Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004164)

HILIC NEGATIVE ION MODE (Analysis AN006913)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12	F13	F14	F15	F16	F17	F18	F19	F20	F21	F22	F23	F24	F25	F26	F27	F28	F29
Lactate	ME1115156	0.65	0.99	0.65	6.16	1.80	0.62	0.63	0.71	0.63	0.60	0.66	0.78	0.52	0.37	0.50	0.48	7.97	0.63	0.41	0.77	1.16	0.26	0.22	0.53	0.38	0.51	0.56	0.43	0.41
Inosine	ME1115154	0.56	0.42	0.70	0.40	0.34	2.69	2.40	2.37	2.58	2.66	2.82	2.52	0.12	0.07	0.13	0.20	0.17	0.20	0.42	0.45	NA	0.51	0.67	0.36	0.80	0.96	0.78	0.72	NA
F6P / G1P	ME1115142	3.60	1.08	0.54	0.86	0.61	1.28	0.90	0.58	2.51	0.38	NA	0.53	1.64	2.58	1.77	0.58	0.48	0.45	2.52	0.37	0.55	0.34	1.41	0.58	2.24	0.64	0.37	0.43	0.98
G6P	ME1115145	1.14	1.04	1.20	0.85	NA	NA	NA	0.72	NA	NA	0.92	1.10	0.80	NA	NA	0.77	1.53	1.15	0.87	NA	1.07	NA	NA	NA	NA	1.28	1.12	0.91	0.77
Arg	ME1115131	0.98	0.76	0.76	1.02	0.69	0.83	0.57	1.16	0.90	0.89	0.86	0.51	2.26	2.30	2.13	1.66	1.97	1.62	0.38	0.80	0.65	NA	NA	NA	0.45	0.63	0.56	0.64	1.14
Thr	ME1115172	1.25	1.34	1.22	1.33	NA	1.14	0.62	0.74	1.16	0.56	0.75	0.71	1.55	0.96	1.51	1.06	2.06	1.29	0.99	0.64	0.75	NA	NA	NA	NA	0.67	NA	NA	0.73
Trp	ME1115175	0.90	1.21	0.60	1.64	NA	0.74	0.52	1.13	1.10	NA	0.95	0.62	2.11	1.13	1.47	1.37	2.50	1.41	0.65	0.69	0.85	NA	0.50	NA	0.74	0.67	NA	NA	0.74
UMP	ME1115178	1.90	1.24	1.00	1.16	0.82	1.41	1.34	1.22	1.48	0.17	0.20	0.22	1.65	1.67	1.57	0.99	0.51	0.93	1.56	0.35	0.85	0.72	1.13	0.98	1.62	0.86	0.81	0.78	0.96
Lys	ME1115158	0.93	1.14	1.26	1.22	0.91	0.77	0.69	0.84	0.74	1.05	1.13	1.01	1.60	1.47	1.51	1.87	2.61	1.94	0.69	0.70	0.68	0.41	0.47	0.35	0.62	0.89	0.83	0.75	1.14
Xanthine	ME1115183	1.31	1.56	1.64	1.49	1.37	0.66	0.60	0.84	0.95	0.62	0.66	0.81	1.27	1.08	1.45	2.07	1.85	1.27	0.93	0.79	1.01	0.49	0.60	0.42	0.76	1.18	0.91	0.88	0.75
IMP	ME1115153	1.32	1.17	1.24	1.11	0.86	1.34	1.18	1.70	1.48	1.11	1.37	1.34	0.91	0.72	0.90	0.77	0.87	0.92	0.85	0.83	0.67	1.46	1.42	0.95	1.65	1.83	1.66	1.45	0.48
UDP	ME1115177	1.17	1.26	1.57	1.50	1.23	1.56	1.75	1.41	1.30	0.98	0.98	1.12	0.92	0.96	1.06	0.97	1.34	1.09	1.38	0.60	0.61	0.99	0.78	0.87	1.43	1.49	1.33	1.17	0.59
3-PG	ME1115127	0.45	0.83	0.89	0.88	1.02	0.60	0.69	0.38	0.37	0.82	0.77	0.75	0.78	0.75	0.54	1.00	0.96	1.06	0.69	0.54	1.26	1.08	1.18	0.83	1.00	1.47	1.31	1.23	1.39
Total protein	ME1115122	0.96	1.28	0.94	0.83	0.69	1.26	0.89	0.96	0.98	1.10	1.14	0.94	0.83	1.10	0.98	0.80	1.44	0.92	1.10	0.98	1.00	1.05	0.96	0.96	0.89	0.96	1.05	1.62	0.90
Fenclonine (IS)	ME1115123	1.20	0.88	0.86	0.80	0.82	1.07	1.11	1.02	1.00	0.71	0.78	0.69	1.15	1.02	1.10	0.79	0.83	0.80	1.04	0.80	1.12	1.03	0.91	0.88	1.19	0.95	0.94	0.91	1.15
2-PG	ME1115126	0.86	0.84	0.96	1.11	0.96	0.91	0.92	0.89	0.91	0.85	0.91	0.85	1.09	1.00	1.01	0.85	0.88	0.90	1.04	0.87	1.02	1.07	1.16	0.81	1.20	1.23	1.16	1.18	1.08
PEP	ME1115163	0.72	0.85	0.93	1.03	1.03	0.87	0.81	0.65	0.70	0.91	1.00	0.84	0.93	0.97	0.85	0.91	0.90	1.09	0.90	0.76	1.07	1.10	1.20	0.89	1.08	1.29	1.02	1.19	1.17
Gln	ME1115148	1.53	1.59	1.83	1.33	1.00	1.32	1.09	1.30	1.13	1.61	1.62	1.20	0.99	0.80	1.14	1.22	1.36	1.02	1.24	1.15	0.86	0.55	0.56	0.58	0.80	0.94	0.89	0.68	0.59
Pro	ME1115165	1.33	1.25	1.63	1.45	1.24	1.06	0.97	0.97	0.94	1.11	1.29	1.29	1.00	0.75	0.94	1.00	1.52	1.19	1.07	1.18	0.89	0.48	0.66	0.59	1.07	1.25	1.20	1.03	0.72
Succinate	ME1115171	1.31	1.47	1.73	1.39	1.61	0.97	1.01	1.07	1.06	1.55	1.60	1.62	0.88	0.74	1.13	1.12	1.59	1.30	0.89	1.24	0.75	0.58	0.47	0.53	0.87	1.14	1.13	0.92	0.64
R5P	ME1115167	1.14	1.25	1.43	1.48	0.83	1.25	1.12	0.89	0.80	0.97	1.09	0.83	1.28	0.73	0.94	0.95	1.54	0.91	1.14	1.47	0.73	0.88	0.84	0.47	1.30	1.35	1.23	1.00	0.86
Ala	ME1115129	1.52	1.33	1.44	1.17	1.11	1.07	0.91	1.28	1.20	1.09	1.08	1.23	1.21	0.97	1.34	1.05	1.46	1.13	1.07	1.12	0.88	0.58	0.61	0.80	0.98	1.02	0.86	0.81	0.74
Gly	ME1115150	1.56	1.26	1.44	1.48	1.01	1.22	1.12	1.29	1.16	1.10	1.22	1.14	1.30	1.00	1.33	1.02	1.72	1.02	1.35	1.31	0.83	0.62	0.63	0.53	1.08	0.94	0.82	0.74	0.63
Ser	ME1115170	1.52	1.13	1.24	1.45	0.94	1.27	1.14	1.25	1.07	1.01	1.00	0.96	1.34	1.06	1.23	0.92	1.61	0.99	1.38	1.33	0.89	0.67	0.69	0.72	1.23	0.85	0.81	0.71	0.71
Asp	ME1115133	1.38	0.96	1.03	0.98	0.93	1.01	0.95	1.13	0.93	0.81	0.94	1.04	1.35	1.21	1.36	1.02	1.15	1.00	1.18	1.27	1.07	0.49	0.74	0.69	1.01	0.90	0.85	0.79	0.91
Citrate	ME1115135	1.53	1.18	1.25	1.26	1.28	1.21	1.09	1.33	1.23	1.11	1.23	1.27	1.12	1.00	1.15	0.96	1.10	1.09	1.30	1.24	0.77	0.66	0.78	0.69	1.02	1.09	0.97	0.92	0.76
Glu	ME1115149	1.46	1.13	1.26	1.11	1.10	1.30	1.16	1.22	1.11	0.95	1.11	1.22	1.09	0.93	1.20	0.90	1.02	0.93	1.29	1.26	0.91	0.82	0.90	0.89	1.15	1.03	1.12	0.97	0.66
Inositol	ME1115155	1.30	1.04	1.30	1.15	0.90	1.25	1.11	1.10	0.97	0.88	1.07	1.01	1.28	1.01	1.01	0.84	1.07	1.05	1.36	1.31	0.92	0.74	0.97	0.81	1.09	1.01	1.04	0.93	0.82
Phe	ME1115164	1.30	1.01	1.25	1.51	0.73	1.39	0.92	1.22	0.94	0.80	1.10	0.84	1.55	1.39	1.45	1.10	2.40	1.33	0.98	1.02	0.88	0.37	0.67	0.52	1.09	0.88	0.80	0.62	0.78
Leu	ME1115157	1.32	1.16	1.29	1.41	0.93	1.12	1.06	1.20	1.09	0.84	0.99	1.00	1.33	1.14	1.34	1.23	2.14	1.21	0.95	1.03	0.87	0.54	0.64	0.58	1.02	0.95	0.87	0.84	0.79
Val	ME1115182	1.23	1.01	1.08	1.55	0.88	1.01	0.97	1.03	0.97	0.84	0.96	0.85	1.43	1.22	1.34	1.21	2.14	1.18	1.04	1.02	0.95	0.13	0.75	0.41	1.09	0.98	0.87	0.87	0.88
Ile	ME1115152	1.26	0.86	0.96	1.33	0.86	1.08	1.01	1.14	1.06	0.78	0.80	0.77	1.65	1.34	1.48	1.09	1.96	1.18	1.08	0.97	0.94	0.65	0.79	0.57	1.15	0.91	0.84	0.75	0.85
Tyr	ME1115176	1.04	0.76	1.06	1.29	0.77	1.05	1.24	1.03	0.89	0.88	0.88	0.78	1.28	1.12	1.20	1.20	1.82	1.04	1.04	0.85	1.00	0.68	0.94	0.40	1.14	0.91	0.96	0.85	0.98
2-HG	ME1115125	1.75	0.79	1.33	1.02	0.91	1.29	1.19	1.19	1.17	0.78	0.85	0.96	1.51	1.13	2.16	1.10	1.65	1.14	1.20	1.45	0.74	0.69	0.71	0.69	1.21	0.80	0.88	0.48	0.79
Malate	ME1115160	1.67	1.19	1.28	1.08	1.05	0.93	0.95	1.19	1.10	0.85	0.98	1.09	1.37	1.21	2.12	1.60	1.45	1.48	0.95	1.11	0.72	0.45	0.51	0.70	0.91	0.91	0.81	0.69	0.89
Hypoxanthine	ME1115143	2.15	1.86	2.29	1.81	1.77	1.04	0.99	1.18	1.08	0.81	0.96	1.06	1.43	1.32	1.51	1.28	1.29	1.34	1.80	1.71	0.66	0.54	0.64	0.41	0.77	0.87	0.74	0.64	0.35
Asn	ME1115132	2.16	1.31	1.41	1.01	0.99	1.72	1.22	1.46	1.01	1.05	1.10	1.12	1.55	0.81	1.35	0.78	1.01	0.60	1.76	1.83	0.80	0.59	0.54	0.54	1.34	0.85	0.70	0.71	0.47
UTP	ME1115181	2.14	1.30	1.44	1.27	1.12	2.01	1.54	1.55	1.52	1.33	1.50	1.40	0.93	0.81	0.86	0.68	0.68	0.68	1.88	2.39	0.45	0.70	1.24	0.74	1.57	1.10	1.09	0.90	0.42

Factors:

F1	Sample source:mouse primary astrocytes \| Genotype:Ent10 knockout \| treatment:TNF𝝰/IL-1𝝰
F2	Sample source:mouse primary astrocytes \| Genotype:Ent11 knockout \| treatment:TNF𝝰/IL-1𝝰
F3	Sample source:mouse primary astrocytes \| Genotype:Ent12 knockout \| treatment:TNF𝝰/IL-1𝝰
F4	Sample source:mouse primary astrocytes \| Genotype:Ent13 knockout \| treatment:TNF𝝰/IL-1𝝰
F5	Sample source:mouse primary astrocytes \| Genotype:Ent14 knockout \| treatment:TNF𝝰/IL-1𝝰
F6	Sample source:mouse primary astrocytes \| Genotype:Ent15 knockout \| treatment:TNF𝝰/IL-1𝝰/Forodesine
F7	Sample source:mouse primary astrocytes \| Genotype:Ent16 knockout \| treatment:TNF𝝰/IL-2𝝰/Forodesine
F8	Sample source:mouse primary astrocytes \| Genotype:Ent17 knockout \| treatment:TNF𝝰/IL-3𝝰/Forodesine
F9	Sample source:mouse primary astrocytes \| Genotype:Ent18 knockout \| treatment:TNF𝝰/IL-4𝝰/Forodesine
F10	Sample source:mouse primary astrocytes \| Genotype:Ent19 knockout \| treatment:TNF𝝰/IL-5𝝰/Forodesine
F11	Sample source:mouse primary astrocytes \| Genotype:Ent20 knockout \| treatment:TNF𝝰/IL-6𝝰/Forodesine
F12	Sample source:mouse primary astrocytes \| Genotype:Ent21 knockout \| treatment:TNF𝝰/IL-7𝝰/Forodesine
F13	Sample source:mouse primary astrocytes \| Genotype:Ent2 knockout \| treatment:Vehicle
F14	Sample source:mouse primary astrocytes \| Genotype:Ent3 knockout \| treatment:Vehicle
F15	Sample source:mouse primary astrocytes \| Genotype:Ent4 knockout \| treatment:Vehicle
F16	Sample source:mouse primary astrocytes \| Genotype:Ent5 knockout \| treatment:Vehicle
F17	Sample source:mouse primary astrocytes \| Genotype:Ent6 knockout \| treatment:Vehicle
F18	Sample source:mouse primary astrocytes \| Genotype:Ent7 knockout \| treatment:Vehicle
F19	Sample source:mouse primary astrocytes \| Genotype:Ent8 knockout \| treatment:TNF𝝰/IL-1𝝰
F20	Sample source:mouse primary astrocytes \| Genotype:Ent9 knockout \| treatment:TNF𝝰/IL-1𝝰
F21	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-1𝝰
F22	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-1𝝰/Forodesine
F23	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-2𝝰/Forodesine
F24	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-3𝝰/Forodesine
F25	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-4𝝰/Forodesine
F26	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-5𝝰/Forodesine
F27	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-6𝝰/Forodesine
F28	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:TNF𝝰/IL-7𝝰/Forodesine
F29	Sample source:mouse primary astrocytes \| Genotype:Wild-type \| treatment:Vehicle

Data matrix