Clustering data with hclust algorithm for (Study ST004205)
(Analysis AN006992)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| N-Oleoylethanolamine | ME1136253 | NA | NA | NA | 3.21 | 0.24 | NA | NA | 0.26 | 3.21 | 0.28 |
| DG(18:0_22:6) | ME1136212 | 0.20 | 0.26 | 1.59 | 0.72 | 0.95 | 1.00 | 1.46 | 0.96 | 1.58 | 0.88 |
| TG(18:1_34:3) | ME1136303 | 1.31 | 1.47 | 0.80 | 0.32 | 0.22 | 0.98 | 0.42 | 0.21 | 2.42 | 2.16 |
| TG(18:1_34:2) | ME1136302 | 1.41 | 1.09 | 0.70 | 0.41 | 0.22 | 0.99 | 0.70 | 0.23 | 2.61 | 1.63 |
| TG(20:4_36:2) | ME1136308 | 1.75 | 0.95 | 0.76 | 0.56 | 0.21 | 0.90 | 0.85 | 0.30 | 2.30 | 1.32 |
| TG(20:4_34:3) | ME1136306 | 1.40 | 2.60 | 1.48 | 0.40 | 0.46 | 0.96 | 0.33 | 0.46 | 1.17 | 2.05 |
| PE(40:7) | ME1136285 | 1.30 | 1.86 | 1.09 | 0.87 | 0.65 | 0.99 | 0.50 | 0.45 | 1.34 | 1.62 |
| TG(20:4_36:3) | ME1136309 | 1.72 | 1.51 | 1.21 | 0.60 | 0.34 | 0.94 | 0.67 | 0.52 | 1.42 | 1.49 |
| TG(20:4_32:1) | ME1136304 | 1.59 | 1.74 | 1.16 | 0.44 | 0.30 | 0.92 | 0.54 | 0.35 | 1.71 | 1.84 |
| TG(20:4_34:2) | ME1136305 | 1.55 | 1.54 | 1.08 | 0.42 | 0.29 | 0.91 | 0.50 | 0.36 | 1.85 | 1.92 |
| LPC(18:1) | ME1136234 | 1.26 | 0.81 | 0.82 | 1.60 | 0.77 | 0.94 | 1.35 | 0.78 | 1.03 | 0.47 |
| PC(O-18:0/2:0) | ME1136271 | 1.28 | 0.63 | 0.79 | 1.72 | 0.79 | 0.91 | 1.56 | 0.79 | 0.87 | 0.34 |
| LPC(16:0) | ME1136230 | 1.27 | 0.72 | 0.81 | 1.83 | 0.79 | 0.93 | 1.58 | 0.80 | 0.71 | 0.29 |
| LPC(18:0) | ME1136232 | 1.29 | 0.65 | 0.75 | 1.88 | 0.81 | 0.91 | 1.52 | 0.79 | 0.76 | 0.30 |
| DG(18:0_20:4) | ME1136211 | 1.70 | 0.40 | 0.26 | 3.01 | 0.15 | 0.82 | 1.52 | 0.13 | 1.21 | 0.17 |
| DG(18:1_20:4) | ME1136214 | 1.57 | 0.84 | 0.61 | 2.06 | 0.23 | 0.90 | 1.19 | 0.25 | 1.58 | 0.56 |
| DG(16:0_20:4) | ME1136209 | 1.55 | 0.94 | 0.70 | 2.31 | 0.34 | 0.88 | 1.25 | 0.41 | 1.09 | 0.40 |
| DG(18:0_18:1) | ME1136210 | 1.51 | 0.58 | 0.41 | 2.45 | 0.38 | 0.89 | 1.36 | 0.39 | 1.12 | 0.44 |
| Cholesteryl hexoside | ME1136205 | 1.50 | 0.57 | 0.35 | 1.12 | 0.30 | 0.77 | 2.50 | 0.37 | 1.73 | 0.30 |
| LPC(24:0) | ME1136237 | 2.06 | 0.54 | 0.32 | 1.33 | 0.26 | 0.79 | 2.03 | 0.25 | 1.79 | 0.11 |
| LPC(24:1) | ME1136238 | 2.02 | 0.38 | 0.25 | 1.28 | 0.24 | 0.76 | 2.04 | 0.21 | 2.08 | 0.09 |
| LacCer(d18:1/18:0) | ME1136243 | 1.46 | 0.40 | 0.27 | 1.42 | 0.34 | 0.83 | 1.90 | 0.31 | 1.96 | 0.48 |
| HexCer(d18:1/18:0) | ME1136225 | 1.78 | 0.35 | 0.20 | 1.76 | 0.21 | 0.79 | 1.78 | 0.21 | 2.03 | 0.19 |
| Cer(d18:1/18:0) | ME1136200 | 1.77 | 0.67 | 0.43 | 1.58 | 0.31 | 0.80 | 1.72 | 0.34 | 1.78 | 0.21 |
| HexCer(d18:1/24:1) | ME1136228 | 1.76 | 0.50 | 0.30 | 1.65 | 0.29 | 0.93 | 1.76 | 0.27 | 1.79 | 0.21 |
| LPC(26:0) | ME1136239 | 1.57 | 0.48 | 0.48 | 1.09 | 0.48 | 0.48 | 1.33 | 0.48 | 1.57 | 0.48 |
| LPC(26:1) | ME1136240 | 1.61 | 0.38 | 0.38 | 1.14 | 0.38 | 0.66 | 1.51 | 0.38 | 1.32 | 0.38 |
| PC(36:1) | ME1136262 | 1.56 | 0.93 | 0.63 | 1.43 | 0.44 | 1.03 | 1.39 | 0.46 | 1.46 | 0.53 |
| Cer(d18:1/24:1) | ME1136202 | 1.71 | 0.73 | 0.55 | 1.49 | 0.36 | 0.90 | 1.70 | 0.34 | 1.57 | 0.34 |
| HexCer(d18:1/22:0) | ME1136226 | 1.65 | 0.93 | 0.54 | 1.43 | 0.51 | 0.88 | 1.67 | 0.57 | 1.39 | 0.27 |
| HexCer(d18:1/24:0) | ME1136227 | 1.73 | 0.88 | 0.51 | 1.42 | 0.46 | 0.89 | 1.67 | 0.50 | 1.53 | 0.22 |
| TG(18:0_36:2) | ME1136301 | 1.58 | 0.79 | 0.52 | 0.68 | 0.21 | 0.93 | 1.32 | 0.35 | 2.61 | 0.72 |
| TG(20:4_36:0) | ME1136307 | 1.99 | 0.94 | 0.69 | 0.75 | 0.29 | 0.90 | 1.30 | 0.42 | 2.08 | 0.52 |
| DG(18:1/18:1) | ME1136213 | 1.45 | 0.83 | 0.59 | 1.55 | 0.26 | 0.94 | 1.05 | 0.25 | 2.01 | 0.85 |
| PE(36:2) | ME1136277 | 1.47 | 1.09 | 0.60 | 1.48 | 0.37 | 0.91 | 0.95 | 0.28 | 1.61 | 1.21 |
| LacCer(d18:1/16:0) | ME1136241 | 0.81 | 0.48 | 0.53 | 0.94 | 0.63 | 0.85 | 1.33 | 0.65 | 1.95 | 1.32 |
| LacCer(d18:1/24:1) | ME1136245 | 1.32 | 0.65 | 0.41 | 1.06 | 0.45 | 0.89 | 1.56 | 0.40 | 2.02 | 0.82 |
| Palmitoylethanolamine | ME1136286 | 1.38 | 0.98 | 0.63 | NA | 0.76 | 1.73 | 1.67 | 0.65 | 1.27 | 0.83 |
| PC(16:0/5:0(CHO)) | ME1136256 | 0.87 | 1.28 | 1.28 | 0.96 | 1.37 | 1.19 | 0.91 | 1.42 | 0.46 | 0.55 |
| PC(O-16:0/2:0) | ME1136270 | 1.01 | 0.78 | 0.99 | 0.94 | 0.82 | 1.08 | 1.45 | 1.07 | 1.03 | 0.67 |
| PC(O-16:0/0:0) | ME1136269 | 0.95 | 0.95 | 0.95 | 1.42 | 0.95 | 0.95 | 0.95 | 0.95 | 0.95 | 0.95 |
| PC(16:0/9:0(COOH)) | ME1136258 | 0.99 | 0.88 | 1.02 | 1.10 | 0.88 | 0.99 | 0.88 | 1.10 | 1.21 | 0.88 |
| MG(16:0) | ME1136247 | 0.92 | 0.82 | 0.90 | 1.09 | 0.93 | 1.04 | 1.19 | 0.90 | 1.08 | 0.98 |
| MG(18:0) | ME1136249 | 0.94 | 0.88 | 0.84 | 1.12 | 0.93 | 0.98 | 1.16 | 0.97 | 1.05 | 1.00 |
| MG(18:1) | ME1136251 | 0.95 | 0.88 | 0.80 | 1.12 | 0.92 | 1.02 | 1.15 | 0.92 | 1.12 | 1.00 |
| PC(36:2) | ME1136263 | 1.33 | 1.26 | 0.85 | 0.96 | 0.58 | 1.01 | 0.91 | 0.54 | 1.53 | 1.19 |
| PE(34:1) | ME1136275 | 1.45 | 1.54 | 0.90 | 1.22 | 0.52 | 0.96 | 0.83 | 0.42 | 1.37 | 1.18 |
| SM(d18:1/18:0) | ME1136289 | 1.37 | 1.56 | 0.97 | 1.06 | 0.67 | 0.99 | 0.90 | 0.56 | 1.35 | 0.97 |
| SM(d18:1/24:1) | ME1136291 | 1.36 | 1.62 | 1.08 | 0.93 | 0.70 | 1.05 | 0.82 | 0.55 | 1.29 | 1.07 |
| LPC(22:6) | ME1136236 | 1.39 | 1.29 | 0.93 | 0.99 | 0.72 | 1.04 | 1.02 | 0.75 | 1.31 | 0.75 |
| HexCer(d18:1/16:0) | ME1136224 | 1.22 | 1.29 | 0.84 | 0.97 | 0.77 | 0.96 | 1.08 | 0.74 | 1.19 | 1.11 |
| PC(34:1) | ME1136261 | 1.21 | 1.19 | 0.97 | 1.06 | 0.77 | 1.01 | 1.02 | 0.76 | 1.13 | 1.02 |
| PC(16:0/9:0(CHO)) | ME1136257 | 1.08 | 1.01 | 1.10 | 0.88 | 0.72 | 1.01 | 0.91 | 0.83 | 1.24 | 1.25 |
| SM(d18:1/16:0) | ME1136288 | 1.17 | 1.40 | 1.04 | 0.85 | 0.79 | 1.01 | 0.80 | 0.72 | 1.24 | 1.28 |
| PE(36:1) | ME1136276 | 1.52 | 1.31 | 0.80 | 1.23 | 0.53 | 0.93 | 1.05 | 0.51 | 1.41 | 0.88 |
| PE(38:5) | ME1136280 | 1.52 | 1.47 | 0.81 | 1.41 | 0.60 | 0.94 | 0.98 | 0.48 | 1.20 | 0.89 |
| Cholesterol | ME1136203 | 1.54 | 1.29 | 0.76 | 1.60 | 0.54 | 0.91 | 1.17 | 0.47 | 1.25 | 0.63 |
| DG(16:0_18:1) | ME1136208 | 1.48 | 1.14 | 0.72 | 1.55 | 0.42 | 0.99 | 1.08 | 0.44 | 1.43 | 0.78 |
| Cer(d18:1/16:0) | ME1136199 | 1.41 | 1.20 | 0.94 | 1.09 | 0.61 | 0.92 | 1.47 | 0.65 | 1.11 | 0.72 |
| LacCer(d18:1/24:0) | ME1136244 | 1.42 | 1.06 | 0.60 | 1.10 | 0.62 | 0.90 | 1.62 | 0.59 | 1.35 | 0.70 |
| GB3(d18:1/16:0) | ME1136215 | 1.82 | 2.17 | 1.30 | 0.83 | 0.68 | 0.94 | 0.95 | 0.84 | 0.76 | 0.67 |
| PE(38:6) | ME1136281 | 1.46 | 2.21 | 1.21 | 1.25 | 0.86 | 1.00 | 0.70 | 0.57 | 0.85 | 0.85 |
| Coenzyme Q10 | ME1136206 | 1.50 | 2.05 | 1.11 | 0.95 | 0.91 | 0.95 | 0.87 | 0.87 | 0.91 | 0.71 |
| PE(40:4) | ME1136282 | 1.45 | 2.09 | 1.17 | 0.93 | 0.72 | 1.00 | 0.77 | 0.77 | 1.01 | 0.95 |
| PE(40:6) | ME1136284 | 1.47 | 1.93 | 1.12 | 1.10 | 0.72 | 1.01 | 0.75 | 0.56 | 1.07 | 1.00 |
| PC(38:6) | ME1136266 | 1.63 | 1.99 | 1.12 | 1.07 | 0.71 | 0.99 | 0.86 | 0.55 | 1.04 | 0.81 |
| SM(d18:1/24:0) | ME1136290 | 1.61 | 1.99 | 1.15 | 0.89 | 0.64 | 1.07 | 0.86 | 0.56 | 1.20 | 0.83 |
| LPC(16:1) | ME1136231 | 1.18 | 1.58 | 1.13 | 1.00 | 0.87 | 1.04 | 0.93 | 0.83 | 1.00 | 0.91 |
| PE(38:4) | ME1136279 | 1.33 | 1.69 | 1.05 | 1.05 | 0.85 | 1.02 | 0.94 | 0.76 | 0.96 | 0.88 |
| PC(40:6) | ME1136268 | 1.57 | 1.57 | 1.08 | 1.19 | 0.76 | 0.98 | 0.95 | 0.60 | 1.05 | 0.69 |
| PE(36:4) | ME1136278 | 1.52 | 1.83 | 0.99 | 1.36 | 0.82 | 0.97 | 0.92 | 0.64 | 0.88 | 0.70 |
| PC(40:5) | ME1136267 | 1.45 | 1.55 | 1.03 | 1.18 | 0.88 | 1.02 | 1.10 | 0.88 | 0.74 | 0.60 |
| PC(36:4) | ME1136264 | 1.16 | 1.28 | 1.02 | 1.13 | 1.04 | 1.04 | 1.12 | 1.00 | 0.77 | 0.65 |
| PC(38:4) | ME1136265 | 1.25 | 1.47 | 1.04 | 1.19 | 1.08 | 1.07 | 1.19 | 1.01 | 0.61 | 0.45 |
| GB3(d18:1/18:0) | ME1136217 | 1.56 | 1.44 | 1.15 | 0.80 | 0.82 | 0.98 | 1.28 | 0.98 | 0.84 | 0.50 |
| GB3(d18:1/24:1) | ME1136219 | 1.31 | 1.43 | 0.93 | 0.85 | 0.73 | 0.99 | 1.45 | 1.11 | 0.87 | 0.65 |
| LPC(20:4) | ME1136235 | 1.15 | 1.48 | 0.99 | 0.95 | 0.93 | 1.11 | 1.33 | 1.20 | 0.75 | 0.47 |
| Cer(d18:1/24:0) | ME1136201 | 1.76 | 1.77 | 0.96 | 1.12 | 0.53 | 0.88 | 1.55 | 0.56 | 1.00 | 0.44 |
| GB3(d18:1/24:0) | ME1136218 | 1.57 | 1.83 | 0.69 | 0.94 | 0.67 | 1.13 | 1.73 | 1.05 | 0.55 | 0.38 |
| TG(22:6_36:2) | ME1136310 | 1.71 | 0.60 | 0.42 | 0.42 | 0.10 | 0.82 | 0.60 | 0.11 | 3.74 | 1.03 |
| TG(22:6_38:1) | ME1136311 | 1.64 | 0.16 | 0.16 | 0.66 | 0.16 | 0.78 | 1.17 | 0.16 | 3.28 | 0.35 |
| TG(22:6_38:2) | ME1136312 | 1.78 | 0.32 | 0.27 | 0.58 | 0.08 | 0.82 | 0.90 | 0.08 | 3.60 | 0.64 |
| CE(20:4) | ME1136191 | 1.61 | 0.12 | 0.16 | 0.82 | 0.07 | 0.78 | 3.54 | 0.09 | 1.83 | 0.10 |
| CE(20:5) | ME1136192 | 2.08 | 0.06 | 0.06 | 0.84 | 0.02 | 0.61 | 3.83 | 0.04 | 1.48 | 0.04 |
| Sphingosine | ME1136295 | 1.96 | 0.15 | 0.13 | 1.07 | 0.08 | 0.76 | 2.17 | 0.11 | 2.61 | 0.10 |
| Sphinganine 1-phosphate | ME1136294 | 2.20 | 0.14 | 0.13 | 0.69 | 0.08 | 0.70 | 1.84 | 0.06 | 3.16 | 0.13 |
| Sphingosine 1-phosphate | ME1136296 | 2.27 | 0.20 | 0.12 | 0.78 | 0.11 | 0.66 | 2.00 | 0.12 | 2.79 | 0.12 |
| CE(22:6) | ME1136193 | 1.82 | 0.05 | 0.05 | 0.56 | 0.02 | 0.68 | 3.16 | 0.02 | 2.66 | 0.04 |
| CE(18:1) | ME1136189 | 1.07 | 0.15 | 0.17 | 0.46 | 0.14 | 0.81 | 2.78 | 0.14 | 3.28 | 0.15 |
| CE(16:1) | ME1136187 | 1.11 | 0.25 | 0.33 | 0.60 | 0.20 | 1.00 | 2.51 | 0.20 | 2.85 | 0.21 |
| CE(18:2) | ME1136190 | 1.24 | 0.30 | 0.42 | 0.65 | 0.21 | 0.92 | 2.58 | 0.22 | 2.53 | 0.26 |
Factors:
| F1 | Genotype:GPR34-KO | Treatment:Myelin | Sample source:iMicroglia |
| F2 | Genotype:GPR34 KO | Treatment:PBS | Sample source:iMicroglia |
| F3 | Genotype:GPR34-KO | Treatment:PBS | Sample source:iMicroglia |
| F4 | Genotype:GPR34/TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F5 | Genotype:GPR34/TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F6 | Genotype:NA | Treatment:NA | Sample source:iMicroglia |
| F7 | Genotype:TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F8 | Genotype:TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F9 | Genotype:WT | Treatment:Myelin | Sample source:iMicroglia |
| F10 | Genotype:WT | Treatment:PBS | Sample source:iMicroglia |