Clustering data with hclust algorithm for (Study ST003457)
(Analysis AN005679)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 |
|---|---|---|---|---|---|---|---|---|
| N1-Methyl-2-pyridone-5-carboxamide | ME903453 | 2.80 | 1.21 | 0.47 | NA | 0.47 | 0.32 | 0.48 |
| AMP | ME903408 | 2.07 | 1.29 | 1.52 | NA | 0.33 | 0.34 | 0.44 |
| Guanosine monophosphate (GMP) | ME903417 | 2.43 | 1.06 | 2.04 | NA | 0.13 | 0.17 | 0.24 |
| IMP | ME903420 | 2.68 | 1.04 | 2.16 | NA | 0.02 | 0.10 | 0.06 |
| VLK | ME903484 | 1.22 | 0.32 | 1.55 | NA | 0.47 | 1.96 | 0.48 |
| 2-(2-amino-3-methylbutanamido)-3-phenylpropanoic acid | ME903464 | 0.49 | 1.23 | 1.38 | NA | 0.31 | 1.49 | 1.26 |
| tert-Butyl N-[1-(aminocarbonyl)-3-methylbutyl]carbamate | ME903482 | 0.60 | 1.09 | 1.19 | NA | 0.57 | 1.40 | 1.28 |
| LLK | ME903477 | 0.30 | 1.55 | 0.80 | NA | 0.37 | 1.27 | 1.88 |
| Leucylalanine | ME903424 | 0.23 | 1.40 | 1.48 | NA | 0.28 | 1.02 | 1.95 |
| Alanyltyrosine | ME903471 | 0.40 | 1.47 | 1.32 | NA | 0.40 | 1.01 | 1.63 |
| Aspartame | ME903472 | 0.30 | 1.53 | 1.30 | NA | 0.27 | 1.25 | 1.58 |
| L-Ergothioneine | ME903476 | 1.51 | 1.23 | 1.00 | NA | 0.93 | 0.35 | 0.97 |
| 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one | ME903470 | 1.38 | 0.77 | 1.58 | NA | 0.71 | 1.11 | 0.47 |
| Glucosamine/ Galactosamine | ME903444 | 1.59 | 0.71 | 1.47 | NA | 0.68 | 1.07 | 0.47 |
| Adenosine | ME903406 | 1.45 | 1.16 | 1.79 | NA | 0.44 | 0.63 | 0.64 |
| Guanosine | ME903447 | 1.46 | 0.91 | 1.54 | NA | 0.57 | 0.80 | 0.82 |
| Clomazone | ME903473 | 1.63 | 0.50 | 0.73 | NA | 0.78 | 1.14 | 1.22 |
| Purine | ME903457 | 0.55 | 1.74 | 0.65 | NA | 0.99 | 0.95 | 1.05 |
| Glycine | ME903446 | 1.13 | 1.16 | 0.72 | NA | 1.29 | 1.10 | 0.39 |
| Isovalerylcarnitine/ 2-Methylbutyroylcarnitine | ME903449 | 0.66 | 1.15 | 0.73 | NA | 0.77 | 1.51 | 1.15 |
| Riboflavin | ME903459 | 0.64 | 0.79 | 0.69 | NA | 1.07 | 1.83 | 0.87 |
| 3-Methylhistidine | ME903404 | 1.04 | 0.92 | 0.94 | NA | 0.83 | 1.42 | 0.78 |
| Propionylcarnitine | ME903429 | 0.53 | 0.87 | 1.32 | NA | 0.92 | 1.12 | 1.42 |
| Nicotinamide riboside | ME903455 | 0.91 | 1.19 | 0.98 | NA | 0.73 | 1.15 | 1.06 |
| 4,4^-dimethoxy[1,1^-biphenyl]-2-carbonitrile | ME903469 | 0.59 | 1.25 | 0.99 | NA | 0.74 | 1.28 | 1.20 |
| Ecgonine | ME903474 | 0.65 | 1.20 | 1.17 | NA | 0.76 | 1.08 | 1.22 |
| Leucine | ME903423 | 0.69 | 1.10 | 1.11 | NA | 0.79 | 1.17 | 1.22 |
| Tiglic acid | ME903483 | 0.74 | 1.15 | 1.09 | NA | 0.90 | 1.01 | 1.19 |
| Tryptophan | ME903434 | 0.69 | 1.16 | 1.20 | NA | 0.85 | 1.07 | 1.10 |
| Asparagine | ME903440 | 0.46 | 1.09 | 1.12 | NA | 1.01 | 1.20 | 1.20 |
| N-Acetylornithine | ME903454 | 0.70 | 0.84 | 1.00 | NA | 1.19 | 1.05 | 1.29 |
| Tyrosine | ME903462 | 0.71 | 0.97 | 1.19 | NA | 0.99 | 1.13 | 1.07 |
| Isoleucine | ME903422 | 0.71 | 0.99 | 1.03 | NA | 1.06 | 1.02 | 1.26 |
| Ketamine | ME903475 | 0.76 | 0.97 | 1.00 | NA | 0.98 | 1.13 | 1.22 |
| Methionine | ME903451 | 0.69 | 1.01 | 1.09 | NA | 0.95 | 1.08 | 1.26 |
| 1-Methyladenosine | ME903403 | 1.25 | 0.98 | 0.79 | NA | 1.15 | 0.88 | 0.87 |
| Anserine | ME903409 | 1.05 | 0.94 | 0.85 | NA | 1.13 | 1.05 | 0.92 |
| Deoxycytidine | ME903443 | 1.11 | 0.89 | 0.83 | NA | 1.12 | 1.09 | 0.89 |
| Cytidine | ME903415 | 1.19 | 1.06 | 0.84 | NA | 0.94 | 1.01 | 0.88 |
| Cytosine | ME903416 | 1.14 | 1.06 | 0.89 | NA | 0.94 | 1.02 | 0.89 |
| 2-Amino-3-methoxybenzoic acid | ME903467 | 1.20 | 0.83 | 0.96 | NA | 1.01 | 1.01 | 0.97 |
| Carnosine | ME903442 | 1.28 | 0.95 | 0.96 | NA | 0.98 | 0.94 | 0.84 |
| 2-Amino-4-methylpyrimidine | ME903468 | 1.10 | 1.04 | 1.00 | NA | 0.93 | 0.88 | 1.07 |
| Carnitine | ME903412 | 0.93 | 1.06 | 1.02 | NA | 0.96 | 0.99 | 1.04 |
| Pyroglutamic acid | ME903430 | 0.92 | 1.04 | 1.03 | NA | 0.96 | 1.06 | 1.01 |
| Choline | ME903413 | 0.75 | 1.10 | 1.00 | NA | 1.06 | 1.05 | 1.04 |
| Glutaric acid | ME903445 | 0.81 | 1.07 | 1.07 | NA | 1.01 | 1.04 | 1.02 |
| Xanthosine | ME903463 | 0.84 | 1.11 | 1.09 | NA | 1.01 | 0.99 | 0.98 |
| Thiamine | ME903432 | 0.97 | 0.91 | 0.92 | NA | 1.03 | 1.10 | 1.06 |
| Hypoxanthine | ME903419 | 0.93 | 1.01 | 0.87 | NA | 1.10 | 1.01 | 1.06 |
| 4-Guanidinobutyric acid | ME903437 | 0.97 | 0.99 | 0.94 | NA | 1.06 | 0.93 | 1.12 |
| 2,2,6,6-Tetramethyl-4-piperidinol | ME903465 | 0.97 | 1.07 | 0.94 | NA | 1.07 | 0.94 | 1.00 |
| Nicotine amide | ME903425 | 0.96 | 1.02 | 0.97 | NA | 1.06 | 0.96 | 1.03 |
| Prolylleucine_1 | ME903479 | 0.94 | 0.90 | 1.05 | NA | 1.09 | 0.99 | 1.07 |
| 2,6-Dimethylpyrazine | ME903466 | 0.97 | 0.94 | 1.00 | NA | 1.12 | 0.99 | 0.97 |
| Creatine | ME903414 | 0.99 | 0.97 | 0.98 | NA | 1.02 | 0.99 | 1.04 |
| Histidine | ME903418 | 1.04 | 0.98 | 0.94 | NA | 1.02 | 0.98 | 1.03 |
| Phosphocholine | ME903427 | 1.03 | 0.97 | 0.94 | NA | 1.03 | 0.99 | 1.02 |
| Prolylleucine_2 | ME903480 | 0.95 | 0.96 | 0.99 | NA | 1.03 | 1.05 | 1.02 |
| Allopurinol | ME903407 | 0.98 | 0.95 | 1.03 | NA | 1.03 | 1.02 | 0.99 |
| Inosine | ME903421 | 0.98 | 0.95 | 1.04 | NA | 1.03 | 1.01 | 0.99 |
| Acetylcarnitine | ME903405 | 0.93 | 0.85 | 0.94 | NA | 1.13 | 1.04 | 1.13 |
| S-Adenosylhomocysteine | ME903481 | 0.93 | 0.77 | 0.89 | NA | 1.19 | 1.13 | 1.09 |
| 3-Methylxanthine | ME903436 | 0.81 | 0.90 | 0.77 | NA | 1.25 | 1.08 | 1.18 |
| γ-Aminobutyric acid | ME903435 | 0.94 | 1.00 | 0.71 | NA | 1.11 | 1.11 | 1.08 |
| Hypotaurine | ME903448 | 1.20 | 1.09 | 1.28 | NA | 0.88 | 0.70 | 0.88 |
| Arginine | ME903410 | 0.90 | 1.11 | 1.24 | NA | 0.88 | 0.97 | 0.96 |
| Proline | ME903428 | 0.89 | 1.07 | 1.17 | NA | 0.92 | 1.01 | 0.98 |
| Lysine | ME903450 | 0.99 | 1.09 | 1.29 | NA | 0.84 | 0.98 | 0.84 |
| Pantothenic acid | ME903426 | 0.99 | 1.16 | 1.20 | NA | 0.76 | 1.04 | 0.85 |
| N6,N6,N6-Trimethyl-L-lysine | ME903478 | 0.92 | 1.25 | 1.25 | NA | 0.66 | 1.02 | 0.94 |
| Spermine | ME903431 | 0.91 | 1.15 | 1.17 | NA | 0.70 | 1.19 | 0.89 |
| Butyrylcarnitine | ME903441 | 0.91 | 0.57 | 1.06 | NA | 1.04 | 1.04 | 1.53 |
| Oxidized glutathione | ME903456 | 0.67 | 0.50 | 0.90 | NA | 1.41 | 1.38 | 1.15 |
| Trimethylamine N-Oxide | ME903461 | 1.11 | 0.79 | 0.59 | NA | 1.36 | 0.78 | 1.35 |
| Betaine | ME903411 | 0.63 | 0.93 | 0.90 | NA | 1.21 | 0.74 | 1.75 |
| Adenine | ME903438 | 0.60 | 0.95 | 0.57 | NA | 1.42 | 0.90 | 1.60 |
| Pyridoxamine | ME903458 | 0.64 | 0.77 | 0.71 | NA | 1.55 | 1.02 | 1.32 |
| S-Adenosylmethionine | ME903460 | 0.67 | 0.80 | 0.63 | NA | 1.37 | 1.07 | 1.49 |
| Alanine | ME903439 | 0.45 | 1.01 | 0.87 | NA | 1.34 | 1.02 | 1.37 |
| Methionine sulfoxide | ME903452 | 0.49 | 0.95 | 0.76 | NA | 1.08 | 1.31 | 1.46 |
| Tiglylcarnitine | ME903433 | 0.62 | 1.02 | 0.83 | NA | 1.09 | 1.13 | 1.35 |
Factors:
| F1 | Sample source:Heart | Group:CLP (24h) / 12C-Serin |
| F2 | Sample source:Heart | Group:CLP (24h) / 13C-Serin |
| F3 | Sample source:Heart | Group:CLP (24h) / Vehicle |
| F4 | Sample source:Heart | Group:QC |
| F5 | Sample source:Heart | Group:Sham / 12C-Serin |
| F6 | Sample source:Heart | Group:Sham / 13C-Serin |
| F7 | Sample source:Heart | Group:Sham / Vehicle |
