Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002835)

HILIC NEGATIVE ION MODE (Analysis AN004632)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10
TMP	ME736795	2.89	1.09	1.00	2.75	0.48	0.48	0.11	0.41	0.23	0.08
Uridine	ME736766	3.72	1.30	0.19	3.40	0.95	0.17	0.03	0.13	0.08	0.03
Glutathione (reduced)	ME736725	0.06	0.20	0.06	0.02	0.15	0.10	1.85	0.66	4.02	2.87
d-ADP	ME736713	1.45	1.31	1.17	0.51	0.67	0.62	NA	NA	NA	1.47
2-deoxyribose-5P	ME736776	1.27	1.44	0.74	1.17	1.00	0.38	NA	NA	NA	NA
Acetylcarnitine	ME736695	1.59	1.64	0.43	1.91	1.84	0.63	0.50	0.40	0.53	0.53
Guanosine	ME736731	1.42	1.03	0.76	2.30	1.77	1.16	0.41	0.60	0.31	0.24
Acetyl-CoA	ME736696	1.75	1.45	1.62	1.44	1.49	0.69	0.14	0.07	NA	0.06
Adenosine	ME736698	1.52	1.41	2.26	1.55	1.39	1.31	0.18	0.14	0.11	0.13
NADP+	ME736747	1.44	1.51	1.18	1.46	1.89	1.27	0.32	0.34	0.27	0.34
Phosphocreatine	ME736753	1.37	1.35	1.28	1.29	1.31	1.28	0.52	0.56	0.52	0.53
Alanine	ME736702	1.60	1.21	1.64	1.37	1.04	0.96	0.49	0.62	0.60	0.47
Creatine	ME736779	1.43	1.24	1.50	1.33	1.08	1.05	0.46	0.58	0.53	0.42
Dihydrouracil	ME736720	1.52	1.28	1.53	1.37	1.10	1.12	0.47	0.60	0.56	0.46
d-CMP	ME736716	1.47	1.06	1.04	1.18	1.14	0.97	0.62	0.85	1.04	0.62
Guanosine triphosphate (GTP)	ME736732	1.64	1.09	1.08	1.43	1.03	1.05	0.78	0.49	0.58	0.82
d-AMP	ME736714	1.71	1.18	1.92	0.28	1.38	0.12	NA	NA	0.05	0.08
cystine	ME736710	1.59	1.27	2.69	0.91	1.01	0.85	0.39	0.34	0.32	0.62
glucose	ME736773	0.89	0.78	2.37	0.82	1.08	0.94	0.89	0.69	0.78	0.72
d-ATP	ME736715	0.89	0.44	0.31	0.21	0.16	0.11	2.64	0.25	2.51	1.98
Thymidine triphosphate	ME736760	1.31	0.53	0.38	0.44	0.22	0.17	2.17	0.20	2.11	2.47
Citrulline	ME736708	1.43	0.15	0.09	0.99	0.12	0.13	1.68	1.90	1.81	1.70
Xanthine	ME736772	1.11	0.10	0.09	1.08	0.11	0.13	1.68	1.89	2.19	1.62
Lactic Acid	ME736739	0.75	0.21	0.00	0.72	0.24	0.26	2.36	1.38	1.81	2.27
Uracil	ME736765	0.95	0.07	0.03	0.99	0.07	0.05	2.19	1.74	1.77	2.14
Inositol	ME736736	0.20	0.19	0.15	0.22	0.22	0.18	2.09	2.36	2.12	2.27
"Fructose1,6-bisphosphate"	ME736721	0.51	0.29	0.49	0.28	0.20	0.29	1.86	0.95	2.48	2.65
Glyceraldehyde 3-phosphate + DHAP	ME736727	0.54	0.28	0.29	0.43	0.32	0.23	1.76	0.95	2.49	2.71
Fumaric acid	ME736722	0.33	0.33	0.38	0.19	0.28	0.33	1.95	1.44	2.14	2.64
Malic acid	ME736741	0.39	0.40	0.49	0.23	0.27	0.38	1.96	1.47	2.13	2.28
Aspartic acid	ME736705	0.24	0.46	0.32	0.17	0.35	0.29	2.17	1.85	2.17	1.97
Pyruvic acid	ME736756	0.36	0.42	0.42	0.31	0.29	0.33	2.01	1.47	2.41	1.99
pantothenic acid	ME736750	2.14	0.70	0.64	1.86	0.63	0.69	0.36	0.90	1.48	0.58
Sedoheptulose 7-P	ME736792	2.36	0.54	0.80	1.79	0.67	0.52	0.48	0.38	1.12	0.99
Hexose-phosphate	ME736733	1.31	0.47	1.92	0.87	0.37	0.66	0.81	0.73	1.54	1.33
6-Phosphono-gluconic acid	ME736694	1.94	0.44	1.67	0.97	0.28	0.74	0.84	0.33	1.39	1.41
"Pentose - Phosphate (ribose, ribulose and xylulose)"	ME736751	1.93	0.65	1.12	1.29	0.48	0.51	0.86	0.52	1.39	1.26
Mevalonic acid	ME736743	0.43	1.11	0.73	1.84	0.48	0.73	2.06	0.83	1.05	0.74
Niacin (NA)	ME736748	0.91	0.70	0.56	0.62	0.85	0.90	0.88	0.92	1.02	2.65
CMP	ME736709	1.00	0.93	0.59	1.20	1.37	0.71	1.08	1.12	1.03	0.97
d-GTP	ME736719	1.21	1.25	0.47	1.22	1.30	0.92	1.07	0.86	1.04	0.72
Adenosine monophosphate (AMP)	ME736700	0.73	1.00	0.66	0.77	1.10	1.20	1.16	1.13	1.08	1.17
d-GMP	ME736718	0.90	0.89	0.77	0.99	0.95	0.75	1.09	1.40	1.12	1.14
Glutathione oxidized	ME736726	1.15	1.15	1.14	1.11	1.10	1.19	0.78	0.74	0.85	0.78
Valine	ME736771	1.17	1.15	1.00	1.00	0.99	1.12	0.91	0.87	0.86	0.93
Cytidine 5^-triphosphate	ME736711	1.27	1.00	0.97	1.30	1.01	0.85	0.94	0.78	0.83	1.05
Uridine 5^-triphosphate	ME736768	1.17	1.15	1.11	1.01	0.98	1.01	0.91	0.53	0.95	1.20
Deoxyguanosine diphosphate	ME736717	1.24	1.08	0.96	1.04	0.95	0.97	1.13	0.73	0.88	1.03
Adenosine diphosphate (ADP)	ME736699	1.02	0.90	1.06	0.97	0.95	0.92	1.12	0.84	1.07	1.13
Adenosine triphosphate (ATP)	ME736701	1.14	0.97	0.97	1.03	0.97	0.96	1.04	0.78	0.96	1.19
Threonine	ME736759	1.10	0.97	1.48	0.70	0.77	0.71	1.11	0.90	1.08	1.17
Isoleucine	ME736737	0.88	0.92	0.98	0.70	0.77	0.83	1.06	1.12	1.43	1.31
Serine	ME736757	1.07	1.01	0.95	0.67	0.62	0.63	0.95	1.24	1.57	1.29
UDP-GlcNAc	ME736764	0.92	0.89	1.06	0.90	0.88	0.94	1.05	0.87	1.23	1.26
Arginine	ME736774	0.94	1.04	0.85	0.85	0.98	0.96	1.02	1.10	1.11	1.25
NAD+	ME736746	0.95	0.94	1.02	0.83	0.90	0.96	1.06	1.04	1.09	1.20
Glucosamine-6-phosphate	ME736723	1.26	1.06	1.04	0.85	0.72	0.80	1.13	0.94	1.07	1.11
Asparagine	ME736704	1.11	1.11	0.92	0.72	0.80	0.83	1.18	0.86	1.22	1.27
Glutamic acid	ME736724	1.08	1.18	1.09	0.62	0.72	0.92	1.08	0.94	1.15	1.22
Glutamine	ME736775	1.00	1.11	1.00	0.76	0.81	0.94	1.08	0.92	1.16	1.21
glycerol	ME736728	1.58	0.45	0.39	1.40	0.45	0.45	1.49	1.18	1.04	1.59
Thymine	ME736761	1.14	1.29	0.32	1.16	0.67	0.56	1.10	1.14	1.04	1.57
Beta-Alanine	ME736706	1.32	0.81	0.42	1.01	0.61	0.49	1.31	1.21	1.36	1.48
GMP	ME736730	0.98	0.65	0.27	1.01	1.01	0.39	1.36	1.32	1.32	1.69
Phosphoenolpyruvic acid	ME736754	0.40	0.89	0.51	0.22	0.85	0.70	1.79	0.99	1.72	1.93
Tryptophan	ME736762	0.19	0.58	0.76	0.25	0.52	0.72	1.83	1.32	1.75	2.09
Histidine	ME736734	0.66	0.35	0.48	0.42	0.79	0.34	1.40	1.35	1.89	1.81
Uridine monophosphate	ME736770	0.54	0.51	0.51	0.53	0.90	0.51	1.55	1.37	1.84	1.74
Glyoxylic acid	ME736785	0.65	0.43	0.30	0.63	0.48	0.57	1.67	1.72	1.97	1.57
N-Acetylneuraminic acid	ME736745	0.51	0.29	0.38	0.32	0.59	0.49	1.71	1.86	1.80	2.05
IMP	ME736735	0.75	0.72	1.45	0.61	0.44	0.59	1.29	1.11	1.33	1.71
Cytosine	ME736712	0.82	0.69	0.40	0.83	0.73	0.47	1.31	1.82	1.54	1.39
Succinic acid	ME736758	1.04	0.51	0.79	0.80	0.87	1.03	1.18	0.98	1.15	1.64
3-Phosphoglyceric acid	ME736693	0.77	0.78	0.80	0.43	0.58	0.66	1.47	0.82	1.70	1.98
3-Aminoisobutanoic acid (2-methyl-beta-alanine)	ME736692	0.88	0.66	0.71	0.48	0.40	0.44	1.58	1.30	1.85	1.71
Uridine diphosphate glucose	ME736769	0.65	0.52	0.70	0.55	0.45	0.54	1.63	1.11	1.93	1.91
Aconitic acid	ME736697	0.94	0.45	0.55	0.70	0.37	0.48	1.56	1.39	1.56	2.00
Uridine 5^-diphosphate (UDP)	ME736767	0.80	0.69	0.77	0.73	0.63	0.61	1.40	1.05	1.66	1.66
alpha-Ketoglutaric acid	ME736703	0.82	0.61	0.46	0.76	0.51	0.76	1.51	1.30	1.66	1.60
Itaconic Acid	ME736738	0.91	0.57	0.61	0.69	0.53	0.63	1.51	1.29	1.52	1.73
Lysine	ME736740	0.73	0.81	0.43	0.76	0.75	0.69	1.42	1.52	1.19	1.70
Ornithine	ME736749	0.68	0.73	0.45	0.56	0.90	0.58	1.53	1.42	1.25	1.91
N-Acetyl-glucosamine 1-phosphate	ME736744	0.84	0.61	0.67	0.55	0.89	0.50	1.74	1.40	1.21	1.59
Phenylpyruvate	ME736791	0.68	0.67	0.44	0.77	0.82	0.64	1.75	1.32	1.32	1.58
Glycine	ME736729	1.00	0.62	0.70	0.62	0.63	0.82	1.40	1.46	1.12	1.62
Glucuronic acid	ME736784	0.89	0.82	0.73	0.80	0.82	0.66	1.26	1.40	1.36	1.50
Phenylalanine	ME736752	0.87	0.78	0.73	0.74	0.71	0.69	1.36	1.16	1.45	1.50
Tyrosine	ME736763	0.72	0.81	0.81	0.58	0.77	0.92	1.42	1.13	1.35	1.48
Citric acid + Isocitric acid	ME736707	0.86	0.78	1.00	0.63	0.53	0.88	1.30	1.19	1.29	1.53
Leucine	ME736778	0.81	0.83	0.93	0.61	0.65	0.85	1.34	1.07	1.36	1.54
Methionine	ME736742	0.54	0.86	0.71	0.54	0.83	0.96	1.37	1.23	1.52	1.43
Proline	ME736755	0.64	0.73	0.66	0.58	0.65	0.71	1.43	1.49	1.60	1.50

Factors:

F1	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 0h as ctrl
F2	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 1h
F3	cell line:ICC13-7 \| treatment:control \| labeling status:13C6-Glucose Isotopic tracing 24h
F4	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 0h as ctrl
F5	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 1h
F6	cell line:ICC13-7 \| treatment:Infigratinib \| labeling status:13C6-Glucose Isotopic tracing 24h
F7	cell line:ICC21 \| treatment:Afatinib \| labeling status:N/A
F8	cell line:ICC21 \| treatment:Combo \| labeling status:N/A
F9	cell line:ICC21 \| treatment:control \| labeling status:N/A
F10	cell line:ICC21 \| treatment:Infigratinib \| labeling status:N/A

Data matrix