Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004032)

(Analysis AN006668)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7
hydroxydeoxyguanosine	ME1070383	1.73	2.20	1.52	1.00	1.63	1.09	0.47
D-Leucine	ME1070376	0.53	0.92	0.69	0.62	0.76	0.66	1.30
7-Methylguanine	ME1070249	1.26	1.32	1.12	1.60	1.83	1.79	0.51
CDP	ME1070411	0.89	1.24	2.16	3.19	1.33	1.24	0.32
7,8-Dimethylalloxazine	ME1070298	1.07	1.10	1.48	1.74	2.90	2.65	0.18
1-Methylguanosine	ME1070256	1.52	1.78	1.15	1.37	1.25	1.57	0.56
4-((2Z)-3-naphthylprop-2-enoyl)phenyl 2,2-dimethylpropanoate	ME1070352	0.00	0.32	0.00	0.22	0.28	0.12	1.84
Azuleno(5,6-c)furan-1(3H)-one, 4,4a,5,6,7,7a,8,9-octahydro-3,4,8-trihydroxy-6,6,8-trimethyl-	ME1070266	0.79	0.63	0.56	0.89	0.84	0.82	1.25
D-Malic acid	ME1070355	0.88	1.08	1.44	1.40	1.58	1.86	0.63
Chlorpropamide	ME1070404	0.25	0.29	0.13	0.90	0.78	0.58	1.51
3-Hydroxyglabrol	ME1070426	0.70	0.80	1.08	0.88	0.93	0.88	1.12
(2S)-1-[2-[[(2Z)-2-[(3,4-dimethoxyphenyl)methylidene]-3-oxo-1-benzofuran-6-yl]oxy]acetyl]pyrrolidine-2-carboxylic acid	ME1070283	0.94	1.16	1.66	1.87	1.96	2.59	0.30
3-Aminobenzamide	ME1070299	0.48	0.93	0.55	0.61	0.71	0.74	1.33
FMN	ME1070331	0.91	1.15	1.12	1.79	1.59	1.51	0.66
4-[5-[[4-[5-[Acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentylamino]-4-oxobutanoic acid	ME1070365	1.11	1.35	0.90	1.03	1.47	1.38	0.79
3,6-Dimethylmangostin	ME1070317	0.80	0.56	0.27	0.80	0.78	0.68	1.35
3-Methylazelaic acid	ME1070432	0.76	0.66	1.04	0.90	0.91	0.84	1.15
(3-chloro-4-methylphenyl)[2-(ethylpropyl)quinazolin-4-yl]amine	ME1070262	1.68	1.46	0.92	1.76	1.49	1.59	0.52
C8H8O5	ME1070259	0.72	0.77	0.85	0.94	0.84	0.82	1.18
5-(benzimidazol-2-ylmethylthio)-1-benzyl-1,2,3,4-tetraazole	ME1070419	0.98	0.85	0.77	0.91	0.56	0.83	1.18
3,9-Dimethoxypterocarpan	ME1070229	1.17	1.27	1.27	1.37	1.20	1.34	0.73
Glucurolactone	ME1070325	0.58	0.45	0.66	0.39	0.65	0.63	1.44
(7R,8R)-7,8-dihydroxy-3,5,7-trimethyl-8H-isochromen-6-one	ME1070276	0.76	0.95	0.92	0.78	0.70	0.77	1.19
2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol	ME1070348	0.70	1.36	1.52	1.74	2.75	1.45	0.41
7-Glucosyl-11-methylodeoside	ME1070273	1.26	1.08	1.32	1.35	1.56	1.55	0.65
Guanosine	ME1070244	1.22	1.30	1.18	1.30	1.11	1.41	0.75
2-(6-amino-4-hydroxypyrimidin-2-ylthio)-N-(2,6-dichlorophenyl)acetamide	ME1070297	1.82	0.64	1.44	2.48	2.90	2.03	0.12
Glu-Thr	ME1070436	0.25	0.22	0.09	0.14	0.13	0.16	1.83
(2R,2^R,4a^S,6^S,7^R,8a^S)-4,6^,7^-Trihydroxy-2^,5^,5^,8a^-tetramethyl-3^,4^,4a^,5^,6^,7,7^,8,8^,8a^-decahydro-2^H-spiro[furo[2,3-e]isoindole-2,1^-naphthalen]-6(3H)-one	ME1070346	0.76	0.77	0.42	0.66	0.25	0.17	1.50
Creatine	ME1070380	0.99	0.96	0.57	0.73	0.80	0.89	1.18
2-(4-chlorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)ethan-1-one	ME1070257	1.22	1.37	1.26	2.20	2.11	1.81	0.34
5-Allyloxypsoralen	ME1070316	0.72	0.87	0.97	0.96	0.91	0.90	1.11
(2-aminoethoxy)[(2R)-2-hydroxy-3-(tetradecanoyloxy)propoxy]phosphinic acid	ME1070422	0.53	0.50	0.50	0.57	0.39	0.33	1.53
Arginine	ME1070327	1.00	0.76	0.74	0.75	0.70	0.67	1.23
Caramboxin	ME1070265	1.89	1.69	1.47	1.33	3.23	2.38	0.00
Chlormequat	ME1070242	1.39	1.33	1.74	1.96	1.65	1.37	0.43
2^-Deoxyadenosine 3^-monophosphate	ME1070372	0.01	0.06	0.29	0.29	0.23	0.20	1.82
Azaserine	ME1070371	0.96	1.05	0.86	0.89	0.53	0.56	1.19
beta-D-Glucosamine	ME1070301	1.02	1.25	1.20	1.34	1.89	1.78	0.59
Caffeic acid	ME1070268	0.87	0.76	0.91	0.86	0.85	0.89	1.14
1-Methylnicotinamide	ME1070233	0.79	0.72	0.53	0.58	0.57	0.50	1.38
1-tetradecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine	ME1070324	0.98	1.93	3.02	1.12	1.53	2.27	0.19
Isoguanosine	ME1070255	1.51	1.13	1.44	1.52	1.42	2.04	0.49
2-Hydroxy-2-Methyl-3-Buten-1-Yl Beta-D-Glucopyranoside	ME1070393	0.49	1.20	1.89	1.41	2.83	1.88	0.38
Cytidine	ME1070230	1.68	1.54	1.66	1.99	1.42	1.57	0.35
6-methoxyflindersine	ME1070270	0.78	0.57	0.27	0.36	0.57	0.42	1.50
Furathiocarb	ME1070309	0.00	0.15	0.30	0.27	0.08	0.50	1.78
7-[(2-fluorophenyl)methoxy]-4-methylchromen-2-one	ME1070397	0.65	0.67	0.51	0.33	0.90	0.75	1.37
Cytosine	ME1070232	1.64	1.54	1.61	1.91	1.37	1.51	0.41
2-Acetamido-3-hydroxypropanoic acid	ME1070367	1.04	0.87	0.51	0.85	0.75	0.84	1.19
4-(beta-D-Glucosyloxy)benzoate	ME1070281	1.16	1.15	1.82	2.12	1.64	2.78	0.22
5-Phenyl-1,2,3,4,7,9-hexahydro-10-thia-6,9-diaza-benzo[a]azulen-8-one	ME1070435	0.69	0.36	0.79	0.66	0.79	0.72	1.33
Guanine	ME1070261	1.04	1.20	1.35	1.49	1.40	1.56	0.66
8-Oxo-7,8-dihydrodeoxyguanine	ME1070275	1.55	1.03	2.10	1.43	1.43	1.82	0.44
Aesculetin	ME1070269	1.10	2.23	1.24	1.99	1.70	2.53	0.20
Citrate ion	ME1070300	1.01	1.71	2.37	1.29	1.92	1.47	0.37
(9Z)-N-(2-hydroxyethyl)hexadec-9-enamide	ME1070305	0.78	0.66	0.61	0.73	0.82	0.70	1.28
beta-Phosphonopropionic acid	ME1070258	1.21	1.14	1.39	1.35	1.52	1.28	0.69
3-(2-Furanyl)-2-propenal	ME1070406	0.61	0.65	0.99	0.76	0.85	1.04	1.18
9-(3-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-10-(4-methylphenyl)-2,3,4,5,6 ,7,9,10-octahydroacridine-1,8-dione	ME1070430	0.98	0.92	0.65	0.53	0.83	0.67	1.24
3-[2-O-(4-Hydroxybenzoyl)-beta-D-glucopyranosyl]-2,4,4^,6-tetrahydroxybenzophenone	ME1070389	1.57	2.29	0.63	0.75	3.10	2.31	0.22
6-Methoxypurine	ME1070263	2.28	2.24	0.90	1.49	2.14	2.10	0.14
beta-Phenylcysteine	ME1070337	0.92	0.97	1.78	1.56	1.34	1.93	0.58
1-Hydroxy-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine	ME1070368	1.09	1.18	0.96	1.07	1.58	1.52	0.77
Glycerophosphoinositol	ME1070333	1.48	1.33	1.31	1.64	1.82	0.77	0.61
3-(2,6-dihydroxyphenyl)-4-hydroxy-6-methyl-3H-2-benzofuran-1-one	ME1070296	0.77	0.64	0.41	0.76	0.79	0.77	1.31
C17H28O16	ME1070284	1.46	1.43	1.00	1.91	2.01	2.99	0.20
1-Palmitoyl-2-myristoyl-sn-glycero-3-phosphocholine	ME1070343	2.84	2.11	2.13	1.90	0.50	1.64	0.15
4-[7-acetyloxy-5-chloro-3-[(1E,3E)-3,5-dimethylhepta-1,3-dienyl]-7-methyl-6,8-dioxoisoquinolin-2-yl]-5-amino-5-oxopentanoic acid	ME1070418	0.19	0.17	0.31	0.44	0.59	0.69	1.60
[3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphono hydrogen phosphate	ME1070390	1.42	0.98	1.15	1.14	1.53	2.60	0.53
Dibutyl phthalate	ME1070274	0.71	0.94	0.87	0.79	0.71	0.79	1.20
Dodecanedioic acid	ME1070388	0.90	0.69	0.87	0.74	0.91	0.79	1.18
6-[(3-nitro-5-phenylthiophenyl)amino]-2H-3,4,5,6-tetrahydropyran-3,4-diol	ME1070356	2.20	1.09	0.97	1.90	1.69	1.14	0.50
4-Methyoxybenzoyl-N-glycine	ME1070334	1.48	0.75	1.24	1.37	2.33	2.25	0.43
Ethyl 6,10-Dimethyl-7-Oxo-4-(Phenylmethyl)-8-Oxa-5,11-Dithia-4,6,9-Triazadodec-9-Enoate	ME1070294	1.63	1.11	1.95	1.56	1.66	1.59	0.42
1-acetyl-4-[(4-chlorophenyl)methoxy]-3-methoxybenzene	ME1070245	1.41	1.46	1.57	1.77	1.78	1.13	0.48
Altamisic acid	ME1070267	1.06	1.19	1.46	1.71	1.48	1.88	0.54
2-Propenal, 3-(4-hydroxy-3,5-dimethoxyphenyl)-	ME1070377	0.37	0.36	0.80	0.83	1.00	0.63	1.33
16-Hydroxy-10-oxohexadecanoic acid	ME1070308	0.78	0.64	0.80	0.85	0.98	0.77	1.20
Creatinine	ME1070381	0.96	0.93	0.65	0.73	0.79	0.92	1.17
1-Methyladenosine	ME1070392	1.72	2.43	0.89	1.32	1.20	1.34	0.51
alosetron??monohydrochloride	ME1070285	1.42	1.94	0.75	1.67	2.72	2.65	0.14
Acetyl-L-carnitine	ME1070374	0.88	0.61	0.58	0.66	0.94	0.53	1.30
2-Acetolactate	ME1070286	0.68	0.67	0.66	0.98	0.89	0.81	1.22
cyclo-D-cysteinyl-D-cysteinyl-L-valyl-D-leucyl-L-valyl	ME1070238	1.35	1.55	1.83	2.02	2.65	2.59	0.00
2H-benzo[d]1,3-dioxolan-5-yl-N-(4,5-dimethyl(1,3-thiazol-2-yl))carboxamide	ME1070260	1.48	1.59	1.76	1.18	1.73	2.56	0.28
2-Ethyl-3-hydroxy-2,4,4-trimethyloxazolidine	ME1070287	0.96	0.92	0.62	0.84	0.58	0.59	1.25
LPS(17:0)	ME1070361	0.77	0.73	0.56	0.63	0.57	0.40	1.39
1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine	ME1070363	0.43	1.13	2.28	1.94	1.74	2.29	0.37
8-[(2-fluorophenyl)methylthio]-9-methylhydropurin-6-one	ME1070282	1.44	1.05	1.63	1.94	1.99	1.23	0.45
Acyclovir	ME1070421	0.47	1.47	1.27	1.21	3.47	2.35	0.29
2-(4-Methyl-1,3-thiazol-5-yl)ethanol	ME1070362	2.64	2.20	1.35	2.51	1.78	0.44	0.18
(2E,4E)-N-Isobutyl-6-(2-thienyl)hexa-2,4-dienamide	ME1070342	0.51	0.41	0.57	0.85	0.82	0.75	1.35
{(1R,2S,3R,5R,6R,8S)-3-[(6-O-Benzoyl-beta-D-glucopyranosyl)oxy]-6-hydroxy-8-methyl-9,10-dioxatetracyclo[4.3.1.0~2,5~.0~3,8~]dec-2-yl}methyl benzoate	ME1070239	1.43	1.52	1.32	1.40	1.21	1.62	0.58
2-Pyrazinoylguanidine	ME1070237	1.55	1.35	1.29	1.70	2.00	2.03	0.35
Dimethenamide ESA	ME1070412	1.04	0.98	0.42	0.59	0.33	0.28	1.39
[(2R)-1,1,2,3,3-pentadeuterio-3-heptadecanoyloxy-2-[(Z)-hexadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate	ME1070350	0.54	0.72	1.01	0.88	0.38	0.46	1.33
3-Methyladenine	ME1070226	1.58	2.10	1.64	1.69	1.83	2.11	0.18
(3,4-dimethoxyphenyl)-N-(???methyl)carboxamide	ME1070405	0.43	0.90	0.63	0.41	0.49	0.55	1.43
Fluorescein	ME1070312	1.89	1.57	0.84	1.09	1.65	2.10	0.48
Chicoric acid	ME1070252	1.37	1.33	1.40	1.43	1.77	2.24	0.41
gamma-Glutamylleucine	ME1070271	0.60	0.56	0.32	0.41	0.42	0.38	1.55
1H-Imidazole-4-carboxamide	ME1070302	1.51	1.60	1.76	1.86	1.06	1.21	0.50
7,8-Dimethoxy-benzo[d][1,2]oxazin-1-one	ME1070415	0.45	0.95	1.65	1.54	2.02	2.06	0.56
(2-methoxyphenyl)-N-{2-[2-methyl-5-(phenylmethoxy)indol-3-yl]ethyl}carboxamide	ME1070264	0.50	0.36	0.22	0.65	0.70	0.62	1.49
Kainic acid	ME1070387	1.30	0.98	0.94	1.47	2.07	2.20	0.51
Geniposidic acid	ME1070322	0.82	1.75	2.73	1.55	1.83	1.50	0.30
Acetyl-DL-carnitine	ME1070290	0.85	0.62	0.65	0.70	0.71	0.51	1.33
Arabinofuranosylthymine	ME1070240	1.11	1.57	1.45	1.51	1.55	1.69	0.52
Antibiotic PF 1052	ME1070395	0.83	0.82	0.62	0.81	0.47	0.41	1.34
(+)-Goniotriol	ME1070410	1.45	1.02	1.83	1.26	1.92	1.43	0.51
4-Thiouridine	ME1070400	1.11	1.11	0.95	1.66	1.90	1.64	0.61
Isopentenyladenine	ME1070250	1.34	1.64	1.13	1.44	1.94	1.87	0.44
5,6-Dihydroxy-2-methylaminotetralin	ME1070433	0.91	1.01	1.06	0.88	0.74	0.80	1.10
5-[(8aS)-2,5,5,8a-tetramethyl-3-oxo-4a,6,7,8-tetrahydro-4H-naphthalen-1-yl]-3-methylpentanoic acid	ME1070280	0.51	0.30	0.54	0.46	0.68	0.71	1.47
LPC(14:1)	ME1070318	0.84	0.70	0.47	0.62	0.37	0.32	1.45
5-Methylcytosine	ME1070278	1.99	1.73	0.87	1.37	2.77	2.05	0.20
Deoxycytidine	ME1070354	1.27	1.59	1.79	1.73	3.93	1.05	0.11
11-[3-methoxy-4-(naphthylmethoxy)phenyl]-3,3-dimethyl-2,3,4-trihydro-5H,10H,11 H-benzo[b]benzo[2,1-f]1,4-diazepin-1-one	ME1070378	1.06	0.97	1.52	2.21	1.90	1.39	0.49
Betaine	ME1070319	0.98	1.01	0.70	0.75	0.58	0.74	1.21
Dexpanthenol	ME1070338	1.18	1.28	1.09	1.53	2.05	2.13	0.46
5^-Methylthioadenosine	ME1070310	1.71	1.75	0.96	1.23	1.47	1.74	0.52
Dihydroxy-Benzoic acid	ME1070398	0.39	0.96	0.40	0.32	0.49	0.28	1.53
1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)-piperazine mono(methanesulfonate) salt	ME1070243	1.73	1.63	1.75	2.21	1.34	1.58	0.30
2-Hydroxy-2-ethylsuccinic acid	ME1070344	0.41	0.64	0.20	0.31	0.24	0.52	1.61
(2S)-1-[(2S)-2-[(5-methoxy-1-methylindole-2-carbonyl)amino]-3-methylbutanoyl]pyrrolidine-2-carboxylic acid	ME1070437	1.15	0.72	0.58	0.59	0.51	0.35	1.35
LPE(P-16:0)	ME1070379	0.34	0.32	0.39	0.36	0.26	0.25	1.68
1-[4-(2-fluorophenyl)piperazinyl]-2-(4-hydroxyquinazolin-2-ylthio)ethan-1-one	ME1070336	0.44	0.30	0.88	0.75	0.66	0.50	1.41
1-[(2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-imino-3-methylpyrimidin-2-one	ME1070291	1.82	1.84	0.92	1.10	2.45	2.78	0.18
[1-(3,4-dimethoxyphenyl)-2-(2,6-dimethoxy-4-prop-2-enylphenoxy)propyl] acetate	ME1070369	1.02	0.59	0.59	0.48	0.94	0.66	1.29

Factors:

F1	Genotype:SIRT3-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F2	Genotype:SIRT4-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F3	Genotype:SIRT5-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F4	Genotype:SIRT6-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F5	Genotype:SIRT7-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F6	Genotype:SIRT8-knockdown \| treatment:NAM \| Sample source:Colorectal cell
F7	Genotype:wild-type \| treatment:control \| Sample source:Colorectal cell

Data matrix