Clustering data with hclust algorithm for (Study ST004093)
HILIC NEGATIVE ION MODE (Analysis AN006785)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| Guanosine | ME1090660 | 1.65 | NA | 0.57 | 0.59 | 0.91 | NA |
| Hypoxanthine | ME1090650 | 1.55 | NA | 0.68 | 0.67 | 1.21 | 0.01 |
| Guanine | ME1090651 | 1.51 | NA | 0.45 | 0.57 | 1.14 | NA |
| Inosine | ME1090659 | 1.45 | NA | 0.59 | 0.59 | 1.10 | NA |
| Uracil | ME1090672 | 2.22 | 0.24 | 0.99 | 0.98 | 1.38 | 0.18 |
| Pentose 5-phosphate | ME1090632 | 2.47 | 0.15 | 0.93 | 0.99 | 1.31 | 0.12 |
| Uridine | ME1090670 | 2.42 | 0.19 | 1.01 | 0.98 | 1.25 | 0.15 |
| Cytidine | ME1090669 | 1.97 | 0.39 | 0.96 | 1.01 | 1.41 | 0.24 |
| Hexose diphosphate | ME1090634 | 1.84 | 0.53 | 1.03 | 1.03 | 1.20 | 0.39 |
| Aminoadipic acid | ME1090642 | 0.58 | 1.19 | 0.94 | 0.70 | NA | 1.19 |
| Ketocaproic and or Ketoisocaproic acid | ME1090679 | NA | 1.30 | 0.79 | 0.75 | NA | 1.01 |
| NAD+ | ME1090648 | NA | 1.11 | 0.60 | 0.61 | NA | 1.42 |
| ATP | ME1090658 | 0.19 | 1.84 | 1.07 | 1.08 | 0.29 | 1.58 |
| Xanthine | ME1090661 | 0.60 | 1.43 | 1.02 | 1.03 | 0.70 | 1.23 |
| Adenine | ME1090649 | 0.48 | 1.62 | 0.99 | 1.02 | 0.59 | 1.30 |
| ADP | ME1090652 | 0.52 | 1.48 | 1.07 | 1.04 | 0.56 | 1.36 |
| Ribitol | ME1090637 | 0.62 | 1.46 | 1.08 | 1.07 | 0.47 | 1.34 |
| dTMP | ME1090663 | 1.43 | 1.15 | 1.00 | 1.16 | 0.50 | 0.82 |
| Oxidized glutathione | ME1090678 | 1.25 | 1.07 | 1.01 | 1.13 | 1.23 | 0.37 |
| Homovanillic acid | ME1090630 | 1.25 | 0.76 | 1.24 | 1.05 | 1.08 | 0.72 |
| N-Acetylglutamic acid | ME1090675 | 1.36 | 0.80 | 1.07 | 1.04 | 1.09 | 0.68 |
| CMP | ME1090667 | 1.47 | 0.82 | 1.04 | 1.03 | 1.01 | 0.65 |
| UMP | ME1090668 | 1.44 | 0.79 | 1.03 | 1.04 | 1.02 | 0.70 |
| Glutathione | ME1090677 | 1.30 | 0.83 | 1.03 | 1.02 | 0.97 | 0.85 |
| GMP | ME1090656 | 1.33 | 0.86 | 1.04 | 1.05 | 0.91 | 0.84 |
| Erythronic and or Threonic acid | ME1090636 | 1.19 | 0.84 | 1.07 | 1.01 | 1.13 | 0.79 |
| Glutamic acid | ME1090674 | 1.28 | 0.92 | 1.02 | 1.03 | 1.04 | 0.73 |
| Dihexose | ME1090631 | 0.55 | 0.92 | 1.25 | 1.16 | 0.99 | 1.13 |
| Hydroxybutyric and or Hydroxyisobutyric acid | ME1090644 | 0.79 | 1.29 | 0.89 | 0.94 | 0.91 | 1.12 |
| Myo-inositol | ME1090689 | 0.92 | 1.18 | 1.09 | 1.08 | 0.76 | 1.02 |
| Adenylsuccinic acid | ME1090657 | 0.85 | 1.11 | 1.05 | 1.10 | 0.75 | 1.19 |
| sn-Glycero-3-phosphate | ME1090680 | 0.85 | 1.09 | 1.11 | 1.08 | 0.79 | 1.13 |
| 2-Hydroxyvaleric and or 2-Hydroxyisovaleric acid | ME1090645 | 0.84 | 1.24 | 0.99 | 1.03 | 0.78 | 1.12 |
| Lactic acid | ME1090681 | 0.91 | 1.16 | 0.96 | 1.03 | 0.81 | 1.12 |
| Uric acid | ME1090662 | 0.91 | 1.14 | 0.98 | 1.05 | 0.82 | 1.11 |
| Taurdeoxycholic and or Taurochenodeoxycholic acid | ME1090692 | 0.94 | 1.48 | 1.10 | 1.06 | 0.57 | 0.91 |
| Pseudouridine | ME1090671 | 0.76 | 1.38 | 1.06 | 1.04 | 0.80 | 0.98 |
| 2-Phosphoglyceric acid | ME1090683 | 0.73 | 1.46 | 1.01 | 0.90 | 0.64 | 1.11 |
| 3-Phosphoglyceric acid | ME1090682 | 0.84 | 1.35 | 1.06 | 1.01 | 0.68 | 1.08 |
| Sorbitol | ME1090638 | 0.81 | 1.36 | 1.07 | 1.08 | 0.61 | 1.13 |
| Fumaric and or Maleic acid | ME1090684 | 0.83 | 1.33 | 1.07 | 1.04 | 0.62 | 1.14 |
| Malic acid | ME1090686 | 0.82 | 1.33 | 1.08 | 1.04 | 0.63 | 1.14 |
| 2-Hydroxycaproic and or 2-Hydroxyisocaproic acid | ME1090646 | 0.73 | 1.06 | 0.94 | 1.01 | 1.15 | 1.09 |
| IMP | ME1090655 | 1.08 | 0.98 | 1.05 | 1.00 | 0.82 | 1.08 |
| 2-Aminobutyric acid | ME1090639 | 1.08 | 1.11 | 1.05 | 1.10 | 0.77 | 0.94 |
| Pantothenic acid | ME1090676 | 1.07 | 1.06 | 1.15 | 1.05 | 0.75 | 0.99 |
| Hexose monophosphate | ME1090633 | 1.20 | 1.00 | 1.06 | 1.06 | 0.69 | 1.01 |
| Hippuric acid | ME1090629 | 1.20 | 1.04 | 1.12 | 1.10 | 0.74 | 0.87 |
| Adipic and or Methylglutaric acid | ME1090641 | 0.87 | 0.93 | 1.10 | 1.10 | 0.93 | 1.14 |
| Glyceric acid | ME1090635 | 0.91 | 0.94 | 1.11 | 1.10 | 1.05 | 0.96 |
| cis-Aconitic acid | ME1090687 | 0.95 | 0.95 | 1.10 | 1.01 | 1.18 | 0.85 |
| Citric and or Isocitric acid | ME1090688 | 0.94 | 1.02 | 1.06 | 1.02 | 1.10 | 0.87 |
| Oxalic acid | ME1090640 | 1.03 | 0.92 | 1.01 | 0.95 | 1.03 | 1.05 |
| Suberic acid | ME1090643 | 1.04 | 0.95 | 1.13 | 1.13 | 0.93 | 0.91 |
| CDP | ME1090664 | 0.96 | 1.09 | 1.06 | 1.03 | 1.01 | 0.89 |
| UDP | ME1090665 | 1.03 | 1.03 | 1.05 | 1.04 | 1.00 | 0.88 |
| UDP-galactose or UDP-glucose | ME1090666 | 1.08 | 1.06 | 1.03 | 1.03 | 0.97 | 0.85 |
| GDP | ME1090653 | 0.91 | 1.07 | 1.04 | 1.04 | 0.91 | 1.06 |
| Malondialdehyde | ME1090690 | 0.91 | 1.12 | 1.00 | 1.11 | 0.89 | 1.01 |
| Aspartic acid | ME1090673 | 1.00 | 1.10 | 1.09 | 1.06 | 0.86 | 0.94 |
| 2-Hydroxyglutaric acid | ME1090647 | 0.94 | 1.11 | 1.02 | 1.02 | 0.96 | 0.96 |
| Glucosan | ME1090691 | 0.99 | 1.07 | 1.04 | 1.04 | 0.93 | 0.96 |
| AMP | ME1090654 | 1.03 | 1.01 | 1.05 | 1.03 | 0.95 | 0.96 |
| Succinic acid | ME1090685 | 1.00 | 1.03 | 1.03 | 1.02 | 0.91 | 1.02 |
Factors:
| F1 | Sample source:T-cells | Genotype:ankrd55 ko | Treatment:25ng/mL IL-6 and 2ng/mL TGF-b1 |
| F2 | Sample source:T-cells | Genotype:ankrd55 ko | Treatment:No added cytokines |
| F3 | Sample source:T-cells | Genotype:NA | Treatment:QC-drift_correction |
| F4 | Sample source:T-cells | Genotype:NA | Treatment:QC-pooled_ref |
| F5 | Sample source:T-cells | Genotype:WT | Treatment:25ng/mL IL-6 and 2ng/mL TGF-b1 |
| F6 | Sample source:T-cells | Genotype:WT | Treatment:No added cytokines |
