Clustering data with hclust algorithm for (Study ST003286)
(Analysis AN005383)Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyruvate | ME862323 | 2.93 | 1.10 | 0.68 | 2.00 | 1.22 | 0.98 | 3.34 | 1.19 | 2.10 | 0.19 | 0.66 | 1.33 | 0.38 | 1.57 | 1.48 | 0.30 | 1.42 | 1.45 | 0.17 | 0.16 | 0.19 | 0.37 | 0.39 | 0.32 | 0.40 | 0.34 | 0.34 |
Aspartate | ME862305 | 1.64 | 1.46 | 0.92 | 3.05 | 1.31 | 2.43 | 2.11 | 2.10 | 2.13 | 0.38 | 0.20 | 0.38 | 0.57 | 0.72 | 0.93 | 1.17 | 0.76 | 0.79 | 0.47 | 0.44 | 0.30 | 0.65 | 0.42 | 0.41 | 0.40 | 0.49 | 0.35 |
Choline | ME862306 | 1.96 | 2.35 | 1.78 | 2.23 | 2.54 | 1.60 | 1.84 | 1.78 | 1.37 | 0.25 | 0.24 | 0.29 | 0.64 | 0.34 | 0.36 | 0.57 | 0.27 | 0.56 | 0.59 | 0.66 | 0.75 | 1.08 | 0.66 | 0.57 | 0.56 | 0.58 | 0.60 |
Fumarate | ME862309 | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.78 | 0.78 | 1.69 | 1.20 | 0.90 | 0.64 | 0.31 | 0.83 | 0.42 | 1.39 | 1.36 | 1.31 | 0.86 | 1.00 | 1.11 | 1.24 | 1.20 | 1.00 |
Serine | ME862324 | 0.57 | 0.54 | 0.45 | 1.33 | 0.95 | 1.30 | 1.16 | 1.32 | 1.26 | 0.49 | 0.17 | 0.22 | 1.13 | 0.39 | 0.52 | 1.08 | 0.26 | 1.57 | 1.55 | 1.43 | 1.39 | 1.36 | 2.31 | 0.64 | 0.77 | 1.14 | 1.69 |
Threonine | ME862325 | 0.54 | 0.95 | 0.59 | 1.15 | 1.20 | 0.59 | 0.84 | 0.78 | 1.01 | 0.64 | 0.28 | 0.69 | 1.44 | 0.19 | 0.33 | 2.16 | 0.18 | 0.35 | 1.65 | 1.42 | 1.58 | 1.55 | 1.11 | 1.32 | 1.66 | 1.48 | 1.30 |
Glycine | ME862313 | 0.72 | 0.88 | 0.65 | 1.91 | 1.60 | 1.59 | 1.27 | 1.34 | 1.37 | 0.62 | 0.30 | 1.08 | 1.89 | 0.30 | 0.73 | 1.66 | 0.82 | 1.05 | 0.49 | 0.65 | 0.56 | 0.89 | 0.48 | 0.61 | 0.67 | 1.57 | 1.31 |
Glutamate | ME862311 | 0.46 | 0.53 | 0.52 | 1.27 | 1.56 | 1.41 | 1.15 | 1.11 | 0.60 | 0.84 | 0.76 | 1.55 | 1.00 | 1.42 | 1.87 | 1.17 | 1.36 | 0.88 | 0.82 | 0.86 | 0.90 | 0.95 | 1.06 | 0.79 | 0.61 | 0.66 | 0.88 |
Arginine | ME862304 | 0.79 | 1.80 | 0.72 | 1.10 | 1.44 | 1.23 | 1.44 | 1.58 | 0.94 | 0.36 | 0.32 | 0.49 | 1.36 | 1.08 | 1.32 | 1.22 | 1.28 | 0.73 | 0.93 | 0.83 | 0.83 | 0.93 | 0.99 | 0.82 | 1.03 | 0.78 | 0.66 |
Cystine | ME862307 | 1.25 | 1.29 | 1.19 | 1.45 | 1.00 | 1.10 | 1.58 | 1.03 | 1.08 | 0.72 | 0.48 | 1.32 | 1.35 | 0.74 | 1.39 | 1.48 | 0.71 | 0.93 | 0.73 | 0.83 | 0.69 | 0.87 | 0.99 | 0.65 | 0.69 | 0.62 | 0.84 |
Methionine | ME862319 | 2.14 | 1.84 | 0.38 | 0.97 | 1.12 | 0.84 | 0.63 | 0.85 | 0.78 | 0.84 | 0.79 | 1.09 | 0.83 | 0.81 | 0.82 | 1.37 | 0.93 | 0.94 | 1.25 | 0.96 | 1.01 | 1.10 | 1.01 | 0.81 | 1.07 | 0.96 | 0.84 |
myo-Inositol | ME862329 | 0.87 | 1.35 | 0.85 | 0.59 | 1.03 | 1.04 | 1.04 | 1.16 | 1.06 | 0.94 | 0.40 | 0.73 | 1.08 | 0.61 | 0.75 | 0.70 | 0.53 | 0.60 | 1.45 | 1.50 | 0.98 | 1.31 | 1.22 | 1.20 | 1.16 | 1.24 | 1.62 |
Tryptophan | ME862326 | 0.98 | 1.28 | 0.71 | 0.95 | 1.15 | 0.65 | 0.90 | 0.65 | 0.71 | 1.49 | 1.45 | 1.13 | 0.85 | 0.89 | 0.80 | 1.08 | 0.71 | 0.88 | 1.07 | 0.96 | 1.36 | 1.04 | 1.24 | 1.00 | 1.03 | 1.16 | 0.88 |
Valine | ME862328 | 1.56 | 1.50 | 1.37 | 0.85 | 0.69 | 0.55 | 0.65 | 0.62 | 0.68 | 1.25 | 0.71 | 1.08 | 1.11 | 0.88 | 0.86 | 1.10 | 0.88 | 1.24 | 1.19 | 1.00 | 1.07 | 1.15 | 1.12 | 0.97 | 1.02 | 0.96 | 0.93 |
Glucose | ME862310 | 1.00 | 0.76 | 0.98 | 0.83 | 0.65 | 0.89 | 0.78 | 0.66 | 0.76 | 1.10 | 0.99 | 1.08 | 1.09 | 1.04 | 1.09 | 1.03 | 1.10 | 1.06 | 1.12 | 1.13 | 1.13 | 1.13 | 1.12 | 1.13 | 1.09 | 1.12 | 1.14 |
Phenylalanine | ME862321 | 0.80 | 1.37 | 1.12 | 0.98 | 1.07 | 0.93 | 0.73 | 0.92 | 0.70 | 1.12 | 0.84 | 1.05 | 0.96 | 0.93 | 1.03 | 1.25 | 0.90 | 1.19 | 1.13 | 1.04 | 1.05 | 1.08 | 1.09 | 0.91 | 0.96 | 0.83 | 1.02 |
Glutamine | ME862312 | 0.54 | 0.32 | 0.22 | 0.95 | 0.26 | 0.39 | 1.13 | 0.53 | 1.05 | 1.39 | 1.39 | 0.98 | 1.26 | 0.95 | 1.22 | 1.36 | 1.05 | 1.33 | 1.23 | 1.20 | 1.15 | 1.22 | 1.27 | 1.07 | 1.05 | 1.21 | 1.27 |
Nicotinurate | ME862320 | 0.56 | 0.70 | 0.26 | 0.90 | 0.54 | 0.91 | 0.63 | 0.73 | 0.48 | 1.63 | 0.94 | 1.51 | 1.09 | 1.15 | 1.46 | 1.21 | 1.03 | 1.19 | 1.12 | 1.28 | 1.10 | 1.25 | 1.17 | 1.08 | 1.02 | 1.10 | 0.95 |
Lysine | ME862318 | 0.42 | 0.46 | 0.54 | 0.85 | 0.73 | 0.56 | 0.86 | 1.12 | 0.74 | 1.03 | 0.78 | 0.86 | 1.10 | 0.92 | 1.27 | 1.37 | 1.08 | 0.81 | 1.43 | 1.31 | 1.30 | 1.21 | 1.23 | 1.20 | 1.27 | 1.37 | 1.20 |
Histidine | ME862314 | 0.73 | 0.67 | 0.63 | 0.52 | 0.73 | 0.56 | 0.70 | 0.66 | 0.63 | 0.94 | 0.62 | 1.31 | 1.18 | 0.99 | 1.22 | 1.40 | 1.19 | 1.38 | 1.31 | 0.98 | 1.21 | 1.39 | 1.37 | 1.16 | 1.28 | 1.06 | 1.20 |
Isoleucine | ME862315 | 0.46 | 0.70 | 0.51 | 0.92 | 0.63 | 0.98 | 0.77 | 0.82 | 0.86 | 1.08 | 0.85 | 0.85 | 1.20 | 0.90 | 1.11 | 1.41 | 1.07 | 1.36 | 1.31 | 1.14 | 1.21 | 1.22 | 1.33 | 1.07 | 1.21 | 1.03 | 1.00 |
Pyroglutamate | ME862322 | 0.69 | 0.72 | 1.50 | 0.82 | 1.04 | 1.26 | 1.27 | 1.33 | 0.72 | 0.86 | 0.80 | 0.86 | 0.95 | 0.98 | 1.05 | 1.00 | 1.16 | 1.05 | 1.16 | 0.98 | 1.02 | 0.86 | 1.20 | 0.77 | 1.06 | 1.03 | 0.88 |
Tyrosine | ME862327 | 0.52 | 0.62 | 0.40 | 1.13 | 1.37 | 1.35 | 0.92 | 1.27 | 1.00 | 0.92 | 0.60 | 0.90 | 1.13 | 0.89 | 1.01 | 1.35 | 1.07 | 1.33 | 1.09 | 1.05 | 0.99 | 1.07 | 1.14 | 0.96 | 0.97 | 1.01 | 0.96 |
Alanine | ME862303 | 0.65 | 0.60 | 0.57 | 1.12 | 1.22 | 1.09 | 1.44 | 1.27 | 1.24 | 1.07 | 0.35 | 1.23 | 0.92 | 1.30 | 0.86 | 0.78 | 1.43 | 0.91 | 0.53 | 0.49 | 0.51 | 1.41 | 1.32 | 1.15 | 1.12 | 1.05 | 1.37 |
Leucine | ME862317 | 0.87 | 0.78 | 0.74 | 1.05 | 1.15 | 0.74 | 0.76 | 0.82 | 0.89 | 1.09 | 0.80 | 0.85 | 1.15 | 1.12 | 1.27 | 1.33 | 1.20 | 1.35 | 0.55 | 0.54 | 0.52 | 1.39 | 1.33 | 1.06 | 1.31 | 1.22 | 1.12 |
Formate | ME862308 | 0.33 | 0.66 | 0.41 | 0.76 | 3.79 | 0.57 | 0.37 | 0.47 | 0.56 | 2.71 | 0.56 | 1.64 | 0.65 | 1.94 | 2.09 | 1.15 | 2.19 | 1.99 | 0.52 | 0.40 | 0.48 | 0.44 | 0.55 | 0.43 | 0.46 | 0.41 | 0.46 |
Acetate | ME862302 | 0.37 | 0.76 | 0.72 | 0.63 | 2.37 | 2.38 | 1.03 | 2.53 | 1.97 | 0.24 | 0.53 | 1.74 | 0.45 | 2.17 | 1.94 | 0.82 | 2.92 | 1.27 | 0.08 | 0.07 | 0.10 | 0.32 | 0.31 | 0.25 | 0.30 | 0.34 | 0.38 |
Lactate | ME862316 | 0.31 | 0.44 | 0.29 | 0.72 | 1.88 | 1.72 | 0.84 | 1.23 | 0.93 | 0.51 | 0.55 | 0.62 | 0.95 | 2.54 | 2.52 | 0.75 | 2.52 | 0.65 | 0.78 | 0.75 | 0.76 | 0.79 | 0.85 | 0.79 | 0.78 | 0.73 | 0.80 |
Factors:
F1 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F2 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab |
F3 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment |
F4 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F5 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab |
F6 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment |
F7 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab |
F8 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab |
F9 | Sample source:Non-small cell lung cancer cells | Cell line:A549 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment |
F10 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F11 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab |
F12 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment |
F13 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F14 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab |
F15 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment |
F16 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab |
F17 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab |
F18 | Sample source:Non-small cell lung cancer cells | Cell line:H292 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment |
F19 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F20 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:Nivolumab |
F21 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Direct Co-culture | Immune checkpoint inhibitor:No treatment |
F22 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Ipilimumab |
F23 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:Nivolumab |
F24 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Indirect Co-culture | Immune checkpoint inhibitor:No treatment |
F25 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:Ipilimumab |
F26 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:Nivolumab |
F27 | Sample source:Non-small cell lung cancer cells | Cell line:PC-9 | Culture Type:Monoculture | Immune checkpoint inhibitor:No treatment |