Clustering data with hclust algorithm for (Study ST004132)
HILIC NEGATIVE ION MODE (Analysis AN006848)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 | F32 | F33 | F34 | F35 | F36 | F37 | F38 | F39 | F40 | F41 | F42 | F43 | F44 | F45 | F46 | F47 | F48 | F49 | F50 | F51 | F52 | F53 | F54 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| inosine | ME1100326 | 7.98 | 0.70 | NA | 0.59 | NA | NA | NA | 0.34 | NA | NA | NA | 0.72 | NA | NA | 0.47 | NA | NA | NA | 0.16 | 0.13 | 0.20 | 0.42 | 0.15 | 0.16 | 0.18 | 0.16 | 0.11 | 0.20 | 0.22 | 0.41 | 0.31 | 0.94 | 0.93 | 0.24 | 0.97 | 3.64 | 0.18 | NA | 0.66 | NA | NA | 0.39 | 5.65 | 0.20 | 4.74 | 0.62 | 0.64 | NA | 0.17 | 0.79 | 0.49 | NA | 0.30 | 1.81 |
| homovanillate | ME1100320 | 0.49 | 0.41 | 0.44 | 0.46 | 0.79 | 0.61 | 0.78 | 0.59 | 0.34 | 0.48 | 0.77 | 0.44 | 1.34 | 1.64 | 1.83 | 1.34 | 1.58 | 1.73 | 1.60 | 8.49 | 0.35 | 0.53 | 0.88 | 0.57 | 0.24 | 0.23 | 1.47 | 0.30 | 0.16 | 0.42 | 0.25 | 0.43 | 0.23 | 0.23 | 0.19 | 3.49 | 0.66 | 0.72 | 0.61 | 0.50 | 0.76 | 0.86 | 0.74 | 0.78 | 0.51 | 0.53 | 0.70 | 0.38 | 1.29 | 2.25 | 1.90 | 1.35 | 1.98 | 1.33 |
| urate | ME1100357 | NA | NA | 3.49 | NA | NA | 1.10 | 3.70 | 3.14 | 0.75 | NA | NA | NA | 2.47 | 2.75 | 0.30 | 3.42 | 0.00 | 0.22 | 0.26 | 0.34 | 0.49 | 0.15 | 0.28 | 0.31 | 0.26 | 0.13 | 0.17 | 0.54 | 0.21 | 0.44 | 0.20 | 0.76 | 0.58 | 0.05 | 0.69 | 1.35 | 0.87 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.45 | NA | NA | 1.31 | 1.78 | NA |
| tartarate | ME1100351 | 1.71 | 0.31 | NA | 1.39 | 0.72 | 0.58 | 0.39 | 0.29 | NA | 0.29 | 0.22 | 0.21 | 0.60 | 0.38 | 3.58 | NA | 0.55 | 0.64 | 5.42 | 1.22 | 0.40 | 0.52 | 1.41 | 1.53 | 1.05 | 1.46 | 1.50 | 1.45 | 2.44 | 2.41 | 0.17 | 0.15 | NA | 1.00 | NA | NA | 0.57 | 2.98 | 0.16 | NA | 0.94 | 0.44 | 0.22 | NA | 0.21 | 0.35 | 0.23 | NA | NA | 0.47 | 0.51 | 0.32 | 0.24 | 2.42 |
| taurocholate | ME1100352 | 0.14 | 1.95 | 1.79 | 1.60 | 2.41 | 0.18 | 3.29 | 0.60 | 0.25 | 0.47 | 0.05 | 2.86 | NA | 1.20 | 0.36 | 0.19 | 0.53 | 0.36 | 0.62 | 0.33 | 1.22 | 3.02 | 1.25 | 1.09 | 1.00 | 1.30 | 2.07 | 2.06 | 0.81 | 0.39 | 0.19 | 0.01 | 0.48 | 0.69 | 0.02 | 0.05 | 0.63 | 0.68 | 4.28 | 1.78 | 2.65 | 0.92 | 0.44 | 0.54 | 1.26 | 0.63 | 1.05 | 0.53 | 0.40 | 0.80 | 0.62 | 0.09 | 0.65 | 0.24 |
| taurodeoxycholate/taurochenodeoxycholate | ME1100353 | 0.17 | 0.99 | 0.78 | 0.89 | 1.18 | 0.09 | 2.61 | 0.51 | 0.27 | 0.34 | 0.32 | 2.30 | 0.49 | 2.05 | 0.91 | 1.18 | 1.13 | 0.73 | 0.27 | 0.27 | 1.08 | 1.16 | 1.05 | 0.29 | 1.93 | 2.20 | 3.04 | 3.78 | 1.56 | 0.53 | 0.32 | 0.03 | 0.63 | 0.95 | 0.09 | 0.13 | 0.47 | 0.70 | 2.54 | 1.29 | 1.81 | 0.59 | 0.41 | 1.12 | 1.29 | 1.00 | 1.31 | 0.78 | 0.81 | 0.86 | 0.75 | 0.45 | 0.94 | 0.60 |
| indole-3-propionate | ME1100323 | NA | NA | NA | NA | NA | NA | 0.66 | 3.68 | 3.29 | 0.28 | 0.79 | 0.99 | NA | 1.31 | 2.04 | 0.70 | NA | NA | NA | NA | NA | NA | NA | NA | 0.87 | 0.49 | 1.06 | 0.73 | 0.83 | 0.97 | 0.96 | 0.63 | NA | 0.60 | NA | 1.23 | NA | 0.15 | NA | NA | NA | 0.69 | 0.54 | 0.82 | 0.81 | 0.26 | 1.48 | 1.11 | 0.73 | 0.23 | NA | NA | NA | 1.08 |
| 2-aminoadipate | ME1100267 | 0.09 | 0.13 | 0.03 | 0.28 | 0.27 | 0.06 | 0.22 | 0.15 | 0.11 | 0.13 | 0.12 | 0.12 | 3.49 | 3.08 | 3.01 | 2.10 | 2.47 | 2.31 | 1.57 | 0.27 | 0.68 | 0.60 | 0.99 | 1.15 | 0.04 | 0.25 | 0.20 | 0.49 | 0.24 | 0.51 | 0.73 | 2.77 | 1.28 | 1.25 | 1.41 | 2.56 | 0.12 | 0.10 | 0.05 | 0.06 | 0.26 | 0.21 | 0.13 | 0.12 | 0.15 | 0.27 | 0.11 | 0.18 | 2.15 | 2.67 | 2.51 | 3.52 | 3.36 | 2.87 |
| indolelactate | ME1100324 | 0.46 | 0.41 | 0.50 | 0.39 | 0.80 | 0.39 | 0.55 | 0.54 | 0.60 | 0.49 | 0.90 | 0.54 | 2.03 | 2.31 | 2.33 | 1.66 | 1.54 | 1.58 | 1.13 | 2.50 | 0.98 | 1.20 | 1.05 | 0.53 | 0.00 | 0.01 | 0.04 | 0.00 | 0.01 | 0.01 | 1.04 | 2.62 | 0.80 | 0.39 | 1.63 | 3.06 | 0.49 | 0.63 | 0.53 | 0.46 | 0.49 | 0.57 | 0.70 | 1.05 | 0.53 | 0.39 | 0.45 | 0.51 | 1.83 | 2.24 | 1.62 | 2.18 | 2.75 | 1.53 |
| N-acetylcarnosine | ME1100333 | NA | NA | NA | NA | NA | NA | NA | 0.57 | 1.13 | 0.49 | 0.70 | 0.66 | 2.47 | 1.23 | 1.04 | 1.19 | 2.77 | 2.22 | 1.22 | 0.79 | 0.95 | 0.55 | 0.73 | 0.85 | 0.56 | 0.56 | 0.71 | 0.68 | 0.65 | 1.01 | 0.39 | 0.55 | 0.65 | 0.50 | 0.48 | 0.64 | NA | NA | NA | NA | 0.56 | NA | NA | NA | 0.70 | 0.96 | 0.71 | 0.49 | 1.43 | 2.83 | 2.01 | 1.63 | 0.81 | 0.93 |
| N-acetylglutamate | ME1100334 | 0.28 | 0.49 | 0.45 | 0.90 | 0.82 | 0.49 | 1.09 | 0.29 | 0.27 | 0.47 | 1.01 | 0.52 | 1.18 | 2.98 | 1.56 | 1.38 | 1.63 | 1.42 | 1.19 | 0.31 | 0.65 | 1.01 | 0.97 | 0.86 | 0.82 | 0.86 | 0.87 | 1.25 | 1.25 | 1.24 | 1.00 | 0.80 | 0.85 | 1.16 | 1.13 | 0.57 | 0.52 | 0.40 | 0.70 | 0.70 | 1.15 | 1.27 | 0.46 | 0.92 | 0.51 | 0.84 | 0.50 | 0.41 | 1.16 | 1.79 | 1.49 | 1.63 | 3.94 | 1.61 |
| quinolinate | ME1100344 | 0.25 | 0.71 | 0.57 | 0.92 | 0.67 | 0.40 | 0.58 | 0.61 | 0.52 | 0.62 | 0.82 | 0.75 | 1.95 | 4.47 | 1.24 | 1.47 | 1.67 | 1.80 | 2.40 | 0.25 | 0.60 | 0.71 | 0.93 | 1.17 | 0.47 | 0.97 | 0.58 | 0.35 | 0.43 | 0.99 | 0.85 | 0.35 | 0.51 | 1.50 | 0.68 | 0.89 | 0.60 | 0.33 | 0.60 | 0.44 | 0.70 | 0.59 | 0.77 | 0.92 | 0.80 | 0.63 | 0.50 | 0.45 | 1.75 | 2.15 | 2.26 | 1.46 | 3.53 | 0.87 |
| succinyladenosine | ME1100349 | NA | NA | NA | NA | 1.39 | NA | NA | NA | NA | NA | 1.50 | NA | 0.75 | 1.42 | 1.04 | 0.90 | 1.24 | 1.00 | 0.47 | 0.10 | 1.27 | NA | 0.60 | 0.60 | NA | 0.37 | NA | NA | NA | NA | NA | 1.95 | 1.19 | NA | 1.18 | 1.42 | NA | NA | 0.42 | NA | 0.16 | 0.68 | NA | 2.48 | NA | 1.32 | NA | NA | NA | 1.98 | 1.61 | 0.26 | 0.53 | 0.17 |
| AMP | ME1100293 | 3.17 | 1.44 | 0.56 | 1.95 | 0.74 | 0.92 | 0.41 | 0.36 | 0.79 | 1.22 | 1.82 | 1.39 | 0.49 | 0.16 | 0.61 | 0.31 | 0.96 | 0.55 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.66 | 0.52 | 0.34 | 0.42 | 0.99 | 1.30 | 1.12 | 0.34 | 0.41 | 4.16 | 0.55 | 1.45 | 0.72 | 1.34 | 0.26 | 0.14 | 0.08 | 3.35 |
| GMP | ME1100314 | 4.63 | 0.89 | NA | 2.26 | 0.80 | 0.45 | NA | NA | NA | 1.03 | 0.94 | 1.16 | 0.42 | 0.11 | 0.72 | NA | 0.97 | 0.39 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.50 | 0.54 | 0.16 | 0.61 | 0.79 | 1.59 | 0.65 | 0.09 | 0.50 | 3.10 | 0.50 | 1.26 | 0.61 | 1.25 | 0.12 | 0.16 | 0.03 | 3.80 |
| ATP | ME1100296 | 1.18 | 1.68 | 0.50 | 3.17 | 0.91 | 0.64 | 0.37 | 0.38 | 1.02 | 1.72 | 0.87 | 1.43 | 0.37 | 0.18 | 0.65 | 0.56 | 0.99 | 0.78 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.45 | 1.00 | 1.45 | 0.27 | 1.73 | 1.67 | 1.54 | 1.03 | 1.76 | 1.33 | 0.48 | 0.70 | 0.53 | 1.60 | 1.37 | 0.32 | 0.14 | 1.21 |
| GDP | ME1100306 | 3.05 | 1.22 | NA | 2.67 | 0.46 | 0.31 | NA | NA | 0.17 | 1.78 | 0.55 | 1.61 | 0.12 | NA | 0.31 | NA | 1.33 | 0.26 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.17 | 0.56 | NA | NA | 1.48 | 1.53 | 0.85 | 0.12 | 0.40 | 2.43 | 0.19 | 0.94 | 0.34 | 0.97 | 0.41 | NA | NA | 2.75 |
| hexose diphosphate | ME1100317 | 2.40 | 1.43 | NA | 3.24 | 0.56 | 0.30 | NA | NA | NA | 1.91 | 0.64 | 1.21 | NA | NA | 0.42 | NA | 1.56 | 0.32 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.82 | 0.64 | 0.45 | 1.12 | 1.31 | 0.86 | 0.41 | 0.76 | 1.88 | 0.30 | 0.47 | 0.26 | 0.49 | 0.36 | NA | 0.34 | 2.54 |
| ADP | ME1100287 | 1.88 | 1.80 | 0.56 | 2.72 | 1.14 | 0.74 | 0.36 | 0.22 | 0.77 | 1.60 | 1.18 | 1.24 | 0.36 | 0.17 | 0.83 | 0.37 | 1.01 | 0.51 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.52 | 0.74 | 0.57 | 0.31 | 1.71 | 1.75 | 1.42 | 0.49 | 0.88 | 2.44 | 0.68 | 1.01 | 0.72 | 1.58 | 0.69 | 0.23 | 0.23 | 2.55 |
| 6-phosphogluconate | ME1100281 | 1.28 | 1.69 | 0.56 | 2.99 | 0.58 | 0.45 | 0.30 | 0.18 | 0.34 | 1.28 | 0.72 | 0.87 | 0.49 | 0.71 | 1.12 | 0.74 | 1.65 | 0.73 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.57 | 0.65 | 1.12 | 0.49 | 1.14 | 1.08 | 1.03 | 0.86 | 1.03 | 2.41 | 0.44 | 0.74 | 0.82 | 1.46 | 1.18 | 0.14 | 1.05 | 3.09 |
| 2-phosphoglycerate | ME1100273 | 1.62 | 1.18 | 0.27 | 2.27 | 0.85 | 0.52 | 0.54 | 0.40 | 0.46 | 1.39 | 0.87 | 1.28 | 0.62 | 0.64 | 1.28 | 0.88 | 1.83 | 0.91 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.59 | 0.91 | 0.75 | 0.82 | 1.32 | 1.40 | 0.81 | 0.62 | 0.83 | 1.69 | 0.68 | 0.87 | 0.78 | 1.15 | 0.90 | 0.36 | 0.87 | 2.85 |
| 3-phosphoglycerate | ME1100276 | 1.68 | 1.18 | 0.43 | 2.40 | 0.96 | 0.63 | 0.55 | 0.35 | 0.45 | 1.33 | 0.90 | 1.27 | 0.57 | 0.63 | 1.34 | 0.89 | 1.61 | 0.70 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.56 | 1.05 | 0.78 | 0.78 | 1.19 | 1.44 | 0.86 | 0.56 | 1.07 | 2.14 | 0.58 | 0.71 | 0.73 | 1.15 | 0.80 | 0.32 | 0.66 | 2.73 |
| indoxylsulfate | ME1100325 | 0.11 | 0.17 | 0.64 | 0.05 | 0.58 | 0.66 | 1.31 | 1.07 | 1.08 | 0.08 | 1.34 | 0.43 | 2.32 | 2.46 | 1.67 | 2.05 | 0.82 | 1.46 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.81 | 0.39 | 0.51 | 0.46 | 0.56 | 0.29 | 0.47 | 1.41 | 0.72 | 0.07 | 0.88 | 0.59 | 2.01 | 2.06 | 1.16 | 2.63 | 2.55 | 0.11 |
| glutathione reduced | ME1100311 | 1.75 | 0.31 | 0.37 | 0.50 | 0.52 | 1.48 | 2.36 | 0.52 | 0.40 | 1.44 | 1.45 | 1.56 | 0.80 | 1.42 | 0.84 | 2.49 | 2.08 | 2.45 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.41 | 0.30 | 0.29 | 0.76 | 1.03 | 0.81 | 0.35 | 0.31 | 0.40 | 0.41 | 0.96 | 0.87 | 0.87 | 0.77 | 0.46 | 1.20 | 1.75 | 1.33 |
| pyruvate | ME1100343 | 1.19 | 1.50 | 0.62 | 2.17 | 0.53 | 0.48 | 0.52 | 1.23 | 0.47 | 0.29 | 0.67 | 0.58 | 0.60 | 0.87 | 2.01 | 0.79 | 1.68 | 1.83 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.51 | 1.12 | 1.22 | 0.61 | 2.02 | 0.45 | 0.27 | 2.15 | 0.55 | 0.62 | 1.56 | 0.38 | 0.89 | 1.72 | 1.45 | 0.47 | 0.75 | 1.24 |
| hippurate | ME1100319 | NA | 0.41 | NA | 0.68 | 0.50 | 0.68 | 0.93 | 0.81 | 1.03 | 1.22 | 1.65 | 1.09 | 0.71 | 0.69 | 1.20 | 1.94 | 1.78 | 0.92 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.62 | 0.62 | 0.54 | 0.40 | 0.93 | 0.77 | 0.99 | 1.79 | 0.87 | 0.73 | 1.14 | 1.31 | 1.45 | 1.79 | 0.86 | 0.84 | 1.12 | 0.97 |
| 1-methylhistidine | ME1100264 | 0.71 | 0.98 | 0.99 | 1.02 | 0.77 | 1.05 | 1.10 | 1.10 | 1.22 | 0.83 | 0.90 | 0.98 | 1.40 | 1.08 | 0.85 | 1.15 | 0.81 | 0.99 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1.14 | 0.71 | 1.16 | 0.86 | 1.12 | 0.86 | 0.87 | 0.88 | 0.95 | 1.03 | 1.12 | 1.33 | 1.00 | 0.78 | 0.92 | 1.43 | 1.13 | 0.78 |
| anhydroDglucose/3-hydroxymethylglutarate | ME1100294 | 0.64 | 0.90 | 0.67 | 0.90 | 0.89 | 0.82 | 1.17 | 0.93 | 0.82 | 0.86 | 1.34 | 1.17 | 1.12 | 0.95 | 1.06 | 0.98 | 1.34 | 1.14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.86 | 0.71 | 1.23 | 0.77 | 0.99 | 1.08 | 0.89 | 1.26 | 1.06 | 0.96 | 1.04 | 0.91 | 0.89 | 1.32 | 1.13 | 1.20 | 1.00 | 0.95 |
| threitol | ME1100354 | 0.71 | 0.61 | 0.70 | 0.84 | 0.93 | 0.93 | 1.04 | 0.87 | 0.83 | 1.02 | 1.07 | 1.01 | 1.12 | 1.19 | 1.01 | 1.09 | 1.26 | 1.08 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 1.03 | 0.86 | 0.83 | 0.64 | 0.85 | 0.98 | 1.15 | 1.18 | 1.21 | 1.03 | 0.90 | 0.88 | 1.17 | 1.48 | 1.03 | 1.10 | 1.40 | 0.97 |
| alpha-glycerophosphate | ME1100288 | 0.85 | 1.04 | 1.23 | 1.16 | 1.25 | 0.75 | 0.92 | 0.76 | 0.54 | 0.97 | 1.06 | 0.96 | 0.95 | 1.39 | 0.85 | 0.90 | 0.85 | 0.80 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.88 | 1.13 | 0.92 | 0.90 | 1.20 | 1.54 | 1.03 | 1.23 | 0.93 | 1.53 | 1.07 | 0.82 | 0.79 | 0.89 | 0.68 | 0.83 | 1.58 | 0.79 |
| hexose monophosphate | ME1100318 | 0.96 | 1.38 | 0.83 | 1.19 | 1.02 | 0.62 | 0.96 | 0.63 | 0.41 | 0.32 | 0.83 | 0.83 | 0.77 | 1.56 | 1.48 | 0.94 | 0.88 | 0.93 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.69 | 1.01 | 1.34 | 0.92 | 1.45 | 1.81 | 0.63 | 1.00 | 0.82 | 1.14 | 0.89 | 0.60 | 0.97 | 1.11 | 0.88 | 1.01 | 1.86 | 1.34 |
| glutathione oxidized | ME1100310 | 0.41 | 1.15 | 0.29 | 1.39 | 0.52 | 0.37 | 0.80 | 0.35 | 0.47 | 0.72 | 0.62 | 0.95 | 0.95 | 2.03 | 2.73 | 1.47 | 1.35 | 1.25 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.29 | 0.34 | 0.72 | 0.10 | 1.00 | 0.89 | 0.46 | 0.04 | 0.88 | 1.05 | 0.17 | 0.26 | 1.08 | 1.32 | 1.24 | 0.19 | 2.64 | 5.53 |
| pentose monophosphate | ME1100339 | 3.20 | 0.75 | 0.15 | 1.30 | 0.20 | 0.18 | 0.37 | 0.28 | 0.46 | 0.90 | 0.23 | 1.30 | 0.16 | 0.17 | 3.56 | 0.44 | 2.34 | 1.20 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.16 | 1.78 | 0.83 | 0.17 | 1.39 | 0.32 | 0.85 | 0.14 | 1.05 | 0.70 | 0.46 | 0.41 | 0.53 | 3.57 | 2.03 | 0.11 | 0.30 | 4.02 |
| corticosterone | ME1100300 | 0.90 | 0.61 | 0.94 | 0.72 | 0.85 | 0.87 | 1.00 | 0.57 | 0.60 | 0.97 | 1.07 | 0.94 | 0.56 | 0.62 | 0.70 | 0.52 | 0.72 | 0.52 | NA | NA | NA | 2.83 | 1.02 | NA | NA | 4.41 | 1.99 | NA | 1.09 | 1.38 | NA | NA | 2.28 | 1.59 | 0.69 | NA | 0.86 | 1.03 | 0.73 | 0.89 | 0.81 | 0.88 | 1.06 | 0.83 | 0.95 | 0.93 | 0.56 | 0.62 | 0.48 | 0.76 | 0.53 | 0.57 | 0.77 | 0.79 |
| chenodeoxycholate/deoxycholate | ME1100298 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.42 | 0.69 | 1.07 | 0.63 | 1.20 | 0.10 | 1.09 | 1.45 | 1.14 | 1.31 | 0.94 | 0.88 | 1.34 | 0.30 | 0.87 | 1.62 | 1.48 | 1.03 | 0.21 | 1.84 | 0.39 | 0.33 | 0.39 | NA | 0.30 | 2.03 | 0.83 | 1.31 | 0.97 | 0.43 | 1.40 | 0.78 | 0.88 | 0.57 | 2.65 | 2.12 |
| butyrate | ME1100297 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.68 | 0.82 | 0.59 | 1.16 | 0.68 | 0.62 | 0.97 | 1.37 | 1.55 | 0.98 | 1.63 | 1.23 | 0.54 | 0.80 | 1.16 | 1.46 | 0.73 | 0.75 | 0.94 | 0.85 | NA | 1.15 | NA | 0.73 | 0.74 | 1.84 | 1.08 | 1.12 | 1.17 | 0.77 | NA | NA | NA | 0.86 | 1.04 | 0.98 |
| isovalerate/valerate/methylbutyrate | ME1100328 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 0.77 | 0.94 | 0.93 | 0.98 | 0.94 | 0.68 | 1.02 | 1.63 | 1.34 | 0.87 | 1.25 | 0.92 | 0.75 | 0.93 | 0.95 | 1.54 | 0.86 | 0.88 | 0.68 | 0.99 | 0.92 | 1.10 | 0.83 | 1.04 | 0.83 | 1.62 | 1.11 | 1.21 | 0.99 | 0.94 | 0.75 | 0.79 | 0.84 | 0.88 | 0.98 | 1.31 |
| 4-hydroxybenzaldehyde | ME1100277 | 1.49 | 1.07 | 0.15 | 2.25 | 0.95 | 0.34 | 0.25 | 0.26 | 0.31 | 1.73 | 0.79 | 1.42 | 0.31 | 0.20 | 0.89 | 0.42 | 2.42 | 0.82 | 0.84 | 0.53 | 0.97 | 2.44 | 0.69 | 0.82 | 1.00 | 1.40 | 0.82 | 1.62 | 1.34 | 0.64 | 0.81 | 0.23 | 0.76 | 1.45 | 0.70 | 1.01 | 0.29 | 1.09 | 0.72 | 0.55 | 1.33 | 1.56 | 1.01 | 0.78 | 1.10 | 2.50 | 0.60 | 0.83 | 0.44 | 1.72 | 1.38 | 0.17 | 0.23 | 3.55 |
| sebacate | ME1100345 | 0.56 | 0.90 | 0.84 | 0.58 | 0.88 | 1.72 | 1.31 | 1.20 | 0.79 | 0.88 | 1.74 | 1.45 | 0.81 | 0.44 | 0.38 | 0.73 | 0.97 | 0.43 | 3.15 | 0.43 | 0.69 | 2.65 | 1.30 | 0.92 | 0.70 | 0.80 | 0.74 | 1.08 | 0.95 | 3.82 | 0.23 | 0.25 | 0.30 | 0.31 | 0.29 | 0.24 | 1.61 | 0.81 | 1.15 | 1.07 | 0.72 | 1.36 | 0.92 | 1.88 | 1.30 | 1.25 | 1.30 | 0.93 | 0.71 | 0.95 | 0.51 | 0.97 | 0.59 | 0.52 |
| suberate | ME1100347 | 0.90 | 0.99 | 0.83 | 0.75 | 0.73 | 0.88 | 0.88 | 0.81 | 0.65 | 0.74 | 0.81 | 0.78 | 0.81 | 0.79 | 0.97 | 0.77 | 0.86 | 0.74 | 5.37 | 0.58 | 0.83 | 2.16 | 1.64 | 0.63 | 0.32 | 0.46 | 0.47 | 0.86 | 0.47 | 2.65 | 0.39 | 0.46 | 0.52 | 0.50 | 0.41 | 0.42 | 0.94 | 1.14 | 0.92 | 1.18 | 1.17 | 1.58 | 0.87 | 1.10 | 0.83 | 1.08 | 1.13 | 1.21 | 0.91 | 1.01 | 1.06 | 0.97 | 1.65 | 1.38 |
| malonate | ME1100332 | 0.66 | 1.15 | 0.60 | 0.84 | 1.03 | 0.58 | 0.57 | 0.79 | 1.00 | 0.90 | 1.66 | 1.16 | 1.10 | 0.50 | 0.71 | 0.39 | 1.10 | 0.55 | 0.79 | 0.32 | 0.55 | 0.87 | 0.63 | 0.95 | 4.12 | 1.49 | 2.40 | 3.88 | 1.71 | 2.21 | 0.32 | 0.42 | 0.32 | 0.63 | 0.43 | 0.39 | 0.63 | 0.59 | 1.04 | 0.68 | 0.81 | 0.99 | 0.89 | 1.64 | 1.21 | 0.98 | 0.91 | 1.20 | 0.54 | 1.01 | 0.75 | 1.01 | 0.47 | 0.97 |
| fumarate/maleate | ME1100305 | 0.55 | 1.01 | 0.51 | 1.28 | 1.20 | 0.75 | 1.15 | 1.01 | 0.70 | 0.67 | 1.07 | 0.84 | 0.92 | 1.16 | 1.03 | 0.87 | 1.45 | 1.23 | 0.50 | 0.32 | 0.60 | 0.54 | 0.52 | 0.37 | 2.89 | 0.95 | 1.24 | 2.40 | 4.16 | 2.76 | 0.18 | 0.48 | 0.35 | 0.19 | 0.53 | 0.61 | 0.76 | 0.82 | 1.06 | 0.78 | 1.14 | 1.11 | 0.64 | 1.06 | 0.74 | 1.03 | 1.11 | 0.72 | 0.90 | 1.35 | 1.09 | 0.79 | 1.03 | 0.90 |
| malate | ME1100331 | 0.55 | 1.02 | 0.52 | 1.31 | 1.22 | 0.74 | 1.15 | 1.03 | 0.70 | 0.67 | 1.07 | 0.84 | 0.93 | 1.18 | 1.06 | 0.87 | 1.44 | 1.23 | 0.48 | 0.31 | 0.60 | 0.54 | 0.52 | 0.36 | 2.90 | 0.95 | 1.26 | 2.42 | 4.22 | 2.78 | 0.16 | 0.47 | 0.33 | 0.17 | 0.52 | 0.61 | 0.76 | 0.83 | 1.07 | 0.74 | 1.09 | 1.08 | 0.65 | 1.06 | 0.74 | 1.04 | 1.06 | 0.68 | 0.92 | 1.39 | 1.08 | 0.77 | 1.00 | 0.87 |
| erythronate/threonate | ME1100302 | 0.61 | 0.90 | 0.75 | 0.82 | 1.24 | 0.73 | 0.99 | 0.64 | 0.53 | 1.03 | 0.72 | 1.04 | 0.82 | 1.01 | 0.85 | 0.91 | 1.28 | 0.93 | 0.66 | 0.79 | 1.09 | 0.62 | 1.24 | 1.16 | 0.54 | 0.54 | 0.48 | 1.08 | 0.89 | 0.81 | 0.62 | 3.87 | 1.84 | 0.52 | 3.10 | 2.94 | 0.82 | 0.66 | 0.78 | 0.62 | 0.75 | 1.26 | 0.94 | 0.74 | 0.99 | 0.97 | 0.62 | 0.92 | 0.77 | 1.03 | 1.02 | 0.81 | 0.93 | 0.77 |
| 2-hydroxy-3-methylpentanoate/hydroxyisocaproate | ME1100271 | 0.83 | 0.71 | 0.85 | 0.74 | 0.97 | 0.91 | 0.98 | 0.68 | 0.66 | 0.75 | 1.39 | 0.82 | 0.88 | 1.08 | 1.24 | 1.08 | 1.55 | 1.48 | 0.31 | 1.11 | 0.34 | 0.84 | 0.34 | 1.41 | 0.70 | 0.41 | 1.13 | 0.62 | 0.46 | 0.35 | 0.62 | 2.54 | 1.05 | 0.78 | 0.88 | 2.87 | 0.91 | 0.64 | 0.99 | 1.63 | 0.95 | 1.15 | 0.75 | 1.08 | 0.76 | 0.76 | 1.08 | 1.07 | 0.85 | 1.22 | 1.24 | 1.38 | 1.50 | 1.66 |
| uridine | ME1100358 | 0.79 | 1.40 | 0.97 | 1.38 | 0.87 | 0.99 | 0.86 | 0.95 | 0.94 | 0.83 | 1.11 | 0.76 | 0.95 | 0.59 | 1.00 | 0.89 | 0.79 | 0.66 | 0.80 | 1.19 | 0.86 | 1.04 | 0.41 | 0.60 | 0.85 | 0.39 | 0.58 | 0.44 | 0.92 | 0.79 | 1.18 | 2.20 | 1.66 | 0.57 | 1.47 | 4.74 | 0.95 | 1.02 | 1.87 | 0.94 | 1.14 | 1.03 | 0.71 | 1.28 | 0.83 | 0.95 | 1.07 | 0.81 | 0.73 | 0.74 | 0.56 | 0.74 | 0.46 | 0.74 |
| sucrose/lactose/trehalose | ME1100350 | 0.72 | 1.00 | 0.49 | 0.99 | 0.78 | 0.70 | 0.92 | 0.66 | 0.55 | 1.41 | 0.85 | 1.00 | 0.93 | 1.18 | 1.63 | 1.38 | 1.54 | 1.27 | 1.00 | 1.04 | 1.65 | 1.87 | 2.36 | 1.31 | 0.76 | 0.71 | 0.80 | 0.78 | 0.73 | 0.71 | 0.60 | 0.64 | 1.09 | 0.63 | 0.86 | 1.41 | 0.53 | 0.61 | 0.58 | 0.45 | 0.73 | 1.02 | 0.74 | 0.72 | 0.74 | 0.80 | 0.59 | 0.51 | 1.11 | 1.42 | 2.87 | 0.88 | 1.31 | 1.43 |
| alpha-ketoglutarate | ME1100291 | 0.65 | 0.98 | 0.75 | 1.06 | 1.25 | 0.74 | 1.12 | 1.28 | 0.98 | 0.55 | 1.31 | 0.77 | 1.10 | 0.77 | 1.04 | 0.85 | 1.43 | 1.47 | 0.91 | 0.17 | 0.77 | 4.19 | 1.03 | 1.72 | 1.35 | 1.46 | 1.01 | 2.94 | 1.63 | 0.85 | 0.28 | 0.06 | 0.20 | 0.55 | 0.11 | 0.15 | 0.73 | 0.91 | 1.17 | 0.83 | 0.91 | 0.86 | 0.56 | 1.48 | 0.79 | 0.87 | 1.05 | 0.62 | 0.96 | 1.45 | 1.39 | 0.78 | 0.54 | 0.62 |
| alpha-keto-beta-methylvalerate/alpha-ketoisocaproate | ME1100290 | 0.78 | 1.38 | 1.25 | 1.23 | 1.16 | 1.23 | 1.25 | 1.50 | 1.04 | 0.71 | 1.35 | 0.93 | 1.12 | 0.80 | 0.99 | 0.99 | 1.21 | 0.99 | 0.45 | 0.17 | 0.70 | 2.55 | 1.00 | 1.23 | 1.03 | 1.04 | 0.68 | 1.60 | 1.41 | 0.71 | 0.37 | 0.09 | 0.56 | 0.77 | 0.28 | 0.43 | 1.18 | 0.71 | 1.59 | 1.33 | 1.42 | 1.14 | 0.73 | 1.03 | 0.79 | 0.89 | 1.46 | 0.97 | 1.11 | 1.12 | 0.82 | 1.14 | 0.88 | 0.69 |
| alpha-ketoisovalerate | ME1100292 | 1.26 | 1.14 | 1.25 | 1.18 | 1.20 | 1.35 | 1.62 | 1.45 | 0.99 | 0.84 | 1.58 | 1.18 | 1.17 | 0.90 | 1.08 | 0.90 | 1.36 | 1.56 | 0.42 | 0.20 | 0.58 | 2.26 | 0.78 | 0.96 | 0.89 | 1.05 | 0.70 | 1.21 | 1.08 | 0.57 | 0.36 | 0.07 | 0.41 | 0.82 | 0.26 | 0.31 | 1.14 | 0.75 | 1.32 | 1.30 | 1.34 | 1.20 | 0.77 | 1.04 | 0.82 | 0.92 | 1.32 | 0.90 | 1.09 | 1.19 | 1.04 | 1.19 | 1.00 | 0.72 |
| adenine | ME1100284 | 1.24 | 0.99 | 0.92 | 1.13 | 1.79 | 0.93 | 1.10 | 0.65 | 0.65 | 1.13 | 1.36 | 1.69 | 0.48 | 0.47 | 0.63 | 0.37 | 0.66 | 0.65 | 1.48 | 0.64 | 1.82 | 1.17 | 1.17 | 1.50 | 1.35 | 0.92 | 1.84 | 1.49 | 1.20 | 1.14 | 0.80 | 0.84 | 0.72 | 0.59 | 0.90 | 1.14 | 1.03 | 0.93 | 0.87 | 0.54 | 0.85 | 2.18 | 0.85 | 1.16 | 1.32 | 1.69 | 1.01 | 0.96 | 0.39 | 0.55 | 0.51 | 0.46 | 0.49 | 0.64 |
| glycerate | ME1100312 | 1.12 | 1.37 | 1.42 | 1.31 | 1.32 | 1.51 | 1.52 | 1.69 | 1.63 | 1.39 | 1.67 | 1.43 | 0.01 | 0.04 | 0.02 | 0.01 | 0.02 | 0.02 | 0.99 | 0.72 | 0.83 | 1.35 | 0.98 | 1.35 | 1.11 | 0.80 | 0.97 | 1.43 | 1.54 | 1.60 | 0.68 | 1.07 | 0.79 | 0.87 | 0.81 | 0.94 | 1.62 | 1.19 | 1.46 | 1.24 | 1.24 | 1.28 | 1.51 | 1.68 | 1.53 | 1.59 | 1.61 | 1.56 | 0.01 | 0.02 | 0.02 | 0.02 | 0.05 | 0.02 |
| pseudouridine | ME1100342 | 1.04 | 1.29 | 1.09 | 1.29 | 1.00 | 1.09 | 1.15 | 1.04 | 1.07 | 1.60 | 1.46 | 1.57 | 0.59 | 0.45 | 0.52 | 0.49 | 0.69 | 0.45 | 0.78 | 0.26 | 1.00 | 1.43 | 0.71 | 0.63 | 0.80 | 0.74 | 0.70 | 1.84 | 1.66 | 2.38 | 0.53 | 0.67 | 0.92 | 0.50 | 0.88 | 0.76 | 1.02 | 1.04 | 1.23 | 1.13 | 1.28 | 1.20 | 1.53 | 1.61 | 1.46 | 1.51 | 1.06 | 1.35 | 0.50 | 0.71 | 0.54 | 0.62 | 0.55 | 0.63 |
| cytidine | ME1100301 | 0.80 | 1.58 | 1.46 | 1.18 | 1.27 | 1.36 | 1.17 | 1.30 | 1.31 | 1.23 | 1.71 | 1.08 | 0.86 | 0.56 | 0.49 | 0.67 | 0.54 | 0.57 | 0.62 | 0.38 | 0.66 | 1.07 | 0.69 | 0.91 | 0.97 | 0.49 | 0.77 | 0.90 | 1.14 | 1.62 | 0.53 | 0.82 | 0.92 | 0.54 | 0.93 | 1.08 | 1.28 | 0.95 | 2.05 | 1.79 | 1.19 | 1.62 | 0.96 | 1.93 | 1.02 | 1.14 | 1.44 | 1.18 | 0.65 | 0.44 | 0.39 | 0.85 | 0.50 | 0.43 |
| adipate/methylglutarate | ME1100285 | 0.61 | 1.24 | 1.02 | 1.34 | 1.44 | 1.19 | 1.38 | 1.08 | 1.11 | 0.98 | 1.80 | 0.99 | 0.51 | 0.49 | 0.57 | 0.43 | 0.53 | 0.56 | 1.42 | 0.67 | 1.02 | 0.83 | 1.09 | 1.11 | 0.91 | 1.00 | 1.05 | 1.05 | 1.22 | 1.31 | 0.80 | 0.64 | 0.87 | 0.90 | 0.72 | 0.55 | 1.28 | 0.96 | 1.39 | 1.08 | 1.28 | 1.86 | 1.21 | 1.69 | 1.06 | 1.36 | 1.26 | 1.07 | 0.52 | 0.81 | 0.72 | 0.59 | 0.71 | 0.69 |
| adonitol/arabitol | ME1100286 | 0.79 | 0.98 | 1.13 | 1.19 | 1.20 | 1.25 | 1.12 | 1.11 | 1.19 | 1.13 | 1.23 | 0.96 | 0.93 | 0.59 | 0.63 | 0.70 | 0.71 | 0.59 | 1.82 | 0.87 | 1.15 | 1.09 | 1.36 | 0.96 | 0.66 | 0.67 | 0.65 | 0.86 | 1.90 | 1.04 | 0.92 | 0.92 | 1.34 | 0.91 | 1.36 | 0.91 | 1.26 | 0.97 | 1.07 | 0.95 | 0.87 | 1.15 | 1.13 | 1.64 | 1.02 | 1.12 | 1.02 | 1.08 | 0.69 | 0.77 | 0.60 | 0.75 | 0.54 | 0.54 |
| 2-aminobutyrate | ME1100268 | 0.50 | 0.88 | 1.09 | 0.94 | 0.84 | 0.96 | 0.83 | 0.78 | 0.89 | 0.66 | 0.68 | 0.66 | 1.15 | 1.65 | 1.24 | 1.50 | 1.35 | 1.11 | 0.37 | 0.42 | 0.62 | 1.82 | 0.65 | 0.52 | 1.18 | 1.69 | 1.82 | 1.52 | 0.90 | 0.81 | 0.50 | 1.00 | 0.91 | 0.99 | 0.67 | 0.97 | 1.06 | 0.58 | 0.90 | 1.10 | 1.01 | 0.92 | 0.75 | 0.70 | 0.69 | 0.84 | 0.82 | 0.90 | 1.56 | 1.62 | 1.18 | 1.22 | 1.92 | 1.13 |
| 3-methyladipate/pimelate | ME1100275 | 0.86 | 0.81 | 0.72 | 1.15 | 1.00 | 1.02 | 1.29 | 0.93 | 1.00 | 0.96 | 1.47 | 1.05 | 0.80 | 1.16 | 0.79 | 0.81 | 1.02 | 0.89 | 2.93 | 0.76 | 0.68 | 0.72 | 0.82 | 0.98 | 0.77 | 0.92 | 0.93 | 0.92 | 1.15 | 1.55 | 0.68 | 0.60 | 0.55 | 0.56 | 0.66 | 0.57 | 0.98 | 0.91 | 0.88 | 0.80 | 1.18 | 1.53 | 1.06 | 1.07 | 0.91 | 1.35 | 1.11 | 1.15 | 0.81 | 1.10 | 1.05 | 0.91 | 1.61 | 1.12 |
| 2-hydroxy-3-methylbutyrate/hydroxyisovalerate | ME1100270 | 0.99 | 0.56 | 0.79 | 0.66 | 0.76 | 0.76 | 0.81 | 0.53 | 0.67 | 0.77 | 1.02 | 0.90 | 1.23 | 1.57 | 1.45 | 1.49 | 1.44 | 1.71 | 1.11 | 0.81 | 0.98 | 0.65 | 0.86 | 1.16 | 0.95 | 0.72 | 0.66 | 0.68 | 0.75 | 0.96 | 0.84 | 1.19 | 0.99 | 0.82 | 1.00 | 1.60 | 0.72 | 0.75 | 0.64 | 1.33 | 0.86 | 0.85 | 0.76 | 0.92 | 0.75 | 0.63 | 0.79 | 0.94 | 1.37 | 1.28 | 1.36 | 1.58 | 1.97 | 1.69 |
| aconitate | ME1100283 | 0.74 | 0.71 | 0.70 | 0.92 | 0.95 | 0.75 | 1.03 | 0.76 | 0.74 | 0.81 | 1.15 | 0.96 | 1.07 | 1.37 | 1.18 | 1.08 | 1.25 | 1.26 | 2.03 | 0.70 | 0.49 | 0.54 | 0.96 | 1.27 | 0.66 | 0.80 | 0.71 | 0.69 | 1.18 | 1.40 | 1.62 | 1.07 | 0.80 | 0.88 | 0.65 | 0.83 | 0.77 | 0.84 | 0.78 | 1.07 | 1.05 | 1.27 | 0.81 | 1.13 | 0.92 | 0.97 | 0.96 | 0.91 | 1.01 | 1.31 | 1.23 | 1.23 | 1.68 | 1.31 |
| citrate/isocitrate | ME1100299 | 0.81 | 0.78 | 0.74 | 0.97 | 1.02 | 0.87 | 1.11 | 0.92 | 0.87 | 0.88 | 1.15 | 1.02 | 1.19 | 1.34 | 1.22 | 1.10 | 1.25 | 1.28 | 1.44 | 0.33 | 0.29 | 0.30 | 0.87 | 1.29 | 0.49 | 0.61 | 0.42 | 0.47 | 1.09 | 1.33 | 1.54 | 1.08 | 0.97 | 0.81 | 0.71 | 1.01 | 0.89 | 0.97 | 0.84 | 1.17 | 1.14 | 1.34 | 0.89 | 1.15 | 0.99 | 1.02 | 1.12 | 1.07 | 1.01 | 1.28 | 1.20 | 1.35 | 1.63 | 1.40 |
| oxalate | ME1100337 | 0.89 | 1.08 | 0.82 | 1.26 | 0.95 | 0.85 | 0.76 | 0.93 | 1.11 | 0.84 | 1.07 | 0.91 | 1.17 | 1.19 | 1.02 | 0.98 | 1.00 | 1.00 | 1.30 | 0.22 | 1.08 | 1.09 | 1.63 | 1.09 | 0.64 | 1.13 | 1.62 | 1.14 | 1.41 | 0.94 | 0.34 | 0.40 | 0.19 | 1.03 | 0.18 | 0.19 | 0.98 | 0.87 | 0.81 | 1.02 | 1.52 | 1.26 | 0.88 | 1.00 | 0.89 | 0.97 | 1.23 | 1.47 | 1.12 | 1.05 | 1.17 | 1.37 | 1.46 | 1.48 |
| inositol | ME1100327 | 0.82 | 1.00 | 1.91 | 1.09 | 0.95 | 0.88 | 1.13 | 1.20 | 0.92 | 0.87 | 1.46 | 0.90 | 1.19 | 0.79 | 0.70 | 0.92 | 0.75 | 0.90 | 0.63 | 0.43 | 1.29 | 0.52 | 1.04 | 0.73 | 0.63 | 0.47 | 0.59 | 1.78 | 1.21 | 1.08 | 0.37 | 1.05 | 1.10 | 0.48 | 1.54 | 1.40 | 1.03 | 1.00 | 1.17 | 0.99 | 1.27 | 1.13 | 0.92 | 1.62 | 0.96 | 1.29 | 1.33 | 0.96 | 0.96 | 0.95 | 0.93 | 1.22 | 0.91 | 0.63 |
| aspartate | ME1100295 | 1.23 | 1.66 | 1.13 | 1.63 | 1.00 | 0.95 | 0.87 | 1.02 | 0.82 | 0.88 | 1.05 | 1.10 | 0.82 | 1.25 | 1.03 | 0.78 | 0.85 | 0.79 | 0.65 | 0.32 | 1.00 | 1.44 | 1.12 | 1.05 | 0.93 | 0.70 | 0.81 | 1.28 | 1.16 | 1.13 | 0.35 | 0.71 | 0.71 | 0.79 | 0.79 | 0.80 | 0.80 | 1.54 | 1.17 | 1.14 | 1.69 | 1.12 | 0.69 | 0.87 | 0.97 | 1.15 | 0.98 | 0.65 | 0.81 | 1.47 | 0.78 | 0.61 | 1.49 | 1.47 |
| glutamate | ME1100309 | 1.28 | 1.42 | 1.44 | 1.88 | 0.85 | 0.76 | 0.63 | 0.81 | 0.72 | 0.66 | 0.90 | 0.95 | 0.92 | 1.50 | 1.09 | 0.89 | 0.88 | 0.79 | 0.76 | 0.25 | 0.99 | 0.91 | 1.01 | 1.01 | 1.13 | 0.90 | 0.95 | 1.62 | 1.49 | 1.52 | 0.47 | 0.62 | 0.76 | 0.85 | 0.83 | 0.73 | 0.84 | 1.26 | 1.21 | 1.09 | 1.46 | 1.31 | 0.65 | 0.91 | 0.93 | 1.11 | 0.91 | 0.71 | 0.97 | 1.18 | 0.93 | 0.77 | 1.33 | 1.24 |
| fructose/glucose/galactose | ME1100304 | 0.87 | 0.91 | 0.84 | 0.97 | 0.91 | 0.80 | 0.93 | 0.92 | 0.84 | 0.92 | 0.88 | 0.96 | 1.22 | 1.14 | 1.43 | 1.29 | 1.18 | 1.20 | 0.55 | 0.46 | 0.64 | 1.04 | 0.83 | 0.72 | 1.03 | 1.23 | 1.48 | 1.58 | 1.55 | 1.82 | 0.56 | 0.58 | 0.83 | 1.02 | 0.67 | 0.62 | 0.85 | 1.00 | 0.95 | 0.77 | 0.91 | 0.91 | 0.98 | 0.91 | 0.99 | 0.96 | 0.85 | 0.82 | 1.39 | 1.40 | 1.26 | 1.13 | 1.19 | 1.29 |
| thymine | ME1100355 | 0.74 | 0.95 | 1.06 | 0.76 | 0.84 | 0.93 | 0.96 | 0.77 | 0.99 | 0.83 | 1.23 | 0.80 | 1.63 | 0.91 | 1.39 | 1.01 | 1.41 | 1.11 | 0.62 | 0.40 | 0.90 | 0.82 | 0.83 | 1.06 | 1.08 | 0.96 | 0.99 | 1.61 | 1.35 | 1.54 | 0.54 | 0.86 | 0.96 | 1.06 | 0.82 | 0.98 | 0.92 | 0.73 | 1.02 | 0.94 | 0.74 | 0.79 | 0.83 | 0.99 | 0.80 | 1.02 | 0.74 | 0.92 | 1.19 | 1.48 | 1.16 | 1.68 | 1.07 | 1.32 |
| lactate | ME1100329 | 0.85 | 1.33 | 0.72 | 1.34 | 0.92 | 0.93 | 1.00 | 1.29 | 0.82 | 0.64 | 0.93 | 0.77 | 0.81 | 1.30 | 1.38 | 1.19 | 1.23 | 1.30 | 0.82 | 0.82 | 0.86 | 0.48 | 0.63 | 0.71 | 0.85 | 0.66 | 1.08 | 1.45 | 0.89 | 0.71 | 0.80 | 1.43 | 1.17 | 0.61 | 0.96 | 1.37 | 1.05 | 0.87 | 1.34 | 0.65 | 1.37 | 1.03 | 0.66 | 1.00 | 0.80 | 1.08 | 1.37 | 0.76 | 1.16 | 1.44 | 1.31 | 0.68 | 1.11 | 1.22 |
| uracil | ME1100356 | 0.81 | 1.34 | 1.06 | 1.28 | 0.99 | 1.07 | 0.97 | 0.99 | 0.97 | 0.88 | 1.30 | 0.88 | 1.10 | 0.74 | 1.14 | 0.98 | 1.01 | 0.79 | 0.86 | 0.46 | 1.07 | 1.06 | 0.95 | 0.98 | 0.88 | 0.89 | 0.83 | 1.29 | 1.45 | 1.43 | 0.59 | 0.87 | 0.97 | 0.80 | 1.11 | 0.93 | 1.08 | 1.02 | 1.64 | 0.91 | 1.12 | 1.20 | 0.82 | 1.42 | 0.94 | 1.09 | 1.00 | 0.82 | 0.92 | 1.04 | 0.74 | 1.01 | 0.70 | 0.85 |
| inosine-15N4 | ME1100262 | 1.20 | 0.82 | 0.86 | 0.90 | 0.99 | 1.14 | 1.11 | 0.89 | 0.87 | 1.13 | 1.11 | 1.13 | 0.87 | 1.03 | 0.91 | 1.10 | 1.18 | 1.25 | 0.83 | 1.33 | 0.92 | 0.77 | 0.83 | 0.83 | 0.86 | 0.88 | 0.81 | 0.76 | 0.81 | 0.80 | 1.25 | 1.25 | 1.13 | 1.10 | 1.13 | 1.09 | 1.10 | 1.19 | 1.03 | 0.91 | 0.93 | 0.94 | 1.09 | 1.05 | 1.02 | 1.13 | 0.94 | 0.99 | 0.82 | 0.87 | 1.01 | 1.09 | 1.06 | 0.92 |
| glycocholate-d4 | ME1100263 | 1.19 | 0.84 | 0.94 | 0.90 | 1.00 | 1.14 | 1.09 | 0.92 | 0.88 | 1.14 | 1.11 | 1.16 | 0.92 | 1.00 | 0.97 | 1.08 | 1.19 | 1.24 | 0.94 | 1.05 | 0.97 | 0.90 | 0.96 | 0.93 | 0.96 | 0.94 | 0.97 | 0.99 | 0.95 | 0.97 | 0.97 | 0.97 | 0.99 | 0.99 | 0.96 | 1.04 | 1.08 | 1.27 | 1.25 | 0.89 | 0.88 | 0.92 | 1.12 | 1.02 | 1.08 | 1.19 | 0.83 | 0.88 | 0.87 | 0.87 | 1.02 | 0.90 | 0.90 | 0.89 |
| thymine-d4 | ME1100261 | 1.05 | 0.98 | 1.12 | 0.96 | 1.02 | 1.18 | 1.13 | 1.10 | 1.04 | 1.08 | 1.08 | 1.05 | 1.02 | 0.98 | 0.92 | 1.00 | 0.96 | 1.05 | 0.94 | 1.08 | 0.90 | 0.89 | 0.86 | 0.90 | 0.94 | 1.01 | 0.96 | 0.96 | 0.91 | 0.85 | 1.02 | 0.99 | 0.95 | 0.94 | 0.93 | 1.05 | 1.12 | 1.10 | 1.07 | 1.02 | 1.01 | 1.05 | 1.05 | 1.10 | 0.98 | 1.06 | 0.99 | 0.97 | 1.00 | 0.95 | 0.89 | 1.04 | 0.98 | 0.83 |
| 2-hydroxyglutarate | ME1100272 | 0.61 | 0.54 | 0.48 | 0.71 | 0.79 | 0.57 | 0.87 | 0.64 | 0.62 | 0.77 | 0.87 | 0.77 | 1.61 | 1.57 | 1.51 | 1.42 | 1.92 | 2.06 | 1.02 | 0.33 | 1.04 | 0.85 | 1.05 | 1.60 | 1.02 | 0.63 | 1.29 | 1.29 | 1.53 | 1.43 | 0.45 | 0.59 | 0.66 | 0.50 | 0.61 | 0.97 | 0.55 | 0.52 | 0.82 | 0.60 | 0.76 | 1.14 | 0.59 | 0.95 | 0.99 | 0.85 | 0.70 | 0.66 | 1.38 | 1.85 | 1.83 | 1.58 | 1.62 | 1.42 |
| pantothenate | ME1100338 | 1.05 | 0.52 | 0.50 | 0.70 | 0.60 | 0.86 | 1.36 | 0.49 | 0.43 | 1.27 | 1.72 | 1.31 | 1.07 | 0.95 | 1.76 | 1.60 | 1.25 | 1.54 | 0.56 | 0.31 | 1.18 | 1.29 | 0.81 | 0.76 | 0.59 | 0.55 | 0.63 | 1.14 | 1.18 | 1.85 | 0.50 | 1.48 | 0.94 | 0.87 | 0.98 | 0.68 | 0.76 | 1.02 | 1.17 | 0.68 | 0.96 | 0.83 | 0.99 | 1.22 | 0.94 | 0.96 | 0.72 | 0.72 | 1.05 | 1.09 | 1.32 | 1.29 | 1.40 | 1.57 |
| alpha-hydroxybutyrate/beta-hydroxybutyrate/hydroxyisobutyrate | ME1100289 | 0.58 | 1.40 | 1.88 | 1.04 | 0.98 | 0.97 | 1.00 | 1.22 | 1.40 | 0.91 | 1.23 | 1.13 | 1.23 | 0.77 | 0.61 | 0.90 | 0.69 | 0.70 | 0.67 | 1.75 | 0.64 | 0.60 | 0.47 | 0.48 | 1.24 | 0.69 | 1.35 | 1.10 | 1.01 | 1.05 | 0.96 | 1.25 | 1.31 | 0.83 | 1.02 | 0.97 | 1.03 | 0.72 | 1.52 | 1.79 | 0.99 | 0.87 | 0.80 | 1.29 | 1.06 | 0.84 | 1.14 | 1.31 | 0.79 | 0.72 | 0.67 | 1.13 | 0.74 | 0.57 |
| glucuronate | ME1100308 | 0.51 | 0.84 | 0.64 | 0.79 | 1.07 | 1.01 | 1.27 | 0.61 | 0.87 | 0.95 | 1.65 | 1.07 | 0.85 | 0.83 | 0.74 | 0.87 | 0.99 | 0.75 | 0.46 | 0.57 | 0.55 | 1.19 | 0.42 | 0.56 | 0.77 | 0.93 | 2.14 | 2.43 | 0.90 | 1.07 | 0.79 | 0.82 | 1.07 | 1.23 | 1.16 | 0.99 | 1.09 | 0.81 | 1.28 | 0.75 | 0.89 | 1.27 | 1.12 | 1.65 | 1.28 | 1.37 | 0.76 | 0.82 | 0.83 | 1.12 | 1.17 | 1.08 | 1.43 | 0.93 |
| propionate | ME1100341 | 0.58 | 0.75 | 1.20 | 1.21 | 1.55 | 1.12 | 1.34 | 1.18 | 0.66 | 0.81 | 1.72 | 0.79 | 1.02 | 1.11 | 1.07 | 0.57 | 1.20 | 0.77 | 0.60 | 0.48 | 0.56 | 0.90 | 0.44 | 0.30 | 1.04 | 1.37 | 1.67 | 0.90 | 1.46 | 1.07 | 1.16 | 1.03 | 1.03 | 1.44 | 1.08 | 0.80 | 0.83 | 0.70 | 1.10 | 1.05 | 0.98 | 1.80 | 0.85 | 1.69 | 1.02 | 1.32 | 0.97 | 0.61 | 0.89 | 1.34 | 1.07 | 0.64 | 0.58 | 0.60 |
| succinate | ME1100348 | 1.00 | 0.87 | 0.98 | 1.27 | 1.34 | 0.73 | 1.34 | 1.07 | 0.67 | 1.12 | 2.57 | 1.13 | 0.81 | 0.72 | 0.80 | 0.54 | 0.89 | 0.80 | 0.35 | 0.62 | 0.42 | 0.57 | 0.42 | 0.51 | 1.13 | 1.23 | 1.87 | 0.88 | 0.84 | 0.86 | 1.15 | 1.74 | 0.83 | 1.69 | 0.62 | 1.06 | 0.79 | 1.11 | 0.85 | 1.00 | 1.09 | 1.58 | 1.19 | 2.01 | 1.19 | 1.11 | 1.01 | 0.75 | 0.66 | 1.02 | 0.94 | 0.82 | 0.66 | 0.73 |
| ethyl glucuronide | ME1100303 | 0.94 | 0.58 | 0.79 | 1.04 | 1.42 | 0.49 | 2.25 | 0.75 | 0.49 | 1.10 | 1.01 | 0.97 | 1.86 | 1.04 | 0.51 | 1.89 | 0.53 | 0.37 | 0.98 | 0.85 | 1.51 | 1.21 | 1.96 | 1.21 | 0.66 | 0.80 | 0.72 | 0.82 | 0.81 | 1.17 | 0.57 | 0.74 | 0.84 | 0.59 | 0.68 | 0.81 | 0.55 | 0.94 | 0.50 | 0.79 | 1.14 | 1.58 | 1.20 | 0.84 | 1.07 | 2.33 | 0.84 | 0.54 | 1.97 | 0.56 | 0.35 | 2.10 | 1.28 | 0.43 |
| 4-pyridoxate | ME1100280 | 0.30 | 0.71 | 0.40 | 0.74 | 1.21 | 0.96 | 1.76 | 0.61 | 0.67 | 1.47 | 2.03 | 1.26 | 0.91 | 0.78 | 0.70 | 1.18 | 1.09 | 0.93 | 3.06 | 0.84 | 0.81 | 1.06 | 0.94 | 1.69 | 0.50 | 0.67 | 0.55 | 0.54 | 0.51 | 1.55 | 0.94 | 0.83 | 1.00 | 1.16 | 1.10 | 1.12 | 0.92 | 0.34 | 1.19 | 0.35 | 0.72 | 1.24 | 1.52 | 1.80 | 1.27 | 1.40 | 0.69 | 0.70 | 1.05 | 1.09 | 1.01 | 0.93 | 0.75 | 0.45 |
| sorbitol | ME1100346 | 0.54 | 0.56 | 0.78 | 0.88 | 1.58 | 1.04 | 1.82 | 1.29 | 1.20 | 2.00 | 2.03 | 2.19 | 1.13 | 0.68 | 0.56 | 0.76 | 0.89 | 0.73 | 0.85 | 0.54 | 1.25 | 1.19 | 1.41 | 1.67 | 0.55 | 0.70 | 0.83 | 0.87 | 1.22 | 1.14 | 0.17 | 0.37 | 0.41 | 0.28 | 0.34 | 0.30 | 0.94 | 0.53 | 0.44 | 0.56 | 0.65 | 1.39 | 2.02 | 1.77 | 2.32 | 2.06 | 0.96 | 1.00 | 0.75 | 0.95 | 0.68 | 1.03 | 0.71 | 0.51 |
Factors:
| F1 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:11 |
| F2 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:12 |
| F3 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:13 |
| F4 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:17 |
| F5 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:20 |
| F6 | Sample source:Cardiac Puncture | Strain:129 J | Injection order:7 |
| F7 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:10 |
| F8 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:14 |
| F9 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:15 |
| F10 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:6 |
| F11 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:8 |
| F12 | Sample source:Cardiac Puncture | Strain:129 T | Injection order:9 |
| F13 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:16 |
| F14 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:18 |
| F15 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:19 |
| F16 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:3 |
| F17 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:4 |
| F18 | Sample source:Cardiac Puncture | Strain:C57Bl6 | Injection order:5 |
| F19 | Sample source:Cecal Contents | Strain:129 J | Injection order:51 |
| F20 | Sample source:Cecal Contents | Strain:129 J | Injection order:55 |
| F21 | Sample source:Cecal Contents | Strain:129 J | Injection order:56 |
| F22 | Sample source:Cecal Contents | Strain:129 J | Injection order:57 |
| F23 | Sample source:Cecal Contents | Strain:129 J | Injection order:61 |
| F24 | Sample source:Cecal Contents | Strain:129 J | Injection order:64 |
| F25 | Sample source:Cecal Contents | Strain:129 T | Injection order:50 |
| F26 | Sample source:Cecal Contents | Strain:129 T | Injection order:52 |
| F27 | Sample source:Cecal Contents | Strain:129 T | Injection order:53 |
| F28 | Sample source:Cecal Contents | Strain:129 T | Injection order:54 |
| F29 | Sample source:Cecal Contents | Strain:129 T | Injection order:58 |
| F30 | Sample source:Cecal Contents | Strain:129 T | Injection order:59 |
| F31 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:47 |
| F32 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:48 |
| F33 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:49 |
| F34 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:60 |
| F35 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:62 |
| F36 | Sample source:Cecal Contents | Strain:C57Bl6 | Injection order:63 |
| F37 | Sample source:Portal Vein | Strain:129 J | Injection order:29 |
| F38 | Sample source:Portal Vein | Strain:129 J | Injection order:33 |
| F39 | Sample source:Portal Vein | Strain:129 J | Injection order:34 |
| F40 | Sample source:Portal Vein | Strain:129 J | Injection order:35 |
| F41 | Sample source:Portal Vein | Strain:129 J | Injection order:39 |
| F42 | Sample source:Portal Vein | Strain:129 J | Injection order:42 |
| F43 | Sample source:Portal Vein | Strain:129 T | Injection order:28 |
| F44 | Sample source:Portal Vein | Strain:129 T | Injection order:30 |
| F45 | Sample source:Portal Vein | Strain:129 T | Injection order:31 |
| F46 | Sample source:Portal Vein | Strain:129 T | Injection order:32 |
| F47 | Sample source:Portal Vein | Strain:129 T | Injection order:36 |
| F48 | Sample source:Portal Vein | Strain:129 T | Injection order:37 |
| F49 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:25 |
| F50 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:26 |
| F51 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:27 |
| F52 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:38 |
| F53 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:40 |
| F54 | Sample source:Portal Vein | Strain:C57Bl6 | Injection order:41 |