Clustering data with hclust algorithm for (Study ST003274)
HILIC NEGATIVE ION MODE (Analysis AN005361)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Xanthosine | ME858566 | 1.13 | 1.02 | 1.18 | 0.99 | 1.06 | 0.88 | 1.03 | 0.99 | 0.95 | 0.95 |
| Glutarylcarnitine | ME858525 | 1.00 | 0.98 | 1.09 | 1.02 | 1.03 | 0.97 | 1.02 | 0.91 | 1.11 | 0.97 |
| Mevalonate | ME858540 | 1.01 | 1.01 | 1.12 | 1.01 | 1.00 | 0.99 | 1.01 | 0.92 | 0.98 | 1.00 |
| Glucose | ME858523 | 1.01 | 1.02 | 0.91 | 1.04 | 0.95 | 0.94 | 1.02 | 1.06 | 1.00 | 1.00 |
| Deoxycholate | ME858517 | 0.99 | 1.00 | 0.84 | 1.01 | 1.02 | 1.01 | 1.01 | 1.01 | 0.95 | 1.00 |
| Glyceraldehyde | ME858527 | 0.98 | 1.06 | 0.87 | 1.01 | 1.00 | 1.00 | 0.96 | 1.05 | 0.99 | 0.97 |
| Ascorbate | ME858511 | 0.98 | 0.95 | 1.12 | 0.97 | 0.98 | 1.03 | 0.97 | 1.00 | 1.04 | 1.06 |
| 3-Hydroxykynurenine | ME858501 | 1.00 | 1.04 | 0.95 | 1.02 | 0.97 | 1.05 | 0.93 | 0.98 | 0.98 | 0.97 |
| Nicotinate | ME858545 | 1.02 | 0.97 | 0.91 | 0.99 | 1.03 | 1.00 | 0.96 | 0.97 | 1.05 | 1.02 |
| Biotin | ME858512 | 0.96 | 0.96 | 0.93 | 1.02 | 1.03 | 1.02 | 1.00 | 1.01 | 1.01 | 1.02 |
| Uridine diphosphate-N-acetylglucosamine | ME858565 | 0.97 | 0.98 | 0.93 | 0.99 | 1.01 | 1.02 | 1.01 | 1.00 | 1.08 | 1.00 |
| Taurodeoxycholate | ME858559 | 0.98 | 0.96 | 1.01 | 0.99 | 1.04 | 1.05 | 0.94 | 0.99 | 0.96 | 1.03 |
| 3-Methyl-2-oxobutyrate | ME858502 | 1.00 | 1.00 | 0.98 | 1.02 | 0.97 | 0.97 | 1.00 | 1.00 | 1.05 | 1.00 |
| Phenyllactic acid | ME858549 | 1.01 | 1.06 | 0.97 | 1.00 | 0.97 | 0.96 | 1.02 | 0.98 | 1.00 | 0.99 |
| S-adenosyl-L-homocysteine | ME858557 | 1.01 | 1.03 | 0.97 | 0.98 | 0.98 | 0.98 | 1.00 | 1.03 | 1.01 | 1.00 |
| Thymidine | ME858561 | 1.01 | 1.02 | 0.97 | 1.00 | 0.98 | 0.97 | 1.00 | 1.02 | 1.00 | 1.01 |
| N-Carbamoyl-L-aspartate | ME858542 | 1.00 | 1.00 | 1.02 | 1.02 | 1.01 | 1.02 | 0.98 | 0.95 | 1.00 | 0.98 |
| Fructose 1,6-bisphosphate | ME858520 | 0.98 | 0.97 | 0.98 | 1.02 | 1.02 | 1.01 | 0.98 | 1.01 | 1.02 | 0.99 |
| Uracil | ME858562 | 1.01 | 0.97 | 0.96 | 1.01 | 1.00 | 1.01 | 0.97 | 1.00 | 0.99 | 1.01 |
| Nicotinamide adenine dinucleotide phosphate | ME858544 | 1.02 | 1.02 | 1.02 | 0.98 | 0.99 | 1.00 | 1.02 | 0.97 | 1.01 | 0.99 |
| Oxaloacetate | ME858546 | 1.01 | 1.02 | 0.98 | 0.97 | 1.01 | 0.99 | 1.02 | 0.98 | 0.99 | 1.01 |
| Acetyl-CoA | ME858505 | 1.03 | 0.97 | 1.02 | 0.98 | 0.97 | 1.01 | 0.99 | 1.01 | 1.02 | 1.02 |
| Cholesterol sulfate | ME858513 | 1.00 | 0.97 | 1.02 | 0.99 | 1.02 | 1.00 | 0.99 | 1.01 | 1.02 | 1.01 |
| Kynurenine | ME858534 | 1.00 | 0.98 | 1.01 | 0.98 | 0.99 | 1.00 | 1.01 | 1.04 | 1.01 | 1.01 |
| Uridine 5^-diphosphate | ME858564 | 1.02 | 0.98 | 1.02 | 1.00 | 0.99 | 1.00 | 0.99 | 1.02 | 0.99 | 1.00 |
| Glyceraldehyde 3-phosphate | ME858528 | 0.98 | 0.99 | 1.03 | 1.01 | 1.01 | 1.00 | 1.00 | 1.02 | 0.98 | 1.01 |
| Lactulose | ME858536 | 1.00 | 1.00 | 1.04 | 1.01 | 1.01 | 1.00 | 0.98 | 1.02 | 1.00 | 0.98 |
| Fumarate | ME858522 | 1.00 | 1.00 | 0.97 | 1.01 | 1.01 | 1.01 | 1.00 | 1.00 | 0.97 | 0.99 |
| 2-Ketohexanoate | ME858499 | 1.00 | 1.00 | 0.95 | 1.01 | 1.00 | 1.00 | 0.98 | 1.01 | 0.99 | 1.00 |
| 2-Hydroxyglutarate | ME858497 | 0.99 | 1.00 | 0.97 | 1.01 | 1.01 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 |
| 3-Phosphoglycerate | ME858503 | 0.99 | 0.99 | 0.97 | 1.01 | 1.01 | 1.00 | 1.00 | 1.01 | 1.01 | 0.99 |
| Citraconate | ME858515 | 0.99 | 1.00 | 0.97 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 0.99 | 1.00 |
| Thiamine pyrophosphate | ME858560 | 1.00 | 1.00 | 0.97 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 |
| Pyroglutamate | ME858552 | 0.99 | 1.01 | 1.00 | 0.99 | 0.99 | 1.00 | 1.02 | 0.99 | 1.00 | 1.01 |
| Reduced nicotinamide adenine dinucleotide phosphate | ME858555 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 | 1.02 | 0.98 | 1.01 | 1.00 |
| Arginosuccinate | ME858510 | 0.98 | 1.01 | 0.99 | 1.01 | 1.00 | 0.99 | 1.00 | 1.00 | 1.01 | 1.01 |
| Hydroxyisocaproate | ME858531 | 1.00 | 1.01 | 0.99 | 0.99 | 0.99 | 0.98 | 1.00 | 1.01 | 1.01 | 1.01 |
| Adenosine triphosphate | ME858508 | 0.99 | 0.98 | 1.00 | 1.00 | 1.01 | 1.02 | 0.99 | 1.00 | 1.00 | 1.00 |
| p-aminobenzoate | ME858548 | 1.00 | 1.00 | 1.00 | 1.01 | 0.98 | 1.01 | 1.00 | 0.99 | 1.01 | 0.99 |
| Malate | ME858537 | 1.00 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 |
| Succinate | ME858558 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 1.01 | 1.00 |
| Saccharopine | ME858556 | 0.99 | 1.00 | 1.00 | 1.01 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Anthranilate | ME858509 | 1.00 | 0.99 | 1.00 | 1.01 | 0.99 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 |
| Inosine | ME858532 | 0.99 | 0.99 | 0.99 | 1.01 | 1.00 | 1.01 | 1.00 | 1.01 | 1.00 | 1.00 |
| Citrate | ME858516 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| 2-Aminoadipate | ME858495 | 1.00 | 1.01 | 1.01 | 0.99 | 1.00 | 0.99 | 1.01 | 1.00 | 0.99 | 1.00 |
| N-Acetyl-L-Alanine | ME858541 | 1.00 | 1.00 | 1.00 | 0.99 | 1.01 | 1.00 | 1.01 | 1.01 | 0.99 | 1.00 |
| 2-Hydroxy-2-methylbutyrate | ME858496 | 1.00 | 0.99 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 | 1.03 | 1.01 | 0.99 |
| Glucose 6-phosphate | ME858524 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.01 | 1.01 | 1.00 |
| 3-Hydroxybutyrate | ME858500 | 1.00 | 0.99 | 0.99 | 1.00 | 1.02 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 |
| Malonate | ME858538 | 1.00 | 0.99 | 0.99 | 1.00 | 1.01 | 1.00 | 1.00 | 1.02 | 1.00 | 0.99 |
| Urate | ME858563 | 1.00 | 0.99 | 0.98 | 1.00 | 1.00 | 1.00 | 1.01 | 1.01 | 1.00 | 1.00 |
| Erythrose 4-phosphate | ME858518 | 1.00 | 0.98 | 0.98 | 0.99 | 1.01 | 1.00 | 1.00 | 1.02 | 1.01 | 1.00 |
| Fructose 6-phosphate | ME858521 | 1.00 | 0.99 | 0.99 | 0.99 | 1.00 | 1.00 | 1.00 | 1.02 | 1.00 | 1.00 |
| Adenosine monophosphate | ME858507 | 1.00 | 0.98 | 1.02 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 |
| Flavin Mononucleotide | ME858519 | 1.01 | 0.99 | 1.02 | 1.01 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 | 0.99 |
| 3-Ureidopropionate | ME858504 | 1.00 | 1.00 | 1.04 | 1.00 | 1.00 | 1.00 | 0.99 | 0.99 | 1.00 | 1.00 |
| Nicotinamide adenine dinucleotide | ME858543 | 0.99 | 0.99 | 1.04 | 1.00 | 0.99 | 1.01 | 1.01 | 0.98 | 1.00 | 1.01 |
| Adenosine diphosphate | ME858506 | 1.00 | 0.98 | 1.02 | 1.01 | 1.01 | 1.01 | 1.00 | 0.98 | 0.99 | 1.00 |
| Glutathione | ME858526 | 0.99 | 1.00 | 1.02 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.01 |
| cis-Aconitic acid | ME858514 | 1.00 | 1.01 | 1.02 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 | 0.99 |
| Isocitrate | ME858533 | 0.99 | 1.00 | 1.01 | 1.00 | 1.01 | 1.01 | 1.00 | 0.98 | 0.99 | 1.00 |
| Oxidized glutathione | ME858547 | 1.00 | 1.02 | 1.00 | 1.01 | 0.99 | 0.99 | 1.00 | 0.99 | 0.99 | 0.99 |
| Phosphoenolpyruvate | ME858550 | 1.00 | 1.02 | 1.00 | 1.00 | 1.01 | 0.99 | 1.00 | 0.98 | 0.98 | 1.00 |
| Reduced nicotinamide Adenine Dinucleotide | ME858554 | 1.00 | 1.01 | 1.03 | 0.99 | 0.98 | 1.01 | 1.01 | 1.00 | 0.99 | 1.00 |
| Guanidoacetate | ME858529 | 1.02 | 1.01 | 1.03 | 0.99 | 0.98 | 0.98 | 0.99 | 0.99 | 0.99 | 1.01 |
| Lactate | ME858535 | 1.01 | 1.01 | 1.02 | 1.00 | 0.99 | 0.99 | 0.99 | 1.00 | 1.00 | 1.00 |
| Pyrophosphate | ME858553 | 1.01 | 1.02 | 1.02 | 0.99 | 1.00 | 0.99 | 1.00 | 1.00 | 0.99 | 0.99 |
| Homocysteate | ME858530 | 1.02 | 0.99 | 1.09 | 1.02 | 0.99 | 1.00 | 0.95 | 1.03 | 0.98 | 0.99 |
| Malonyl-coenzyme A | ME858539 | 1.03 | 0.97 | 1.08 | 0.99 | 0.97 | 1.02 | 0.99 | 1.00 | 1.00 | 1.02 |
| Prephenate | ME858551 | 1.02 | 0.97 | 1.06 | 0.99 | 0.96 | 1.02 | 0.98 | 1.01 | 1.02 | 1.02 |
| 2-Isopropylmalate | ME858498 | 1.00 | 0.97 | 1.07 | 0.99 | 1.01 | 1.01 | 1.00 | 0.97 | 1.03 | 1.02 |
| Xanthurenate | ME858567 | 1.00 | 0.96 | 1.06 | 1.01 | 1.00 | 1.01 | 1.00 | 1.01 | 1.01 | 1.01 |
Factors:
| F1 | Condition:Donor | Sex:F |
| F2 | Condition:Donor | Sex:M |
| F3 | Condition:ICM-DM | Sex:F |
| F4 | Condition:ICM-DM | Sex:M |
| F5 | Condition:ICM-No DM | Sex:F |
| F6 | Condition:ICM-No DM | Sex:M |
| F7 | Condition:NICM-DM | Sex:F |
| F8 | Condition:NICM-DM | Sex:M |
| F9 | Condition:NICM-No DM | Sex:F |
| F10 | Condition:NICM-No DM | Sex:M |
