Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004205)

HILIC POSITIVE ION MODE (Analysis AN006994)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10
Kynurenic acid	ME1136558	0.52	NA	0.69	4.50	1.38	0.69	2.08	1.04	0.69	0.58
Stearoylcarnitine	ME1136625	1.04	NA	NA	1.04	NA	1.04	1.30	1.04	1.04	0.08
Sucrose	ME1136626	1.66	0.07	0.14	1.73	0.16	0.83	1.85	0.21	2.30	0.14
Histamine	ME1136544	1.71	2.00	1.09	NA	NA	0.41	0.16	0.09	NA	NA
Citrulline	ME1136500	2.97	1.14	0.78	0.68	0.58	0.90	0.55	0.52	1.17	0.75
Deoxyadenosine	ME1136516	0.54	0.73	1.06	0.87	0.97	0.75	0.67	1.97	0.73	1.40
gamma-Aminobutyric acid	ME1136650	1.11	1.11	1.11	NA	0.10	1.11	NA	0.08	1.11	1.11
Cystine	ME1136511	0.95	NA	0.95	0.95	0.95	0.95	0.95	0.95	1.43	0.95
Kynurenine	ME1136559	0.84	0.75	0.63	0.94	0.75	1.03	0.56	0.47	1.69	2.06
Ethanolamine	ME1136528	1.74	1.33	0.68	1.33	0.68	0.49	2.12	0.65	0.82	0.32
Palmitoylcarnitine	ME1136604	1.59	0.83	0.89	1.48	0.62	0.81	1.49	0.66	1.07	0.41
Hypoxanthine	ME1136552	1.23	2.33	1.43	1.09	1.19	0.95	1.01	0.91	0.45	0.51
Hydroxyisovaleroyl carnitine	ME1136550	1.74	2.66	1.37	1.00	0.89	1.01	0.74	0.77	0.55	0.61
Isovalerylcarnitine	ME1136556	1.72	2.63	1.43	1.14	1.04	1.01	0.78	0.83	0.36	0.38
Uridine	ME1136641	1.11	1.85	1.36	0.65	1.02	0.65	1.11	1.20	0.62	1.11
1-Methylnicotinamide	ME1136437	1.46	1.56	0.99	1.11	0.91	1.50	1.12	1.07	0.31	0.37
Adenine	ME1136474	1.07	1.11	1.16	0.96	1.15	0.71	1.13	1.35	0.64	0.85
Imidazoleacetic acid	ME1136553	0.90	1.01	0.90	1.07	1.47	0.77	0.91	1.24	0.79	0.93
Taurine	ME1136627	0.91	0.91	0.90	1.07	1.44	0.71	1.03	1.25	0.74	0.94
N1-Acetylspermidine	ME1136583	1.36	1.78	0.75	1.29	1.06	0.78	1.25	1.16	0.62	0.47
Dopa	ME1136522	0.90	1.03	0.69	1.16	1.23	0.97	1.16	1.35	0.39	0.52
3-Hydroxy-N6,N6,N6-Trimethyllysine	ME1136446	1.26	1.32	0.79	1.06	0.93	1.06	1.39	1.19	0.66	0.53
N1-N8-Diacetylspermidine	ME1136587	0.99	1.20	0.73	1.35	1.12	1.00	1.32	1.14	0.70	0.52
Glutamic acid	ME1136533	1.33	2.20	1.24	0.56	0.61	1.06	0.45	0.49	1.31	1.70
Ureidopropionic acid	ME1136639	1.21	2.27	1.13	0.85	0.59	0.85	0.32	0.70	1.54	1.34
Hydroxyhexanoylcarnitine	ME1136549	1.46	2.39	1.30	0.93	0.91	1.02	0.64	0.69	0.86	0.91
Glycerophosphocholine	ME1136539	1.62	2.38	1.26	0.78	0.72	1.07	0.88	0.68	0.88	0.82
Valerobetaine	ME1136642	1.67	2.20	1.33	0.82	0.71	0.96	0.74	0.64	0.98	0.93
cADPRibose	ME1136649	1.50	2.29	1.06	0.86	0.70	1.05	0.73	0.60	1.15	1.08
S-Adenosylhomocysteine	ME1136618	1.51	2.14	1.02	0.83	0.77	1.08	0.78	0.44	1.31	1.00
Ergothioneine	ME1136527	1.71	2.56	1.18	0.70	0.73	0.93	0.55	0.44	1.25	1.17
Carnitine	ME1136497	1.39	2.59	1.01	0.70	0.70	1.08	0.66	0.62	1.19	1.25
Glutathione	ME1136536	1.39	2.48	1.05	0.78	0.72	0.94	0.63	0.45	1.38	1.29
Inosine	ME1136555	0.90	1.03	1.55	0.90	0.69	1.42	0.52	1.03	0.90	1.16
Guanine	ME1136541	0.75	0.81	1.24	0.65	0.85	1.49	0.69	0.93	1.09	1.37
Dopamine	ME1136523	0.95	0.52	0.97	0.76	0.83	1.41	0.80	0.87	1.22	1.31
Xanthosine	ME1136647	0.93	0.50	0.94	0.78	0.80	1.45	0.80	0.90	1.28	1.23
8-Hydroxyguanosine	ME1136468	0.93	0.81	0.87	1.01	0.91	1.71	0.86	0.76	1.03	0.93
Trimethylamine-N-oxide	ME1136634	1.04	1.27	0.92	0.82	0.88	1.47	0.84	0.86	1.02	1.06
Dimethylethanolamine	ME1136519	1.06	0.61	0.81	0.82	0.67	1.98	0.73	0.56	1.30	1.12
Creatinine	ME1136504	1.20	1.06	0.94	0.85	0.67	1.50	0.67	0.55	1.46	1.12
Xanthine	ME1136646	1.17	0.74	0.90	0.92	0.74	1.54	0.74	0.74	1.29	0.99
N1-N12-Diacetylspermine	ME1136586	1.22	0.92	0.64	1.04	0.89	0.74	1.34	1.10	1.10	0.85
Homocysteine	ME1136546	1.02	0.75	1.16	0.86	0.68	1.04	0.95	0.83	1.34	1.23
Arginine	ME1136481	1.17	0.92	1.23	1.00	0.83	0.99	0.95	0.80	1.18	0.94
Mannose	ME1136566	1.16	1.11	1.11	0.92	0.78	0.94	1.11	0.84	1.28	0.86
Uric acid	ME1136640	0.97	0.88	1.24	0.80	0.88	0.96	1.06	0.85	1.46	0.87
Glucose	ME1136532	1.09	0.87	1.07	0.92	0.75	0.95	1.13	0.84	1.41	0.89
Linoleyl carnitine	ME1136563	1.09	0.77	1.02	0.83	0.77	1.15	1.09	0.77	1.47	0.89
Adenosine	ME1136475	1.04	1.20	1.28	1.10	0.85	0.78	1.09	0.93	0.87	1.09
Arabitol	ME1136480	1.03	0.98	1.08	0.73	0.94	0.96	0.98	0.99	1.11	1.19
Betaine	ME1136488	0.99	1.24	0.93	1.01	0.99	0.98	1.04	0.93	0.99	1.05
5-Hydroxyindoleacetic acid	ME1136457	1.17	0.94	0.94	0.94	0.94	0.94	0.94	0.94	1.17	0.94
Cysteinylglycine	ME1136510	1.06	0.99	0.97	1.01	0.94	0.96	1.02	0.96	1.04	1.02
Myristoylcarnitine	ME1136572	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
Octanoylcarnitine	ME1136600	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
4-Trimethylammoniobutanal	ME1136454	1.19	1.06	1.24	0.94	0.79	1.06	0.93	1.06	0.93	0.93
Nicotinamide riboside	ME1136595	1.43	1.13	1.18	0.94	0.98	1.07	0.98	0.76	0.91	0.88
5^-Methylthioadenosine	ME1136455	1.66	1.37	0.86	0.94	0.77	1.39	0.69	0.58	1.20	0.79
Melatonin	ME1136567	1.42	1.03	0.86	1.03	0.77	1.54	0.64	0.69	1.16	0.77
9-Hexadecenoylcarnitine	ME1136470	1.20	1.13	1.08	0.89	0.62	0.84	0.80	0.58	1.58	1.40
Tryptophan	ME1136636	1.33	1.56	0.98	1.02	0.90	1.11	0.91	0.79	0.97	0.86
Acetylcarnitine	ME1136472	1.54	1.47	1.26	0.91	0.75	0.96	0.92	0.77	0.97	0.87
Hydroxybutyrylcarnitine	ME1136548	1.49	1.67	1.20	0.95	0.76	0.99	0.98	0.78	0.91	0.84
4-Hydroxyproline	ME1136453	1.45	1.59	1.10	0.98	0.80	1.01	0.81	0.66	1.10	0.96
S-Adenosylmethionine	ME1136619	1.46	1.82	1.11	1.01	0.80	1.02	0.81	0.68	1.05	0.90
Hexanoylcarnitine	ME1136543	1.67	1.78	1.19	1.00	0.78	0.89	0.78	0.67	1.00	0.89
Niacinamide	ME1136592	1.75	1.60	1.09	0.85	0.74	0.96	0.78	0.66	1.12	0.91
Propionylcarnitine	ME1136613	1.43	2.02	1.16	1.02	0.99	0.99	0.89	0.83	0.74	0.74
Butyrylcarnitine	ME1136492	1.53	1.96	1.14	1.01	0.87	0.98	0.85	0.76	0.91	0.75
N-Acetylaspartic acid	ME1136576	1.53	2.02	1.21	0.89	0.82	0.94	0.85	0.83	0.83	0.90
Choline	ME1136499	1.32	1.74	1.22	0.77	0.83	1.03	0.78	0.75	1.04	1.13
Butyrobetaine	ME1136491	1.26	2.01	1.19	0.86	0.87	1.01	0.74	0.88	0.90	1.08
Thiamine	ME1136631	1.35	2.14	1.21	0.89	0.78	1.06	0.72	0.71	1.06	0.98
Valine	ME1136644	1.34	1.79	0.89	1.04	0.97	0.74	0.89	0.60	1.19	1.12
Asymmetric dimethylarginine	ME1136487	1.13	1.24	1.10	0.89	0.77	0.99	0.91	0.75	1.30	1.12
Pyridoxamine	ME1136616	1.21	1.25	1.00	0.82	0.84	0.93	0.99	0.82	1.23	1.09
Methionine S-oxide	ME1136569	1.35	1.29	0.99	0.87	0.84	0.97	0.99	0.78	1.25	0.89
Serine	ME1136621	1.49	1.24	1.06	0.82	0.76	0.98	0.84	0.72	1.25	1.04
N-Acetylserine	ME1136581	1.11	1.48	0.99	0.74	0.66	0.99	0.62	0.66	1.60	1.36
Creatine	ME1136503	1.17	1.44	1.07	0.82	0.78	0.89	0.75	0.65	1.44	1.32
Asparagine	ME1136484	1.20	1.42	1.11	0.85	0.75	0.97	0.76	0.67	1.29	1.32
Glutamine	ME1136535	1.23	1.48	1.04	0.85	0.74	1.00	0.78	0.63	1.39	1.22
5-Hydroxytryptophan	ME1136458	1.31	1.75	1.05	0.96	0.70	0.96	0.88	0.58	1.40	0.88
N6,N6,N6-Trimethyllysine	ME1136590	1.32	1.59	1.18	0.80	0.64	0.95	0.77	0.58	1.50	1.16
Glycine	ME1136540	1.32	1.66	1.09	0.75	0.75	0.94	0.82	0.66	1.33	1.21
Homoserine	ME1136547	1.33	1.56	1.07	0.80	0.70	0.98	0.79	0.63	1.38	1.19
Methionine	ME1136568	1.39	1.75	1.20	0.84	0.74	0.96	0.75	0.66	1.20	1.12
Epinephrine	ME1136526	1.38	1.70	1.11	0.85	0.73	0.99	0.80	0.64	1.26	1.08
Phenylalanine	ME1136607	1.36	1.66	1.10	0.88	0.75	0.99	0.80	0.65	1.23	1.09
Alanine	ME1136478	1.42	1.61	1.17	0.85	0.70	0.98	0.73	0.70	1.19	1.16
Leucine	ME1136561	1.34	1.64	1.15	0.82	0.71	0.99	0.76	0.66	1.27	1.17
Sarcosine	ME1136620	1.37	1.59	1.18	0.85	0.73	1.00	0.77	0.65	1.22	1.14
Tyrosine	ME1136637	1.45	1.76	1.10	0.88	0.70	0.98	0.72	0.57	1.40	1.03
Proline	ME1136612	1.34	1.75	1.18	0.80	0.70	0.94	0.79	0.60	1.38	1.12
Threonine	ME1136632	1.44	1.74	1.11	0.79	0.67	1.03	0.70	0.58	1.33	1.19
Histidine	ME1136545	1.32	1.47	1.13	0.94	0.77	0.97	0.86	0.65	1.25	1.09
1-Methylhistidine	ME1136436	1.36	1.48	1.15	0.86	0.68	1.05	0.86	0.62	1.36	0.99
Pyroglutamic acid	ME1136617	1.25	1.60	1.18	0.83	0.66	1.01	0.88	0.61	1.40	1.07
Lysine	ME1136564	1.31	1.66	1.22	0.93	0.73	0.93	0.92	0.67	1.29	0.95
Ornithine	ME1136602	1.24	1.54	1.20	0.95	0.73	1.09	1.00	0.62	1.25	0.89

Factors:

F1	Genotype:GPR34-KO \| Treatment:Myelin \| Sample source:iMicroglia
F2	Genotype:GPR34 KO \| Treatment:PBS \| Sample source:iMicroglia
F3	Genotype:GPR34-KO \| Treatment:PBS \| Sample source:iMicroglia
F4	Genotype:GPR34/TREM2-KO \| Treatment:Myelin \| Sample source:iMicroglia
F5	Genotype:GPR34/TREM2-KO \| Treatment:PBS \| Sample source:iMicroglia
F6	Genotype:NA \| Treatment:NA \| Sample source:iMicroglia
F7	Genotype:TREM2-KO \| Treatment:Myelin \| Sample source:iMicroglia
F8	Genotype:TREM2-KO \| Treatment:PBS \| Sample source:iMicroglia
F9	Genotype:WT \| Treatment:Myelin \| Sample source:iMicroglia
F10	Genotype:WT \| Treatment:PBS \| Sample source:iMicroglia

Data matrix