Clustering data with hclust algorithm for (Study ST002999)
(Analysis AN004926)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Citric acid | ME776654 | 2.20 | 0.16 | 0.11 | 0.90 | 0.10 | 0.10 | 0.94 | NA | 3.01 | 0.09 | 0.15 | 3.28 | 0.08 | 0.15 | 2.75 |
| Pyruvate | ME776660 | 0.69 | 1.07 | 0.72 | 1.55 | 0.17 | 0.12 | 0.74 | NA | 0.64 | 0.87 | 0.49 | 3.80 | 0.31 | 0.24 | 2.60 |
| Guanosine triphosphate (GTP) | ME776668 | 1.75 | 0.97 | 0.92 | 1.38 | 0.48 | 0.35 | 0.60 | NA | 1.34 | 1.20 | 1.23 | 1.55 | 0.70 | 0.63 | 0.89 |
| Succinic acid | ME776658 | 1.24 | 0.88 | 0.87 | 1.70 | 0.26 | 0.35 | 0.77 | NA | 1.46 | 0.89 | 1.04 | 2.17 | 0.48 | 0.52 | 1.36 |
| Adenosine triphosphate (ATP) | ME776662 | 0.95 | 1.05 | 1.22 | 1.82 | 0.65 | 0.62 | 0.61 | NA | 0.71 | 1.36 | 1.44 | 1.18 | 0.84 | 0.83 | 0.72 |
| L-Glutamate | ME776655 | 0.49 | 1.53 | 0.99 | 1.67 | 0.81 | 0.47 | 0.77 | NA | 0.41 | 1.63 | 1.12 | 1.85 | 0.72 | 0.47 | 1.06 |
| L-Lactic acid | ME776663 | 1.24 | 0.57 | 1.75 | 1.44 | 0.18 | 0.32 | 0.28 | NA | 1.31 | 0.63 | 2.23 | 2.43 | 0.25 | 0.76 | 0.62 |
| D-Glyceraldehyde 3-phosphate | ME776665 | 1.37 | 0.58 | 0.76 | 0.80 | 0.80 | 0.50 | 0.11 | NA | 1.46 | 1.30 | 1.56 | 1.68 | 1.49 | 1.13 | 0.46 |
| D-Glycerate 3-phosphate | ME776666 | 1.24 | 0.24 | 1.00 | 0.88 | 0.48 | 0.58 | 0.51 | NA | 1.34 | 0.74 | 2.00 | 1.93 | 0.89 | 1.15 | 1.01 |
| L-Malic acid | ME776657 | 0.76 | 0.30 | 0.87 | 2.54 | 0.26 | 0.47 | 0.00 | NA | 1.38 | 0.85 | 1.10 | 2.48 | 0.48 | 0.76 | 1.73 |
| Fumaric acid | ME776656 | 1.31 | 0.14 | 0.72 | 2.36 | 0.20 | 0.32 | 1.81 | NA | 1.03 | 0.70 | 0.92 | 1.73 | 0.40 | 0.63 | 1.73 |
| L-Serine | ME776664 | 1.56 | 0.39 | 0.33 | 1.77 | 0.45 | 0.59 | 1.53 | NA | 1.48 | 0.51 | 0.19 | 2.12 | 0.32 | 0.33 | 2.42 |
| Oxoglutaric acid | ME776659 | 0.19 | 1.43 | 0.77 | 1.96 | 1.13 | 0.73 | 2.38 | NA | 0.18 | 1.36 | 0.83 | 0.46 | 0.65 | 0.64 | 1.30 |
| D-Glucose 6-phosphate | ME776667 | NA | 0.96 | 0.58 | NA | 0.99 | 0.54 | NA | NA | NA | 1.74 | 0.91 | NA | 1.50 | 0.79 | NA |
| Uridine triphosphate (UTP) | ME776661 | 0.47 | 1.69 | 1.58 | 1.50 | 0.72 | 0.66 | 0.23 | NA | 0.35 | 2.12 | 1.73 | 0.40 | 1.05 | 0.95 | 0.30 |
Factors:
| F1 | Genotype:Empty vector | Treatment:CB-839 | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F2 | Genotype:Empty vector | Treatment:DMSO | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F3 | Genotype:Empty vector | Treatment:DMSO | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F4 | Genotype:Empty vector | Treatment:DMSO | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F5 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F6 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F7 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F8 | Genotype:NA | Treatment:NA | Timepoint:NA | Tracer:NA |
| F9 | Genotype:NRF2 overexpression | Treatment:CB-839 | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F10 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F11 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F12 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F13 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F14 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F15 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:8 hours | Tracer:U-C13 Glutamine |
