Clustering data with hclust algorithm for (Study ST002835)
(Analysis AN004631)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
---|---|---|---|---|---|---|---|---|---|---|---|
TMP | ME736691 | 2.89 | 1.09 | 1.00 | 2.75 | 0.48 | 0.48 | 0.11 | 0.41 | 0.23 | 0.08 |
Uridine | ME736662 | 3.72 | 1.30 | 0.19 | 3.40 | 0.95 | 0.17 | 0.03 | 0.13 | 0.08 | 0.03 |
Glutathione (reduced) | ME736621 | 0.06 | 0.20 | 0.06 | 0.02 | 0.15 | 0.10 | 1.85 | 0.66 | 4.02 | 2.87 |
d-ADP | ME736609 | 1.45 | 1.31 | 1.17 | 0.51 | 0.67 | 0.62 | NA | NA | NA | 1.47 |
2-deoxyribose-5P | ME736672 | 1.27 | 1.44 | 0.74 | 1.17 | 1.00 | 0.38 | NA | NA | NA | NA |
Acetylcarnitine | ME736591 | 1.59 | 1.64 | 0.43 | 1.91 | 1.84 | 0.63 | 0.50 | 0.40 | 0.53 | 0.53 |
Guanosine | ME736627 | 1.42 | 1.03 | 0.76 | 2.30 | 1.77 | 1.16 | 0.41 | 0.60 | 0.31 | 0.24 |
Acetyl-CoA | ME736592 | 1.75 | 1.45 | 1.62 | 1.44 | 1.49 | 0.69 | 0.14 | 0.07 | NA | 0.06 |
Adenosine | ME736594 | 1.52 | 1.41 | 2.26 | 1.55 | 1.39 | 1.31 | 0.18 | 0.14 | 0.11 | 0.13 |
NADP+ | ME736643 | 1.44 | 1.51 | 1.18 | 1.46 | 1.89 | 1.27 | 0.32 | 0.34 | 0.27 | 0.34 |
Phosphocreatine | ME736649 | 1.37 | 1.35 | 1.28 | 1.29 | 1.31 | 1.28 | 0.52 | 0.56 | 0.52 | 0.53 |
Alanine | ME736598 | 1.60 | 1.21 | 1.64 | 1.37 | 1.04 | 0.96 | 0.49 | 0.62 | 0.60 | 0.47 |
Creatine | ME736675 | 1.43 | 1.24 | 1.50 | 1.33 | 1.08 | 1.05 | 0.46 | 0.58 | 0.53 | 0.42 |
Dihydrouracil | ME736616 | 1.52 | 1.28 | 1.53 | 1.37 | 1.10 | 1.12 | 0.47 | 0.60 | 0.56 | 0.46 |
d-CMP | ME736612 | 1.47 | 1.06 | 1.04 | 1.18 | 1.14 | 0.97 | 0.62 | 0.85 | 1.04 | 0.62 |
Guanosine triphosphate (GTP) | ME736628 | 1.64 | 1.09 | 1.08 | 1.43 | 1.03 | 1.05 | 0.78 | 0.49 | 0.58 | 0.82 |
d-AMP | ME736610 | 1.71 | 1.18 | 1.92 | 0.28 | 1.38 | 0.12 | NA | NA | 0.05 | 0.08 |
cystine | ME736606 | 1.59 | 1.27 | 2.69 | 0.91 | 1.01 | 0.85 | 0.39 | 0.34 | 0.32 | 0.62 |
glucose | ME736669 | 0.89 | 0.78 | 2.37 | 0.82 | 1.08 | 0.94 | 0.89 | 0.69 | 0.78 | 0.72 |
d-ATP | ME736611 | 0.89 | 0.44 | 0.31 | 0.21 | 0.16 | 0.11 | 2.64 | 0.25 | 2.51 | 1.98 |
Thymidine triphosphate | ME736656 | 1.31 | 0.53 | 0.38 | 0.44 | 0.22 | 0.17 | 2.17 | 0.20 | 2.11 | 2.47 |
Citrulline | ME736604 | 1.43 | 0.15 | 0.09 | 0.99 | 0.12 | 0.13 | 1.68 | 1.90 | 1.81 | 1.70 |
Xanthine | ME736668 | 1.11 | 0.10 | 0.09 | 1.08 | 0.11 | 0.13 | 1.68 | 1.89 | 2.19 | 1.62 |
Lactic Acid | ME736635 | 0.75 | 0.21 | 0.00 | 0.72 | 0.24 | 0.26 | 2.36 | 1.38 | 1.81 | 2.27 |
Uracil | ME736661 | 0.95 | 0.07 | 0.03 | 0.99 | 0.07 | 0.05 | 2.19 | 1.74 | 1.77 | 2.14 |
Inositol | ME736632 | 0.20 | 0.19 | 0.15 | 0.22 | 0.22 | 0.18 | 2.09 | 2.36 | 2.12 | 2.27 |
"Fructose1,6-bisphosphate" | ME736617 | 0.51 | 0.29 | 0.49 | 0.28 | 0.20 | 0.29 | 1.86 | 0.95 | 2.48 | 2.65 |
Glyceraldehyde 3-phosphate + DHAP | ME736623 | 0.54 | 0.28 | 0.29 | 0.43 | 0.32 | 0.23 | 1.76 | 0.95 | 2.49 | 2.71 |
Fumaric acid | ME736618 | 0.33 | 0.33 | 0.38 | 0.19 | 0.28 | 0.33 | 1.95 | 1.44 | 2.14 | 2.64 |
Malic acid | ME736637 | 0.39 | 0.40 | 0.49 | 0.23 | 0.27 | 0.38 | 1.96 | 1.47 | 2.13 | 2.28 |
Aspartic acid | ME736601 | 0.24 | 0.46 | 0.32 | 0.17 | 0.35 | 0.29 | 2.17 | 1.85 | 2.17 | 1.97 |
Pyruvic acid | ME736652 | 0.36 | 0.42 | 0.42 | 0.31 | 0.29 | 0.33 | 2.01 | 1.47 | 2.41 | 1.99 |
pantothenic acid | ME736646 | 2.14 | 0.70 | 0.64 | 1.86 | 0.63 | 0.69 | 0.36 | 0.90 | 1.48 | 0.58 |
Sedoheptulose 7-P | ME736688 | 2.36 | 0.54 | 0.80 | 1.79 | 0.67 | 0.52 | 0.48 | 0.38 | 1.12 | 0.99 |
Hexose-phosphate | ME736629 | 1.31 | 0.47 | 1.92 | 0.87 | 0.37 | 0.66 | 0.81 | 0.73 | 1.54 | 1.33 |
6-Phosphono-gluconic acid | ME736590 | 1.94 | 0.44 | 1.67 | 0.97 | 0.28 | 0.74 | 0.84 | 0.33 | 1.39 | 1.41 |
"Pentose - Phosphate (ribose, ribulose and xylulose)" | ME736647 | 1.93 | 0.65 | 1.12 | 1.29 | 0.48 | 0.51 | 0.86 | 0.52 | 1.39 | 1.26 |
Mevalonic acid | ME736639 | 0.43 | 1.11 | 0.73 | 1.84 | 0.48 | 0.73 | 2.06 | 0.83 | 1.05 | 0.74 |
Niacin (NA) | ME736644 | 0.91 | 0.70 | 0.56 | 0.62 | 0.85 | 0.90 | 0.88 | 0.92 | 1.02 | 2.65 |
CMP | ME736605 | 1.00 | 0.93 | 0.59 | 1.20 | 1.37 | 0.71 | 1.08 | 1.12 | 1.03 | 0.97 |
d-GTP | ME736615 | 1.21 | 1.25 | 0.47 | 1.22 | 1.30 | 0.92 | 1.07 | 0.86 | 1.04 | 0.72 |
Adenosine monophosphate (AMP) | ME736596 | 0.73 | 1.00 | 0.66 | 0.77 | 1.10 | 1.20 | 1.16 | 1.13 | 1.08 | 1.17 |
d-GMP | ME736614 | 0.90 | 0.89 | 0.77 | 0.99 | 0.95 | 0.75 | 1.09 | 1.40 | 1.12 | 1.14 |
Glutathione oxidized | ME736622 | 1.15 | 1.15 | 1.14 | 1.11 | 1.10 | 1.19 | 0.78 | 0.74 | 0.85 | 0.78 |
Valine | ME736667 | 1.17 | 1.15 | 1.00 | 1.00 | 0.99 | 1.12 | 0.91 | 0.87 | 0.86 | 0.93 |
Cytidine 5^-triphosphate | ME736607 | 1.27 | 1.00 | 0.97 | 1.30 | 1.01 | 0.85 | 0.94 | 0.78 | 0.83 | 1.05 |
Uridine 5^-triphosphate | ME736664 | 1.17 | 1.15 | 1.11 | 1.01 | 0.98 | 1.01 | 0.91 | 0.53 | 0.95 | 1.20 |
Deoxyguanosine diphosphate | ME736613 | 1.24 | 1.08 | 0.96 | 1.04 | 0.95 | 0.97 | 1.13 | 0.73 | 0.88 | 1.03 |
Adenosine diphosphate (ADP) | ME736595 | 1.02 | 0.90 | 1.06 | 0.97 | 0.95 | 0.92 | 1.12 | 0.84 | 1.07 | 1.13 |
Adenosine triphosphate (ATP) | ME736597 | 1.14 | 0.97 | 0.97 | 1.03 | 0.97 | 0.96 | 1.04 | 0.78 | 0.96 | 1.19 |
Threonine | ME736655 | 1.10 | 0.97 | 1.48 | 0.70 | 0.77 | 0.71 | 1.11 | 0.90 | 1.08 | 1.17 |
Isoleucine | ME736633 | 0.88 | 0.92 | 0.98 | 0.70 | 0.77 | 0.83 | 1.06 | 1.12 | 1.43 | 1.31 |
Serine | ME736653 | 1.07 | 1.01 | 0.95 | 0.67 | 0.62 | 0.63 | 0.95 | 1.24 | 1.57 | 1.29 |
UDP-GlcNAc | ME736660 | 0.92 | 0.89 | 1.06 | 0.90 | 0.88 | 0.94 | 1.05 | 0.87 | 1.23 | 1.26 |
Arginine | ME736670 | 0.94 | 1.04 | 0.85 | 0.85 | 0.98 | 0.96 | 1.02 | 1.10 | 1.11 | 1.25 |
NAD+ | ME736642 | 0.95 | 0.94 | 1.02 | 0.83 | 0.90 | 0.96 | 1.06 | 1.04 | 1.09 | 1.20 |
Glucosamine-6-phosphate | ME736619 | 1.26 | 1.06 | 1.04 | 0.85 | 0.72 | 0.80 | 1.13 | 0.94 | 1.07 | 1.11 |
Asparagine | ME736600 | 1.11 | 1.11 | 0.92 | 0.72 | 0.80 | 0.83 | 1.18 | 0.86 | 1.22 | 1.27 |
Glutamic acid | ME736620 | 1.08 | 1.18 | 1.09 | 0.62 | 0.72 | 0.92 | 1.08 | 0.94 | 1.15 | 1.22 |
Glutamine | ME736671 | 1.00 | 1.11 | 1.00 | 0.76 | 0.81 | 0.94 | 1.08 | 0.92 | 1.16 | 1.21 |
glycerol | ME736624 | 1.58 | 0.45 | 0.39 | 1.40 | 0.45 | 0.45 | 1.49 | 1.18 | 1.04 | 1.59 |
Thymine | ME736657 | 1.14 | 1.29 | 0.32 | 1.16 | 0.67 | 0.56 | 1.10 | 1.14 | 1.04 | 1.57 |
Beta-Alanine | ME736602 | 1.32 | 0.81 | 0.42 | 1.01 | 0.61 | 0.49 | 1.31 | 1.21 | 1.36 | 1.48 |
GMP | ME736626 | 0.98 | 0.65 | 0.27 | 1.01 | 1.01 | 0.39 | 1.36 | 1.32 | 1.32 | 1.69 |
Phosphoenolpyruvic acid | ME736650 | 0.40 | 0.89 | 0.51 | 0.22 | 0.85 | 0.70 | 1.79 | 0.99 | 1.72 | 1.93 |
Tryptophan | ME736658 | 0.19 | 0.58 | 0.76 | 0.25 | 0.52 | 0.72 | 1.83 | 1.32 | 1.75 | 2.09 |
Histidine | ME736630 | 0.66 | 0.35 | 0.48 | 0.42 | 0.79 | 0.34 | 1.40 | 1.35 | 1.89 | 1.81 |
Uridine monophosphate | ME736666 | 0.54 | 0.51 | 0.51 | 0.53 | 0.90 | 0.51 | 1.55 | 1.37 | 1.84 | 1.74 |
Glyoxylic acid | ME736681 | 0.65 | 0.43 | 0.30 | 0.63 | 0.48 | 0.57 | 1.67 | 1.72 | 1.97 | 1.57 |
N-Acetylneuraminic acid | ME736641 | 0.51 | 0.29 | 0.38 | 0.32 | 0.59 | 0.49 | 1.71 | 1.86 | 1.80 | 2.05 |
IMP | ME736631 | 0.75 | 0.72 | 1.45 | 0.61 | 0.44 | 0.59 | 1.29 | 1.11 | 1.33 | 1.71 |
Cytosine | ME736608 | 0.82 | 0.69 | 0.40 | 0.83 | 0.73 | 0.47 | 1.31 | 1.82 | 1.54 | 1.39 |
Succinic acid | ME736654 | 1.04 | 0.51 | 0.79 | 0.80 | 0.87 | 1.03 | 1.18 | 0.98 | 1.15 | 1.64 |
3-Phosphoglyceric acid | ME736589 | 0.77 | 0.78 | 0.80 | 0.43 | 0.58 | 0.66 | 1.47 | 0.82 | 1.70 | 1.98 |
3-Aminoisobutanoic acid (2-methyl-beta-alanine) | ME736588 | 0.88 | 0.66 | 0.71 | 0.48 | 0.40 | 0.44 | 1.58 | 1.30 | 1.85 | 1.71 |
Uridine diphosphate glucose | ME736665 | 0.65 | 0.52 | 0.70 | 0.55 | 0.45 | 0.54 | 1.63 | 1.11 | 1.93 | 1.91 |
Aconitic acid | ME736593 | 0.94 | 0.45 | 0.55 | 0.70 | 0.37 | 0.48 | 1.56 | 1.39 | 1.56 | 2.00 |
Uridine 5^-diphosphate (UDP) | ME736663 | 0.80 | 0.69 | 0.77 | 0.73 | 0.63 | 0.61 | 1.40 | 1.05 | 1.66 | 1.66 |
alpha-Ketoglutaric acid | ME736599 | 0.82 | 0.61 | 0.46 | 0.76 | 0.51 | 0.76 | 1.51 | 1.30 | 1.66 | 1.60 |
Itaconic Acid | ME736634 | 0.91 | 0.57 | 0.61 | 0.69 | 0.53 | 0.63 | 1.51 | 1.29 | 1.52 | 1.73 |
Lysine | ME736636 | 0.73 | 0.81 | 0.43 | 0.76 | 0.75 | 0.69 | 1.42 | 1.52 | 1.19 | 1.70 |
Ornithine | ME736645 | 0.68 | 0.73 | 0.45 | 0.56 | 0.90 | 0.58 | 1.53 | 1.42 | 1.25 | 1.91 |
N-Acetyl-glucosamine 1-phosphate | ME736640 | 0.84 | 0.61 | 0.67 | 0.55 | 0.89 | 0.50 | 1.74 | 1.40 | 1.21 | 1.59 |
Phenylpyruvate | ME736687 | 0.68 | 0.67 | 0.44 | 0.77 | 0.82 | 0.64 | 1.75 | 1.32 | 1.32 | 1.58 |
Glycine | ME736625 | 1.00 | 0.62 | 0.70 | 0.62 | 0.63 | 0.82 | 1.40 | 1.46 | 1.12 | 1.62 |
Glucuronic acid | ME736680 | 0.89 | 0.82 | 0.73 | 0.80 | 0.82 | 0.66 | 1.26 | 1.40 | 1.36 | 1.50 |
Phenylalanine | ME736648 | 0.87 | 0.78 | 0.73 | 0.74 | 0.71 | 0.69 | 1.36 | 1.16 | 1.45 | 1.50 |
Tyrosine | ME736659 | 0.72 | 0.81 | 0.81 | 0.58 | 0.77 | 0.92 | 1.42 | 1.13 | 1.35 | 1.48 |
Citric acid + Isocitric acid | ME736603 | 0.86 | 0.78 | 1.00 | 0.63 | 0.53 | 0.88 | 1.30 | 1.19 | 1.29 | 1.53 |
Leucine | ME736674 | 0.81 | 0.83 | 0.93 | 0.61 | 0.65 | 0.85 | 1.34 | 1.07 | 1.36 | 1.54 |
Methionine | ME736638 | 0.54 | 0.86 | 0.71 | 0.54 | 0.83 | 0.96 | 1.37 | 1.23 | 1.52 | 1.43 |
Proline | ME736651 | 0.64 | 0.73 | 0.66 | 0.58 | 0.65 | 0.71 | 1.43 | 1.49 | 1.60 | 1.50 |
Factors:
F1 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
F2 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 1h |
F3 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 24h |
F4 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
F5 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 1h |
F6 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 24h |
F7 | cell line:ICC21 | treatment:Afatinib | labeling status:N/A |
F8 | cell line:ICC21 | treatment:Combo | labeling status:N/A |
F9 | cell line:ICC21 | treatment:control | labeling status:N/A |
F10 | cell line:ICC21 | treatment:Infigratinib | labeling status:N/A |