Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003499)

(Analysis AN005743)

Metabolite	Structure	F1	F2	F3
butyrylcarnitine	ME910211	0.35	0.80	1.84
guanidineacetic acid	ME910268	0.47	0.61	1.92
betaine	ME910210	0.70	0.55	1.75
creatine	ME910226	0.78	0.69	1.52
NADH	ME910304	0.64	0.76	1.60
adenylosuccinate	ME910196	0.17	0.22	2.61
succinyladenosine	ME910339	NA	0.13	1.87
ethanolamine phosphate	ME910242	1.66	0.14	1.21
phosphoethanolamine	ME910320	1.67	0.13	1.20
serine	ME910336	1.82	0.31	0.88
guanine	ME910269	1.95	0.19	0.86
guanosine	ME910270	1.89	0.24	0.87
glycine	ME910264	2.32	0.30	0.39
orotate	ME910312	2.34	0.34	0.33
citicoline	ME910221	1.64	0.69	0.67
cystathionine	ME910231	1.59	0.78	0.63
pantothenate	ME910315	1.66	0.61	0.74
hydroxyphenyllactate	ME910274	1.69	0.55	0.77
IMP	ME910279	1.68	0.53	0.80
glycerol 3-phosphate	ME910258	1.82	0.59	0.59
phosphocreatine	ME910318	1.74	0.64	0.63
hypoxanthine	ME910278	2.10	0.40	0.50
inosine	ME910281	2.01	0.41	0.58
uridine	ME910355	1.96	0.45	0.59
cystine	ME910233	2.09	0.58	0.33
glycerophosphorylcholine	ME910261	2.01	0.65	0.34
glycerylphosphorylcholine	ME910263	2.01	0.65	0.34
cytidine	ME910234	1.93	0.57	0.50
2-ketoglutarate	ME910190	1.92	0.68	0.40
glycerophosphoethanolamine	ME910259	1.93	0.66	0.42
pyruvate	ME910326	1.31	1.39	0.30
quinolinic acid	ME910327	1.42	1.46	0.12
4-guanidinobutanoate	ME910191	0.65	1.42	0.93
succinylcarnitine	ME910340	0.54	1.37	1.09
deoxycytidine	ME910235	0.73	1.49	0.78
dimethyllysine	ME910240	0.79	1.49	0.72
S-lactoylglutathione	ME910337	0.78	1.53	0.69
alanine	ME910199	0.85	1.56	0.60
lactate	ME910288	0.93	1.46	0.62
N-acetylaspartylglutamate	ME910296	0.44	1.61	0.96
beta-alanine	ME910208	0.63	1.64	0.73
beta-citrylglutamic acid	ME910209	0.65	1.65	0.70
N-carbamoylaspartate	ME910307	0.52	1.72	0.76
thiamine	ME910343	0.55	1.61	0.84
sedoheptulose 7-phosphate	ME910335	1.10	0.49	1.40
adenosine	ME910195	1.03	0.65	1.32
cysteic acid	ME910232	1.04	0.67	1.29
ADP-ribose	ME910198	0.89	0.88	1.24
glycylglycine	ME910265	0.91	0.84	1.25
Cys-Gly	ME910230	0.95	0.91	1.15
glutathione	ME910256	0.96	0.90	1.14
NADPH	ME910306	1.03	0.82	1.15
deoxyribose 5-phosphate	ME910236	0.99	0.83	1.18
2-aminoadipic acid	ME910188	0.98	0.81	1.21
N-carbamoylglutamate	ME910308	0.98	0.81	1.21
aspartylglucosamine	ME910206	0.90	0.97	1.13
N-acetylaspartate	ME910295	0.83	0.98	1.20
S-adenosylhomocysteine	ME910331	0.87	0.95	1.18
dihydroorotate	ME910237	0.78	1.08	1.14
N-acetylserine	ME910302	0.81	1.04	1.14
taurine	ME910342	0.84	1.07	1.09
hypotaurine	ME910277	0.84	1.11	1.04
orotidine	ME910313	0.87	1.08	1.05
acetylcholine	ME910193	0.80	0.83	1.37
isovalerylcarnitine C5	ME910284	0.70	0.97	1.33
kynurenine	ME910287	0.59	1.00	1.42
acetylcarnitine	ME910192	0.50	1.11	1.38
carnitine	ME910214	0.46	1.16	1.38
propionylcarnitine	ME910323	0.69	1.20	1.12
propionylcholine	ME910324	0.57	1.20	1.23
GMP	ME910266	1.13	0.72	1.15
phosphocholine	ME910317	1.12	0.74	1.15
phosphorylcholine	ME910321	1.12	0.74	1.15
aspartate	ME910205	1.15	0.75	1.09
glucuronic acid	ME910251	1.16	0.77	1.07
hydantoin-5-propionic acid	ME910273	1.15	0.80	1.06
NADP	ME910305	1.13	0.79	1.08
ATP	ME910207	1.33	0.74	0.93
UDP	ME910349	1.35	0.69	0.95
CDP	ME910216	1.34	0.69	0.98
tryptophan	ME910347	1.34	0.68	0.98
FAD	ME910243	1.24	0.76	0.99
lysine	ME910290	1.25	0.76	1.00
CMP	ME910224	1.24	0.75	1.01
UMP	ME910353	1.25	0.74	1.00
choline	ME910219	1.27	0.73	1.00
fructose 1,6-bisphosphate	ME910244	1.29	0.73	0.98
GTP	ME910267	1.29	0.67	1.04
GDP	ME910247	1.23	0.69	1.08
oxidized glutathione	ME910314	1.23	0.72	1.04
ADP	ME910197	1.17	0.82	1.01
cis-aconitate	ME910220	1.14	0.88	0.97
glutamine	ME910253	1.24	0.79	0.97
AMP	ME910201	1.25	0.81	0.94
CMP-acetylneuraminic acid	ME910225	1.25	0.81	0.94
phenylalanine	ME910316	1.28	0.81	0.91
N-acetylneuramic acid	ME910300	1.26	0.84	0.90
S-adenosylmethionine	ME910332	1.24	0.84	0.92
creatinine	ME910227	1.21	0.89	0.90
leucine	ME910289	1.25	0.88	0.87
valine	ME910357	1.24	0.87	0.89
glyceraldehyde 3-phosphate	ME910257	1.21	0.95	0.84
dTTP	ME910241	1.21	0.91	0.87
asparagine	ME910204	1.24	0.91	0.85
phosphoenolpyruvate	ME910319	1.22	0.92	0.85
citrate	ME910222	1.47	0.52	1.01
aminobutyrate	ME910200	1.39	0.58	1.03
glutamate	ME910252	1.40	0.58	1.02
N-acetylhexosamine phosphate	ME910298	1.51	0.70	0.80
CTP	ME910228	1.46	0.61	0.93
threonine	ME910344	1.47	0.62	0.91
UTP	ME910356	1.46	0.67	0.87
carnitinamide	ME910213	1.41	0.70	0.89
2/3-phosphoglycerate	ME910187	1.41	0.66	0.93
methionine	ME910292	1.40	0.68	0.92
CDP-ethanolamine	ME910217	1.64	0.31	1.05
ophthalmic acid	ME910310	1.61	0.41	0.97
UDP-glucose	ME910351	1.59	0.48	0.93
UDP-hexose	ME910352	1.59	0.48	0.93
glucose 6-phosphate	ME910250	1.39	1.03	0.58
succinate	ME910338	1.33	1.04	0.62
S-(2-succinyl)cysteine	ME910328	1.24	1.18	0.58
hydroxyproline	ME910275	1.25	1.12	0.63
hydroxytrimethyllysine	ME910276	1.26	1.09	0.65
carnosine	ME910215	1.37	0.79	0.84
dihydroxyacetone phosphate	ME910238	1.36	0.84	0.80
2-hydroxyglutarate	ME910189	1.29	0.96	0.76
fructose 6-Phosphate	ME910245	1.39	0.92	0.69
UDP-GlcNac	ME910350	1.36	0.91	0.73
N-acetylglutamate	ME910297	1.03	0.99	0.98
glutamylproline	ME910255	0.98	1.00	1.03
valine-d8	ME910358	0.99	1.02	0.99
histidine	ME910271	1.15	1.06	0.80
methionine sulfoxide	ME910293	1.16	1.03	0.81
glutamylcysteine	ME910254	1.17	0.96	0.88
ornithine	ME910311	1.14	1.00	0.86
xanthine	ME910359	1.14	0.99	0.88
isoleucine	ME910283	1.16	1.01	0.84
tyrosine	ME910348	1.17	0.98	0.85
cyclic ADP-ribose	ME910229	0.97	1.10	0.92
inositol	ME910282	0.99	1.09	0.92
NAD	ME910303	1.00	1.08	0.91
GDP-glucose	ME910248	1.04	1.12	0.84
N-acetylornithine	ME910301	1.09	1.09	0.82
homoarginine	ME910272	1.06	1.07	0.86
pyroglutamic acid	ME910325	1.06	1.08	0.85
proline	ME910322	1.10	0.98	0.91
arginine	ME910202	1.07	1.03	0.91
sarcosine	ME910334	1.06	1.05	0.89
glycerophosphoinositol	ME910260	0.89	1.20	0.91
trimethyllysine	ME910345	0.81	1.32	0.86
S-(2-Succinyl)glutathione	ME910329	0.89	1.31	0.80
succinylglutathione	ME910341	0.89	1.31	0.80
acetyl-CoA	ME910194	0.97	1.26	0.77
dimethylarginine	ME910239	0.95	1.23	0.82
gluconate	ME910249	1.16	1.26	0.58
fumarate	ME910246	1.02	1.32	0.66
cAMP	ME910212	1.02	1.28	0.70
argininosuccinate	ME910203	1.02	1.30	0.69
malate	ME910291	1.03	1.30	0.67
N-acetylhistidine	ME910299	1.11	1.19	0.70
glycerophosphoserine	ME910262	1.10	1.12	0.78
uric acid	ME910354	1.05	1.15	0.80
citrulline	ME910223	1.08	1.17	0.75
N-acetylarginine	ME910294	1.06	1.17	0.78
nicotinamide riboside	ME910309	1.06	1.18	0.76

Factors:

F1	Phenotype:Control \| Genotype:Wildtype
F2	Phenotype:Mild \| Genotype:R309H/c.1191+5G->C
F3	Phenotype:Mild \| Genotype:T450S/D332H

Data matrix