Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002835)

(Analysis AN004631)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10
TMP	ME736691	2.89	1.09	1.00	2.75	0.48	0.48	0.11	0.41	0.23	0.08
Uridine	ME736662	3.72	1.30	0.19	3.40	0.95	0.17	0.03	0.13	0.08	0.03
Glutathione (reduced)	ME736621	0.06	0.20	0.06	0.02	0.15	0.10	1.85	0.66	4.02	2.87
d-ADP	ME736609	1.45	1.31	1.17	0.51	0.67	0.62	NA	NA	NA	1.47
2-deoxyribose-5P	ME736672	1.27	1.44	0.74	1.17	1.00	0.38	NA	NA	NA	NA
Acetylcarnitine	ME736591	1.59	1.64	0.43	1.91	1.84	0.63	0.50	0.40	0.53	0.53
Guanosine	ME736627	1.42	1.03	0.76	2.30	1.77	1.16	0.41	0.60	0.31	0.24
Acetyl-CoA	ME736592	1.75	1.45	1.62	1.44	1.49	0.69	0.14	0.07	NA	0.06
Adenosine	ME736594	1.52	1.41	2.26	1.55	1.39	1.31	0.18	0.14	0.11	0.13
NADP+	ME736643	1.44	1.51	1.18	1.46	1.89	1.27	0.32	0.34	0.27	0.34
Phosphocreatine	ME736649	1.37	1.35	1.28	1.29	1.31	1.28	0.52	0.56	0.52	0.53
Alanine	ME736598	1.60	1.21	1.64	1.37	1.04	0.96	0.49	0.62	0.60	0.47
Creatine	ME736675	1.43	1.24	1.50	1.33	1.08	1.05	0.46	0.58	0.53	0.42
Dihydrouracil	ME736616	1.52	1.28	1.53	1.37	1.10	1.12	0.47	0.60	0.56	0.46
d-CMP	ME736612	1.47	1.06	1.04	1.18	1.14	0.97	0.62	0.85	1.04	0.62
Guanosine triphosphate (GTP)	ME736628	1.64	1.09	1.08	1.43	1.03	1.05	0.78	0.49	0.58	0.82
d-AMP	ME736610	1.71	1.18	1.92	0.28	1.38	0.12	NA	NA	0.05	0.08
cystine	ME736606	1.59	1.27	2.69	0.91	1.01	0.85	0.39	0.34	0.32	0.62
glucose	ME736669	0.89	0.78	2.37	0.82	1.08	0.94	0.89	0.69	0.78	0.72
d-ATP	ME736611	0.89	0.44	0.31	0.21	0.16	0.11	2.64	0.25	2.51	1.98
Thymidine triphosphate	ME736656	1.31	0.53	0.38	0.44	0.22	0.17	2.17	0.20	2.11	2.47
Citrulline	ME736604	1.43	0.15	0.09	0.99	0.12	0.13	1.68	1.90	1.81	1.70
Xanthine	ME736668	1.11	0.10	0.09	1.08	0.11	0.13	1.68	1.89	2.19	1.62
Lactic Acid	ME736635	0.75	0.21	0.00	0.72	0.24	0.26	2.36	1.38	1.81	2.27
Uracil	ME736661	0.95	0.07	0.03	0.99	0.07	0.05	2.19	1.74	1.77	2.14
Inositol	ME736632	0.20	0.19	0.15	0.22	0.22	0.18	2.09	2.36	2.12	2.27
"Fructose1,6-bisphosphate"	ME736617	0.51	0.29	0.49	0.28	0.20	0.29	1.86	0.95	2.48	2.65
Glyceraldehyde 3-phosphate + DHAP	ME736623	0.54	0.28	0.29	0.43	0.32	0.23	1.76	0.95	2.49	2.71
Fumaric acid	ME736618	0.33	0.33	0.38	0.19	0.28	0.33	1.95	1.44	2.14	2.64
Malic acid	ME736637	0.39	0.40	0.49	0.23	0.27	0.38	1.96	1.47	2.13	2.28
Aspartic acid	ME736601	0.24	0.46	0.32	0.17	0.35	0.29	2.17	1.85	2.17	1.97
Pyruvic acid	ME736652	0.36	0.42	0.42	0.31	0.29	0.33	2.01	1.47	2.41	1.99
pantothenic acid	ME736646	2.14	0.70	0.64	1.86	0.63	0.69	0.36	0.90	1.48	0.58
Sedoheptulose 7-P	ME736688	2.36	0.54	0.80	1.79	0.67	0.52	0.48	0.38	1.12	0.99
Hexose-phosphate	ME736629	1.31	0.47	1.92	0.87	0.37	0.66	0.81	0.73	1.54	1.33
6-Phosphono-gluconic acid	ME736590	1.94	0.44	1.67	0.97	0.28	0.74	0.84	0.33	1.39	1.41
"Pentose - Phosphate (ribose, ribulose and xylulose)"	ME736647	1.93	0.65	1.12	1.29	0.48	0.51	0.86	0.52	1.39	1.26
Mevalonic acid	ME736639	0.43	1.11	0.73	1.84	0.48	0.73	2.06	0.83	1.05	0.74
Niacin (NA)	ME736644	0.91	0.70	0.56	0.62	0.85	0.90	0.88	0.92	1.02	2.65
CMP	ME736605	1.00	0.93	0.59	1.20	1.37	0.71	1.08	1.12	1.03	0.97
d-GTP	ME736615	1.21	1.25	0.47	1.22	1.30	0.92	1.07	0.86	1.04	0.72
Adenosine monophosphate (AMP)	ME736596	0.73	1.00	0.66	0.77	1.10	1.20	1.16	1.13	1.08	1.17
d-GMP	ME736614	0.90	0.89	0.77	0.99	0.95	0.75	1.09	1.40	1.12	1.14
Glutathione oxidized	ME736622	1.15	1.15	1.14	1.11	1.10	1.19	0.78	0.74	0.85	0.78
Valine	ME736667	1.17	1.15	1.00	1.00	0.99	1.12	0.91	0.87	0.86	0.93
Cytidine 5^-triphosphate	ME736607	1.27	1.00	0.97	1.30	1.01	0.85	0.94	0.78	0.83	1.05
Uridine 5^-triphosphate	ME736664	1.17	1.15	1.11	1.01	0.98	1.01	0.91	0.53	0.95	1.20
Deoxyguanosine diphosphate	ME736613	1.24	1.08	0.96	1.04	0.95	0.97	1.13	0.73	0.88	1.03
Adenosine diphosphate (ADP)	ME736595	1.02	0.90	1.06	0.97	0.95	0.92	1.12	0.84	1.07	1.13
Adenosine triphosphate (ATP)	ME736597	1.14	0.97	0.97	1.03	0.97	0.96	1.04	0.78	0.96	1.19
Threonine	ME736655	1.10	0.97	1.48	0.70	0.77	0.71	1.11	0.90	1.08	1.17
Isoleucine	ME736633	0.88	0.92	0.98	0.70	0.77	0.83	1.06	1.12	1.43	1.31
Serine	ME736653	1.07	1.01	0.95	0.67	0.62	0.63	0.95	1.24	1.57	1.29
UDP-GlcNAc	ME736660	0.92	0.89	1.06	0.90	0.88	0.94	1.05	0.87	1.23	1.26
Arginine	ME736670	0.94	1.04	0.85	0.85	0.98	0.96	1.02	1.10	1.11	1.25
NAD+	ME736642	0.95	0.94	1.02	0.83	0.90	0.96	1.06	1.04	1.09	1.20
Glucosamine-6-phosphate	ME736619	1.26	1.06	1.04	0.85	0.72	0.80	1.13	0.94	1.07	1.11
Asparagine	ME736600	1.11	1.11	0.92	0.72	0.80	0.83	1.18	0.86	1.22	1.27
Glutamic acid	ME736620	1.08	1.18	1.09	0.62	0.72	0.92	1.08	0.94	1.15	1.22
Glutamine	ME736671	1.00	1.11	1.00	0.76	0.81	0.94	1.08	0.92	1.16	1.21
glycerol	ME736624	1.58	0.45	0.39	1.40	0.45	0.45	1.49	1.18	1.04	1.59
Thymine	ME736657	1.14	1.29	0.32	1.16	0.67	0.56	1.10	1.14	1.04	1.57
Beta-Alanine	ME736602	1.32	0.81	0.42	1.01	0.61	0.49	1.31	1.21	1.36	1.48
GMP	ME736626	0.98	0.65	0.27	1.01	1.01	0.39	1.36	1.32	1.32	1.69
Phosphoenolpyruvic acid	ME736650	0.40	0.89	0.51	0.22	0.85	0.70	1.79	0.99	1.72	1.93
Tryptophan	ME736658	0.19	0.58	0.76	0.25	0.52	0.72	1.83	1.32	1.75	2.09
Histidine	ME736630	0.66	0.35	0.48	0.42	0.79	0.34	1.40	1.35	1.89	1.81
Uridine monophosphate	ME736666	0.54	0.51	0.51	0.53	0.90	0.51	1.55	1.37	1.84	1.74
Glyoxylic acid	ME736681	0.65	0.43	0.30	0.63	0.48	0.57	1.67	1.72	1.97	1.57
N-Acetylneuraminic acid	ME736641	0.51	0.29	0.38	0.32	0.59	0.49	1.71	1.86	1.80	2.05
IMP	ME736631	0.75	0.72	1.45	0.61	0.44	0.59	1.29	1.11	1.33	1.71
Cytosine	ME736608	0.82	0.69	0.40	0.83	0.73	0.47	1.31	1.82	1.54	1.39
Succinic acid	ME736654	1.04	0.51	0.79	0.80	0.87	1.03	1.18	0.98	1.15	1.64
3-Phosphoglyceric acid	ME736589	0.77	0.78	0.80	0.43	0.58	0.66	1.47	0.82	1.70	1.98
3-Aminoisobutanoic acid (2-methyl-beta-alanine)	ME736588	0.88	0.66	0.71	0.48	0.40	0.44	1.58	1.30	1.85	1.71
Uridine diphosphate glucose	ME736665	0.65	0.52	0.70	0.55	0.45	0.54	1.63	1.11	1.93	1.91
Aconitic acid	ME736593	0.94	0.45	0.55	0.70	0.37	0.48	1.56	1.39	1.56	2.00
Uridine 5^-diphosphate (UDP)	ME736663	0.80	0.69	0.77	0.73	0.63	0.61	1.40	1.05	1.66	1.66
alpha-Ketoglutaric acid	ME736599	0.82	0.61	0.46	0.76	0.51	0.76	1.51	1.30	1.66	1.60
Itaconic Acid	ME736634	0.91	0.57	0.61	0.69	0.53	0.63	1.51	1.29	1.52	1.73
Lysine	ME736636	0.73	0.81	0.43	0.76	0.75	0.69	1.42	1.52	1.19	1.70
Ornithine	ME736645	0.68	0.73	0.45	0.56	0.90	0.58	1.53	1.42	1.25	1.91
N-Acetyl-glucosamine 1-phosphate	ME736640	0.84	0.61	0.67	0.55	0.89	0.50	1.74	1.40	1.21	1.59
Phenylpyruvate	ME736687	0.68	0.67	0.44	0.77	0.82	0.64	1.75	1.32	1.32	1.58
Glycine	ME736625	1.00	0.62	0.70	0.62	0.63	0.82	1.40	1.46	1.12	1.62
Glucuronic acid	ME736680	0.89	0.82	0.73	0.80	0.82	0.66	1.26	1.40	1.36	1.50
Phenylalanine	ME736648	0.87	0.78	0.73	0.74	0.71	0.69	1.36	1.16	1.45	1.50
Tyrosine	ME736659	0.72	0.81	0.81	0.58	0.77	0.92	1.42	1.13	1.35	1.48
Citric acid + Isocitric acid	ME736603	0.86	0.78	1.00	0.63	0.53	0.88	1.30	1.19	1.29	1.53
Leucine	ME736674	0.81	0.83	0.93	0.61	0.65	0.85	1.34	1.07	1.36	1.54
Methionine	ME736638	0.54	0.86	0.71	0.54	0.83	0.96	1.37	1.23	1.52	1.43
Proline	ME736651	0.64	0.73	0.66	0.58	0.65	0.71	1.43	1.49	1.60	1.50

Factors:

F1	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 0h as ctrl
F2	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 1h
F3	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 24h
F4	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 0h as ctrl
F5	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 1h
F6	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 24h
F7	cell line:ICC21 \| treatment:Afatinib \| labeling status:N/A
F8	cell line:ICC21 \| treatment:Combo \| labeling status:N/A
F9	cell line:ICC21 \| treatment:control \| labeling status:N/A
F10	cell line:ICC21 \| treatment:Infigratinib \| labeling status:N/A

Data matrix