic acid	ME543166	0.83	1.07	1.09	1.03
NADH	ME543183	0.85	0.99	1.01	1.15
Pyridoxal 5^-phosphate	ME543203	0.85	1.02	0.97	1.16
Cis-Aconitic acid	ME543120	0.85	1.07	0.99	1.11
Sphinganine	ME543211	0.83	1.05	1.03	1.09
2,5-Furandicarboxylic acid	ME543081	0.99	0.89	1.01	1.11
Pyridine	ME543201	0.97	0.88	1.00	1.16
Traumatic acid	ME543222	1.03	0.87	1.11	1.00
Isobutyric acid	ME543157	1.03	0.88	1.04	1.05
Tryptamine	ME543226	0.97	0.89	1.08	1.06
Cortisol	ME543122	1.07	1.01	1.05	0.88
2-Hydroxyadenine	ME543083	1.00	1.06	1.07	0.87
Tetrahydrocortisone	ME543218	1.03	1.08	1.05	0.85
Guanine	ME543145	0.97	0.93	1.17	0.94
17a-Ethynylestradiol	ME543079	1.04	0.95	1.11	0.90
o-Tyrosine	ME543188	1.01	0.97	1.09	0.93
Homoveratric acid	ME543148	0.96	1.13	0.99	0.91
Medroxyprogesterone	ME543176	1.00	1.12	0.97	0.90
1-Methylhistidine	ME543075	1.10	1.07	0.88	0.94
2-Hydroxy-3-methylbutyric acid	ME543082	1.03	1.06	0.90	1.01
Acetaminophen	ME543102	1.04	1.05	0.94	0.96
Doxylamine	ME543135	1.01	1.09	0.94	0.96
Alpha-Aspartyl-lysine	ME543108	0.98	0.97	0.96	1.11
Acetic acid	ME543103	0.92	1.01	0.98	1.09
Isoguanine	ME543158	0.96	1.01	0.99	1.05
Metoprolol	ME543179	1.04	1.02	1.00	0.94
Glucosamine	ME543140	1.04	1.00	1.00	0.96
N1-Acetylspermine	ME543182	1.04	0.99	1.02	0.95
Citramalic acid	ME543121	1.04	0.96	1.01	1.00
Diaminopimelic acid	ME543132	1.02	0.96	1.05	0.97
Linoleic acid	ME543174	1.04	0.96	1.03	0.97
DL-a-glycerophosphate	ME543134	1.01	0.97	0.98	1.05
Phosphoric acid	ME543198	1.01	0.98	0.97	1.04
Deoxycholic acid glycine conjugate	ME543128	1.05	0.99	0.92	1.04
3-Methoxyphenylacetic acid	ME543091	1.03	0.99	0.96	1.01
Biotin	ME543117	1.03	1.03	0.95	1.00
Caffeine	ME543118	0.90	1.07	1.00	1.04
Dehydroascorbic acid	ME543126	0.90	1.11	0.97	1.02
Glycyl-L-leucine	ME543144	0.95	1.09	1.01	0.95
Estrone	ME543138	0.95	1.06	1.00	0.98
Erythrose	ME543137	0.94	1.06	0.99	1.01
L(-)-Nicotine pestanal	ME543160	0.95	1.06	0.99	1.00
Trans-Cinnamic acid	ME543221	0.99	1.03	0.98	0.99
Melatonin	ME543177	0.98	1.04	1.00	0.98
Syringic acid	ME543215	0.97	1.04	1.01	0.97
Glycerophosphocholine	ME543142	0.98	1.04	1.03	0.96
Urocanic acid	ME543231	0.99	1.03	1.02	0.97
1,3,5-Trimethoxybenzene	ME543073	0.94	0.97	1.08	1.00
Sorbitol	ME543209	0.96	0.99	1.07	0.97
Ureidosuccinic acid	ME543227	0.94	1.00	1.09	0.97
Heptadecanoic acid	ME543147	0.98	1.05	1.04	0.93
2-Isopropylmalic acid	ME543086	0.94	1.04	1.06	0.96
Uridine	ME543228	0.95	1.04	1.09	0.92
Spermine	ME543210	1.82	1.06	0.70	0.34
11a-Hydroxyprogesterone	ME543077	1.61	0.69	0.67	0.90
Deoxycorticosterone	ME543129	1.57	0.84	0.72	0.88
Tricosanoic acid	ME543223	1.39	NA	1.00	0.41
Indoleacetic acid	ME543154	1.88	0.23	1.36	0.53
Quercetin	ME543206	1.56	0.28	0.96	0.93
Uridine 5^-monophosphate	ME543229	1.94	0.24	0.89	0.84

Factors:

F1	Treatment:Control
F2	Treatment:Drug Free PLGA Nanoparticle
F3	Treatment:Free PTX
F4	Treatment:PTX-PLGA Nanoparticle

Data matrix