Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST003867)

(Analysis AN006355)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
cotinine	ME1021497	0.31	0.02	15.71	0.01	0.02	0.29	0.02	0.03
acetylcholine	ME1021490	0.69	0.12	0.06	0.05	10.73	0.59	1.31	0.40
diacetylspermine	ME1021551	0.54	0.24	0.07	0.01	9.01	0.60	0.69	0.36
hippurate	ME1021445	0.35	0.15	0.28	0.06	1.14	1.32	8.36	0.54
caffeine	ME1021547	1.04	0.55	0.18	0.14	0.00	0.60	7.95	0.72
metoprolol	ME1021524	0.54	0.47	0.00	0.00	0.00	1.53	7.93	0.00
adrenochrome	ME1021544	0.49	1.21	5.62	0.09	0.76	0.32	1.04	0.83
hydroxycotinine	ME1021557	0.15	0.03	7.90	NA	NA	0.52	NA	0.04
C16:0 Ceramide (d18:1)	ME1021615	0.03	0.72	NA	4.73	0.15	0.49	0.02	1.95
sphingosine_A*	ME1021612	0.10	0.49	0.01	7.64	0.37	0.42	0.06	2.73
sphingosine_B*	ME1021613	0.11	0.46	0.01	8.03	0.40	0.39	0.06	2.65
sphinganine	ME1021595	0.74	1.07	2.32	0.24	4.90	0.41	0.14	0.59
acetaminophen glucuronide	ME1021542	0.34	0.04	0.00	NA	4.23	2.84	0.00	0.92
methylguanidine	ME1021480	0.45	0.13	0.07	0.08	6.28	1.71	1.79	0.45
methylimidazole acetic acid	ME1021564	0.50	0.13	0.09	0.08	5.83	1.60	1.84	0.82
DMGV	ME1021553	0.56	0.07	0.33	0.01	4.94	1.86	1.86	0.71
phenylacetylglutamine	ME1021587	0.57	0.19	0.28	0.12	4.75	1.40	2.00	1.29
C8 carnitine	ME1021513	0.63	0.22	0.42	0.06	6.88	1.28	0.40	1.05
N1,N12-diacetylspermine	ME1021566	0.42	0.38	NA	NA	6.57	0.44	0.54	0.50
3-(N-acetyl-L-cystein-S-yl) acetaminophen	ME1021527	0.37	0.05	NA	NA	5.54	0.79	NA	0.67
C10 carnitine	ME1021514	0.73	0.26	0.58	0.14	5.27	1.34	0.59	1.28
1-methylhistidine	ME1021523	0.56	0.35	0.26	0.39	5.50	1.55	0.66	0.79
N2,N2-dimethylguanosine	ME1021569	0.44	0.29	0.18	0.25	5.97	1.59	0.89	0.80
proline betaine	ME1021590	0.83	0.22	0.02	0.50	4.66	0.93	4.11	0.72
trigonelline	ME1021596	0.68	0.39	0.03	0.18	1.88	1.66	4.52	0.38
4-hydroxyhippurate	ME1021534	0.49	0.08	0.21	0.01	3.46	1.27	4.82	1.30
N-methylproline	ME1021585	0.63	0.34	NA	0.45	2.61	0.53	5.72	1.24
N-lauroylglycine	ME1021584	0.88	0.60	0.99	0.76	2.17	0.82	3.16	0.99
alpha-hydroxymetoprolol	ME1021545	0.18	0.53	NA	NA	NA	1.06	4.23	NA
3-methylxanthine	ME1021530	0.85	0.51	0.11	1.10	0.53	1.37	3.84	0.91
urocanic acid	ME1021598	1.15	0.44	0.38	0.84	0.56	1.32	4.34	0.47
5-acetylamino-6-amino-3-methyluracil	ME1021535	0.52	0.36	0.33	0.03	0.26	2.23	3.55	0.77
N-acetylhistamine	ME1021575	0.64	0.60	NA	0.64	0.03	1.76	3.32	0.54
3-methoxytyramine	ME1021521	0.35	0.28	0.04	0.15	0.02	3.77	0.05	0.11
bilirubin	ME1021442	1.02	1.10	2.30	0.07	1.44	0.70	0.91	0.89
N-ethylglycinexylidide	ME1021583	1.25	1.10	1.01	0.45	2.50	0.16	NA	1.16
N-acetylornithine	ME1021578	0.60	0.46	0.10	1.11	2.29	1.80	2.44	0.40
methylthioadenosine	ME1021525	1.18	0.75	0.28	1.46	3.53	0.85	1.17	0.44
N-acetylmethionine	ME1021577	0.98	0.80	0.27	1.04	3.12	0.88	1.80	0.66
4-acetamidobutanoate	ME1021531	0.62	0.34	0.23	0.28	4.20	1.44	2.50	0.72
2^-O-methyladenosine	ME1021526	0.58	0.27	0.13	0.36	3.40	1.79	2.58	0.63
N4-acetylcytidine	ME1021570	0.75	0.48	0.15	0.76	3.22	1.35	2.47	0.67
ectoine	ME1021554	0.65	0.34	0.41	0.40	3.52	1.31	1.49	1.48
allantoin	ME1021478	0.64	0.33	0.21	0.13	3.11	2.03	1.41	0.73
cytosine	ME1021495	0.62	0.40	0.19	0.58	3.12	1.84	1.40	0.75
5-methylcytosine	ME1021538	0.73	0.48	0.36	0.34	2.77	1.64	1.67	0.87
pseudouridine	ME1021591	0.83	0.50	0.26	0.65	3.09	1.39	1.77	0.84
glycine	ME1021450	0.86	0.48	1.33	0.49	3.50	0.79	0.80	1.88
C12:1 carnitine	ME1021516	0.67	0.44	0.73	0.14	3.38	1.64	0.54	1.24
C14:1 carnitine	ME1021518	0.55	0.42	0.74	0.14	3.64	1.44	0.33	1.53
butyrobetaine	ME1021500	0.72	0.48	0.52	0.38	3.79	1.16	0.72	1.68
C5-DC carnitine	ME1021511	0.74	0.51	0.44	0.37	4.23	1.30	0.91	1.05
C6 carnitine	ME1021512	0.67	0.47	0.32	0.21	4.10	1.46	0.55	1.30
kynurenic acid	ME1021481	0.67	0.65	0.37	0.15	2.25	2.06	0.53	0.59
trimethylamine-N-oxide	ME1021493	0.57	0.55	0.26	0.30	2.19	2.01	1.18	0.77
3-methylhistamine	ME1021528	0.62	0.61	0.22	0.89	2.82	1.64	0.74	0.53
3-methylhistidine	ME1021529	0.48	0.41	0.30	0.69	3.40	2.00	0.85	0.64
4-acetamidophenylglucuronide	ME1021532	0.27	0.05	NA	NA	3.13	2.13	NA	0.70
5-hydroxytryptophan	ME1021472	0.69	0.16	0.10	0.26	3.04	1.88	0.53	0.85
NH4_C34:2 DAG	ME1021621	0.63	0.23	0.82	0.22	2.08	1.57	1.61	1.79
citrulline	ME1021470	0.66	0.45	0.51	0.32	1.93	1.67	1.38	1.47
N-acetylhistidine	ME1021576	0.59	0.42	0.48	0.30	1.91	1.80	1.36	1.45
phosphocholine	ME1021488	0.81	0.43	0.58	0.88	1.74	1.58	0.54	1.65
C12 carnitine	ME1021515	0.67	0.33	0.91	0.14	1.58	1.75	0.87	1.92
hydroxyproline	ME1021468	0.80	0.37	0.98	0.38	1.54	1.49	0.78	2.07
proline	ME1021467	0.75	0.30	0.91	0.31	2.27	1.20	0.81	2.55
N-alpha-acetylarginine	ME1021581	0.62	0.52	0.36	0.19	2.33	1.29	1.14	2.18
NH4_C36:3 DAG	ME1021622	0.55	0.37	0.66	0.03	2.03	1.45	1.10	2.44
C5 carnitine	ME1021509	0.81	0.63	0.33	0.63	1.73	1.21	0.97	1.95
pterin	ME1021592	0.67	0.54	0.08	0.22	1.98	1.49	0.69	2.18
C18:3 LPC	ME1021601	0.80	0.76	0.70	0.47	3.19	1.04	0.56	1.36
C16:0 LPC_B	ME1021600	0.87	0.76	1.01	0.44	3.26	0.93	0.62	1.26
C18:1 LPC	ME1021603	0.86	0.87	1.03	0.50	3.15	0.87	0.64	1.14
C18:2 LPC	ME1021602	0.90	0.83	0.81	0.67	2.76	0.96	0.93	1.07
7-Methylguanine	ME1021540	0.94	0.83	0.42	0.80	2.97	0.95	1.08	1.00
N1-acetylspermidine	ME1021567	0.87	0.69	0.49	0.97	3.06	1.16	0.77	1.02
N-acetylspermidine	ME1021580	0.87	0.69	0.48	0.96	3.11	1.15	0.76	1.02
5-hydroxymethy4-methyluracil	ME1021536	0.84	0.62	0.29	0.73	2.56	1.47	1.68	0.62
C3-DC-CH3 carnitine	ME1021506	0.79	0.65	0.18	0.83	2.09	1.50	1.74	0.74
6,8-dihydroxypurine	ME1021539	0.94	1.00	0.33	0.48	2.31	0.92	1.15	1.11
C5:1 carnitine	ME1021510	0.85	0.85	0.22	0.81	2.26	1.19	0.99	1.07
1-methylguanosine	ME1021522	0.80	0.86	0.62	0.74	2.18	1.08	1.15	1.14
N-acetyalanine	ME1021572	0.88	0.78	0.43	0.82	2.32	1.12	1.39	1.00
N6-acetyllysine	ME1021571	0.74	0.53	0.48	0.32	2.69	1.36	1.26	1.47
creatinine	ME1021492	0.88	0.61	0.40	0.57	2.63	1.27	1.39	1.13
SDMA	ME1021476	0.69	0.60	0.32	0.60	2.40	1.46	1.35	1.21
trimethyllysine	ME1021597	0.63	0.72	0.52	0.54	2.20	1.42	1.36	1.10
C18:0 LPC	ME1021604	0.88	0.85	1.11	0.43	2.04	1.00	0.55	1.52
C14:2 carnitine	ME1021519	0.71	0.64	0.83	0.16	2.84	1.38	0.59	1.38
C4 carnitine	ME1021507	0.77	0.63	0.24	0.40	2.85	1.45	0.64	1.30
dimethylglycine	ME1021474	0.61	0.46	0.58	0.26	2.41	1.59	0.76	1.76
C4-OH carnitine	ME1021508	0.76	0.64	0.43	0.38	2.01	1.63	0.65	1.28
C3 carnitine	ME1021505	0.89	0.69	0.37	0.77	2.21	1.23	0.47	1.58
C2 carnitine	ME1021504	0.87	0.64	0.44	0.55	2.44	1.31	0.74	1.39
carnitine	ME1021503	0.87	0.65	0.59	0.59	2.32	1.22	0.79	1.50
2-aminooctanoic acid	ME1021552	0.98	0.88	0.33	2.61	0.18	0.80	0.67	1.83
7-methylxanthine	ME1021541	0.99	0.92	0.14	1.96	0.23	0.93	2.06	1.15
NH4_C44:1 TAG	ME1021624	0.78	0.77	0.70	1.97	0.77	0.93	2.04	1.30
NH4_C46:2 TAG	ME1021626	0.77	0.75	0.65	2.10	0.81	0.92	2.06	1.33
NH4_C44:2 TAG	ME1021623	0.75	0.73	0.63	2.43	0.74	0.94	2.00	1.27
NH4_C46:3 TAG	ME1021625	0.70	0.67	0.57	2.74	0.72	0.87	2.18	1.42
histamine	ME1021483	1.19	1.50	0.32	1.34	0.18	0.77	0.29	0.88
1-methylhistamine	ME1021482	1.62	1.49	0.08	2.34	0.85	0.33	0.50	0.30
inosine	ME1021447	0.84	1.05	0.32	2.29	0.71	1.33	0.52	0.55
linoleoyl ethanolamide	ME1021561	1.70	0.75	0.84	2.06	1.09	0.60	1.30	0.73
N-acetylaspartic acid	ME1021573	1.24	1.24	0.21	2.13	0.78	0.61	1.21	0.65
acetyl-galactosamine	ME1021543	1.04	1.18	0.39	1.40	0.66	0.76	1.64	0.93
N-acetylgalactosamine	ME1021574	1.00	1.12	0.39	1.30	1.06	0.82	1.48	0.93
putrescine	ME1021501	1.04	0.95	0.66	1.47	1.47	0.85	1.06	1.02
5-methylcytidine	ME1021537	1.00	1.19	0.32	1.76	1.33	0.78	0.97	0.76
alpha-glycerophosphocholine	ME1021489	1.09	1.21	0.34	1.60	1.21	0.63	1.23	0.87
cortisone	ME1021549	0.91	1.50	0.53	1.57	0.87	0.73	0.87	0.52
cytidine	ME1021443	1.04	1.36	0.53	1.46	1.24	0.70	0.47	0.78
creatine	ME1021491	1.08	0.94	0.50	1.66	1.18	0.98	0.58	1.11
aminoisobutyric acid	ME1021479	0.89	0.84	0.53	1.93	1.27	1.23	0.38	1.04
GABA	ME1021473	0.93	0.88	0.53	2.11	1.27	1.20	0.24	0.94
methionine	ME1021454	0.89	0.74	0.71	1.54	1.04	1.00	0.47	1.94
tyrosine	ME1021465	0.95	0.89	0.71	1.60	0.86	1.14	0.57	1.21
threonine	ME1021453	0.92	0.91	0.82	1.44	0.79	1.04	0.30	1.58
tryptophan	ME1021466	1.03	0.84	0.80	1.48	0.96	1.06	0.39	1.41
xanthosine	ME1021496	1.11	0.84	0.55	1.18	1.41	0.80	0.57	1.78
phenylalanine	ME1021464	0.92	0.74	0.73	1.67	1.34	1.04	0.61	1.51
leucine	ME1021462	0.94	0.73	0.57	1.77	1.67	0.97	0.52	1.57
valine	ME1021461	0.96	0.77	0.59	1.71	1.50	1.04	0.50	1.40
asparagine	ME1021456	0.91	0.73	0.54	1.45	1.63	1.01	0.74	1.60
isoleucine	ME1021463	0.90	0.65	0.53	1.76	1.59	1.00	0.70	1.74
glutamate	ME1021455	0.77	1.42	0.68	0.46	1.33	0.76	0.59	1.23
cortisol	ME1021548	0.88	1.17	0.50	1.02	1.56	1.02	1.37	0.48
N-acetylputrescine	ME1021579	0.94	0.97	0.40	1.08	1.89	0.96	1.44	0.82
choline	ME1021487	0.90	0.85	0.44	0.88	1.27	1.09	1.50	1.27
1-methyladenosine	ME1021448	0.93	0.99	0.26	1.17	1.36	1.07	1.32	0.92
taurine	ME1021471	0.93	1.08	0.34	1.11	1.25	1.02	1.16	0.94
imidazoleacetic acid	ME1021559	0.69	0.96	0.41	0.48	1.64	1.11	1.24	1.45
ADMA	ME1021475	0.69	0.77	0.50	0.88	1.60	1.36	1.01	1.31
methionine sulfoxide	ME1021502	0.85	0.91	0.39	0.69	1.67	1.19	0.95	1.23
N-carbamoyl-beta-alanine	ME1021484	0.90	0.78	0.39	0.69	1.41	1.40	1.25	1.04
1-methylguanine	ME1021520	0.78	0.89	0.44	0.84	1.58	1.17	1.31	1.17
NMMA	ME1021477	0.73	0.92	0.34	1.07	1.53	1.28	1.14	1.00
cyclohexylamine	ME1021550	1.12	1.31	0.89	0.99	0.65	0.79	0.77	0.83
L-threo-Sphingosine	ME1021562	1.01	0.90	0.97	1.46	0.83	1.07	1.07	0.92
methyl N-methylanthranilate	ME1021563	0.87	1.08	0.93	0.59	1.11	1.04	1.23	0.99
myristoleate	ME1021565	0.89	1.04	1.19	0.83	0.89	1.08	1.07	0.91
sphingosine_D*	ME1021614	1.02	0.94	0.94	0.87	1.26	1.08	1.03	0.91
S-methyl-L-cysteine-S-oxide	ME1021594	1.20	1.12	1.08	1.09	0.96	0.72	1.07	0.87
4-Hydroxy-3-methylacetophenone	ME1021533	1.13	1.05	0.82	1.12	1.04	0.88	1.21	0.82
1,2,4-trimethylbenzene	ME1021441	1.06	1.03	0.97	1.08	0.97	0.92	1.14	0.91
phenylalanine-d8	ME1021440	1.00	0.99	1.02	1.00	1.02	1.00	0.99	1.01
valine-d8	ME1021439	1.00	1.01	0.98	1.00	0.98	1.00	1.01	0.99
phytosphingosine	ME1021588	0.86	1.22	0.28	0.72	0.48	1.06	0.98	1.31
xanthine	ME1021449	0.92	1.30	0.46	0.88	0.57	1.05	0.59	1.02
homoarginine	ME1021556	0.83	1.23	0.43	1.45	0.50	1.05	0.59	1.11
pyridoxamine	ME1021593	0.79	1.14	0.36	1.25	1.14	1.08	0.55	1.17
lysine	ME1021460	0.84	0.99	0.32	1.22	1.03	1.20	0.55	1.31
serine	ME1021452	0.88	0.95	0.50	1.27	1.01	1.11	0.58	1.40
guanine	ME1021444	0.79	0.81	0.62	1.20	0.67	1.30	0.91	1.50
arginine	ME1021459	0.85	0.91	0.44	1.07	0.77	1.17	0.95	1.49
glutamine	ME1021457	0.86	0.93	0.36	1.12	0.85	1.26	0.95	1.24
pyroglutamic acid	ME1021498	0.93	0.85	0.51	1.08	1.07	1.32	0.91	1.06
hypoxanthine	ME1021446	0.82	0.97	0.68	1.26	0.71	1.22	0.79	1.19
niacinamide	ME1021485	0.84	0.99	0.51	1.05	0.80	1.32	0.74	1.07
histidine	ME1021458	0.64	0.67	0.33	1.30	1.05	1.47	0.65	1.77
ornithine	ME1021469	0.65	0.70	0.34	1.01	0.79	1.48	0.65	1.93
alanine	ME1021451	0.86	0.67	0.70	1.00	1.09	1.26	1.06	1.59
betaine	ME1021486	0.84	0.80	0.77	0.64	1.11	1.13	0.70	1.86
1-methylnicotinamide	ME1021499	0.73	0.90	0.24	0.39	1.05	1.82	0.74	0.79
L-a-glutamyl-L-Lysine	ME1021560	0.64	0.96	0.27	0.60	1.22	1.52	0.47	1.32
imidazole propionate	ME1021558	0.83	0.31	0.16	0.17	1.45	2.18	1.26	1.11
N1-Methyl-2-pyridone-5-carboxamide	ME1021568	0.68	0.51	0.14	0.57	1.07	2.25	0.80	0.91
Ne,Ne dimethyllysine	ME1021582	0.51	0.36	0.44	0.81	0.99	2.23	0.82	1.33
adenosine	ME1021494	0.92	0.22	0.60	0.25	0.73	1.98	2.16	1.24
Pantothenol	ME1021586	1.21	0.59	0.45	0.88	0.33	1.86	1.49	0.43
piperine	ME1021589	0.38	1.40	0.14	0.05	0.21	2.00	0.04	1.18
warfarin	ME1021599	0.10	0.87	NA	NA	NA	1.69	NA	3.29
guanidoacetic acid	ME1021555	0.74	0.58	1.16	0.40	1.62	0.92	0.44	2.78
biliverdin	ME1021546	0.31	0.08	0.69	NA	0.08	1.81	0.82	2.04
C22:0 SM	ME1021620	0.54	0.77	0.38	NA	0.46	1.21	0.55	2.41
C36:2 PC	ME1021607	0.75	0.83	0.51	0.09	0.73	1.16	0.70	2.47
C14 carnitine	ME1021517	0.70	0.51	0.92	0.03	1.32	1.31	0.63	2.13
C18:0 SM	ME1021618	0.65	0.44	0.55	0.07	1.20	1.64	0.77	2.34
C20:0 SM	ME1021619	0.71	0.54	0.66	0.03	1.12	1.45	0.70	2.43
C38:5 PE plasmalogen	ME1021610	0.46	0.27	0.42	NA	0.90	1.86	0.60	2.44
C34:3 PC	ME1021606	0.72	0.33	0.74	0.35	0.89	1.51	0.58	2.79
C16:0 SM	ME1021616	0.57	0.43	0.41	0.03	0.91	1.68	0.57	2.74
C18:1 SM	ME1021617	0.63	0.43	0.53	0.06	0.98	1.49	0.77	2.84
C30:0 PC	ME1021605	0.66	0.47	0.63	0.17	0.85	1.46	0.65	2.76
C36:5 PE plasmalogen	ME1021608	0.36	0.32	0.71	NA	1.27	1.99	0.47	1.60
C38:6 PE plasmalogen	ME1021609	0.48	0.49	0.47	NA	0.73	1.94	0.14	2.01
C40:7 PE plasmalogen	ME1021611	0.55	0.68	0.34	0.03	1.09	1.61	0.39	2.18

Factors:

F1	Sample source:pooled vitreous QC \| Dianosis:NA \| Disease Status:NA
F2	Sample source:Vitreous humor \| Dianosis:Epiretinal membrane (ERM) \| Disease Status:Control
F3	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with macular edema and pre-retinal hemorrhage
F4	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with neovascular glaucoma
F5	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with tractional retinal detachments
F6	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with vitreous hemorrhage
F7	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with vitreous hemorrhage and cataract
F8	Sample source:Vitreous humor \| Dianosis:Proliferative diabetic retinopathy (PDR) \| Disease Status:Active with vitreous hemorrhage and tractional retinal detachments

Data matrix