Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003551)

HILIC NEGATIVE ION MODE (Analysis AN005838)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
CYTIDINE MONOPHOSPHATE	ME926983	0.83	0.93	1.07	1.14	0.86	0.94	1.04	1.02
NADH	ME927054	0.93	0.98	1.80	1.38	0.43	0.32	1.12	0.70
PHOSPHOENOLPYRUVATE	ME927067	1.10	0.79	1.15	1.13	0.96	0.70	1.06	0.96
DEOXYURIDINE MONOPHOSPHATE	ME926994	0.82	0.69	1.01	1.01	0.97	0.78	0.83	1.44
N-ACETYLGLUCOSAMINE / MANNOSAMINE / GALACTOSAMINE	ME927046	0.97	0.91	1.03	1.09	1.00	0.91	0.98	1.00
PIPERIDINE 6-CARBOXYLATE (P6C / P2C)	ME927071	0.01	0.01	0.01	0.03	0.53	0.17	0.46	4.54
BETA-GLYCEROPHOSPHATE	ME926966	0.95	2.24	0.74	0.53	1.00	2.21	0.86	0.51
DEOXYADENOSINE TRIPHOSPHATE	ME926987	1.00	0.73	0.97	1.15	1.07	0.78	0.94	1.11
COENZYME A	ME926974	1.07	0.73	0.89	1.27	0.99	0.73	0.95	1.07
ASPARAGINE	ME926962	0.90	1.15	0.96	0.96	0.99	1.22	0.90	0.99
N-EPSILON-ACETYLLYSINE	ME927056	1.22	1.40	1.08	0.66	1.25	1.47	0.99	0.62
N,N,N-TRIMETHYLLYSINE	ME927041	1.16	1.76	0.92	0.50	1.31	1.99	0.92	0.49
CYS-GLY	ME926978	0.97	0.93	1.03	1.07	1.06	0.93	0.91	1.00
BETA-ALANINE	ME926965	0.77	0.57	1.02	1.29	0.77	0.59	1.09	1.30
ADP / dGDP	ME926953	1.14	1.02	0.95	1.10	1.11	0.96	0.87	0.89
URIDINE	ME927095	0.86	0.88	0.96	0.90	1.09	1.23	1.08	1.05
OXALOACETATE	ME927063	1.10	1.05	0.97	0.99	1.14	1.00	0.93	0.91
CYTOSINE_iso1	ME926985	0.86	0.64	1.03	1.19	0.92	0.72	1.06	1.18
SACCHAROPINE	ME927079	0.17	0.14	0.27	0.71	0.78	0.63	1.28	2.78
S-ADENOSYLHOMOCYSTEINE	ME927080	0.83	0.53	1.21	1.43	1.03	0.63	1.09	0.88
N-ACETYLSERINE	ME927052	0.99	1.01	1.09	1.01	0.98	1.00	1.02	0.92
INDOLE-3-LACTIC ACID	ME927028	0.94	0.92	1.12	1.11	0.81	0.85	1.19	0.95
INOSINE MONOPHOSPHATE	ME927030	1.21	0.81	1.09	1.06	1.03	0.89	0.98	0.93
BUTYRYL-L-CARNITINE	ME926969	0.84	0.79	1.07	1.24	0.78	0.75	1.01	1.13
CITICOLINE	ME926973	0.87	0.96	0.90	0.90	1.06	1.20	1.23	1.00
5-METHYLCYTIDINE	ME926949	1.13	0.93	1.05	1.02	1.09	0.90	0.93	0.96
PHOSPHOSERINE	ME927069	1.06	0.85	0.99	1.20	1.06	0.86	0.81	0.99
PIPECOLATE	ME927070	0.70	0.70	0.70	0.65	0.51	0.61	0.72	2.44
METHYLTHIOADENOSINE	ME927040	0.99	0.86	1.02	1.18	1.08	0.91	0.84	0.96
INOSINE	ME927029	0.85	0.78	0.82	0.69	0.90	0.99	0.70	1.82
N-ACETYLNEURAMINATE	ME927049	0.80	2.25	0.71	0.68	0.84	2.09	0.71	0.66
N-ACETYLASPARTATE	ME927044	1.07	1.02	1.09	0.99	1.05	0.99	0.98	0.90
NICOTINAMIDE	ME927058	0.92	0.84	1.14	1.16	0.88	0.88	0.95	1.02
N-FORMYL-L-METHIONINE	ME927057	0.96	1.06	1.06	1.08	0.89	0.95	1.01	0.94
PHOSPHORYLCHOLINE	ME927068	1.04	1.01	1.00	1.03	0.99	0.99	0.97	0.97
ARGININOSUCCINIC ACID	ME926961	0.79	0.60	1.19	1.28	0.76	0.58	1.10	1.18
DEOXYADENOSINE	ME926986	0.98	0.66	1.08	1.20	1.02	0.73	0.86	1.12
TRYPTOPHAN	ME927090	0.94	0.93	1.08	1.08	0.96	0.91	0.98	1.01
TAURINE	ME927085	0.80	0.73	1.05	1.21	0.79	0.72	1.09	1.19
BETAINE	ME926968	0.85	0.96	0.90	1.16	0.96	1.02	1.02	0.99
GLYCERALDEHYDE 3-PHOSPHATE	ME927016	0.95	0.70	0.99	1.14	1.06	0.67	0.92	1.21
METHYL GALACTOSIDE_NF	ME927039	0.81	0.80	1.07	1.05	0.83	0.92	1.29	1.08
2-PHOSPHOGLYCERATE	ME927105	1.01	0.68	1.28	1.10	0.97	0.70	1.23	0.92
DIHYDROBIOPTERIN	ME926997	1.02	0.82	1.03	1.16	0.81	0.69	1.10	1.09
LEUCINE	ME927110	0.99	0.98	1.00	1.05	0.97	0.96	0.96	1.02
DEOXYGUANOSINE	ME926993	0.81	0.94	0.98	0.84	1.06	1.24	1.20	1.05
XANTHINE	ME927102	0.23	0.21	1.58	1.24	0.22	0.25	2.24	1.30
DEOXYCYTIDINE MONOPHOSPHATE	ME926991	0.87	0.62	1.07	1.29	0.76	0.68	1.05	1.17
CITRATE / ISOCITRATE	ME927108	1.07	1.03	0.96	0.98	1.11	1.05	0.98	0.93
GLUCURONATE	ME927011	1.02	0.95	0.96	1.01	1.07	1.01	1.02	0.98
3-METHYL-2-OXOBUTYRATE	ME926943	0.99	0.76	0.87	1.03	1.29	0.93	0.76	1.19
CARNOSINE	ME926970	0.77	0.81	1.06	1.07	0.81	0.86	1.23	1.15
4-HYDROXY-L-PROLINE	ME926946	1.07	1.00	1.09	1.01	1.03	0.98	1.02	0.89
DEOXYCYTIDINE TRIPHOSPHATE	ME926992	1.02	0.79	0.98	1.08	1.14	0.81	0.93	1.09
GUANIDINOACETATE	ME927021	0.36	0.18	0.75	2.02	0.37	0.18	0.76	1.72
DEOXYCYTIDINE DIPHOSPHATE	ME926990	0.91	0.70	0.97	1.13	1.29	0.75	0.84	1.15
GLYCOCHENODEOXYCHOLATE	ME927020	1.06	1.04	1.02	1.06	0.95	1.02	0.88	0.95
N,N-DIMETHYLARGININE	ME927042	1.03	1.82	0.81	0.64	1.12	1.98	0.78	0.62
SERINE	ME927082	1.10	1.21	0.94	0.95	1.07	1.20	0.88	0.86
L-CARNITINE	ME927034	0.75	0.81	1.10	1.25	0.70	0.76	1.11	1.12
PROLINE	ME927073	0.99	0.95	0.99	1.10	0.94	0.92	0.95	1.03
HYPOXANTHINE	ME927027	0.83	0.75	0.84	0.70	0.93	1.00	0.77	1.77
ISOPENTENYL PYROPHOSPHATE	ME927031	1.01	0.93	0.92	1.10	1.19	0.98	0.83	0.98
SUCCINATE	ME927083	0.94	0.73	1.02	1.13	0.95	0.72	1.09	1.15
NORADRENALINE	ME927059	0.97	0.87	1.05	1.14	0.94	0.84	0.98	1.03
ISOLEUCINE	ME927109	1.01	1.00	1.02	1.03	0.98	0.98	0.96	1.00
KYNURENINE	ME927032	1.25	1.34	0.62	0.82	1.39	1.32	0.63	0.97
O-ACETYLCARNITINE	ME927060	0.87	0.90	1.28	1.05	0.81	0.85	1.27	0.91
LACTATE	ME927033	0.93	0.70	0.99	1.13	1.02	0.76	1.06	1.15
OROTATE	ME927062	0.75	0.40	1.12	1.41	0.76	0.54	0.97	1.31
N-ACETYLPHENYLALANINE	ME927050	0.96	1.19	0.86	0.83	1.26	1.35	0.94	0.91
PTERIN	ME927075	0.95	1.00	0.98	0.88	1.05	1.29	1.32	0.83
2-OXOADIPIC ACID	ME926942	0.61	0.71	0.70	2.11	0.65	1.19	0.78	0.61
3-HYDROXYMETHYLGLUTARATE	ME927106	1.05	1.07	1.15	1.11	0.88	0.90	0.90	0.89
4-GUANIDINOBUTANOATE	ME926945	1.61	1.93	0.49	0.46	1.62	2.03	0.59	0.49
N-ACETYLPUTRESCINE	ME927051	0.78	0.25	1.25	1.52	0.71	0.24	1.00	1.32
GUANOSINE	ME927022	0.83	0.88	0.99	0.80	1.07	1.24	1.32	1.03
PHOSPHORIBOSYL PYROPHOSPHATE_NF	ME927114	1.35	0.90	0.91	1.01	1.51	1.02	0.67	0.82
AICAR	ME926954	0.75	0.66	1.22	1.38	0.60	0.53	1.09	1.16
GDP-MANNOSE	ME927008	1.00	0.95	1.00	1.10	0.97	0.92	1.02	0.97
ATP / dGTP	ME926964	1.01	0.84	1.00	1.11	1.08	0.90	0.96	1.00
2,3-DIHYDROXYBENZOATE	ME926940	1.51	1.07	0.56	1.01	1.49	1.27	0.56	0.83
GUANOSINE TRIPHOSPHATE	ME927025	1.01	0.86	0.95	1.09	1.16	0.98	0.88	1.00
CYTIDINE	ME926981	0.81	0.72	1.18	1.07	0.91	0.84	1.24	1.05
4-IMIDAZOLEACETATE	ME926947	0.68	0.50	0.81	1.63	0.67	0.52	0.72	1.45
ADENOSINE DIPHOSPHATE RIBOSE_NF	ME926952	1.13	0.39	1.20	1.72	0.05	0.09	1.94	0.85
3-PHOSPHOGLYCERATE	ME927107	1.01	0.68	1.28	1.10	0.97	0.70	1.23	0.92
GUANOSINE DIPHOSPHATE	ME927023	1.03	1.00	0.95	1.10	1.07	1.00	0.91	0.93
6-PHOSPHOGLUCONATE	ME926950	1.04	0.75	1.14	1.25	0.83	0.64	1.32	0.87
N-ACETYLGLUTAMATE	ME927047	1.09	1.11	1.12	0.86	1.09	1.08	1.07	0.84
10-HYDROXYDECANOATE	ME926938	1.03	0.98	0.96	0.97	1.27	1.15	0.84	0.92
DIHYDROOROTATE	ME926998	0.77	0.33	1.34	1.46	0.43	0.34	1.41	1.18
PROPIONYL-L-CARNITINE	ME927074	0.64	0.65	1.06	1.42	0.59	0.61	1.01	1.29
2,3-DIPHOSPHO-D-GLYCERIC ACID	ME927104	1.07	0.48	0.89	1.33	1.35	0.59	0.75	1.13
ALANINE / SARCOSINE	ME926955	0.94	0.75	1.10	1.13	0.93	0.77	1.05	1.09
GLUTATHIONE OXIDIZED	ME927014	0.96	0.85	1.03	1.13	0.93	0.96	1.17	0.91
4-PYRIDOXATE	ME926948	0.85	0.90	1.18	0.97	0.88	0.96	1.38	0.93
DEOXYCARNITINE	ME926988	0.67	0.66	1.08	1.34	0.64	0.63	1.11	1.25
3-SULFINOALANINE	ME926944	0.87	1.29	0.64	0.46	1.43	1.79	1.20	1.00
DIETHANOLAMINE	ME926996	1.03	0.99	0.97	1.04	1.07	1.03	0.92	0.96
MALEATE	ME927037	0.88	0.88	0.69	0.87	1.59	1.65	0.80	0.93
P-OCTOPAMINE	ME927072	0.80	0.81	1.22	1.13	0.82	0.81	1.16	1.02
ASPARTATE	ME926963	1.01	0.95	0.98	1.10	0.99	0.95	0.91	1.01
DIHYDROXYACETONE PHOSPHATE	ME926999	1.03	1.46	0.58	0.81	1.42	1.16	0.44	1.21
GLYCINE	ME927019	1.13	1.09	0.96	0.97	1.08	1.08	0.91	0.91
AMINOADIPATE	ME926958	0.34	0.14	0.74	3.49	0.12	0.04	0.37	0.68
CREATININE	ME926976	0.59	0.30	1.41	1.37	0.44	0.33	1.13	1.45
D-GLUCOSE	ME926995	1.02	1.19	0.99	0.98	0.99	1.16	0.90	0.90
CYTIDINE TRIPHOSPHATE	ME926984	0.99	0.68	1.02	1.21	1.05	0.73	0.93	1.08
PYROGLUTAMATE	ME927077	1.01	0.88	1.10	1.08	0.95	0.87	0.96	1.02
PHOSPHOCREATINE	ME927066	0.71	0.58	1.03	1.43	0.63	0.51	1.05	1.31
THREITOL	ME927086	0.83	0.96	1.09	1.03	0.82	0.93	1.25	1.01
AMP / dGMP	ME926959	1.08	1.08	1.06	1.01	0.98	0.88	1.10	0.89
THYMIDINE MONOPHOSPHATE	ME927088	0.80	0.53	0.99	1.16	0.90	0.65	1.11	1.35
GLUTAMATE	ME927012	1.10	1.07	0.99	0.98	1.08	1.05	0.93	0.91
RIBOSE 1,5-BISPHOSPHATE	ME927115	1.17	1.05	0.99	0.93	1.14	1.11	0.96	0.87
XANTHOSINE-MONOPHOSPHATE	ME927103	1.03	0.76	1.03	1.12	1.19	0.78	0.77	1.09
GLUTATHIONE REDUCED	ME927015	1.04	0.99	0.97	1.05	1.09	0.96	0.88	0.99
PHENYLALANINE	ME927065	1.02	0.95	1.02	1.08	0.99	0.94	0.93	0.99
D-RIBOSE 5-PHOSPHATE	ME927000	1.04	0.83	0.84	1.13	1.17	0.91	0.76	1.12
N6-(DELTA2-ISOPENTENYL)-ADENINE	ME927111	0.80	0.59	1.12	1.11	1.01	0.86	1.11	1.12
PYRIDOXINE	ME927076	0.97	0.87	1.05	1.14	0.94	0.84	0.98	1.03
ALPHA-KETOGLUTARIC ACID	ME926957	0.90	0.80	1.12	1.14	1.02	0.84	0.95	1.03
GUANOSINE MONOPHOSPHATE	ME927024	0.71	0.75	1.19	1.38	0.67	0.69	1.37	0.89
TARTRATE / MESO-TARTRATE	ME927084	0.69	0.82	0.64	0.58	2.06	2.19	0.89	0.83
VALINE	ME927101	1.03	1.02	1.02	1.02	1.00	1.01	0.96	0.96
ORNITHINE	ME927061	0.82	0.85	0.86	1.31	0.84	0.87	0.74	1.22
GLYCEROL 3-PHOSPHATE	ME927017	0.90	1.04	1.09	0.98	0.94	1.06	1.11	0.94
VALERYL-L-CARNITINE	ME927100	0.78	0.89	1.01	1.33	0.67	0.76	0.94	1.15
CREATINE	ME926975	0.73	0.63	1.04	1.21	0.84	0.75	1.05	1.26
ALPHA-HYDROXYISOBUTYRATE	ME926956	1.04	0.95	0.94	1.06	1.06	0.98	0.99	0.97
BETA-HYDROXY(ISO)BUTYRATE	ME926967	0.95	0.74	1.00	1.15	0.94	0.77	1.03	1.13
THYMIDINE_NF	ME927089	0.87	0.80	1.07	1.03	0.92	0.91	1.29	1.03
METHIONINE	ME927038	1.09	1.06	1.03	1.03	1.03	1.01	0.91	0.90
N-ACETYLALANINE	ME927043	1.24	1.37	0.92	1.05	0.98	0.88	0.82	0.86
ARGININE	ME926960	0.44	0.26	0.80	1.86	0.45	0.29	0.72	1.69
DEOXYCYTIDINE	ME926989	0.87	0.65	1.08	1.17	0.91	0.72	1.10	1.16
CDP-ETHANOLAMINE	ME926971	0.57	0.81	0.92	0.94	0.86	1.05	1.53	1.20
URIDINE TRIPHOSPHATE	ME927098	0.99	0.70	1.03	1.19	1.05	0.75	1.00	1.05
TYROSINE	ME927091	1.00	0.95	1.03	1.06	1.00	0.94	0.95	1.00
UDP-GLUCURONIC ACID	ME927093	1.03	0.88	0.98	1.07	1.07	0.90	0.96	1.02
UROCANATE	ME927099	0.77	0.82	1.18	1.05	0.78	0.80	1.06	1.21
GLUTAMINE	ME927013	1.06	1.05	1.01	1.00	1.02	1.03	0.95	0.94
O-PHOSPHOETHANOLAMINE	ME927112	0.21	0.35	1.33	1.00	0.42	0.83	2.16	1.29
URIDINE 5^-DIPHOSPHATE	ME927096	1.01	0.85	0.95	1.11	1.14	0.87	0.88	1.04
FRUCTOSE 6-PHOSPHATE	ME927003	1.06	1.01	0.94	1.09	1.03	0.99	0.83	1.00
UDP-N-ACETYLGALACTOSAMINE / GLUCOSAMINE	ME927094	1.03	0.80	1.05	1.15	0.99	0.81	0.96	1.03
URIDINE MONOPHOSPHATE	ME927097	0.91	0.59	1.71	1.15	0.52	0.44	1.45	0.92
UDP-GLUCOSE / GALACTOSE	ME927092	1.01	0.76	0.97	1.19	1.00	0.76	0.92	1.10
N-ACETYLCYSTEINE	ME927045	0.94	1.14	1.00	0.87	1.08	1.17	1.04	0.95
CIS-ACONITIC ACID	ME926972	1.05	1.00	1.04	1.01	1.06	0.97	0.97	0.94
THREONINE	ME927087	1.11	1.11	1.03	0.95	1.11	1.06	0.91	0.89
GLUCOSAMINE 6-PHOSPHATE	ME927009	1.00	0.91	1.04	1.05	1.04	0.88	0.98	1.02
GALACTITOL	ME927006	0.90	1.06	1.04	1.01	1.15	1.04	0.92	0.93
GAMMA-AMINOBUTYRATE	ME927007	0.65	0.58	0.97	1.47	0.64	0.57	0.97	1.35
FUMARATE	ME927005	1.01	0.72	1.02	1.19	0.99	0.72	0.97	1.10
1-METHYLNICOTINAMIDE_NF	ME926939	1.08	1.24	0.84	0.68	1.28	1.53	1.10	0.80
2-HYDROXYGLUTARIC ACID	ME926941	1.05	0.80	1.07	1.13	0.99	0.80	0.99	1.01
CYSTATHIONINE	ME926979	1.09	1.01	0.96	0.94	1.12	1.07	0.95	0.97
GLYCEROPHOSPHOCHOLINE	ME927018	1.08	2.35	0.76	0.49	1.01	2.15	0.87	0.44
NAD	ME927053	0.99	0.91	0.99	1.09	1.02	0.92	0.92	1.03
FRUCTOSE BISPHOSPHATE	ME927004	1.16	0.78	0.88	1.09	1.27	0.95	0.85	0.99
CYSTEATE	ME926980	0.97	1.23	0.92	0.76	1.12	1.49	1.03	0.87
LYSINE	ME927035	0.39	0.21	0.62	2.03	0.39	0.23	0.59	1.81
NADP	ME927055	1.05	1.00	0.88	1.08	1.16	1.03	0.69	1.04
N-ACETYLMETHIONINE	ME927048	0.94	0.99	1.10	1.08	0.91	0.93	0.99	0.97
CYCLIC AMP	ME926977	1.03	0.82	1.05	1.17	0.97	0.82	0.98	0.99
CYTIDINE DIPHOSPHATE	ME926982	0.99	0.78	0.93	1.15	1.12	0.85	0.88	1.10
DTDP-D-GLUCOSE	ME927001	0.95	0.79	1.00	1.19	0.99	0.80	0.89	1.11
GLUCOSE 6-PHOSPHATE	ME927010	0.97	1.04	0.98	1.06	0.96	1.02	0.94	0.99
PANTOTHENATE	ME927064	0.92	0.98	1.09	1.15	0.83	0.87	1.01	0.98
OXALATE	ME927113	0.82	0.80	0.85	0.78	1.57	1.65	1.05	0.87
MALATE	ME927036	0.98	0.73	1.06	1.17	0.96	0.73	1.00	1.09
RIBOFLAVIN	ME927078	0.85	0.72	1.76	1.27	0.48	0.41	1.56	0.71
ADENOSINE 2^,3^-CYCLIC PHOSPHATE	ME926951	1.02	0.80	1.04	1.16	0.98	0.84	0.99	1.00
ETHYL 3-UREIDOPROPIONATE	ME927002	0.98	0.76	1.10	1.09	1.01	0.95	0.96	1.02
HYPOTAURINE	ME927026	0.80	0.75	1.08	1.18	0.78	0.73	1.14	1.16
S-ADENOSYLMETHIONINE	ME927081	0.99	0.82	0.98	1.06	1.02	0.88	0.99	1.10

Factors:

F1	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (10 mM)
F2	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (20 mM)
F3	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:N-methyl-arginine (5 mM)
F4	Genotype:CRISPR/Cas9 Control (sgTomato) \| Treatment:PBS
F5	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (10 mM)
F6	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (20 mM)
F7	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:N-methyl-arginine (5 mM)
F8	Genotype:CRISPR/Cas9 KO (sgALDH7A1) \| Treatment:PBS

Data matrix