Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003845)

(Analysis AN006319)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
Hypoxanthine	ME1017374	0.14	6.82	0.19	0.20	0.15	0.10	0.31	0.09
Ethanol	ME1017365	0.33	0.76	0.36	0.91	0.59	1.43	2.91	0.71
Methylsuccinate	ME1017463	1.16	1.03	0.66	0.77	0.86	0.64	2.00	0.89
Pyruvate	ME1017467	0.82	0.86	0.90	0.77	0.91	0.62	2.54	0.58
Pyruvic acid	ME1017392	0.87	1.04	0.90	0.64	0.93	0.63	2.45	0.53
Glycolate	ME1017366	0.45	1.37	0.42	0.92	1.52	0.44	2.31	0.57
Malonate	ME1017407	0.61	1.99	0.75	1.12	1.30	0.06	2.03	0.12
Trimethylamine N-oxide	ME1017472	0.55	0.99	0.72	0.55	1.27	0.97	0.75	2.20
Methionine	ME1017408	1.31	1.41	1.06	1.59	0.88	0.48	0.40	0.65
1-Methylnicotinamide	ME1017421	1.33	1.95	0.95	1.88	0.39	0.84	0.15	0.51
L-Glutamine	ME1017405	1.35	1.80	0.76	1.65	0.64	0.74	0.52	0.49
Pyridoxine	ME1017466	0.65	2.30	0.86	1.49	0.48	0.80	0.52	0.91
Trimethylamine	ME1017471	1.02	2.48	0.97	1.82	0.26	0.84	0.19	0.41
L-Lactic acid	ME1017386	1.44	1.10	0.93	0.77	0.57	0.77	0.68	1.73
3-Aminoisobutyrate	ME1017424	0.55	1.07	0.72	1.47	1.04	0.99	0.92	1.24
3-Indoxylsulfate	ME1017426	0.66	1.07	1.10	1.56	0.70	1.13	0.95	0.83
3-Methylhistidine	ME1017401	0.93	1.25	1.25	1.54	0.95	0.76	0.65	0.63
Mandelate	ME1017459	0.62	1.22	1.23	1.48	0.91	0.84	0.76	0.94
Fumaric acid	ME1017371	0.91	1.01	0.94	1.21	0.82	1.57	0.62	0.91
Carnitine	ME1017440	0.98	1.39	1.12	0.94	1.11	1.11	0.35	1.00
Phosphorylcholine	ME1017413	1.41	0.86	1.07	1.53	0.75	1.00	0.37	0.96
L-Histidine	ME1017383	1.17	0.98	0.98	1.03	0.85	1.26	0.41	1.33
Methylmalonic acid	ME1017389	1.28	1.04	0.83	1.08	0.57	1.13	0.67	1.33
Thymine	ME1017468	1.13	1.16	1.06	1.25	0.74	1.00	0.59	1.08
Isovaleric acid	ME1017410	1.27	1.17	1.24	1.01	0.60	1.07	0.68	0.96
2-Hydroxyvalerate	ME1017423	1.26	1.24	1.24	1.13	0.59	1.12	0.40	1.02
Valine	ME1017411	1.36	1.28	1.03	1.24	0.62	1.06	0.52	0.92
Cadaverine	ME1017439	1.35	1.38	1.16	1.01	0.85	0.70	0.56	0.98
Caffeine	ME1017415	1.57	1.28	1.06	1.07	0.91	0.96	0.48	0.67
L-Serine	ME1017385	0.75	1.43	0.68	0.83	1.11	1.08	1.18	0.94
Tyramine	ME1017473	0.81	1.20	0.86	0.91	1.40	0.76	1.33	0.74
Urocanate	ME1017474	0.65	1.30	0.74	0.80	1.34	0.83	1.60	0.74
Cytosine	ME1017445	1.13	1.03	1.46	0.91	0.87	0.87	0.89	0.85
Methanol	ME1017416	0.95	0.98	1.06	0.80	1.15	0.74	1.05	1.26
Imidazole	ME1017454	1.00	0.98	0.94	1.00	1.06	1.02	1.04	0.96
Indole-3-lactate	ME1017455	0.86	1.07	0.91	0.84	0.98	1.25	1.08	1.03
Formate	ME1017448	0.80	1.77	0.91	0.84	0.82	0.76	1.28	0.83
Inosine	ME1017456	1.03	1.65	0.83	0.89	0.75	0.69	1.42	0.74
Adipate	ME1017433	0.97	1.40	1.06	1.31	0.72	0.56	1.01	0.98
L-Glutamic acid	ME1017373	1.02	1.40	0.96	1.06	0.75	0.86	1.21	0.73
Adenosine	ME1017432	1.13	1.31	0.76	1.02	0.93	0.77	1.23	0.85
2-Hydroxyisovalerate	ME1017422	0.92	1.34	0.92	0.82	1.04	0.77	1.25	0.94
Butyrate	ME1017438	0.92	1.30	0.94	0.94	0.95	0.84	1.19	0.92
Isobutyrate	ME1017457	0.93	1.31	0.92	0.97	0.94	0.85	1.15	0.93
Pyroglutamic acid	ME1017396	0.95	1.66	0.96	1.00	0.68	0.87	1.01	0.86
Methylmalonate	ME1017462	0.92	1.42	1.07	1.09	0.74	0.83	1.00	0.93
cis-Aconitate	ME1017442	1.01	1.39	0.96	0.96	0.81	0.97	0.98	0.91
L-Cystine	ME1017388	0.99	1.52	0.97	0.90	0.71	0.94	0.95	1.01
p-Cresol sulfate	ME1017420	1.00	1.43	1.11	0.87	0.92	0.97	0.85	0.85
Tyrosine	ME1017375	1.01	1.33	1.07	0.91	0.95	0.91	1.05	0.77
Glycine	ME1017368	1.04	1.17	1.01	1.07	0.98	1.09	0.78	0.86
Acetone	ME1017414	1.09	1.25	1.06	1.09	0.78	0.91	0.96	0.86
Propylene glycol	ME1017417	1.01	1.21	1.12	1.12	0.85	0.87	0.91	0.92
Dimethylamine	ME1017446	1.04	1.78	1.24	0.94	0.37	0.91	1.06	0.66
Uracil	ME1017399	1.14	1.51	1.12	1.09	0.30	0.74	1.16	0.83
Isocitrate	ME1017458	0.73	1.82	0.65	1.28	1.29	0.66	0.88	0.69
Creatinine	ME1017444	0.89	1.76	0.99	1.37	0.94	0.63	0.71	0.71
ADP	ME1017434	1.13	1.69	1.01	1.24	1.15	0.54	0.58	0.67
Ethanolamine	ME1017447	0.88	1.61	1.03	1.15	1.16	0.69	0.60	0.88
Choline	ME1017441	1.12	1.73	1.07	1.24	0.52	1.30	0.34	0.68
Glycerol	ME1017370	0.71	1.85	1.04	1.09	0.85	0.64	0.94	0.88
Mannitol	ME1017460	0.58	1.98	1.06	0.99	0.91	0.71	1.05	0.71
L-Arginine	ME1017402	0.91	1.97	0.93	1.05	0.88	0.74	0.75	0.72
Urea	ME1017398	0.80	2.13	1.06	1.06	0.95	0.58	0.80	0.62
Glucose	ME1017449	0.73	1.92	1.24	0.86	0.62	0.80	1.07	0.76
ATP	ME1017437	0.82	1.92	0.84	1.09	0.69	0.74	0.89	1.00
Glucuronate	ME1017450	0.90	1.88	0.99	0.92	0.56	0.82	0.97	0.96
L-Cysteine	ME1017403	1.13	1.39	0.95	1.33	0.86	0.93	0.64	0.85
Dimethyl sulfone	ME1017419	0.98	1.58	0.98	1.34	0.56	0.86	0.71	0.99
L-Alanine	ME1017377	0.98	1.59	1.07	1.34	0.72	0.89	0.63	0.79
Tryptophan	ME1017412	1.17	1.48	1.03	0.98	0.63	1.20	0.61	0.89
3-Hydroxybutyric acid	ME1017400	1.22	1.57	0.98	1.10	0.58	1.02	0.65	0.89
5-Aminopentanoate	ME1017418	1.13	1.48	1.07	1.06	0.66	1.01	0.61	0.98
Creatine	ME1017364	0.98	1.60	1.28	1.16	0.68	0.84	0.64	0.82
L-Threonine	ME1017379	1.10	1.36	1.27	1.11	0.69	0.89	0.68	0.91
4-Aminobutyrate	ME1017427	0.83	1.64	1.08	1.07	0.69	1.08	0.51	1.10
L-Lysine	ME1017384	1.13	1.55	1.12	1.01	0.67	1.00	0.41	1.11
Succinate	ME1017395	0.98	1.57	1.18	0.98	0.68	1.14	0.34	1.13
Guanidoacetate	ME1017369	0.90	1.57	0.96	1.10	0.81	1.08	0.69	0.90
L-Asparagine	ME1017380	1.00	1.81	0.91	1.12	0.73	0.92	0.71	0.81
L-Fucose	ME1017382	1.04	1.75	0.83	1.03	0.72	0.90	0.88	0.84
Acetamide	ME1017428	0.81	1.66	1.19	0.96	0.59	1.09	0.75	0.95
Histamine	ME1017453	0.93	1.57	0.94	1.01	0.55	1.00	0.81	1.20
D-Glucose	ME1017367	1.01	1.68	0.87	0.84	0.78	0.98	0.80	1.04
Acetate	ME1017429	0.92	1.56	1.03	0.94	0.81	0.87	0.70	1.17
L-Leucine	ME1017406	0.84	1.68	1.01	1.06	0.85	0.86	0.68	1.03
Glutarate	ME1017451	1.01	1.51	1.19	0.85	0.67	0.89	0.83	1.04
AMP	ME1017435	0.99	1.69	1.18	0.88	0.67	0.87	0.69	1.04
Methylguanidine	ME1017461	0.93	1.63	1.08	1.01	0.69	0.95	0.69	1.01
N,N-Dimethylglycine	ME1017464	1.26	2.02	1.21	1.17	0.56	0.78	0.36	0.64
Isoleucine	ME1017381	1.02	2.24	0.98	1.16	0.53	0.72	0.67	0.69
Acetoacetate	ME1017430	0.85	2.18	1.05	1.00	0.61	0.84	0.72	0.75
Sorbitol	ME1017393	0.86	2.21	1.12	0.97	0.53	0.88	0.64	0.80
trans-Aconitate	ME1017469	0.93	2.14	1.11	1.13	0.77	0.66	0.47	0.80
Anserine	ME1017436	0.86	1.88	1.16	1.10	0.96	0.89	0.38	0.77
Trigonelline	ME1017470	0.94	1.98	1.10	1.05	0.76	0.87	0.43	0.87
Methylamine	ME1017378	1.08	1.77	1.20	1.08	0.60	0.97	0.45	0.86
Gluconic acid	ME1017404	1.00	1.76	1.14	1.03	0.69	0.97	0.62	0.78
Hippuric acid	ME1017409	1.04	1.73	1.04	1.16	0.56	0.98	0.64	0.84
D-Galactose	ME1017372	1.08	1.91	1.12	0.91	0.73	0.99	0.49	0.76
O-Acetylcarnitine	ME1017465	0.94	1.96	1.18	0.86	0.74	0.87	0.62	0.83
Sarcosine	ME1017397	1.00	1.91	1.07	0.88	0.73	0.91	0.79	0.71
Citrate	ME1017443	0.83	1.21	2.06	1.01	0.68	0.63	0.78	0.80
3-Hydroxyisovalerate	ME1017425	0.61	1.23	1.37	0.54	1.00	1.01	1.58	0.66
Guanosine	ME1017452	0.64	1.18	1.37	0.71	1.29	0.66	1.26	0.89
Taurine	ME1017394	0.74	2.12	0.79	1.17	1.47	0.38	1.03	0.29
Adenine	ME1017431	1.30	2.35	0.87	0.85	0.38	0.85	0.63	0.77
Aspartate	ME1017387	0.76	3.15	0.83	0.88	0.47	0.78	0.53	0.59
L-Phenylalanine	ME1017376	0.71	3.02	0.85	0.86	0.58	0.67	0.64	0.67
Myo-inositol	ME1017391	0.73	2.46	0.93	1.00	0.78	0.85	0.70	0.56
Phenylacetate	ME1017390	0.75	2.70	0.79	0.84	0.70	0.94	0.83	0.79

Factors:

F1	Dose:0.03 µg/kg TCDD
F2	Dose:0.1 µg/kg TCDD
F3	Dose:0.3 µg/kg TCDD
F4	Dose:0 µg/kg TCDD
F5	Dose:10 µg/kg TCDD
F6	Dose:1 µg/kg TCDD
F7	Dose:30 µg/kg TCDD
F8	Dose:3 µg/kg TCDD

Data matrix