Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003551)

HILIC POSITIVE ION MODE (Analysis AN005837)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
PIPERIDINE 6-CARBOXYLATE (P6C / P2C)	ME926893	0.01	0.01	0.01	0.03	0.53	0.17	0.46	4.54
SACCHAROPINE	ME926901	0.17	0.14	0.27	0.71	0.78	0.63	1.28	2.78
AMINOADIPATE	ME926780	0.34	0.14	0.74	3.49	0.12	0.04	0.37	0.68
TARTRATE / MESO-TARTRATE	ME926906	0.69	0.82	0.64	0.58	2.06	2.19	0.89	0.83
4-GUANIDINOBUTANOATE	ME926767	1.61	1.93	0.49	0.46	1.62	2.03	0.59	0.49
N,N-DIMETHYLARGININE	ME926864	1.03	1.82	0.81	0.64	1.12	1.98	0.78	0.62
N,N,N-TRIMETHYLLYSINE	ME926863	1.16	1.76	0.92	0.50	1.31	1.99	0.92	0.49
N-ACETYLNEURAMINATE	ME926871	0.80	2.25	0.71	0.68	0.84	2.09	0.71	0.66
BETA-GLYCEROPHOSPHATE	ME926788	0.95	2.24	0.74	0.53	1.00	2.21	0.86	0.51
GLYCEROPHOSPHOCHOLINE	ME926840	1.08	2.35	0.76	0.49	1.01	2.15	0.87	0.44
ARGININE	ME926782	0.44	0.26	0.80	1.86	0.45	0.29	0.72	1.69
GUANIDINOACETATE	ME926843	0.36	0.18	0.75	2.02	0.37	0.18	0.76	1.72
LYSINE	ME926857	0.39	0.21	0.62	2.03	0.39	0.23	0.59	1.81
2-OXOADIPIC ACID	ME926764	0.61	0.71	0.70	2.11	0.65	1.19	0.78	0.61
PIPECOLATE	ME926892	0.70	0.70	0.70	0.65	0.51	0.61	0.72	2.44
HYPOXANTHINE	ME926849	0.83	0.75	0.84	0.70	0.93	1.00	0.77	1.77
INOSINE	ME926851	0.85	0.78	0.82	0.69	0.90	0.99	0.70	1.82
DIHYDROXYACETONE PHOSPHATE	ME926821	1.03	1.46	0.58	0.81	1.42	1.16	0.44	1.21
KYNURENINE	ME926854	1.25	1.34	0.62	0.82	1.39	1.32	0.63	0.97
2,3-DIHYDROXYBENZOATE	ME926762	1.51	1.07	0.56	1.01	1.49	1.27	0.56	0.83
PHOSPHORIBOSYL PYROPHOSPHATE_NF	ME926936	1.35	0.90	0.91	1.01	1.51	1.02	0.67	0.82
MALEATE	ME926859	0.88	0.88	0.69	0.87	1.59	1.65	0.80	0.93
OXALATE	ME926935	0.82	0.80	0.85	0.78	1.57	1.65	1.05	0.87
3-SULFINOALANINE	ME926766	0.87	1.29	0.64	0.46	1.43	1.79	1.20	1.00
N-EPSILON-ACETYLLYSINE	ME926878	1.22	1.40	1.08	0.66	1.25	1.47	0.99	0.62
1-METHYLNICOTINAMIDE_NF	ME926761	1.08	1.24	0.84	0.68	1.28	1.53	1.10	0.80
CYSTEATE	ME926802	0.97	1.23	0.92	0.76	1.12	1.49	1.03	0.87
N-ACETYLPHENYLALANINE	ME926872	0.96	1.19	0.86	0.83	1.26	1.35	0.94	0.91
GUANOSINE MONOPHOSPHATE	ME926846	0.71	0.75	1.19	1.38	0.67	0.69	1.37	0.89
S-ADENOSYLHOMOCYSTEINE	ME926902	0.83	0.53	1.21	1.43	1.03	0.63	1.09	0.88
N-ACETYLPUTRESCINE	ME926873	0.78	0.25	1.25	1.52	0.71	0.24	1.00	1.32
CREATININE	ME926798	0.59	0.30	1.41	1.37	0.44	0.33	1.13	1.45
DIHYDROOROTATE	ME926820	0.77	0.33	1.34	1.46	0.43	0.34	1.41	1.18
4-IMIDAZOLEACETATE	ME926769	0.68	0.50	0.81	1.63	0.67	0.52	0.72	1.45
OROTATE	ME926884	0.75	0.40	1.12	1.41	0.76	0.54	0.97	1.31
AICAR	ME926776	0.75	0.66	1.22	1.38	0.60	0.53	1.09	1.16
GAMMA-AMINOBUTYRATE	ME926829	0.65	0.58	0.97	1.47	0.64	0.57	0.97	1.35
PHOSPHOCREATINE	ME926888	0.71	0.58	1.03	1.43	0.63	0.51	1.05	1.31
DEOXYCARNITINE	ME926810	0.67	0.66	1.08	1.34	0.64	0.63	1.11	1.25
PROPIONYL-L-CARNITINE	ME926896	0.64	0.65	1.06	1.42	0.59	0.61	1.01	1.29
2,3-DIPHOSPHO-D-GLYCERIC ACID	ME926926	1.07	0.48	0.89	1.33	1.35	0.59	0.75	1.13
N-ACETYLALANINE	ME926865	1.24	1.37	0.92	1.05	0.98	0.88	0.82	0.86
CDP-ETHANOLAMINE	ME926793	0.57	0.81	0.92	0.94	0.86	1.05	1.53	1.20
PTERIN	ME926897	0.95	1.00	0.98	0.88	1.05	1.29	1.32	0.83
URIDINE	ME926917	0.86	0.88	0.96	0.90	1.09	1.23	1.08	1.05
GUANOSINE	ME926844	0.83	0.88	0.99	0.80	1.07	1.24	1.32	1.03
CITICOLINE	ME926795	0.87	0.96	0.90	0.90	1.06	1.20	1.23	1.00
DEOXYGUANOSINE	ME926815	0.81	0.94	0.98	0.84	1.06	1.24	1.20	1.05
DEOXYURIDINE MONOPHOSPHATE	ME926816	0.82	0.69	1.01	1.01	0.97	0.78	0.83	1.44
ORNITHINE	ME926883	0.82	0.85	0.86	1.31	0.84	0.87	0.74	1.22
N-ACETYLGLUTAMATE	ME926869	1.09	1.11	1.12	0.86	1.09	1.08	1.07	0.84
D-GLUCOSE	ME926817	1.02	1.19	0.99	0.98	0.99	1.16	0.90	0.90
SERINE	ME926904	1.10	1.21	0.94	0.95	1.07	1.20	0.88	0.86
ASPARAGINE	ME926784	0.90	1.15	0.96	0.96	0.99	1.22	0.90	0.99
N-ACETYLCYSTEINE	ME926867	0.94	1.14	1.00	0.87	1.08	1.17	1.04	0.95
10-HYDROXYDECANOATE	ME926760	1.03	0.98	0.96	0.97	1.27	1.15	0.84	0.92
NADP	ME926877	1.05	1.00	0.88	1.08	1.16	1.03	0.69	1.04
DEOXYCYTIDINE DIPHOSPHATE	ME926812	0.91	0.70	0.97	1.13	1.29	0.75	0.84	1.15
XANTHOSINE-MONOPHOSPHATE	ME926925	1.03	0.76	1.03	1.12	1.19	0.78	0.77	1.09
DEOXYCYTIDINE TRIPHOSPHATE	ME926814	1.02	0.79	0.98	1.08	1.14	0.81	0.93	1.09
CYTIDINE DIPHOSPHATE	ME926804	0.99	0.78	0.93	1.15	1.12	0.85	0.88	1.10
URIDINE 5^-DIPHOSPHATE	ME926918	1.01	0.85	0.95	1.11	1.14	0.87	0.88	1.04
GUANOSINE TRIPHOSPHATE	ME926847	1.01	0.86	0.95	1.09	1.16	0.98	0.88	1.00
ISOPENTENYL PYROPHOSPHATE	ME926853	1.01	0.93	0.92	1.10	1.19	0.98	0.83	0.98
METHYLTHIOADENOSINE	ME926862	0.99	0.86	1.02	1.18	1.08	0.91	0.84	0.96
PHOSPHOSERINE	ME926891	1.06	0.85	0.99	1.20	1.06	0.86	0.81	0.99
FRUCTOSE BISPHOSPHATE	ME926826	1.16	0.78	0.88	1.09	1.27	0.95	0.85	0.99
3-METHYL-2-OXOBUTYRATE	ME926765	0.99	0.76	0.87	1.03	1.29	0.93	0.76	1.19
D-RIBOSE 5-PHOSPHATE	ME926822	1.04	0.83	0.84	1.13	1.17	0.91	0.76	1.12
N-FORMYL-L-METHIONINE	ME926879	0.96	1.06	1.06	1.08	0.89	0.95	1.01	0.94
N-ACETYLMETHIONINE	ME926870	0.94	0.99	1.10	1.08	0.91	0.93	0.99	0.97
TRYPTOPHAN	ME926912	0.94	0.93	1.08	1.08	0.96	0.91	0.98	1.01
CYTIDINE MONOPHOSPHATE	ME926805	0.83	0.93	1.07	1.14	0.86	0.94	1.04	1.02
PANTOTHENATE	ME926886	0.92	0.98	1.09	1.15	0.83	0.87	1.01	0.98
NICOTINAMIDE	ME926880	0.92	0.84	1.14	1.16	0.88	0.88	0.95	1.02
ADENOSINE 2^,3^-CYCLIC PHOSPHATE	ME926773	1.02	0.80	1.04	1.16	0.98	0.84	0.99	1.00
CYCLIC AMP	ME926799	1.03	0.82	1.05	1.17	0.97	0.82	0.98	0.99
2-HYDROXYGLUTARIC ACID	ME926763	1.05	0.80	1.07	1.13	0.99	0.80	0.99	1.01
UDP-N-ACETYLGALACTOSAMINE / GLUCOSAMINE	ME926916	1.03	0.80	1.05	1.15	0.99	0.81	0.96	1.03
PYROGLUTAMATE	ME926899	1.01	0.88	1.10	1.08	0.95	0.87	0.96	1.02
NORADRENALINE	ME926881	0.97	0.87	1.05	1.14	0.94	0.84	0.98	1.03
PYRIDOXINE	ME926898	0.97	0.87	1.05	1.14	0.94	0.84	0.98	1.03
ALPHA-KETOGLUTARIC ACID	ME926779	0.90	0.80	1.12	1.14	1.02	0.84	0.95	1.03
ETHYL 3-UREIDOPROPIONATE	ME926824	0.98	0.76	1.10	1.09	1.01	0.95	0.96	1.02
3-HYDROXYMETHYLGLUTARATE	ME926928	1.05	1.07	1.15	1.11	0.88	0.90	0.90	0.89
AMP / dGMP	ME926781	1.08	1.08	1.06	1.01	0.98	0.88	1.10	0.89
5-METHYLCYTIDINE	ME926771	1.13	0.93	1.05	1.02	1.09	0.90	0.93	0.96
INOSINE MONOPHOSPHATE	ME926852	1.21	0.81	1.09	1.06	1.03	0.89	0.98	0.93
N-ACETYLSERINE	ME926874	0.99	1.01	1.09	1.01	0.98	1.00	1.02	0.92
CIS-ACONITIC ACID	ME926794	1.05	1.00	1.04	1.01	1.06	0.97	0.97	0.94
4-HYDROXY-L-PROLINE	ME926768	1.07	1.00	1.09	1.01	1.03	0.98	1.02	0.89
N-ACETYLASPARTATE	ME926866	1.07	1.02	1.09	0.99	1.05	0.99	0.98	0.90
GLUCOSE 6-PHOSPHATE	ME926832	0.97	1.04	0.98	1.06	0.96	1.02	0.94	0.99
GLYCOCHENODEOXYCHOLATE	ME926842	1.06	1.04	1.02	1.06	0.95	1.02	0.88	0.95
METHIONINE	ME926860	1.09	1.06	1.03	1.03	1.03	1.01	0.91	0.90
GLUTAMINE	ME926835	1.06	1.05	1.01	1.00	1.02	1.03	0.95	0.94
PHOSPHORYLCHOLINE	ME926890	1.04	1.01	1.00	1.03	0.99	0.99	0.97	0.97
VALINE	ME926923	1.03	1.02	1.02	1.02	1.00	1.01	0.96	0.96
ALPHA-HYDROXYISOBUTYRATE	ME926778	1.04	0.95	0.94	1.06	1.06	0.98	0.99	0.97
GLUCURONATE	ME926833	1.02	0.95	0.96	1.01	1.07	1.01	1.02	0.98
FRUCTOSE 6-PHOSPHATE	ME926825	1.06	1.01	0.94	1.09	1.03	0.99	0.83	1.00
GLUTATHIONE REDUCED	ME926837	1.04	0.99	0.97	1.05	1.09	0.96	0.88	0.99
DIETHANOLAMINE	ME926818	1.03	0.99	0.97	1.04	1.07	1.03	0.92	0.96
GUANOSINE DIPHOSPHATE	ME926845	1.03	1.00	0.95	1.10	1.07	1.00	0.91	0.93
S-ADENOSYLMETHIONINE	ME926903	0.99	0.82	0.98	1.06	1.02	0.88	0.99	1.10
ATP / dGTP	ME926786	1.01	0.84	1.00	1.11	1.08	0.90	0.96	1.00
UDP-GLUCURONIC ACID	ME926915	1.03	0.88	0.98	1.07	1.07	0.90	0.96	1.02
CYS-GLY	ME926800	0.97	0.93	1.03	1.07	1.06	0.93	0.91	1.00
NAD	ME926875	0.99	0.91	0.99	1.09	1.02	0.92	0.92	1.03
GLUCOSAMINE 6-PHOSPHATE	ME926831	1.00	0.91	1.04	1.05	1.04	0.88	0.98	1.02
N-ACETYLGLUCOSAMINE / MANNOSAMINE / GALACTOSAMINE	ME926868	0.97	0.91	1.03	1.09	1.00	0.91	0.98	1.00
GDP-MANNOSE	ME926830	1.00	0.95	1.00	1.10	0.97	0.92	1.02	0.97
PROLINE	ME926895	0.99	0.95	0.99	1.10	0.94	0.92	0.95	1.03
ISOLEUCINE	ME926931	1.01	1.00	1.02	1.03	0.98	0.98	0.96	1.00
LEUCINE	ME926932	0.99	0.98	1.00	1.05	0.97	0.96	0.96	1.02
ASPARTATE	ME926785	1.01	0.95	0.98	1.10	0.99	0.95	0.91	1.01
PHENYLALANINE	ME926887	1.02	0.95	1.02	1.08	0.99	0.94	0.93	0.99
TYROSINE	ME926913	1.00	0.95	1.03	1.06	1.00	0.94	0.95	1.00
GALACTITOL	ME926828	0.90	1.06	1.04	1.01	1.15	1.04	0.92	0.93
ADP / dGDP	ME926775	1.14	1.02	0.95	1.10	1.11	0.96	0.87	0.89
RIBOSE 1,5-BISPHOSPHATE	ME926937	1.17	1.05	0.99	0.93	1.14	1.11	0.96	0.87
THREONINE	ME926909	1.11	1.11	1.03	0.95	1.11	1.06	0.91	0.89
GLUTAMATE	ME926834	1.10	1.07	0.99	0.98	1.08	1.05	0.93	0.91
GLYCINE	ME926841	1.13	1.09	0.96	0.97	1.08	1.08	0.91	0.91
OXALOACETATE	ME926885	1.10	1.05	0.97	0.99	1.14	1.00	0.93	0.91
CITRATE / ISOCITRATE	ME926930	1.07	1.03	0.96	0.98	1.11	1.05	0.98	0.93
CYSTATHIONINE	ME926801	1.09	1.01	0.96	0.94	1.12	1.07	0.95	0.97
BETAINE	ME926790	0.85	0.96	0.90	1.16	0.96	1.02	1.02	0.99
GLYCEROL 3-PHOSPHATE	ME926839	0.90	1.04	1.09	0.98	0.94	1.06	1.11	0.94
BETA-ALANINE	ME926787	0.77	0.57	1.02	1.29	0.77	0.59	1.09	1.30
ARGININOSUCCINIC ACID	ME926783	0.79	0.60	1.19	1.28	0.76	0.58	1.10	1.18
DEOXYCYTIDINE MONOPHOSPHATE	ME926813	0.87	0.62	1.07	1.29	0.76	0.68	1.05	1.17
CREATINE	ME926797	0.73	0.63	1.04	1.21	0.84	0.75	1.05	1.26
THYMIDINE MONOPHOSPHATE	ME926910	0.80	0.53	0.99	1.16	0.90	0.65	1.11	1.35
VALERYL-L-CARNITINE	ME926922	0.78	0.89	1.01	1.33	0.67	0.76	0.94	1.15
UROCANATE	ME926921	0.77	0.82	1.18	1.05	0.78	0.80	1.06	1.21
L-CARNITINE	ME926856	0.75	0.81	1.10	1.25	0.70	0.76	1.11	1.12
BUTYRYL-L-CARNITINE	ME926791	0.84	0.79	1.07	1.24	0.78	0.75	1.01	1.13
HYPOTAURINE	ME926848	0.80	0.75	1.08	1.18	0.78	0.73	1.14	1.16
TAURINE	ME926907	0.80	0.73	1.05	1.21	0.79	0.72	1.09	1.19
N6-(DELTA2-ISOPENTENYL)-ADENINE	ME926933	0.80	0.59	1.12	1.11	1.01	0.86	1.11	1.12
CYTOSINE_iso1	ME926807	0.86	0.64	1.03	1.19	0.92	0.72	1.06	1.18
DEOXYCYTIDINE	ME926811	0.87	0.65	1.08	1.17	0.91	0.72	1.10	1.16
ALANINE / SARCOSINE	ME926777	0.94	0.75	1.10	1.13	0.93	0.77	1.05	1.09
LACTATE	ME926855	0.93	0.70	0.99	1.13	1.02	0.76	1.06	1.15
BETA-HYDROXY(ISO)BUTYRATE	ME926789	0.95	0.74	1.00	1.15	0.94	0.77	1.03	1.13
SUCCINATE	ME926905	0.94	0.73	1.02	1.13	0.95	0.72	1.09	1.15
COENZYME A	ME926796	1.07	0.73	0.89	1.27	0.99	0.73	0.95	1.07
GLYCERALDEHYDE 3-PHOSPHATE	ME926838	0.95	0.70	0.99	1.14	1.06	0.67	0.92	1.21
DEOXYADENOSINE	ME926808	0.98	0.66	1.08	1.20	1.02	0.73	0.86	1.12
FUMARATE	ME926827	1.01	0.72	1.02	1.19	0.99	0.72	0.97	1.10
MALATE	ME926858	0.98	0.73	1.06	1.17	0.96	0.73	1.00	1.09
CYTIDINE TRIPHOSPHATE	ME926806	0.99	0.68	1.02	1.21	1.05	0.73	0.93	1.08
URIDINE TRIPHOSPHATE	ME926920	0.99	0.70	1.03	1.19	1.05	0.75	1.00	1.05
DEOXYADENOSINE TRIPHOSPHATE	ME926809	1.00	0.73	0.97	1.15	1.07	0.78	0.94	1.11
DTDP-D-GLUCOSE	ME926823	0.95	0.79	1.00	1.19	0.99	0.80	0.89	1.11
UDP-GLUCOSE / GALACTOSE	ME926914	1.01	0.76	0.97	1.19	1.00	0.76	0.92	1.10
DIHYDROBIOPTERIN	ME926819	1.02	0.82	1.03	1.16	0.81	0.69	1.10	1.09
PHOSPHOENOLPYRUVATE	ME926889	1.10	0.79	1.15	1.13	0.96	0.70	1.06	0.96
4-PYRIDOXATE	ME926770	0.85	0.90	1.18	0.97	0.88	0.96	1.38	0.93
O-ACETYLCARNITINE	ME926882	0.87	0.90	1.28	1.05	0.81	0.85	1.27	0.91
THYMIDINE_NF	ME926911	0.87	0.80	1.07	1.03	0.92	0.91	1.29	1.03
CARNOSINE	ME926792	0.77	0.81	1.06	1.07	0.81	0.86	1.23	1.15
METHYL GALACTOSIDE_NF	ME926861	0.81	0.80	1.07	1.05	0.83	0.92	1.29	1.08
CYTIDINE	ME926803	0.81	0.72	1.18	1.07	0.91	0.84	1.24	1.05
P-OCTOPAMINE	ME926894	0.80	0.81	1.22	1.13	0.82	0.81	1.16	1.02
GLUTATHIONE OXIDIZED	ME926836	0.96	0.85	1.03	1.13	0.93	0.96	1.17	0.91
INDOLE-3-LACTIC ACID	ME926850	0.94	0.92	1.12	1.11	0.81	0.85	1.19	0.95
THREITOL	ME926908	0.83	0.96	1.09	1.03	0.82	0.93	1.25	1.01
6-PHOSPHOGLUCONATE	ME926772	1.04	0.75	1.14	1.25	0.83	0.64	1.32	0.87
2-PHOSPHOGLYCERATE	ME926927	1.01	0.68	1.28	1.10	0.97	0.70	1.23	0.92
3-PHOSPHOGLYCERATE	ME926929	1.01	0.68	1.28	1.10	0.97	0.70	1.23	0.92
O-PHOSPHOETHANOLAMINE	ME926934	0.21	0.35	1.33	1.00	0.42	0.83	2.16	1.29
XANTHINE	ME926924	0.23	0.21	1.58	1.24	0.22	0.25	2.24	1.30
ADENOSINE DIPHOSPHATE RIBOSE_NF	ME926774	1.13	0.39	1.20	1.72	0.05	0.09	1.94	0.85
NADH	ME926876	0.93	0.98	1.80	1.38	0.43	0.32	1.12	0.70
RIBOFLAVIN	ME926900	0.85	0.72	1.76	1.27	0.48	0.41	1.56	0.71
URIDINE MONOPHOSPHATE	ME926919	0.91	0.59	1.71	1.15	0.52	0.44	1.45	0.92

Factors:

F1	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (10 mM)
F2	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (20 mM)
F3	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (5 mM)
F4	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:PBS
F5	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (10 mM)
F6	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (20 mM)
F7	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (5 mM)
F8	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:PBS

Data matrix