Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002872)

(Analysis AN004708)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
Phosphoenolpyruvic acid	ME746533	0.05	0.06	0.15	0.08	2.48	3.54	0.16	0.14
Uridine 5^-diphosphate	ME746553	0.02	0.03	0.18	0.06	2.47	3.61	0.13	0.14
Uridine diphosphate glucuronic acid	ME746556	0.03	0.02	0.04	0.02	2.91	3.44	0.05	0.04
3-Phosphoglyceric acid	ME746400	0.06	0.07	0.23	0.08	2.81	3.08	0.21	0.17
Oxoglutaric acid	ME746529	0.08	0.08	0.19	0.10	2.67	3.21	0.24	0.14
ADP	ME746411	0.08	0.15	0.34	0.18	2.34	2.92	0.53	0.37
Guanosine diphosphate	ME746465	0.14	0.12	0.31	0.13	2.27	3.07	0.56	0.28
Guanidoacetic acid	ME746462	0.32	0.34	0.42	0.36	1.98	2.81	0.40	0.44
NADP	ME746520	0.41	0.39	0.28	0.25	1.99	2.56	0.80	0.48
3-Methylhistidine	ME746399	0.38	0.47	0.46	0.25	2.07	2.54	0.48	0.48
Uridine diphosphate glucose	ME746555	0.34	0.30	0.34	0.23	2.17	2.59	0.62	0.50
6-Phosphogluconic acid	ME746404	0.34	0.36	0.61	0.33	2.04	2.44	0.68	0.37
Citric acid	ME746427	0.28	0.27	0.57	0.32	2.09	2.64	0.53	0.39
5-Thymidylic acid	ME746403	0.17	0.18	0.34	0.20	2.45	2.27	0.49	0.23
CDP	ME746422	0.03	0.03	0.25	0.08	2.08	2.56	0.11	0.13
Uridine triphosphate	ME746558	NA	0.04	0.31	0.06	1.16	2.69	0.15	0.38
Adenosine triphosphate	ME746410	0.04	0.08	0.35	0.07	1.78	3.86	0.28	0.32
Deoxyribose 5-phosphate	ME746448	0.29	0.33	0.67	0.33	0.94	3.66	0.48	0.43
Caprylic acid	ME746420	0.39	0.31	0.31	0.25	4.30	0.72	0.52	0.21
Deoxyinosine	ME746447	0.80	0.66	0.55	0.55	2.42	1.21	0.79	0.50
Nicotinamide riboside	ME746523	0.80	0.65	0.52	0.47	2.95	0.84	0.72	0.46
N-Acetylputrescine	ME746513	0.73	2.74	1.30	0.65	0.56	0.51	0.88	0.95
L-Pipecolic acid	ME746496	0.57	0.52	1.85	0.69	0.66	0.74	1.14	2.02
Ureidosuccinic acid	ME746550	0.49	0.42	2.74	1.70	0.81	0.75	0.57	0.65
AICAR	ME746413	0.74	0.63	2.22	1.08	0.65	0.79	1.01	1.05
Gluconic acid	ME746455	0.65	0.77	2.75	0.66	0.74	0.84	0.79	0.95
N-Acetylglutamine	ME746511	0.61	0.79	2.75	1.04	0.54	0.41	0.97	1.23
Glycine	ME746461	1.20	1.00	1.28	0.81	0.34	0.40	2.44	0.96
Uridine diphosphate-N-acetylglucosamine	ME746557	1.05	1.01	1.58	0.91	0.12	0.18	2.03	1.69
D-Ribose 5-phosphate	ME746443	1.81	1.29	1.44	1.15	0.61	0.65	0.72	0.57
Hippuric acid	ME746468	2.05	0.93	1.52	0.90	0.55	0.77	1.05	0.46
Purine	ME746537	2.42	1.68	0.64	1.04	0.23	0.25	1.41	0.82
Deoxyadenosine	ME746446	1.60	1.59	1.02	1.00	0.22	0.26	1.84	0.99
Guanosine	ME746464	1.92	1.61	0.68	0.84	0.38	0.50	1.62	0.84
Adenosine	ME746408	1.97	1.61	0.88	1.02	0.27	0.30	1.45	0.97
Hypoxanthine	ME746470	1.88	1.59	0.91	1.04	0.34	0.45	1.33	0.86
NADH	ME746519	1.40	1.33	1.38	1.13	0.10	0.17	1.68	1.40
Thiamine	ME746545	1.20	1.30	1.20	1.07	0.40	0.38	1.58	1.28
Isovalerylcarnitine	ME746476	1.64	1.27	0.68	0.93	0.38	0.45	1.83	1.21
Propionylcarnitine	ME746536	1.36	1.38	0.72	1.16	0.52	0.55	1.45	1.17
Inosinic acid	ME746475	1.55	1.08	1.00	1.37	0.48	0.64	1.65	0.51
D-Ribulose 5-phosphate	ME746444	1.54	1.28	0.74	0.78	0.91	1.10	1.03	0.61
Adenine	ME746407	1.56	1.34	0.70	0.90	0.64	0.90	1.22	0.90
Inosine	ME746474	1.75	1.58	0.71	0.95	0.35	0.84	1.29	0.81
3-Hydroxymethylglutaric acid	ME746398	0.49	0.58	2.63	0.76	1.22	1.12	0.53	0.54
D-Glyceraldehyde 3-phosphate	ME746441	0.54	0.49	2.48	0.62	1.13	1.56	0.50	0.45
Allantoin	ME746414	0.55	0.54	1.33	0.45	1.50	1.76	0.74	0.70
Indolelactic acid	ME746472	0.59	0.50	2.01	0.38	1.50	1.29	0.80	0.68
Imidazoleacetic acid	ME746471	0.54	0.44	1.54	0.57	1.45	1.47	0.97	0.72
Indoxyl sulfate	ME746473	0.55	0.29	1.82	0.52	1.46	1.38	0.98	0.71
Urocanic acid	ME746559	0.50	0.41	1.91	0.43	1.47	1.98	0.40	0.42
Glucosamine 6-phosphate	ME746456	0.31	0.62	2.08	0.53	1.11	1.41	0.84	0.93
Fructose 6-phosphate	ME746451	0.12	0.47	2.02	0.46	1.44	1.74	0.45	0.91
D-Erythrose 4-phosphate	ME746437	0.17	0.49	2.05	0.48	1.52	1.54	0.48	0.92
Glucose 6-phosphate	ME746457	0.16	0.48	2.15	0.46	1.45	1.58	0.45	0.94
Carnosine	ME746421	0.69	1.04	0.94	1.52	0.94	1.48	0.46	0.78
D-Glucuronic acid	ME746440	0.87	1.42	1.17	0.70	0.85	0.77	1.49	0.86
NADPH	ME746521	1.26	1.03	0.94	0.76	0.57	0.71	1.92	1.04
Hexanoylcarnitine	ME746467	1.13	1.00	1.40	0.56	0.63	0.75	1.61	1.13
Asymmetric dimethylarginine	ME746417	1.04	1.03	1.35	0.84	0.68	0.81	1.36	1.06
Cytidine	ME746433	0.94	1.06	1.34	0.78	0.56	0.75	1.56	1.24
N6,N6,N6-Trimethyl-L-lysine	ME746517	1.09	1.19	0.98	0.68	0.62	0.68	1.54	1.46
Butyrylcarnitine	ME746419	1.24	1.08	1.20	0.78	0.57	0.71	1.45	1.21
Citicoline	ME746426	1.29	1.21	1.01	0.88	0.56	0.59	1.46	1.29
Hypotaurine	ME746469	0.78	1.03	0.76	0.88	0.86	1.22	1.03	1.41
L-Tyrosine	ME746501	0.76	0.88	0.56	0.89	1.25	1.35	0.94	1.17
1-Methylnicotinamide	ME746395	0.89	0.83	1.32	0.64	1.04	0.88	1.33	1.11
L-Methionine	ME746494	0.78	0.86	1.25	0.90	0.90	0.82	1.35	1.23
L-Kynurenine	ME746490	0.95	0.88	1.55	0.56	0.87	0.99	1.24	1.00
L-Homoserine	ME746488	0.93	0.94	1.46	0.88	0.81	0.89	1.14	1.05
L-Proline	ME746497	0.77	0.94	1.45	0.79	0.95	0.92	1.07	1.16
Betaine	ME746418	0.79	0.82	1.12	1.12	1.03	1.04	0.93	1.15
L-Cystathionine	ME746483	0.71	0.81	1.39	0.90	0.95	1.16	0.86	1.18
4-Trimethylammoniobutanoic acid	ME746402	0.77	0.76	1.12	1.08	0.98	1.00	1.34	0.95
Creatine	ME746430	0.91	0.94	0.96	0.82	1.08	1.14	1.07	1.00
L-Glutamine	ME746485	0.86	0.90	0.91	0.74	1.22	1.19	1.02	1.02
Galactonic acid	ME746453	0.80	0.77	1.13	0.79	1.08	1.16	1.17	1.03
Thymine	ME746548	0.89	0.83	1.17	0.87	0.96	1.17	1.10	0.96
Oxidized glutathione	ME746528	0.92	1.01	0.73	0.66	0.97	0.94	1.53	1.27
Glycerophosphocholine	ME746460	0.80	0.80	0.94	0.64	1.02	1.08	1.40	1.29
O-Phosphoethanolamine	ME746525	0.88	0.90	1.08	0.72	0.91	0.99	1.43	1.13
L-Aspartic acid	ME746481	1.22	0.88	0.77	0.81	0.84	0.99	1.33	1.22
L-Tryptophan	ME746500	1.14	0.95	0.95	0.75	0.79	0.86	1.47	1.21
Phosphocreatine	ME746532	1.01	0.87	0.91	0.99	0.95	0.85	1.31	1.17
Uric acid	ME746551	1.13	1.01	0.88	1.07	0.96	0.69	1.21	1.15
L-Phenylalanine	ME746495	0.95	1.02	1.03	0.79	0.80	0.84	1.34	1.34
L-Acetylcarnitine	ME746477	0.91	0.99	0.96	0.91	0.90	0.98	1.18	1.21
L-Lactic acid	ME746491	0.87	1.11	1.00	0.92	0.75	0.94	1.22	1.28
N-Acetyl-L-methionine	ME746507	0.98	1.16	0.84	0.83	1.26	1.13	0.99	0.68
D-Sedoheptulose 7-phosphate	ME746445	1.16	0.91	0.93	0.71	1.19	1.23	1.03	0.70
Nicotinamide ribotide	ME746524	1.28	0.90	0.91	0.70	1.12	1.06	1.09	0.90
Pyroglutamic acid	ME746538	1.21	1.17	0.97	0.93	0.91	1.13	0.79	0.89
Uracil	ME746549	1.08	1.05	1.14	1.05	0.90	0.98	0.95	0.88
L-Carnitine	ME746482	1.10	1.15	0.70	1.06	0.95	0.99	1.08	1.01
Succinic acid	ME746543	1.15	1.12	0.94	0.90	0.81	0.95	1.19	1.01
Argininosuccinic acid	ME746416	1.05	1.02	1.05	0.88	0.78	1.01	1.34	0.94
Cytosine	ME746435	1.09	1.06	1.05	0.90	0.80	0.93	1.27	0.99
L-Leucine	ME746492	1.04	1.26	0.85	0.87	0.90	0.85	1.26	1.05
L-Valine	ME746502	0.95	1.09	0.81	0.74	1.10	1.05	1.19	1.01
L-Alanine	ME746478	1.04	1.11	0.84	0.80	0.96	1.05	1.19	1.00
L-Isoleucine	ME746489	1.01	1.18	0.89	0.80	1.00	0.95	1.22	0.96
Niacinamide	ME746522	1.15	1.13	1.05	0.79	0.91	1.07	1.09	0.83
Choline	ME746424	1.14	1.07	0.93	0.73	0.87	1.14	1.14	0.98
Uridine	ME746552	1.00	1.07	0.85	0.74	0.94	1.26	1.14	0.94
Coenzyme A	ME746429	1.12	1.01	0.65	0.67	0.69	1.33	1.47	1.04
Cyclic AMP	ME746432	0.83	0.86	0.70	0.60	0.93	1.28	1.60	1.13
Guanine	ME746463	1.51	0.97	0.63	0.65	0.99	0.96	1.53	0.77
Adenosine monophosphate	ME746409	0.98	0.95	0.87	0.69	1.10	1.04	1.45	0.88
Guanosine monophosphate	ME746466	1.16	0.99	1.01	0.65	0.89	0.91	1.67	0.77
1-Methyladenosine	ME746394	1.04	0.79	1.57	0.68	0.76	0.44	1.56	0.63
N-Acetyl-glucosamine 1-phosphate	ME746504	1.05	0.87	1.90	0.59	0.82	1.05	0.93	0.85
2-Hydroxyvaleric acid	ME746397	0.50	1.21	1.52	1.08	0.64	0.98	0.60	1.58
N-Acetylaspartylglutamic acid	ME746509	1.11	0.97	0.91	0.77	1.37	0.59	0.80	1.49
Palmitic acid	ME746530	1.23	0.87	1.33	0.89	0.83	0.66	0.60	1.76
Riboflavin	ME746540	0.85	0.96	1.32	NA	0.95	1.37	0.78	0.56
Xanthine	ME746560	0.78	0.64	0.33	0.47	1.79	2.24	0.62	0.45
ADP-glucose	ME746412	0.59	0.50	0.59	0.35	1.65	2.14	0.97	0.61
FAD	ME746450	0.58	0.56	0.44	0.30	1.59	2.25	1.10	0.57
N-Acetylornithine	ME746512	0.42	0.46	0.48	0.36	1.82	2.35	0.59	0.79
N-Formyl-L-methionine	ME746515	0.53	0.69	0.66	0.49	1.67	2.11	0.71	0.56
cis-Aconitic acid	ME746425	0.32	0.33	0.75	0.45	1.93	2.29	0.66	0.51
L-Glyceric acid	ME746486	0.46	0.47	0.73	0.50	1.90	2.06	0.61	0.60
L-Serine	ME746498	0.47	0.45	0.88	0.70	1.73	1.94	0.64	0.65
Orotic acid	ME746527	0.60	0.55	0.89	0.76	1.80	1.73	0.60	0.57
D-2-Hydroxyglutaric acid	ME746436	0.72	0.65	0.81	0.58	1.80	1.67	0.56	0.72
Fumaric acid	ME746452	0.67	0.65	0.62	0.60	1.71	1.82	0.74	0.67
Malic acid	ME746503	0.64	0.64	0.66	0.66	1.63	1.74	0.85	0.72
Pantothenic acid	ME746531	0.85	0.49	0.91	0.30	1.62	1.64	0.99	0.77
Thiamine monophosphate	ME746546	0.89	0.70	0.39	0.35	1.75	1.65	0.88	0.92
GDP-glucose	ME746454	0.67	0.65	0.54	0.37	1.68	1.70	1.16	0.76
L-Arginine	ME746479	0.67	0.75	0.55	0.54	1.52	1.75	1.06	0.74
NAD	ME746518	0.61	0.56	0.59	0.50	1.56	1.88	1.02	0.81
D-Glucose	ME746439	0.59	1.21	0.99	0.81	1.82	0.92	0.67	0.72
D-Fructose	ME746438	0.54	1.24	0.67	0.59	1.64	1.22	0.89	0.91
N-acetyltryptophan	ME746514	0.70	0.95	0.74	0.63	1.46	1.13	0.97	1.11
Ornithine	ME746526	0.75	0.70	0.82	0.60	1.68	1.09	1.01	1.08
D-Ribose	ME746442	1.20	0.85	0.79	0.78	1.25	1.51	0.91	0.45
S-Adenosylhomocysteine	ME746541	0.97	0.79	0.66	0.54	1.53	1.51	1.11	0.55
Creatinine	ME746431	0.78	0.96	1.09	0.72	1.07	1.49	0.83	0.88
Citrulline	ME746428	0.70	0.69	1.16	0.69	1.12	1.51	0.96	0.97
L-Asparagine	ME746480	0.77	0.73	0.95	0.78	1.14	1.51	0.98	0.93
N-Acetyl-L-aspartic acid	ME746506	0.93	0.88	0.73	0.56	1.43	1.49	0.87	0.81
L-Histidine	ME746487	0.75	0.87	0.86	0.70	1.41	1.42	0.86	0.85
N-Acetyl-L-alanine	ME746505	0.73	0.76	0.97	0.69	1.44	1.47	0.86	0.78
CDP-Ethanolamine	ME746423	0.66	0.78	0.95	0.56	1.44	1.56	0.85	0.87
L-Threonine	ME746499	0.69	0.69	0.95	0.66	1.41	1.63	0.86	0.77
L-Lysine	ME746493	0.69	0.63	0.76	0.52	1.44	1.49	1.19	0.98
N-Acetylglutamic acid	ME746510	0.83	0.81	1.07	0.60	1.29	1.28	1.11	0.82
Phosphorylcholine	ME746534	0.71	0.74	0.96	0.72	1.33	1.32	1.11	0.89
Glycerol 3-phosphate	ME746459	0.80	0.88	0.65	0.65	1.23	1.43	1.08	1.05
L-Glutamic acid	ME746484	0.83	0.77	0.82	0.69	1.22	1.37	1.16	0.93
Taurine	ME746544	0.81	0.83	0.84	0.68	1.27	1.38	1.02	0.96
Phosphoserine	ME746535	0.82	0.52	1.16	0.71	1.14	1.40	1.01	0.53
Thymidine	ME746547	0.93	0.65	1.22	0.68	1.12	1.39	1.13	0.71
Cytidine monophosphate	ME746434	0.58	0.66	1.27	0.57	1.38	1.32	1.10	0.89
Uridine 5^-monophosphate	ME746554	0.43	0.48	1.23	0.61	1.55	1.30	1.23	0.89
Aminoadipic acid	ME746415	0.59	0.53	1.21	0.62	1.52	1.50	0.99	0.69
Deoxyuridine	ME746449	0.73	0.45	1.25	0.54	1.28	1.55	1.18	0.75
2-Hydroxycaproic acid	ME746396	0.75	0.74	1.02	0.76	1.68	1.18	0.81	0.76
N-Acetylasparagine	ME746508	0.75	0.73	1.20	0.63	1.51	1.34	0.84	0.72
4-Hydroxyproline	ME746401	0.61	0.68	1.46	0.98	1.21	1.33	0.80	0.75
N6-Acetyl-L-lysine	ME746516	0.71	0.68	1.42	0.76	1.33	1.18	0.91	0.84
Acetyl-CoA	ME746405	1.08	0.83	0.85	0.73	0.86	1.69	1.01	0.76
Acetylcysteine	ME746406	0.41	0.53	0.94	0.55	1.16	1.96	1.05	1.03
Pyruvic acid	ME746539	0.69	0.69	0.75	0.64	1.19	2.10	0.76	0.75
Glutathione	ME746458	0.77	0.74	0.79	0.68	1.23	1.72	0.89	0.86
S-Adenosylmethionine	ME746542	0.75	0.76	0.69	0.61	1.17	1.82	1.12	0.75

Factors:

F1	Genotype:KIKO \| Treatment:KIKO_700 F
F2	Genotype:KIKO \| Treatment:KIKO_700 M
F3	Genotype:Mutant \| Treatment:G127V F
F4	Genotype:Mutant \| Treatment:G127V M
F5	Genotype:Mutant \| Treatment:YG8-800
F6	Genotype:Wild-type \| Treatment:Control
F7	Genotype:Wild-type \| Treatment:Control F
F8	Genotype:Wild-type \| Treatment:Control M

Data matrix