Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003657)

(Analysis AN006007)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15	F16	F17	F18	F19	F20	F21	F22	F23	F24
Isobutyrate	ME953902	0.26	0.56	0.34	0.38	4.73	0.25	2.79	0.27	1.10	0.85	0.43	1.14	0.08	2.52	0.34	0.26	1.01	0.21	3.14	0.19	0.40	0.35	0.21	0.26
Histidine	ME953901	0.36	0.75	0.34	0.09	0.52	0.35	0.67	1.13	0.55	0.48	0.15	0.51	0.40	1.67	0.27	0.11	0.49	0.39	3.34	1.18	3.08	3.67	0.13	1.45
Histamine	ME953900	2.25	0.84	1.69	0.07	1.07	1.86	0.87	0.09	0.86	0.81	0.68	0.53	1.71	2.06	1.80	0.09	0.82	2.45	1.38	0.13	1.04	1.51	0.43	0.94
Acetate	ME953884	0.05	0.71	0.04	1.03	1.96	0.04	0.65	1.09	1.93	0.51	0.85	1.81	0.26	0.47	0.18	1.18	1.75	0.24	0.59	1.05	2.07	0.43	1.01	1.78
Formate	ME953893	0.39	0.57	0.30	0.66	0.58	0.32	2.10	1.18	1.11	1.22	0.92	0.81	0.42	0.53	0.61	1.10	0.67	0.56	2.52	1.39	1.18	1.32	1.25	0.96
Isocitrate	ME953903	NA	0.35	NA	0.99	0.54	NA	2.74	1.10	0.83	1.28	1.05	0.60	NA	0.48	NA	0.64	0.26	NA	2.73	0.69	0.44	1.78	0.81	0.86
Citrate	ME953888	0.91	0.68	1.12	1.64	0.55	0.72	2.00	2.04	1.13	1.39	1.28	1.22	0.24	0.51	1.14	0.59	0.28	0.64	1.86	0.69	0.57	1.42	0.84	0.37
Glutathione	ME953898	1.29	0.57	0.87	0.69	0.58	0.81	1.02	1.69	1.27	1.43	1.14	0.75	0.28	0.75	0.67	0.46	0.31	0.28	1.88	1.22	1.33	2.08	1.09	0.82
3-Methyl-2-oxovalerate	ME953883	1.48	1.23	1.16	1.78	1.00	1.15	0.94	1.94	0.86	1.03	1.53	0.94	0.80	0.30	0.82	1.28	0.73	0.97	0.36	1.00	1.03	0.35	0.99	0.78
Fumarate	ME953894	0.52	1.57	0.65	1.17	1.08	0.54	1.52	1.31	0.98	1.57	0.93	1.65	0.55	1.11	0.95	0.58	0.73	0.74	1.37	0.58	0.78	0.97	0.64	0.75
Alanine	ME953885	0.98	1.42	1.22	1.37	1.24	0.97	1.08	1.38	1.15	1.42	1.01	1.18	0.26	0.79	0.72	1.00	0.93	0.49	0.85	0.88	0.92	0.74	0.81	0.77
Lactate	ME953906	0.50	1.00	0.70	1.37	1.19	0.50	1.30	1.46	1.23	1.15	1.14	1.17	0.24	0.53	0.56	1.34	1.12	0.40	0.73	1.17	1.26	0.58	1.11	1.12
Choline	ME953887	0.97	1.49	0.76	0.64	0.82	0.57	1.01	0.63	1.03	0.90	0.85	0.94	1.27	2.03	0.89	0.83	0.95	1.06	1.08	0.70	0.80	1.98	0.65	0.87
Glucose	ME953895	0.91	1.24	0.69	0.69	1.02	0.75	1.05	0.86	0.94	1.15	0.72	0.82	1.04	1.69	0.82	0.70	0.95	0.95	1.69	0.81	0.84	1.47	0.80	0.96
Serine	ME953914	1.04	1.03	0.51	1.04	0.96	0.72	1.32	1.20	0.48	0.92	0.90	0.70	1.14	1.57	0.74	0.63	0.97	0.88	1.61	0.78	1.03	1.42	0.93	1.04
Glutamine	ME953897	0.87	0.32	0.22	0.97	1.07	0.52	0.61	1.30	1.39	0.46	1.04	1.33	1.08	0.99	0.50	1.31	1.12	0.53	1.16	1.31	1.26	1.18	1.34	1.20
Tryptophan	ME953917	1.07	0.57	0.77	1.36	0.98	0.85	0.39	1.37	1.25	0.68	1.22	1.13	1.19	0.88	0.56	1.37	0.96	0.96	0.82	1.30	1.04	0.69	1.36	1.08
Lysine	ME953908	0.80	0.90	0.83	1.22	1.17	0.83	0.70	0.91	1.23	0.78	0.91	1.22	0.86	0.81	0.79	1.22	1.31	0.61	0.93	1.13	1.17	0.93	1.22	1.03
Tyrosine	ME953918	1.03	0.61	0.86	1.41	1.25	0.85	0.74	1.30	0.97	0.71	0.74	1.05	1.14	0.83	0.97	1.20	0.98	1.06	0.97	1.19	1.11	1.06	1.20	0.89
Glutamate	ME953896	0.27	1.25	0.36	1.10	1.01	0.52	1.42	1.22	1.03	0.92	0.95	0.95	0.97	1.08	0.86	1.06	1.08	1.34	0.85	1.04	1.05	1.22	0.96	0.86
Pyroglutamate	ME953912	0.81	1.22	0.79	1.01	1.22	0.71	0.81	1.02	1.12	1.17	0.75	0.99	0.78	1.20	0.73	0.93	1.21	0.77	0.88	0.90	1.12	1.20	0.88	1.14
Glycine	ME953899	0.39	1.10	0.24	0.82	1.18	0.29	0.94	0.95	1.20	0.92	0.79	1.10	0.64	1.32	0.52	1.08	1.20	0.60	1.42	1.08	1.26	1.29	1.06	1.18
Isoleucine	ME953904	0.60	1.09	0.51	0.99	1.19	0.51	0.67	1.16	1.09	0.77	0.89	1.09	0.79	1.24	0.57	1.05	1.16	0.73	1.41	1.17	1.13	1.20	1.17	0.90
Threonine	ME953916	0.64	0.91	0.53	1.01	1.23	0.52	0.80	1.15	1.27	1.00	0.90	1.11	0.77	1.25	0.66	0.91	1.17	0.72	1.00	1.01	1.21	1.11	0.99	1.16
Valine	ME953920	0.57	1.05	0.49	0.90	1.21	0.46	0.96	1.04	1.20	0.90	0.84	1.14	0.73	1.28	0.58	0.95	1.19	0.64	1.27	1.01	1.16	1.13	1.01	1.19
Methionine	ME953909	0.88	0.63	0.62	1.24	1.56	0.67	1.20	1.23	0.94	0.89	1.10	0.77	0.97	1.00	0.87	1.17	0.86	0.92	0.98	1.26	0.78	1.25	1.19	0.76
Arginine	ME953886	0.98	1.04	0.77	1.15	1.07	0.78	0.68	1.26	0.68	0.80	1.00	0.91	1.12	1.08	0.75	1.01	1.00	1.01	1.29	1.11	0.97	1.67	0.94	0.79
Leucine	ME953907	0.67	0.81	0.51	1.01	1.48	0.50	0.52	1.17	1.15	0.36	1.02	1.19	0.87	1.58	0.68	0.97	1.11	0.74	1.27	1.19	1.05	1.43	1.07	0.83
Phenylalanine	ME953910	0.86	0.65	0.71	1.21	1.01	0.73	0.79	1.30	1.04	0.60	1.06	0.84	0.80	1.44	0.78	1.19	1.03	0.89	1.40	1.26	1.12	1.25	1.22	0.49
Isopropanol	ME953905	NA	1.37	NA	0.87	1.56	NA	1.92	1.48	0.70	1.04	1.12	1.04	NA	0.43	NA	0.71	0.66	NA	0.41	1.29	0.59	0.76	1.20	0.88
Creatine	ME953889	NA	1.21	NA	0.52	1.23	NA	1.19	1.13	0.75	1.43	0.88	0.96	NA	1.54	NA	0.52	0.62	NA	1.08	0.82	0.51	1.63	1.19	0.72
Creatine phosphate	ME953890	NA	0.71	NA	0.37	1.46	NA	1.35	1.67	1.38	0.80	0.98	1.16	NA	1.13	NA	0.62	0.84	NA	0.89	0.79	0.55	1.14	1.18	0.83
Cysteine	ME953891	NA	1.03	NA	0.90	1.17	NA	0.80	0.67	0.49	1.21	0.45	0.98	NA	1.27	NA	0.51	0.60	NA	1.85	0.60	0.86	2.13	0.86	1.48
Proline	ME953911	NA	0.85	NA	0.52	1.10	NA	1.70	0.73	1.14	1.47	0.62	1.27	NA	0.77	NA	0.53	0.64	NA	1.49	0.75	0.94	1.61	0.74	1.01
myo-Inositol	ME953921	0.59	1.37	0.50	0.80	0.96	0.57	1.30	0.64	1.43	1.42	0.44	1.02	0.22	1.80	0.26	0.60	1.20	0.37	1.77	0.78	0.95	1.65	0.74	1.06
Ethanol	ME953892	0.25	2.96	0.25	1.03	0.70	0.25	1.48	1.07	0.68	1.45	0.80	0.66	0.41	1.61	0.40	1.06	0.70	0.35	1.61	0.96	0.75	1.38	0.97	0.71
Pyruvate	ME953913	0.18	1.89	0.17	1.07	0.99	0.16	1.53	1.22	1.11	1.05	0.93	1.02	0.13	1.81	0.37	0.87	0.82	0.23	1.87	0.91	1.12	0.99	0.86	0.86
Succinate	ME953915	0.29	2.25	0.21	0.35	0.66	0.19	2.77	0.98	0.65	1.78	0.77	1.06	0.31	1.35	0.30	0.58	0.78	0.31	2.41	0.65	0.99	0.92	0.56	0.95
Uracil	ME953919	0.63	2.48	0.73	0.31	1.80	0.68	2.27	0.46	1.10	1.85	0.31	1.32	NA	1.48	NA	0.33	0.87	NA	2.13	0.46	1.39	1.43	0.21	0.76

Factors:

F1	Sample source:U251 \| Condition:anti-GLS1 siRNA \| Method of exposure:Transfection
F2	Sample source:U251 \| Condition:Control \| Method of exposure:Direct exposure
F3	Sample source:U251 \| Condition:Control \| Method of exposure:Transfection
F4	Sample source:U251 \| Condition:Control \| Method of exposure:Transwell b.End3
F5	Sample source:U251 \| Condition:Control \| Method of exposure:Transwell b.End3 + iNHA
F6	Sample source:U251 \| Condition:Lipofectamine \| Method of exposure:Transfection
F7	Sample source:U251 \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Direct exposure
F8	Sample source:U251 \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Transwell b.End3
F9	Sample source:U251 \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Transwell b.End3 + iNHA
F10	Sample source:U251 \| Condition:PUREG4-LA12 \| Method of exposure:Direct exposure
F11	Sample source:U251 \| Condition:PUREG4-LA12 \| Method of exposure:Transwell b.End3
F12	Sample source:U251 \| Condition:PUREG4-LA12 \| Method of exposure:Transwell b.End3 + iNHA
F13	Sample source:U-87MG \| Condition:anti-GLS1 siRNA \| Method of exposure:Transfection
F14	Sample source:U-87MG \| Condition:Control \| Method of exposure:Direct exposure
F15	Sample source:U-87MG \| Condition:Control \| Method of exposure:Transfection
F16	Sample source:U-87MG \| Condition:Control \| Method of exposure:Transwell b.End3
F17	Sample source:U-87MG \| Condition:Control \| Method of exposure:Transwell b.End3 + iNHA
F18	Sample source:U-87MG \| Condition:Lipofectamine \| Method of exposure:Transfection
F19	Sample source:U-87MG \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Direct exposure
F20	Sample source:U-87MG \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Transwell b.End3
F21	Sample source:U-87MG \| Condition:PUREG4-LA12-anti-GLS1 siRNA \| Method of exposure:Transwell b.End3 + iNHA
F22	Sample source:U-87MG \| Condition:PUREG4-LA12 \| Method of exposure:Direct exposure
F23	Sample source:U-87MG \| Condition:PUREG4-LA12 \| Method of exposure:Transwell b.End3
F24	Sample source:U-87MG \| Condition:PUREG4-LA12 \| Method of exposure:Transwell b.End3 + iNHA

Data matrix