Clustering data with hclust algorithm for (Study ST003031)
HILIC NEGATIVE ION MODE (Analysis AN004968)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| GLYCOCHOLATE | ME781629 | 0.33 | 0.93 | 1.99 | 0.30 | 1.16 | 1.16 |
| 2_HYDROXYPHENYLACETIC ACID | ME781602 | 0.65 | 0.97 | 0.82 | 0.70 | 2.06 | 0.77 |
| D_GLUCURONIC ACID | ME781596 | 0.99 | 0.82 | 1.48 | 0.79 | 0.97 | 0.97 |
| URACIL | ME781594 | 1.11 | 0.96 | 0.83 | 1.39 | 0.90 | 0.78 |
| XANTHINE | ME781620 | 1.20 | 0.94 | 0.82 | 1.22 | 1.03 | 0.76 |
| N_ACETYL_L_LEUCINE | ME781647 | 1.26 | 1.04 | 0.89 | 0.95 | 0.99 | 0.88 |
| THEOPHYLLINE | ME781623 | 1.29 | 0.98 | 1.05 | 0.96 | 0.85 | 0.89 |
| N_PAI_METHYL_L_HISTIDINE | ME781614 | 1.14 | 0.93 | 0.84 | 1.13 | 0.98 | 0.97 |
| HYPOTAURINE | ME781633 | 1.24 | 0.92 | 1.02 | 1.04 | 1.01 | 0.78 |
| THIOPURINE S_METHYLETHER | ME781646 | 1.16 | 0.88 | 0.95 | 1.12 | 1.04 | 0.84 |
| SHIKIMATE | ME781593 | 0.83 | 0.82 | 0.90 | 1.24 | 1.02 | 1.15 |
| CREATINE | ME781637 | 0.96 | 1.13 | 1.09 | 0.80 | 1.14 | 0.91 |
| L_ASPARAGINE | ME781622 | 0.82 | 1.15 | 1.09 | 0.76 | 1.17 | 1.03 |
| L_TYROSINE | ME781638 | 0.66 | 1.08 | 1.11 | 0.88 | 1.15 | 1.13 |
| L_THREONINE | ME781634 | 0.75 | 1.11 | 1.14 | 0.85 | 1.11 | 1.06 |
| L_GLUTAMINE | ME781617 | 0.80 | 1.05 | 1.12 | 0.87 | 1.08 | 1.09 |
| N_ACETYL_D_GLUCOSAMINE | ME781588 | 0.81 | 1.04 | 1.08 | 0.89 | 1.05 | 1.13 |
| L_ARGININE | ME781642 | 0.87 | 0.94 | 1.24 | 0.74 | 1.17 | 1.06 |
| NALPHA_ACETYL_L_LYSINE | ME781624 | 0.91 | 1.02 | 1.16 | 0.81 | 1.06 | 1.06 |
| SUBERIC ACID | ME781608 | 0.88 | 1.04 | 1.18 | 0.76 | 1.07 | 1.11 |
| CITRATE | ME781585 | 0.81 | 1.11 | 1.28 | 0.86 | 0.98 | 0.99 |
| GLUCONIC ACID | ME781589 | 0.78 | 1.00 | 1.42 | 0.72 | 1.00 | 1.11 |
| N_METHYL_L_GLUTAMATE | ME781653 | 0.94 | 1.09 | 0.98 | 0.94 | 1.22 | 0.83 |
| N_ACETYL_DL_METHIONINE | ME781625 | 0.96 | 0.94 | 1.01 | 0.90 | 1.21 | 0.99 |
| HOMOGENTISATE | ME781609 | 0.83 | 1.08 | 1.06 | 0.95 | 1.09 | 1.00 |
| MALEIC ACID | ME781600 | 0.88 | 1.07 | 1.02 | 0.96 | 1.11 | 0.97 |
| 4_ACETAMIDOBUTANOATE | ME781651 | 0.86 | 1.04 | 1.01 | 0.98 | 1.17 | 0.94 |
| L_METHIONINE | ME781636 | 0.90 | 1.01 | 1.02 | 0.93 | 1.14 | 0.99 |
| 2_METHYLMALEATE | ME781606 | 0.92 | 1.01 | 0.98 | 1.02 | 1.08 | 0.99 |
| S_DIHYDROOROTATE | ME781591 | 0.97 | 1.01 | 1.05 | 1.01 | 1.06 | 0.92 |
| 4_HYDROXY_2_QUINOLINECARBOXYLIC_ACID | ME781628 | 1.08 | 0.94 | 1.06 | 0.94 | 1.06 | 0.92 |
| KYNURENINE | ME781640 | 1.07 | 0.99 | 1.03 | 0.99 | 1.05 | 0.88 |
| L_SERINE | ME781618 | 0.91 | 1.02 | 1.16 | 0.97 | 1.04 | 0.91 |
| MANNITOL | ME781631 | 0.95 | 1.04 | 1.10 | 0.93 | 1.02 | 0.97 |
| 5_OXO_L_PROLINE | ME781641 | 0.97 | 0.96 | 1.12 | 0.85 | 1.14 | 0.99 |
| L_HISTIDINE | ME781649 | 1.02 | 0.98 | 1.17 | 0.87 | 1.03 | 0.96 |
| 3_4_HYDROXYPHENYL_LACTATE | ME781610 | 0.94 | 0.99 | 0.98 | 0.88 | 1.06 | 1.15 |
| D_PANTOTHENIC ACID | ME781626 | 0.91 | 0.90 | 0.93 | 0.97 | 1.11 | 1.17 |
| 2_5_DIHYDROXYBENZOATE | ME781605 | 1.04 | 0.82 | 0.99 | 1.07 | 1.12 | 0.95 |
| 10_HYDROXYDECANOATE | ME781603 | 1.01 | 0.90 | 1.00 | 1.15 | 0.86 | 1.05 |
| 4_HYDROXY_L_PROLINE | ME781643 | 0.98 | 0.99 | 0.94 | 1.05 | 0.98 | 1.05 |
| 5_HYDROXYINDOLEACETATE | ME781648 | 0.98 | 1.08 | 0.93 | 1.05 | 0.97 | 0.98 |
| ITACONATE | ME781607 | 0.84 | 0.98 | 1.01 | 1.11 | 0.99 | 1.04 |
| TAURINE | ME781635 | 0.95 | 0.88 | 0.94 | 1.13 | 0.99 | 1.09 |
| D_TRYPTOPHAN | ME781639 | 0.92 | 0.90 | 1.02 | 1.05 | 1.02 | 1.08 |
| XANTHURENIC ACID | ME781627 | 0.99 | 0.90 | 1.05 | 1.03 | 1.03 | 0.99 |
| QUINATE | ME781590 | 1.05 | 0.87 | 1.15 | 0.74 | 1.16 | 1.05 |
| D_+_GALACTURONIC ACID | ME781599 | 1.03 | 0.98 | 1.23 | 0.70 | 0.88 | 1.21 |
| D_SORBITOL | ME781632 | 0.97 | 0.93 | 1.26 | 0.80 | 0.95 | 1.12 |
| URATE | ME781613 | 1.13 | 0.91 | 1.06 | 0.93 | 0.94 | 1.04 |
| L_GLUTAMIC ACID | ME781587 | 0.95 | 0.79 | 1.22 | 0.91 | 1.02 | 1.11 |
| MYO_INOSITOL | ME781616 | 0.99 | 0.99 | 1.18 | 0.94 | 0.85 | 1.07 |
| 3_HYDROXY_3_METHYLGLUTARATE | ME781652 | 0.99 | 0.89 | 1.23 | 0.96 | 0.84 | 1.10 |
| SUM_Glucose_Fructose_Galactose | ME781611 | 0.96 | 0.91 | 1.22 | 0.93 | 0.90 | 1.09 |
| CITRULLINE | ME781619 | 0.98 | 0.89 | 1.09 | 0.98 | 0.96 | 1.10 |
| MELIBIOSE | ME781612 | 0.93 | 0.92 | 1.18 | 0.94 | 0.97 | 1.07 |
| OPHTHALMIC ACID | ME781644 | 0.78 | 1.25 | 1.13 | 0.73 | 1.29 | 0.83 |
| L_ASPARTATE | ME781650 | 0.82 | 1.09 | 0.87 | 0.92 | 1.41 | 0.86 |
| R_MALATE | ME781595 | 0.81 | 1.08 | 0.97 | 0.85 | 1.27 | 1.03 |
| ALPHA_KETOGLUTARIC ACID | ME781630 | 0.78 | 1.06 | 0.92 | 0.95 | 1.32 | 0.96 |
| MANDELIC ACID | ME781601 | 0.81 | 0.96 | 0.94 | 1.01 | 1.28 | 0.98 |
| 2_QUINOLINECARBOXYLIC ACID | ME781604 | 0.89 | 1.22 | 0.86 | 0.80 | 1.10 | 1.15 |
| L_TRYPTOPHANAMIDE | ME781645 | 0.89 | 1.13 | 0.86 | 0.71 | 1.28 | 1.15 |
| BIOTIN | ME781615 | 1.66 | 0.69 | 0.72 | 1.52 | 0.74 | 0.64 |
| URIDINE | ME781621 | 1.64 | 0.72 | 0.70 | 1.55 | 0.75 | 0.61 |
| N_ACETYLNEURAMINATE | ME781586 | 1.35 | 0.79 | 1.26 | 1.08 | 0.66 | 0.88 |
| 3_HYDROXYBUTANOIC ACID | ME781598 | 1.63 | 0.45 | 1.35 | 1.20 | 0.37 | 1.01 |
| HYDROXYPYRUVATE | ME781597 | 1.58 | 0.47 | 1.29 | 1.13 | 0.51 | 1.03 |
| MALONATE | ME781592 | 1.62 | 0.40 | 1.37 | 1.13 | 0.51 | 0.99 |
Factors:
| F1 | Treatment Group:DP1 | Timepoint:Fasting |
| F2 | Treatment Group:DP1 | Timepoint:Hour 2 |
| F3 | Treatment Group:DP1 | Timepoint:Hour 4 |
| F4 | Treatment Group:DP2 | Timepoint:Fasting |
| F5 | Treatment Group:DP2 | Timepoint:Hour 2 |
| F6 | Treatment Group:DP2 | Timepoint:Hour 4 |
