Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002709)

(Analysis AN004391)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
asparagine	ME639537	0.18	0.21	0.15	2.48	0.36	0.30	0.25	4.07
cysteine	ME639556	0.18	NA	NA	0.44	0.53	NA	0.15	3.70
AICAR	ME639528	0.34	3.35	1.06	1.88	0.46	0.26	0.14	0.50
cystine	ME639558	2.00	NA	0.35	0.05	1.88	0.11	0.68	NA
N-acetylglucosamine-phosphate	ME639609	2.46	0.71	0.19	0.40	2.55	0.74	0.19	0.77
cysteine-glutathione disulfide	ME639557	2.64	0.15	0.57	0.13	3.12	0.16	1.07	0.16
oleic acid	ME639616	2.81	0.36	0.23	0.21	3.55	0.29	0.24	0.32
methioninesulfoxide	ME639607	0.21	0.34	2.40	0.24	0.53	0.37	3.58	0.34
kynurenic acid	ME639598	1.00	1.05	1.42	0.67	0.69	0.60	1.99	0.59
kynurenine	ME639599	0.51	0.51	1.57	0.40	0.99	0.79	2.55	0.68
S-(2-Succinyl)-L-cysteine	ME639638	0.42	0.25	0.29	0.16	2.80	1.16	1.62	1.30
FAICAR	ME639567	0.35	0.68	NA	0.48	1.86	1.24	1.00	1.21
GSSG	ME639590	1.17	0.66	0.76	0.44	2.40	0.77	0.99	0.82
phosphoserine	ME639629	0.50	0.62	0.36	0.35	2.43	1.36	1.17	1.21
phosphoribosylamine	ME639627	0.76	0.72	0.50	0.48	2.57	0.81	0.84	1.32
rib/ribul/xylul-ose-phosphate	ME639635	0.69	0.62	0.35	0.32	2.72	1.24	0.74	1.31
saccharopine	ME639639	0.24	0.35	0.20	0.28	1.64	1.66	0.83	2.81
AIR	ME639529	0.14	0.15	0.11	0.17	2.27	1.57	1.05	2.53
FGAM	ME639568	0.09	0.11	0.05	0.08	2.89	1.52	0.88	2.37
FGAR	ME639569	0.25	0.67	0.35	0.36	1.64	1.74	1.03	1.96
fumarate	ME639575	0.35	0.44	0.27	0.25	1.95	1.65	1.28	1.82
S-(1;2-Dicarboxyethyl)glutathione	ME639637	0.21	0.31	0.17	0.16	2.08	1.83	1.27	1.98
argininosuccinate	ME639535	0.17	0.22	0.12	0.11	2.43	1.92	1.27	1.76
SAICAR	ME639642	0.12	0.31	0.14	0.14	2.63	1.86	1.13	1.67
adenylosuccinic acid	ME639526	0.30	0.51	0.20	0.27	2.41	1.63	0.96	1.72
IMP	ME639597	0.34	0.48	0.27	0.36	2.30	1.42	0.89	1.95
gamma-glutamylcysteine	ME639577	2.14	0.51	1.82	0.63	1.09	0.41	0.69	0.73
stearic acid	ME639647	NA	1.23	0.90	0.83	NA	0.86	0.87	1.31
GAR	ME639578	NA	1.90	0.31	1.15	0.87	0.44	0.66	1.21
CAIR	ME639541	NA	1.83	0.17	0.88	NA	1.28	0.24	1.59
dTMP	ME639565	0.30	2.35	0.70	1.14	0.37	1.24	0.61	1.28
CDP-ethanolamine	ME639546	1.72	2.00	0.55	0.79	0.95	0.92	0.30	0.78
fructose-1-phosphate	ME639573	1.53	2.12	0.37	1.36	0.98	0.68	0.10	0.86
cis-aconitate	ME639548	1.39	1.81	1.26	1.30	0.46	0.54	0.30	0.94
hydroxyglutarate	ME639594	1.40	1.89	1.14	1.59	0.39	0.51	0.29	0.80
1-methylnicotinamide	ME639519	0.84	1.71	1.10	1.45	0.65	0.52	0.53	1.20
alpha-ketoglutarate	ME639531	1.06	1.63	0.97	1.37	0.55	0.81	0.44	1.16
citrate / isocitrate	ME639549	1.27	1.66	1.13	1.17	0.68	0.66	0.35	1.08
propionyl-carnitine	ME639631	1.45	1.47	1.30	0.86	0.77	0.81	0.66	0.68
carnitine	ME639543	1.39	1.65	1.21	1.18	0.67	0.63	0.51	0.76
betaine	ME639540	1.32	1.35	1.24	1.13	0.80	0.71	0.68	0.78
gamma-butyrobetaine	ME639576	1.22	1.46	1.17	1.14	0.78	0.73	0.66	0.83
creatine	ME639552	1.17	1.19	1.07	1.18	0.83	0.79	0.74	1.04
urocanic acid	ME639659	1.19	0.92	1.18	1.36	1.10	0.64	0.72	0.90
ascorbate	ME639536	2.15	2.71	1.18	1.28	0.24	0.19	0.11	0.15
malate	ME639605	1.76	2.05	1.45	1.54	0.33	0.28	0.21	0.37
proline	ME639630	1.80	1.80	1.39	1.70	0.37	0.30	0.24	0.40
orotate	ME639618	1.69	1.70	1.48	1.02	0.59	0.63	0.35	0.55
carbamoyl-aspartate	ME639542	1.77	1.87	1.36	1.36	0.44	0.41	0.34	0.44
aspartate	ME639538	1.77	1.97	1.33	1.15	0.61	0.41	0.36	0.40
dihydroorotate	ME639563	1.83	2.04	1.36	1.17	0.49	0.39	0.35	0.38
cystathionine	ME639555	0.73	0.59	0.64	NA	1.04	0.62	1.11	1.63
uric acid	ME639658	1.72	1.14	0.88	0.48	0.97	1.22	0.93	0.65
CoA	ME639551	0.69	1.55	0.82	0.88	0.74	1.16	0.74	1.43
PRPP	ME639632	0.53	1.51	0.61	0.59	1.19	1.14	0.56	1.86
dihydroxyacetone-phosphate	ME639564	0.77	1.11	0.71	0.74	1.20	1.78	0.80	0.89
pyruvate	ME639633	0.87	1.14	0.76	0.97	0.75	1.53	1.05	0.93
ornithine	ME639617	0.89	0.89	0.73	0.81	1.30	1.22	1.20	0.95
quinolinic acid	ME639634	0.95	0.65	0.65	0.99	1.40	1.19	1.28	0.88
6-phosphogluconic acid	ME639523	0.90	0.96	0.68	0.53	1.90	0.91	0.92	1.22
CMP	ME639550	0.92	1.10	0.66	0.79	1.25	1.20	0.78	1.31
NADP+	ME639613	0.88	1.21	0.75	0.79	1.26	1.04	0.76	1.31
fructose-1;6-bisphosphate	ME639572	0.82	1.32	0.63	0.75	1.39	1.09	0.67	1.33
GDP	ME639579	0.84	1.14	0.68	0.69	1.51	1.06	0.72	1.36
GTP	ME639591	0.79	1.27	0.65	0.64	1.62	0.97	0.63	1.43
histidine	ME639593	0.92	1.06	0.71	0.77	1.54	1.09	0.88	1.04
lysine	ME639604	0.86	1.07	0.68	0.80	1.39	1.18	0.97	1.04
sedoheptulose-7-phosphate	ME639644	0.73	0.91	0.55	0.62	1.60	1.18	0.97	1.44
glutamine	ME639583	0.74	0.88	0.58	0.66	1.60	1.28	0.98	1.29
tyrosine	ME639653	0.73	0.88	0.54	0.63	1.67	1.31	0.97	1.26
valine	ME639661	0.88	0.80	0.67	0.79	1.45	1.14	1.13	1.15
phenylalanine	ME639620	0.82	0.79	0.64	0.70	1.50	1.29	1.12	1.15
leucine / isoleucine	ME639603	0.85	0.87	0.62	0.67	1.59	1.20	1.03	1.17
threonine	ME639650	0.81	0.88	0.62	0.67	1.57	1.27	1.02	1.15
GMP	ME639588	0.74	0.96	0.60	0.67	1.38	1.37	0.87	1.40
fructose-6-phosphate	ME639574	0.85	1.05	0.79	0.65	1.30	1.16	0.89	1.31
glycerophosphocholine	ME639586	0.81	0.94	0.73	0.73	1.29	1.21	1.06	1.25
hypotaurine	ME639595	0.80	0.96	0.69	0.62	1.44	1.20	0.97	1.31
glycine	ME639587	0.51	0.96	0.55	0.63	1.83	1.37	1.03	1.13
succinate	ME639648	0.69	0.79	0.51	0.48	1.78	1.47	1.11	1.18
N-trimethyllysine	ME639615	0.63	0.76	0.52	0.57	1.63	1.40	1.09	1.41
serine	ME639645	0.59	0.70	0.47	0.54	1.69	1.50	1.14	1.36
glyceraldehyde-3-phosphate	ME639584	0.68	0.83	0.50	0.55	1.74	1.27	0.86	1.58
XMP	ME639662	0.70	1.08	0.27	0.71	1.67	1.38	0.52	1.42
tryptophan	ME639652	0.81	0.96	0.41	0.68	1.73	1.38	0.73	1.30
methionine	ME639606	0.87	0.90	0.40	0.75	1.63	1.42	0.72	1.32
xylulose	ME639664	0.84	0.91	0.41	0.65	1.66	1.46	0.71	1.36
choline	ME639547	1.37	0.88	0.52	1.11	1.39	0.75	0.67	1.30
CDP-choline	ME639545	1.32	1.29	0.69	0.65	1.48	1.00	0.54	1.03
folate	ME639570	0.97	1.34	0.43	0.96	1.44	1.24	0.57	1.05
riboflavin	ME639636	1.03	1.30	0.33	0.99	1.59	1.35	0.48	0.94
lauric acid	ME639602	1.25	1.11	0.64	0.74	1.33	0.85	0.82	1.26
myristic acid	ME639608	1.24	1.22	0.76	0.74	1.03	0.67	0.84	1.51
palmitic acid	ME639619	1.12	1.22	0.74	0.75	1.05	0.77	0.93	1.41
NADH	ME639612	0.87	1.01	0.77	0.81	1.00	1.20	0.84	1.50
guanosine	ME639592	1.06	1.28	0.67	0.90	1.34	1.09	0.50	1.17
N-acetylglutamate	ME639610	1.13	1.26	0.72	0.97	1.26	0.93	0.52	1.21
3-hydroxy-trimethyllysine	ME639520	1.08	1.23	0.93	0.86	1.09	0.91	0.69	1.20
L-2-aminobutyric acid	ME639600	1.11	1.16	0.93	1.00	1.12	0.97	0.62	1.07
acetyl-CoA	ME639525	1.00	1.25	0.82	0.82	1.32	0.97	0.74	1.07
ADP	ME639527	1.05	1.25	0.77	0.81	1.23	1.00	0.70	1.20
UDP-N-acetylglucosamine	ME639656	1.05	1.30	0.81	0.74	1.18	1.01	0.73	1.17
UMP	ME639657	0.94	1.21	0.76	0.80	1.19	1.13	0.77	1.19
NAD+	ME639611	0.95	1.21	0.87	0.84	1.19	0.99	0.85	1.10
AMP	ME639532	0.95	1.24	0.79	0.85	1.19	1.08	0.77	1.13
trifluoromethanesulfonate	ME639651	0.95	1.23	0.84	0.81	1.20	1.02	0.79	1.15
ATP	ME639539	0.99	1.42	0.86	0.81	1.24	0.89	0.60	1.19
CDP	ME639544	1.01	1.41	0.81	0.81	1.22	0.94	0.63	1.16
UDP-glucuronic acid	ME639655	1.00	1.43	0.81	0.78	1.25	0.90	0.64	1.19
glycerol-3-phosphate	ME639585	0.86	1.45	0.78	0.91	1.11	1.04	0.71	1.13
phosphocreatine	ME639624	0.96	1.34	0.95	0.83	1.03	0.99	0.77	1.13
phosphorylethanolamine	ME639628	0.97	1.40	0.88	0.90	1.14	0.91	0.70	1.09
creatinine	ME639553	0.99	1.26	1.01	1.03	0.95	0.94	0.85	0.97
imidazoleacetic acid	ME639596	0.86	1.33	0.95	1.01	0.86	1.08	0.79	1.12
S-adenosyl-homocysteine	ME639640	0.82	1.30	0.90	0.89	0.94	1.06	0.94	1.16
S-adenosyl-methionine	ME639641	0.90	1.18	0.71	0.98	0.98	1.22	0.83	1.20
5^-methylthioadenosine	ME639522	0.86	1.33	0.78	1.12	0.94	0.97	0.71	1.29
4-aminobutyrate	ME639521	0.95	1.16	0.78	1.01	1.08	0.96	0.73	1.34
glutamate	ME639582	0.95	1.20	0.81	0.93	1.09	1.01	0.78	1.23
glucose	ME639580	0.92	1.15	1.01	0.76	1.15	1.02	1.18	0.81
lactate	ME639601	1.12	0.95	0.81	0.96	1.20	0.93	1.02	1.00
acetyl-carnitine	ME639524	0.88	0.92	0.96	0.89	1.04	1.09	1.14	1.08
sorbitol	ME639646	0.76	1.08	0.92	0.65	1.19	1.12	1.06	1.23
GSH	ME639589	1.01	1.01	0.85	0.71	1.34	0.97	0.91	1.20
arachidic acid	ME639533	0.93	1.22	0.88	0.73	1.17	0.90	1.00	1.17
glucose-6-phosphate	ME639581	0.92	1.18	0.84	0.73	1.24	0.96	0.95	1.19
nicotinamide	ME639614	0.96	1.11	0.82	0.87	1.28	1.06	0.94	0.97
arginine	ME639534	0.87	1.06	0.76	0.85	1.27	1.14	1.01	1.04
taurine	ME639649	0.91	1.03	0.85	0.80	1.24	1.08	1.00	1.09
phosphate	ME639621	0.95	1.18	0.84	0.93	1.14	1.05	0.90	1.00
phosphocholine	ME639623	1.00	1.07	0.91	0.93	1.10	1.00	0.92	1.08
fructose	ME639571	0.93	1.13	1.01	0.75	1.08	1.03	0.97	1.10
alanine	ME639530	0.92	1.08	0.90	0.82	1.06	1.17	0.93	1.13
sarcosine	ME639643	0.89	1.02	0.91	0.85	1.10	1.05	1.04	1.15
dCTP	ME639562	0.89	1.95	1.07	0.67	1.15	0.76	0.58	0.93
phosphatidylethanolamine	ME639622	1.23	1.66	0.71	1.23	1.07	0.65	0.36	1.09
xylonic acid	ME639663	1.24	1.57	0.94	0.90	1.04	0.66	0.74	0.91
phosphoenolpyruvate	ME639625	1.14	1.49	0.88	0.85	1.10	0.95	0.60	0.97
dATP	ME639561	1.24	1.67	0.69	0.93	1.21	0.80	0.44	1.02
phosphoglycerate	ME639626	1.24	1.54	0.84	0.94	1.12	0.73	0.49	1.10
CTP	ME639554	1.05	1.60	0.81	0.81	1.24	0.78	0.52	1.20
dTTP	ME639566	1.18	1.59	0.82	0.82	1.19	0.83	0.50	1.06
UDP	ME639654	1.09	1.56	0.86	0.85	1.17	0.83	0.53	1.11
UTP	ME639660	1.10	1.59	0.91	0.87	1.17	0.75	0.50	1.11

Factors:

F1	Genotype:FH \| Tracers used:3,3,3',3'-D4 Cystine
F2	Genotype:FH \| Tracers used:none
F3	Genotype:FH \| Tracers used:U-C13 glucose
F4	Genotype:FH \| Tracers used:U-C13 glutamine
F5	Genotype:WT \| Tracers used:3,3,3',3'-D4 Cystine
F6	Genotype:WT \| Tracers used:none
F7	Genotype:WT \| Tracers used:U-C13 glucose
F8	Genotype:WT \| Tracers used:U-C13 glutamine

Data matrix